158 completed, 65 unknown, 21 not yet recruiting, 18 recruiting. 155 Not applicable, 39 Phase 2, 36 Phase 4, 19 Phase 3, 15 Phase 1.
Follow Hyperpigmentation: new trials by email Literature Review of Hyperpigmentation trials Research Report on Hyperpigmentation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Baseline Dermoscopic Vascular Score and Response to Oral Tranexamic Acid in Facial Melasma Tranexamic acid, Standardised sunscreen and emollient - Melasma | Phase 4 | Not yet recruiting | Allied Hospital Faisalabad | 128 | 2026-11-01 | 2026-10-19 |
| COMPARISON OF TOPICAL VITAMIN C VS NIACINAMIDE IN TREATMENT OF MELASMA Ascorbic acid, niacinamide - Melasma | Not applicable | Not yet recruiting | Pak Emirates Military Hospital | 100 | 2026-11-01 | 2026-10-22 |
| New Treatment in Melasma Tranexamic Acid - topical, Microneedling with Topical Tranexamic acid, Modified Kligman's Formula - Female, With | Not applicable | Not yet recruiting | Sohag University | 75 | 2026-10-18 | 2026-10-21 |
| Chinese Multicenter Registry for Peutz-Jeghers Syndrome Peutz-Jeghers Syndrome | Not yet recruiting | First People's Hospital of Hangzhou | 1000 | 2026-10-01 | 2026-10-22 | |
| Foam Sclerotherapy With or Without Transdermal Laser for Reticular Veins and Telangiectasias Polidocanol foam sclerotherapy, Transdermal 1064 nm Nd:YAG Laser - Telangiectasias, Reticular Veins | Phase 4 | Recruiting | University of Sao Paulo | 70 | 2026-09-01 | 2026-10-05 |
| Topical Metformin Versus Triple Regimen for Epidermal Melasma Topical 30% metformin cream, Topical Triple Regimen - Epidermal Melasma, Facial Hyperpigmentation | Phase 2 | Not yet recruiting | Combined Military Hospital, Pakistan | 104 | 2026-08-15 | 2026-08-21 |
| Clinical Efficacy and Mechanisms of a Topical Azone-Tranexamic Acid-Aloe Polysaccharide Gel in the Treatment of Melasma Ligustrazine - tranexamic acid - aloe polysaccharide composite gel - Melasma, Treatment of Stable Melasma | Not applicable | Not yet recruiting | The First Affiliated Hospital of Xinxiang Medical College | 10 | 2026-08-12 | 2026-04-14 |
| Efficacy and Safety Of Fractional Carbon Dioxide Laser Plus Topical Metformin In Treatment Of Acanthosis Nigricans Topical metformin - Acanthosis Nigricans | Phase 1 | Not yet recruiting | Al-Azhar University | 34 | 2026-08-10 | 2026-08-12 |
| Oral Tranexamic Acid Plus Triple Combination vs Triple Combination Alone in Melasma Oral tranexamic acid + triple combination cream (fluocinolone acetonide + hydroquinone + tretinoin), Triple combination cream (fluocinolone acetonide + hydroquinone + tretinoin) alone - Melasma, Melasma (Facial Melasma) | Phase 4 | Not yet recruiting | Combined Military Hospital Abbottabad | 128 | 2026-07-15 | 2026-07-28 |
| Efficacy Evaluation of a Cosmetic Product for Facial Hyperpigmentation Blancy Pro - Hyperpigmentation, Melasma (Facial Melasma) | Not applicable | Recruiting | Brainfarma Industria Química e Farmacêutica S/A | 40 | 2026-07-13 | 2026-09-16 |
| Microneedling-Assisted Metformin, Tranexamic Acid, and Modified Kligman's Formula for Melasma Metformin 30% Topical Lotion, Tranexamic Acid 0.5% Topical Solution, Modified Kligman's Formula - Melasma (Facial Melasma) | Phase 4 | Enrolling by invitation | Sameh Sarsik | 80 | 2026-07-10 | 2026-07-28 |
| Comparative Evaluation of Topical 30% Metformin and Kligman's Regimen in Women With Melasma Topical 30% metformin cream, Kligman's Regimen - Melasma (Facial Melasma), Melasma | Not applicable | Not yet recruiting | Foundation University Islamabad | 82 | 2026-07-01 | 2026-03-20 |
| Comparative Evaluation of Topical Metformin and Topical Tranexamic Acid in Melasma topical 3% tranexamic acid solution, Topical 30% metformin cream - Melasma | Not applicable | Not yet recruiting | Foundation University Islamabad | 70 | 2026-07-01 | 2026-03-27 |
| Efficacy and Safety of a Combined Topical Formula Versus Placebo in Patients With Melasma Topical azelaic acid 12% plus tranexamic acid 5%, Placebo topical formulation - Melasma | Not applicable | Completed | University of Guadalajara | 40 | 2026-06-12 | 2026-07-27 |
| A Clinical Study to Evaluate the Efficacy in Improving Dark Spots After 8 Weeks of Use of Facial Sunscreens in Adult Participants Sunscreen untinted, Sunscreen tinted - Post-inflammatory Hyperpigmentation, Melasma | Not applicable | Recruiting | Kenvue Brands LLC | 152 | 2026-06-02 | 2026-07-01 |
| Comparison Between Efficacy of Topical Tranexamic Acid Vs Topical Ethyl Ascorbic Acid In Treatment Of Melasma Ethyl ascorbic acid topical application, Tranxemic acid topical application - Melasma | Phase 4 | Not yet recruiting | Hayatabad Medical Complex | 128 | 2026-06-01 | 2026-04-13 |
| Expert Consensus on the Clinical Management of Melasma: A Delphi Method Study Melasma, Melasma (Facial Melasma) | Enrolling by invitation | Venus Research Center | 15 | 2026-06-01 | 2025-12-29 | |
| Comparative Efficacy of Intralesional Tranexamic Acid Versus Mandelic Acid Peel in the Treatment of Melasma Mandelic Acid Peel, Intralesional Tranexamic Acid - Melasma | Not applicable | Not yet recruiting | Combined Military Hospital Abbottabad | 120 | 2026-05-01 | 2026-05-28 |
| Study on the Functional Impact of Cosmetics on Improving Self-Esteem and Quality of Life in Black Women Niacinamide and Bioceramide-Based Skincare Regimen - Post-inflammatory Hyperpigmentation | Not applicable | Recruiting | Hospital Israelita Albert Einstein | 60 | 2026-03-19 | 2026-06-04 |
| Evaluation of Efficacy and Tolerabilty of MelaB3 Serum in Combination of 35% Glycolic Acid Peeling Compared to 35% Glycolic Acid Peeling Alone in Various Hyperpigmentation Conditions Glycolic acid peel alone, MelaB3 serum - Hyperpigmentation, Melasma | Not applicable | Not yet recruiting | Cosmetique Active International | 80 | 2026-03-04 | 2026-02-24 |
Showing 20 of 294. Sign in to see all of them.
Melanosis (169) · Peutz-Jeghers Syndrome (22) · Acanthosis Nigricans (18) · Acne Vulgaris (14) · Lentigo (13) · Colorectal Neoplasms, Hereditary Nonpolyposis (9) · Skin Diseases (9) · Pigmentation Disorders (8) · Pancreatic Neoplasms (7) · Obesity (6) · Telangiectasis (6) · Vitiligo (6) · Cicatrix (4) · Dysplastic Nevus Syndrome (4)
Skin and Connective Tissue Diseases (294) · Pigmentation Disorders (286) · Skin Diseases (285) · Melanosis (52) · Pathological Conditions, Signs and Symptoms (39) · Neoplasms (31) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (28) · Genetic Diseases, Inborn (25) · Lentigo (24) · Digestive System Diseases (23) · Neoplastic Syndromes, Hereditary (23) · Pathologic Processes (23) · Gastrointestinal Diseases (22) · Intestinal Diseases (22)
Tranexamic Acid (25) · hydroquinone (19) · Tretinoin (11) · Metformin (9) · Lasers (6) · Percutaneous Collagen Induction (6) · Fluocinolone Acetonide (5) · Niacinamide (5) · Sunscreening Agents (5) · Lasers, Solid-State (4) · Saline Solution (4) · glycolic acid (4) · 3-ingenyl angelate (3) · Gels (3) · Melatonin (3)
Cosmetique Active International (13) · Assiut University (11) · Cryonove Pharma (9) · Universidad Autonoma de San Luis Potosí (7) · Centre Hospitalier Universitaire de Nice (6) · Universitas Indonesia (6) · Cairo University (5) · Combined Military Hospital Abbottabad (5) · Northwestern University (5) · Dr.dr.Irma Bernadette, SpKK (K) (4) · Galderma R&D (4) · Henry Ford Health System (4) · Jinnah Postgraduate Medical Centre (4) · Revision Skincare (4) · Cutera Inc. (3)
United States (82) · Pakistan (22) · China (21) · Brazil (16) · Egypt (16) · France (12) · Indonesia (12) · Mexico (12) · Thailand (7) · India (4) · Singapore (4) · South Africa (4) · Taiwan (4) · Italy (3) · Malaysia (3)
Murad Alam, MD (5) · Bertha Torres-Alvarez, MD (4) · Juan P Castanedo-Cazares, MD (3) · Iltefat Hamzavi, MD (2) · Irma B Sitohang, MD, PhD (2) · Jared Jagdeo, MD MS (2) · Kari Larson, MBA (2) · Nayan Patel (2) · Patricia Krantz (2) · Ronald W Gottschalk, MD (2) · Sergio Schalka (2) · Thierry Passeron, PhD (2)
PMID 25184917, PMID 25068546, PMID 28726212, PMID 11096382, PMID 16631967, PMID 17199653, PMID 17875874, PMID 18021205, PMID 18419607, PMID 19043850, PMID 20083690, PMID 20398959, PMID 20458532, PMID 20514787, PMID 20981308, PMID 21384391, PMID 21920241, PMID 21920242, PMID 22154461, PMID 22676819, PMID 23003920, PMID 23200980, PMID 24292155, PMID 24629163, PMID 24746304, PMID 24756109, PMID 24854088, PMID 24858737, PMID 25251767, PMID 25396122, PMID 25396123, PMID 25481712, PMID 25715311, PMID 25787765, PMID 26367281, PMID 26381025, PMID 26479922, PMID 26955093, PMID 27206758, PMID 28678558, PMID 28748406, PMID 28805671, PMID 28842328, PMID 29020467, PMID 29371475, PMID 29386825, PMID 29706998, PMID 30215845, PMID 30320904, PMID 30422338
2018 (1), 2019 (1), M01RR006022 (1), R01CA176828 (1), U01CA210170 (1)