32 completed, 12 unknown, 5 not yet recruiting, 4 recruiting. 21 Phase 2, 14 Phase 3, 12 Not applicable, 10 Phase 4, 7 Phase 1.
Follow Silymarin: new trials by email Literature Review of Silymarin trials Research Report on Silymarin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Vitamin E Versus Silymarin in Non Diabetic MASLD Patients Vitamin E 800 IU/d, Silymarin 420 mg, Placebo - Metabolic Dysfunction-Associated Steatoic Liver Disease | Phase 3 | Not yet recruiting | Kafrelsheikh University | 120 | 2026-10-16 | 2026-10-13 |
| Misocholic Tablets for Non-Viral Elevated Liver Enzymes Misocholic Tab, Placebo, Silymarin (Silybum marianum) - Alcohol-Related Liver Disease, Drug-Induced Liver Injury | Phase 3 | Not yet recruiting | Hanoi Medical University | 60 | 2026-09-15 | 2026-09-22 |
| Clinical Study Evaluating the Efficacy and Safety of Fenofibrates Versus Silymarin in Adult Patients With Sepsis Fenofibrate, Silymarin - Sepsis | Phase 2 | Not yet recruiting | Tanta University | 66 | 2026-05-01 | 2026-05-07 |
| Comparison of the Outcome of Treatment With Silymarin or N-Aceylcysteine in Patients Taking Anti-Tuberculous Drugs for Tuberculosis at a Tertiary Care Hospital , Karachi Silymarin 420 mg, N Acetyl Cysteine, Rifampicin (RMP) Ethambutol (E) Isoniazid (H) Pyrazinamid (Z) - Drug Induced Liver Injury, Tuberculosis (TB) | Phase 1 | Not yet recruiting | Liaquat National Hospital & Medical College | 410 | 2025-07-01 | 2025-07-10 |
| Glucocorticoids for Acute Drug Induced Liver Injury With Hyperbilirubinemia Methylprednisolone, Magnesium isoglycyrrhizinate, Glutathione - Drug Induced Liver Injury | Not applicable | Recruiting | General Hospital of Shenyang Military Region | 232 | 2025-06-24 | 2025-12-18 |
| Effect of Silymarin as Add on Therapy on Oxidative Stress, Pulmonary Function and Quality of Life in Stable COPD Patients. Silymarin, Placebo - COPD (Chronic Obstructive Pulmonary Disease) | Not applicable | Enrolling by invitation | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | 70 | 2025-06-20 | 2025-08-14 |
| Role of Silymarin in Neuroprotection and Symptom Management in Parkinson's Disease levodopa-carbidopa, Silymarin - Parkinson Disease | Phase 2 | Recruiting | Tanta University | 50 | 2025-05-10 | 2025-09-10 |
| Beneficial Effect of Silymarin in Ulcerative Colitis Silymarin, Mesalamine, Azathioprine - Ulcerative Colitis | Phase 2 | Recruiting | Tanta University | 44 | 2025-02-01 | 2025-03-05 |
| Effect of Silymarin in Rheumatoid Arthritis Patients Treated With Methotrexate MTX S.C or IM and Silymarin 140 mg tab, MTX S.C or IM - Rheumatoid Arthritis (RA) | Phase 4 | Not yet recruiting | Tanta University | 44 | 2024-12-10 | 2024-12-09 |
| Silymarin vs Hesperidin/Diosmin in Fibromyalgia Silymarin (LEGALON), Diosmin / Hesperidin (Daflon), no intervention (control group) - Fibromyalgia (FM) | Not applicable | Recruiting | Ain Shams University | 90 | 2024-11-16 | 2025-12-19 |
| Effect of Silymarin Against Methotrexate-induced Liver Injury in Rheumatic Diseases Silymarin, Placebo - Rheumatoid Arthritis, Psoriatic Arthritis | Not applicable | Unknown | Phramongkutklao College of Medicine and Hospital | 72 | 2024-02-01 | 2024-02-26 |
| Silymarin Effects on Fatty Liver in Type 2 Diabetics Silymarin (Silybum marianum) - Type 2 Diabetes, Fatty Liver | Not applicable | Completed | University of Mosul | 120 | 2024-01-02 | 2026-10-13 |
| Silymarin for the Prevention of Atrial Fibrillation After Cardiac Surgery Silymarin - Atrial Fibrillation New Onset | Phase 3 | Completed | University of Novi Sad | 160 | 2023-01-01 | 2024-12-04 |
| Effect of Silymarin in Metastatic Colorectal Cancer Patients Silymarin - Metastatic Colorectal Cancer | Phase 3 | Unknown | Tanta University | 64 | 2022-12-31 | 2023-12-22 |
| Role of Silymarin in Chemotherapy Toxicity and Cognition Improvement in Breast Cancer Patients Silymarin, Placebo - Breast Cancer, Peripheral Neuropathy | Phase 2 / Phase 3 | Unknown | Tanta University | 56 | 2022-10-28 | 2022-10-26 |
| Study to Evaluate the Effectiveness of Legalon® Legalon® 140 mg - Non-alcoholic Fatty Liver Disease (NAFLD) | Completed | Mylan Inc. | 362 | 2022-08-08 | 2025-09-30 | |
| Silymarin Cream Versus Combined Silymarin Cream and Microneedling in Treatment of Melasma Silymarin, Microneedling - Melasma | Phase 4 | Unknown | Assiut University | 30 | 2022-05-01 | 2021-10-29 |
| Impact of Silymarin Adjunct Therapy on Proteinuria in Type 2 Diabetic Patients on RAS Inhibitors Silymarin, Placebo - Type 2 Diabetes Mellitus | Phase 2 | Completed | Lahore General Hospital | 70 | 2022-02-25 | 2024-05-22 |
| Nutraceutical Composition Containing Natural Products Derivatives on the Modulation of the Endocrine Neuroimmune Axis Composition with Silymarin, Low-mineral composition without Silymarin - Insulin Resistance, Inflammatory Bowel Diseases | Not applicable | Completed | University of Sao Paulo General Hospital | 162 | 2021-05-20 | 2024-02-01 |
| Silymarin Cream Versus Salicylic Acid in Treatment of Acne Vulgaris Silymarin, Salicylic acid - Acne Vulgaris | Phase 4 | Unknown | Assiut University | 30 | 2021-04-01 | 2021-03-12 |
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Non-alcoholic Fatty Liver Disease (8) · Hepatitis C (5) · Chemical and Drug Induced Liver Injury (4) · Hepatitis C, Chronic (3) · Tuberculosis (3) · Arthritis, Rheumatoid (2) · Breast Neoplasms (2) · COVID-19 (2) · Cardiotoxicity (2) · Colorectal Neoplasms (2) · Diabetes Mellitus, Type 2 (2) · HIV Infections (2) · Hepatitis (2) · Melanosis (2) · Proteinuria (2)
Tanta University (6) · National Center for Complementary and Integrative Health (NCCIH) (4) · University of Chicago (3) · Assiut University (2) · Isfahan University of Medical Sciences (2) · University of Maryland, Baltimore (2) · Zagazig University (2) · Ain Shams University (1) · Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh (1) · Bukwang Pharmaceutical (1) · Cairo University (1) · Camila Ribeiro de Avelar (1) · F.D. Roosevelt Teaching Hospital with Policlinic Banska Bystrica (1) · General Hospital of Shenyang Military Region (1) · Hanoi Medical University (1)
United States (13) · Egypt (10) · Iran (4) · China (3) · South Korea (3) · Thailand (3) · Brazil (2) · Pakistan (2) · Taiwan (2) · Vietnam (2) · Bangladesh (1) · Canada (1) · Croatia (1) · Iraq (1) · Malaysia (1)
Jon E Grant, JD, MD, MPH (3) · K. Rajender Reddy, MD (3) · Michael Fried, MD (3) · Nezam Afdhal, MD (3) · Victor Navarro, MD (3) · Abhasnee Sobhonslidsuk, MD (1) · Amr S Hanafy, md (1) · Ana Flavia M Pessoa, Ph.D (1) · Ariba Sultan (1) · Behjat Moayedi, Professor (1) · Byung Chul Yoo, MD. PhD. (1) · Chote Luangchosiri, MD (1) · Dalia R Mohammed ElAfify, Asst.Prof (1) · David A Wohl, MD (1) · Deog Kyeom Kim, M.D. (1)
PMID 26400476, PMID 19286903, PMID 20014183, PMID 20127732, PMID 20589684, PMID 21865319, PMID 22150039, PMID 22797645, PMID 22802154, PMID 22806342, PMID 23492971, PMID 25090948, PMID 26729950, PMID 27426618, PMID 27648206, PMID 28367205, PMID 28419855, PMID 29473041, PMID 29736302, PMID 30758786, PMID 31536511, PMID 32517353, PMID 33038868, PMID 36130734, PMID 36778595, PMID 36899430, PMID 38402364, PMID 38478366, PMID 38750102, PMID 3883172, PMID 39012843, PMID 39183394, PMID 39981988, PMID 41993723, PMID 42080196, PMID 8200971
R21AT003892 (1), R21NR008860 (1)