8 completed, 8 unknown, 3 not yet recruiting, 1 active not recruiting. 21 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 21 | Completed 8, Unknown 8, Not yet recruiting 3, Active not recruiting 1, Terminated 1 |
Follow Melasma: new trials by email Literature Review of Melasma trials Research Report on Melasma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Baseline Dermoscopic Vascular Score and Response to Oral Tranexamic Acid in Facial Melasma Tranexamic acid, Standardised sunscreen and emollient - Melasma | Phase 4 | Not yet recruiting | Allied Hospital Faisalabad | 128 | 2026-11-01 | 2026-10-19 |
| Oral Tranexamic Acid Plus Triple Combination vs Triple Combination Alone in Melasma Oral tranexamic acid + triple combination cream (fluocinolone acetonide + hydroquinone + tretinoin), Triple combination cream (fluocinolone acetonide + hydroquinone + tretinoin) alone - Melasma, Melasma (Facial Melasma) | Phase 4 | Not yet recruiting | Combined Military Hospital Abbottabad | 128 | 2026-07-15 | 2026-07-28 |
| Comparison Between Efficacy of Topical Tranexamic Acid Vs Topical Ethyl Ascorbic Acid In Treatment Of Melasma Ethyl ascorbic acid topical application, Tranxemic acid topical application - Melasma | Phase 4 | Not yet recruiting | Hayatabad Medical Complex | 128 | 2026-06-01 | 2026-04-13 |
| Efficacy of New Trio Combination for Melasma New trio combination, Kligman's formula (trio) - Melasma | Phase 4 | Completed | Ghurki Trust and Teaching Hospital | 56 | 2025-05-07 | 2026-06-30 |
| Effectiveness of Oral Melatonin vs Oral Tranexamic Acid in the Treatment and Recurrence of Melasma Tranexamic Acid (TXA), melatonin (Circadin), Placebo - Melasma, Treatment Outcome | Phase 4 | Active not recruiting | Thammasat University | 75 | 2024-11-12 | 2025-06-24 |
| Silymarin Cream Versus Combined Silymarin Cream and Microneedling in Treatment of Melasma Silymarin, Microneedling - Melasma | Phase 4 | Unknown | Assiut University | 30 | 2022-05-01 | 2021-10-29 |
| Trichloroacetic Acid (TCA) Combined With Microdermabrasion in Treatment of Melasma TCA - Melasma | Phase 4 | Unknown | Assiut University | 60 | 2021-04-01 | 2021-03-30 |
| Different Dermatological Approaches the Treatment of Melasma chemicalpeeling, cryopeeling, microneedling - Melasma | Phase 4 | Unknown | Assiut University | 40 | 2020-02-01 | 2020-01-13 |
| Tranexamic Acid vs. Combination With Fractional Carbon Dioxide Laser in Melasma Fractional CO2 laser, Tranexamic acid intradermal microinjections - Melasma | Phase 4 | Unknown | Cairo University | 25 | 2019-04-01 | 2019-04-02 |
| USE THE SYSTEMIC METFORMIN IN MELASMA MetFORMIN 1000 Mg Oral Tablet, Placebos, Trichloroacetic Acid Peeling - Melasma | Phase 4 | Unknown | Assiut University | 60 | 2019-04-01 | 2021-08-03 |
| Oral Tranexamic Acid and Laser for Treatment of Melasma Tranexamic Acid - Melasma | Phase 4 | Unknown | Laser and Skin Surgery Center of New York | 32 | 2018-10-01 | 2018-09-27 |
| Modified Jessner's Solution With Trichloroacetic Acid Versus Glycolic Acid With Trichloroacetic Acid Modified Jessner's solution, Glycolic acid, Trichloroacetic acid - Melasma | Phase 4 | Unknown | Assiut University | 30 | 2018-03-15 | 2018-01-25 |
| Evaluation of an Herbal-Based De-Pigmenting System Herbal depigmenting agent (Epionce), Hydroquinone - Melasma, Hyperpigmentation | Phase 4 | Completed | Sadick Research Group | 28 | 2013-10-01 | 2015-11-18 |
| Ultraviolet and UV-Visible Light Photoprotection for the Treatment of Melasma 290-400 nm sunscreen, 290-800 nm sunscreen - Melasma | Phase 4 | Completed | Universidad Autonoma de San Luis Potosí | 68 | 2012-09-01 | 2014-12-02 |
| Clinical Trial of Hydroquinone Versus Miconazol in Melasma Miconazole, Hydroquinone - Melasma | Phase 4 | Unknown | Universidad Autonoma de San Luis Potosí | 60 | 2011-10-01 | 2014-12-02 |
| Treatment w/ Tri-Luma® Cream & Intense Pulsed Light (IPL) vs a Mild Inactive Control Cream & Intense Pulsed Light (IPL) in Melasma Fluocinolone acetonide 0.01%, hydroquinone 4%, tretinoin 0.05%, Cetaphil® Moisturizing Cream as Inactive Control - Melasma | Phase 4 | Terminated | Galderma R&D | 56 | 2008-01-01 | 2022-08-23 |
| Salicylic Acid Peels Combined With 4% Hydroquinone in the Treatment of Moderate to Severe Melasma in Hispanic Women 20-30% Salicylic Acid peels to the right side of the face, 20-30% Salicylic Acid peels to the left side of the face - Melasma | Phase 4 | Completed | University of Texas Southwestern Medical Center | 20 | 2008-01-01 | 2020-08-10 |
| Treatment of Melasma With Jessner's Solution vs. Trichloroacetic Acid Jessner's solution chemical peel, Trichloroacetic acid chemical peel - Melasma | Phase 4 | Completed | Emory University | 19 | 2008-01-01 | 2013-11-14 |
| Comparison of Two Tri-Luma® Maintenance Regimens in the Treatment of Melasma Tri-Luma Maintenance regimen - Melasma | Phase 4 | Completed | Galderma R&D | 340 | 2006-11-01 | 2021-02-17 |
| Efficacy and Safety of Therapy With Tri-Luma® Cream in Sequence With Glycolic Acid Peels for Melasma Fluocinolone acetonide 0.1%/hydroquinone 4%/tretinoin 0.05% Cream in sequence with glycolic acid peels - Melasma | Phase 4 | Completed | Galderma R&D | 20 | 2006-11-01 | 2022-07-29 |
Showing 20 of 21. Sign in to see all of them.
Melanosis (21) · Hyperpigmentation (4) · Pigmentation Disorders (1) · Recurrence (1)
Skin Diseases (21) · Skin and Connective Tissue Diseases (21) · Pigmentation Disorders (20) · Hyperpigmentation (17) · Disease Attributes (1) · Pathologic Processes (1) · Pathological Conditions, Signs and Symptoms (1)
hydroquinone (6) · Fluocinolone Acetonide (4) · Tranexamic Acid (4) · Percutaneous Collagen Induction (2) · Tretinoin (2) · Base Sequence (1) · Chemexfoliation (1) · Clotrimazole (1) · Emollients (1) · Melatonin (1) · Metformin (1) · Miconazole (1) · Proto-Oncogene Proteins c-raf (1) · Shade UVAGuard (1) · Silymarin (1)
Assiut University (5) · Galderma R&D (4) · Universidad Autonoma de San Luis Potosí (2) · Allied Hospital Faisalabad (1) · Cairo University (1) · Combined Military Hospital Abbottabad (1) · Emory University (1) · Ghurki Trust and Teaching Hospital (1) · Hayatabad Medical Complex (1) · Laser and Skin Surgery Center of New York (1) · Sadick Research Group (1) · Thammasat University (1) · University of Texas Southwestern Medical Center (1)
United States (7) · Mexico (3) · Pakistan (2) · Brazil (1) · Egypt (1) · Thailand (1)
Ronald W Gottschalk, MD (2) · Ali Amar, MBBS, FCPS, CHPE (1) · Amalia Reyes-Herrera, M.D. (1) · Amara Safdar, MBBS, FCPS (1) · Amit Pandya, M.D. (1) · Assoc. Prof. Premjit Juntongjin, MD (1) · Bertha Torres-Alvarez, M.D. (1) · Bertha Torres-Alvarez, MD (1) · Carl Washington, MD (1) · Diana Hernandez-Blanco, MD (1) · Dr Aliza Hamadani (1) · Dr. Ayesha Asad Chattha (1) · Dr. Iram Kausar (1) · Dr. Meshaal Azhar (1) · Ereny Ramsis, Master (1)
PMID 20398959, PMID 21920241, PMID 21920242, PMID 24629163, PMID 24756109, PMID 25068546, PMID 25184917, PMID 25396123, PMID 26955093, PMID 29386825, PMID 38416809