107 completed, 55 unknown, 20 not yet recruiting, 13 recruiting. 110 Not applicable, 31 Phase 2, 29 Phase 4, 14 Phase 3, 11 Phase 1.
Follow Melanosis: new trials by email Literature Review of Melanosis trials Research Report on Melanosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Baseline Dermoscopic Vascular Score and Response to Oral Tranexamic Acid in Facial Melasma Tranexamic acid, Standardised sunscreen and emollient - Melasma | Phase 4 | Not yet recruiting | Allied Hospital Faisalabad | 128 | 2026-11-01 | 2026-10-19 |
| COMPARISON OF TOPICAL VITAMIN C VS NIACINAMIDE IN TREATMENT OF MELASMA Ascorbic acid, niacinamide - Melasma | Not applicable | Not yet recruiting | Pak Emirates Military Hospital | 100 | 2026-11-01 | 2026-10-22 |
| New Treatment in Melasma Tranexamic Acid - topical, Microneedling with Topical Tranexamic acid, Modified Kligman's Formula - Female, With | Not applicable | Not yet recruiting | Sohag University | 75 | 2026-10-18 | 2026-10-21 |
| Chinese Multicenter Registry for Peutz-Jeghers Syndrome Peutz-Jeghers Syndrome | Not yet recruiting | First People's Hospital of Hangzhou | 1000 | 2026-10-01 | 2026-10-22 | |
| Topical Metformin Versus Triple Regimen for Epidermal Melasma Topical 30% metformin cream, Topical Triple Regimen - Epidermal Melasma, Facial Hyperpigmentation | Phase 2 | Not yet recruiting | Combined Military Hospital, Pakistan | 104 | 2026-08-15 | 2026-08-21 |
| Clinical Efficacy and Mechanisms of a Topical Azone-Tranexamic Acid-Aloe Polysaccharide Gel in the Treatment of Melasma Ligustrazine - tranexamic acid - aloe polysaccharide composite gel - Melasma, Treatment of Stable Melasma | Not applicable | Not yet recruiting | The First Affiliated Hospital of Xinxiang Medical College | 10 | 2026-08-12 | 2026-04-14 |
| Efficacy and Safety Of Fractional Carbon Dioxide Laser Plus Topical Metformin In Treatment Of Acanthosis Nigricans Topical metformin - Acanthosis Nigricans | Phase 1 | Not yet recruiting | Al-Azhar University | 34 | 2026-08-10 | 2026-08-12 |
| Oral Tranexamic Acid Plus Triple Combination vs Triple Combination Alone in Melasma Oral tranexamic acid + triple combination cream (fluocinolone acetonide + hydroquinone + tretinoin), Triple combination cream (fluocinolone acetonide + hydroquinone + tretinoin) alone - Melasma, Melasma (Facial Melasma) | Phase 4 | Not yet recruiting | Combined Military Hospital Abbottabad | 128 | 2026-07-15 | 2026-07-28 |
| Efficacy Evaluation of a Cosmetic Product for Facial Hyperpigmentation Blancy Pro - Hyperpigmentation, Melasma (Facial Melasma) | Not applicable | Recruiting | Brainfarma Industria Química e Farmacêutica S/A | 40 | 2026-07-13 | 2026-09-16 |
| Microneedling-Assisted Metformin, Tranexamic Acid, and Modified Kligman's Formula for Melasma Metformin 30% Topical Lotion, Tranexamic Acid 0.5% Topical Solution, Modified Kligman's Formula - Melasma (Facial Melasma) | Phase 4 | Enrolling by invitation | Sameh Sarsik | 80 | 2026-07-10 | 2026-07-28 |
| Comparative Evaluation of Topical 30% Metformin and Kligman's Regimen in Women With Melasma Topical 30% metformin cream, Kligman's Regimen - Melasma (Facial Melasma), Melasma | Not applicable | Not yet recruiting | Foundation University Islamabad | 82 | 2026-07-01 | 2026-03-20 |
| Comparative Evaluation of Topical Metformin and Topical Tranexamic Acid in Melasma topical 3% tranexamic acid solution, Topical 30% metformin cream - Melasma | Not applicable | Not yet recruiting | Foundation University Islamabad | 70 | 2026-07-01 | 2026-03-27 |
| Efficacy and Safety of a Combined Topical Formula Versus Placebo in Patients With Melasma Topical azelaic acid 12% plus tranexamic acid 5%, Placebo topical formulation - Melasma | Not applicable | Completed | University of Guadalajara | 40 | 2026-06-12 | 2026-07-27 |
| A Clinical Study to Evaluate the Efficacy in Improving Dark Spots After 8 Weeks of Use of Facial Sunscreens in Adult Participants Sunscreen untinted, Sunscreen tinted - Post-inflammatory Hyperpigmentation, Melasma | Not applicable | Recruiting | Kenvue Brands LLC | 152 | 2026-06-02 | 2026-07-01 |
| Comparison Between Efficacy of Topical Tranexamic Acid Vs Topical Ethyl Ascorbic Acid In Treatment Of Melasma Ethyl ascorbic acid topical application, Tranxemic acid topical application - Melasma | Phase 4 | Not yet recruiting | Hayatabad Medical Complex | 128 | 2026-06-01 | 2026-04-13 |
| Expert Consensus on the Clinical Management of Melasma: A Delphi Method Study Melasma, Melasma (Facial Melasma) | Enrolling by invitation | Venus Research Center | 15 | 2026-06-01 | 2025-12-29 | |
| Comparative Efficacy of Intralesional Tranexamic Acid Versus Mandelic Acid Peel in the Treatment of Melasma Mandelic Acid Peel, Intralesional Tranexamic Acid - Melasma | Not applicable | Not yet recruiting | Combined Military Hospital Abbottabad | 120 | 2026-05-01 | 2026-05-28 |
| Evaluation of Efficacy and Tolerabilty of MelaB3 Serum in Combination of 35% Glycolic Acid Peeling Compared to 35% Glycolic Acid Peeling Alone in Various Hyperpigmentation Conditions Glycolic acid peel alone, MelaB3 serum - Hyperpigmentation, Melasma | Not applicable | Not yet recruiting | Cosmetique Active International | 80 | 2026-03-04 | 2026-02-24 |
| Secretome TGF Beta 3 Concentrated secretome Injection 3 mL, Concentrated secretome Injection 3 mL with addition of TGF Beta 3 - Melasma | Not applicable | Not yet recruiting | Universitas Indonesia | 34 | 2026-02-14 | 2025-08-22 |
| Evaluation of the Efficacy of Oral Tranexamic Acid and Glutathione-assisted Microneedling in Treatment of Melasma microneedling, Oral tranexamic acid, Glutathione - Melasma | Phase 2 / Phase 3 | Not yet recruiting | Assiut University | 42 | 2026-02-01 | 2026-03-04 |
Showing 20 of 221. Sign in to see all of them.
Hyperpigmentation (30) · Peutz-Jeghers Syndrome (22) · Acanthosis Nigricans (18) · Lentigo (13) · Colorectal Neoplasms, Hereditary Nonpolyposis (9) · Pancreatic Neoplasms (7) · Obesity (6) · Pigmentation Disorders (6) · Dysplastic Nevus Syndrome (4) · Hereditary pancreatitis (4) · Keratosis, Actinic (4) · Melanoma (4) · Skin Diseases (4) · Acne Vulgaris (3)
Skin and Connective Tissue Diseases (221) · Skin Diseases (217) · Pigmentation Disorders (215) · Hyperpigmentation (191) · Neoplasms (29) · Pathological Conditions, Signs and Symptoms (26) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (24) · Lentigo (24) · Digestive System Diseases (23) · Genetic Diseases, Inborn (23) · Neoplastic Syndromes, Hereditary (23) · Gastrointestinal Diseases (22) · Intestinal Diseases (22) · Intestinal Polyposis (22)
Tranexamic Acid (22) · hydroquinone (19) · Tretinoin (10) · Metformin (9) · Fluocinolone Acetonide (5) · Percutaneous Collagen Induction (5) · Lasers (4) · Saline Solution (4) · Sunscreening Agents (4) · 3-ingenyl angelate (3) · Lasers, Solid-State (3) · Melatonin (3) · Niacinamide (3) · Secretin (3) · Trichloroacetic Acid (3)
Assiut University (11) · Cosmetique Active International (9) · Centre Hospitalier Universitaire de Nice (6) · Universidad Autonoma de San Luis Potosí (6) · Combined Military Hospital Abbottabad (5) · Northwestern University (5) · Universitas Indonesia (5) · Cairo University (4) · Dr.dr.Irma Bernadette, SpKK (K) (4) · Galderma R&D (4) · Jinnah Postgraduate Medical Centre (4) · Cryonove Pharma (3) · Cynosure, Inc. (3) · CynosureLutronic (3) · Goldman, Butterwick, Fitzpatrick and Groff (3)
United States (56) · China (20) · Pakistan (20) · Egypt (14) · Mexico (11) · Brazil (10) · Indonesia (10) · France (9) · Singapore (4) · Thailand (4) · India (3) · Italy (2) · Netherlands (2) · Taiwan (2) · Australia (1)
Murad Alam, MD (5) · Bertha Torres-Alvarez, MD (3) · Juan P Castanedo-Cazares, MD (3) · Irma B Sitohang, MD, PhD (2) · Kari Larson, MBA (2) · Patricia Krantz (2) · Ronald W Gottschalk, MD (2) · Sergio Schalka (2) · Thierry Passeron, PhD (2) · Adriana Rodriguez-Arambula, MD (1) · Aimee Lucas, MD, MS (1) · Alaa H Ghazally, MD (1) · Albert Wolkerstorfer, MD PhD (1)
PMID 25184917, PMID 25068546, PMID 28726212, PMID 11096382, PMID 16631967, PMID 18021205, PMID 18419607, PMID 20083690, PMID 20398959, PMID 20458532, PMID 20514787, PMID 21384391, PMID 21920241, PMID 21920242, PMID 22154461, PMID 23200980, PMID 24292155, PMID 24629163, PMID 24746304, PMID 24756109, PMID 24854088, PMID 24858737, PMID 25396122, PMID 25396123, PMID 25481712, PMID 25715311, PMID 25787765, PMID 26367281, PMID 26381025, PMID 26479922, PMID 26955093, PMID 27206758, PMID 28748406, PMID 28842328, PMID 29020467, PMID 29371475, PMID 29386825, PMID 29706998, PMID 30215845, PMID 30320904, PMID 30422338, PMID 30538291, PMID 30586845, PMID 30646266, PMID 30779300, PMID 31097585, PMID 31116404, PMID 31197699, PMID 31354327, PMID 31421157
2018 (1), 2019 (1), M01RR006022 (1), R01CA176828 (1), U01CA210170 (1)