61 completed, 33 unknown, 17 not yet recruiting, 5 active not recruiting. 69 Not applicable, 21 Phase 4, 16 Phase 2, 10 Phase 3, 9 Phase 1.
Follow Melasma: new trials by email Literature Review of Melasma trials Research Report on Melasma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Baseline Dermoscopic Vascular Score and Response to Oral Tranexamic Acid in Facial Melasma Tranexamic acid, Standardised sunscreen and emollient - Melasma | Phase 4 | Not yet recruiting | Allied Hospital Faisalabad | 128 | 2026-11-01 | 2026-10-19 |
| COMPARISON OF TOPICAL VITAMIN C VS NIACINAMIDE IN TREATMENT OF MELASMA Ascorbic acid, niacinamide - Melasma | Not applicable | Not yet recruiting | Pak Emirates Military Hospital | 100 | 2026-11-01 | 2026-10-22 |
| New Treatment in Melasma Tranexamic Acid - topical, Microneedling with Topical Tranexamic acid, Modified Kligman's Formula - Female, With | Not applicable | Not yet recruiting | Sohag University | 75 | 2026-10-18 | 2026-10-21 |
| Clinical Efficacy and Mechanisms of a Topical Azone-Tranexamic Acid-Aloe Polysaccharide Gel in the Treatment of Melasma Ligustrazine - tranexamic acid - aloe polysaccharide composite gel - Melasma, Treatment of Stable Melasma | Not applicable | Not yet recruiting | The First Affiliated Hospital of Xinxiang Medical College | 10 | 2026-08-12 | 2026-04-14 |
| Oral Tranexamic Acid Plus Triple Combination vs Triple Combination Alone in Melasma Oral tranexamic acid + triple combination cream (fluocinolone acetonide + hydroquinone + tretinoin), Triple combination cream (fluocinolone acetonide + hydroquinone + tretinoin) alone - Melasma, Melasma (Facial Melasma) | Phase 4 | Not yet recruiting | Combined Military Hospital Abbottabad | 128 | 2026-07-15 | 2026-07-28 |
| Comparative Evaluation of Topical 30% Metformin and Kligman's Regimen in Women With Melasma Topical 30% metformin cream, Kligman's Regimen - Melasma (Facial Melasma), Melasma | Not applicable | Not yet recruiting | Foundation University Islamabad | 82 | 2026-07-01 | 2026-03-20 |
| Comparative Evaluation of Topical Metformin and Topical Tranexamic Acid in Melasma topical 3% tranexamic acid solution, Topical 30% metformin cream - Melasma | Not applicable | Not yet recruiting | Foundation University Islamabad | 70 | 2026-07-01 | 2026-03-27 |
| Efficacy and Safety of a Combined Topical Formula Versus Placebo in Patients With Melasma Topical azelaic acid 12% plus tranexamic acid 5%, Placebo topical formulation - Melasma | Not applicable | Completed | University of Guadalajara | 40 | 2026-06-12 | 2026-07-27 |
| A Clinical Study to Evaluate the Efficacy in Improving Dark Spots After 8 Weeks of Use of Facial Sunscreens in Adult Participants Sunscreen untinted, Sunscreen tinted - Post-inflammatory Hyperpigmentation, Melasma | Not applicable | Recruiting | Kenvue Brands LLC | 152 | 2026-06-02 | 2026-07-01 |
| Comparison Between Efficacy of Topical Tranexamic Acid Vs Topical Ethyl Ascorbic Acid In Treatment Of Melasma Ethyl ascorbic acid topical application, Tranxemic acid topical application - Melasma | Phase 4 | Not yet recruiting | Hayatabad Medical Complex | 128 | 2026-06-01 | 2026-04-13 |
| Expert Consensus on the Clinical Management of Melasma: A Delphi Method Study Melasma, Melasma (Facial Melasma) | Enrolling by invitation | Venus Research Center | 15 | 2026-06-01 | 2025-12-29 | |
| Comparative Efficacy of Intralesional Tranexamic Acid Versus Mandelic Acid Peel in the Treatment of Melasma Mandelic Acid Peel, Intralesional Tranexamic Acid - Melasma | Not applicable | Not yet recruiting | Combined Military Hospital Abbottabad | 120 | 2026-05-01 | 2026-05-28 |
| Evaluation of Efficacy and Tolerabilty of MelaB3 Serum in Combination of 35% Glycolic Acid Peeling Compared to 35% Glycolic Acid Peeling Alone in Various Hyperpigmentation Conditions Glycolic acid peel alone, MelaB3 serum - Hyperpigmentation, Melasma | Not applicable | Not yet recruiting | Cosmetique Active International | 80 | 2026-03-04 | 2026-02-24 |
| Secretome TGF Beta 3 Concentrated secretome Injection 3 mL, Concentrated secretome Injection 3 mL with addition of TGF Beta 3 - Melasma | Not applicable | Not yet recruiting | Universitas Indonesia | 34 | 2026-02-14 | 2025-08-22 |
| Evaluation of the Efficacy of Oral Tranexamic Acid and Glutathione-assisted Microneedling in Treatment of Melasma microneedling, Oral tranexamic acid, Glutathione - Melasma | Phase 2 / Phase 3 | Not yet recruiting | Assiut University | 42 | 2026-02-01 | 2026-03-04 |
| Injectable Platelet-Rich Fibrin Versus Intradermal Tranexamic Acid for Melasma Injectable Platelet-Rich Fibrin, Tranexamic acid 100 mg/mL (Kapron) - Melasma, Facial Melasma | Not applicable | Recruiting | Kasr El Aini Hospital | 21 | 2026-02-01 | 2026-04-22 |
| Microfocused Ultrasound for Facial Pigmentary Diseases and Rosacea Microfocused Ultrasound Treatment, Sham Microfocused Ultrasound Stimulation - Melasma, Rosacea | Not applicable | Active not recruiting | Xiangya Hospital of Central South University | 200 | 2025-10-01 | 2026-06-30 |
| Efficacy and Safety of a Combined Serum Containing Melasyl™, 10% Niacinamide, Hyaluronic Acid, and HEPES a combination serum containing Melasyl™, 10% Niacinamide, Hyaluronic Acid, and HEPES, 2% hydroquinone cream - Melasma, Post-acne Hyperpigmentation | Not applicable | Not yet recruiting | Dr.dr.Irma Bernadette, SpKK (K) | 68 | 2025-09-15 | 2025-08-13 |
| A 4-week Study Investigating Two Targeted Brightening Serum (A and B) Versus 4% Hydroquinone in Women With Mild to Severe Full-face Hyperpigmentation Facial Cleanser, Facial Moisturizer, Sunscreen SPF 55 - Hyperpigmentation, Melasma | Not applicable | Completed | Revision Skincare | 18 | 2025-08-11 | 2026-06-12 |
| Comparative Efficacy of Resveratrol 1 % Gel and Trichloroacetic Acid 20% in Treatment of Melasma: A Split-face Study resveratrol 1 % gel, TCA20% - Melasma | Not applicable | Not yet recruiting | Assiut University | 41 | 2025-07-22 | 2025-07-11 |
Showing 20 of 130. Sign in to see all of them.
Melanosis (130) · Hyperpigmentation (14) · Pigmentation Disorders (3) · Rosacea (3) · Acne Vulgaris (2) · Facies (2) · Lentigo (2) · Vitiligo (2) · Dermatitis, Seborrheic (1) · Exanthema (1) · Hyperthyroidism (1) · Hypertrophy (1) · Hypopigmentation (1) · Inflammation (1) · Margins of Excision (1)
Skin Diseases (130) · Skin and Connective Tissue Diseases (130) · Pigmentation Disorders (127) · Hyperpigmentation (116) · Pathological Conditions, Signs and Symptoms (9) · Pathologic Processes (7) · Disease Attributes (3) · Acneiform Eruptions (2) · Sebaceous Gland Diseases (2) · Dermatitis (1) · Endocrine System Diseases (1) · Hypopigmentation (1) · Metaplasia (1) · Morphological and Microscopic Findings (1) · Pathological Conditions, Anatomical (1)
Tranexamic Acid (18) · hydroquinone (16) · Tretinoin (8) · Fluocinolone Acetonide (5) · Percutaneous Collagen Induction (5) · Metformin (4) · Lasers (3) · Lasers, Solid-State (3) · Niacinamide (3) · Sunscreening Agents (3) · Ascorbic Acid (2) · Laser Therapy (2) · Saline Solution (2) · Silymarin (2) · Tablets (2)
Assiut University (11) · Universidad Autonoma de San Luis Potosí (6) · Combined Military Hospital Abbottabad (5) · Universitas Indonesia (5) · Centre Hospitalier Universitaire de Nice (4) · Cosmetique Active International (4) · Dr.dr.Irma Bernadette, SpKK (K) (4) · Galderma R&D (4) · Cynosure, Inc. (3) · CynosureLutronic (3) · Cairo University (2) · China Medical University Hospital (2) · Foundation University Islamabad (2) · Fujian Medical University Union Hospital (2) · Jinnah Postgraduate Medical Centre (2)
United States (26) · Pakistan (15) · Egypt (10) · Indonesia (10) · China (9) · Mexico (9) · Brazil (8) · France (4) · Singapore (3) · Taiwan (2) · Thailand (2) · Austria (1) · Canada (1) · Cuba (1) · El Salvador (1)
Bertha Torres-Alvarez, MD (2) · Irma B Sitohang, MD, PhD (2) · Juan P Castanedo-Cazares, MD (2) · Kari Larson, MBA (2) · Murad Alam, MD (2) · Patricia Krantz (2) · Ronald W Gottschalk, MD (2) · Adriana Rodriguez-Arambula, MD (1) · Alaa H Ghazally, MD (1) · Alfredo Abreu Daniel, PhD (1) · Ali Amar, MBBS, FCPS(dermatology), CHPE (1) · Ali Amar, MBBS, FCPS, CHPE (1) · Amalia Reyes-Herrera, M.D. (1) · Amara Safdar, MBBS, FCPS (1)
PMID 25068546, PMID 25184917, PMID 18419607, PMID 20083690, PMID 20398959, PMID 20514787, PMID 21920241, PMID 21920242, PMID 24629163, PMID 24746304, PMID 24756109, PMID 24858737, PMID 25396122, PMID 25396123, PMID 25715311, PMID 25787765, PMID 26381025, PMID 26479922, PMID 26955093, PMID 27206758, PMID 28726212, PMID 28748406, PMID 28842328, PMID 29386825, PMID 30422338, PMID 30779300, PMID 31097585, PMID 31354327, PMID 31502392, PMID 31603285, PMID 31779194, PMID 31802394, PMID 31887321, PMID 32443482, PMID 32649234, PMID 32720446, PMID 32856757, PMID 33633737, PMID 33741391, PMID 33849384, PMID 34844552, PMID 35357753, PMID 36345697, PMID 37365922, PMID 37479524, PMID 38192412, PMID 38416809, PMID 38896402, PMID 39369111, PMID 40586974
2019 (1)