7 completed, 4 unknown, 2 not yet recruiting, 2 recruiting. 16 Phase 2, 4 Phase 3, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 16 | Completed 7, Unknown 4, Not yet recruiting 2, Recruiting 2, Suspended 1 |
| Phase 3 | 4 | Unknown 2, Not yet recruiting 1, Suspended 1 |
| Phase 1 | 1 | Recruiting 1 |
Follow Melasma: new trials by email Literature Review of Melasma trials Research Report on Melasma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluation of the Efficacy of Oral Tranexamic Acid and Glutathione-assisted Microneedling in Treatment of Melasma microneedling, Oral tranexamic acid, Glutathione - Melasma | Phase 2 / Phase 3 | Not yet recruiting | Assiut University | 42 | 2026-02-01 | 2026-03-04 |
| Topical Metformin Versus Topical Ketotifen in Melasma Treatment Micro-Needling Combined with ketofin and metformin, ketofin and metformin Alone - Melasma | Phase 2 | Not yet recruiting | Assiut University | 60 | 2025-06-01 | 2025-04-24 |
| Oral Metformin for Treating Melasma in Latin American Women Metformin - Melasma | Phase 1 / Phase 2 | Recruiting | University of Puerto Rico | 30 | 2025-02-20 | 2025-02-25 |
| Randomized Study Using SM-030 Gel for Adults With Melasma SM-030 gel 0.64%, Placebo gel, SM-030 gel 0.08% - Melasma | Phase 2 | Recruiting | DermBiont, Inc. | 138 | 2024-06-27 | 2024-12-13 |
| Efficacy of Eflornithine Hydrochloride Cream in the Treatment of Melasma: A Randomized, Double-blinded, Split-face Controlled Study Eflornithine hydrochloride cream, Hydroquinone cream - Melasma | Phase 2 | Completed | National Skin Centre | 20 | 2023-06-06 | 2025-05-05 |
| To Evaluate the Effectiveness of Topical Eflornithine 9.58% + Hydroquinone 4% + Fluocinolone 0.01% as Compared to Topical Tretinoin 0.05% + Hydroquinone 4% + Fluocinolone 0.01% for the Treatment of Melasma Eflornithine 9.58% + Hydroquinone 4% + Fluocinolone 0.01% cream, Tretinoin 0.05% + hydroquinone 4% + fluocinolone 0.01% cream - Melasma, Melasma (Facial Melasma) | Phase 2 | Completed | National Skin Centre | 30 | 2023-06-06 | 2026-11-05 |
| Tranexamic Acid With Microneedling in Melasma Hyaluronic acid combined with tranexamic acid microneedling, tranexamic acid microneedling - Melasma | Phase 2 | Unknown | Zagazig University | 27 | 2023-06-01 | 2023-06-18 |
| Comparison Of Efficacy Of Combination Of TAM Formula Vs Kligman Formula For Melasma. TAM formula (hydroquinone 2%, tretinoin 0.05% and 5% vitamin C), Kligman formula (hydroquinone 4%, fluocinolone acetonide 0.01% and tretinoin 0.05%) - Melasma | Phase 2 | Unknown | Jinnah Postgraduate Medical Centre | 122 | 2022-08-01 | 2023-08-28 |
| Comparison of 30% Metformin and 2% Nicotinamide Lotion With Kligman Formula in the Treatment of Melasma Metformin and Nicotinamide vs Kligman Formula - Melasma | Phase 2 | Completed | Ishtiaq Ahmed | 88 | 2022-02-01 | 2023-05-23 |
| Evaluation of Laser and Tranexamic Acid in Treatment of Melasma Tranexamic acid - Melasma | Phase 2 / Phase 3 | Unknown | Assiut University | 40 | 2020-12-01 | 2020-10-22 |
| Comparison of Topical Silymarin With Hydroquinone in the Treatment of Melasma Hydroquinone 4% Cream, silymarin 0.7% cream - Melasma | Phase 2 | Completed | Islamabad Medical and Dental College | 92 | 2019-07-15 | 2020-02-12 |
| Efficacy of Platelet-rich Plasma in Treatment of Melasma Platelet-Rich Plasma - Melasma | Phase 2 | Completed | Instituto Mexicano del Seguro Social | 20 | 2017-05-01 | 2019-01-28 |
| A Comparative Study for Efficacy and Safety Between 4% Hydroquinone Cream With or Without Fractional Picosecond 1,064 nm Laser for the Treatment of Dermal or Mixed Type Melasma Fractional Picosecond 1,064 nm laser, 4% hydroquinone cream - Picoseconds Laser, Melasma | Phase 2 | Completed | Mae Fah Luang University Hospital | 30 | 2016-06-01 | 2017-02-09 |
| Topical Composition Therapy (2013-MCN-333) for the Treatment of Melasma Illuminate Cream - Melasma | Phase 2 | Completed | Mayo Clinic | 19 | 2016-05-15 | 2017-10-20 |
| Azelaic Acid Iontophoresis Versus Topical Azelaic Acid Cream in the Treatment of Melasma Iontophoresis, Azelaic acid cream - Melasma | Phase 2 / Phase 3 | Unknown | Medical University of Vienna | 70 | 2009-01-01 | 2010-07-15 |
| Efficiency And Safety Of Association Arbutin, Triamcinolone And Tretinoin In Treatment Of Melasma arbutin, tretinoin, triamcinolone, Triluma - Melasma | Phase 2 / Phase 3 | Suspended | Azidus Brasil | 110 | 2008-07-01 | 2022-11-03 |
Melanosis (16)
Hyperpigmentation (16) · Pigmentation Disorders (16) · Skin Diseases (16) · Skin and Connective Tissue Diseases (16)
Metformin (3) · Tretinoin (3) · hydroquinone (3) · Lasers (2) · Percutaneous Collagen Induction (2) · Tranexamic Acid (2) · Arbutin (1) · Ascorbic Acid (1) · Eflornithine (1) · Fluocinolone Acetonide (1) · Glutathione (1) · Iontophoresis (1) · Silymarin (1) · Therapeutics (1) · Triamcinolone (1)
Assiut University (3) · National Skin Centre (2) · Azidus Brasil (1) · DermBiont, Inc. (1) · Instituto Mexicano del Seguro Social (1) · Ishtiaq Ahmed (1) · Islamabad Medical and Dental College (1) · Jinnah Postgraduate Medical Centre (1) · Mae Fah Luang University Hospital (1) · Mayo Clinic (1) · Medical University of Vienna (1) · University of Puerto Rico (1) · Zagazig University (1)
Pakistan (3) · Singapore (2) · Austria (1) · Brazil (1) · El Salvador (1) · Mexico (1) · Puerto Rico (1) · United States (1)
Clotilde Fuentes, pHD (1) · Cristina Brau (1) · Daivd Zepeda, MD (1) · Ishtiaq Ahmed, MBBS (1) · JB Schmidt, MD (1) · Jason C Sluzevich, M.D. (1) · Oliver Schanab, MD (1) · Radwa Bakr, Assistant professor (1) · Sumaira Abdullah, MBBS, MCPS, MD (1)
2019 (1)