33 completed, 15 unknown, 12 not yet recruiting, 4 active not recruiting. 69 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 69 | Completed 33, Unknown 15, Not yet recruiting 12, Active not recruiting 4, Terminated 3, Recruiting 2 |
Follow Melasma: new trials by email Literature Review of Melasma trials Research Report on Melasma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| COMPARISON OF TOPICAL VITAMIN C VS NIACINAMIDE IN TREATMENT OF MELASMA Ascorbic acid, niacinamide - Melasma | Not applicable | Not yet recruiting | Pak Emirates Military Hospital | 100 | 2026-11-01 | 2026-10-22 |
| New Treatment in Melasma Tranexamic Acid - topical, Microneedling with Topical Tranexamic acid, Modified Kligman's Formula - Female, With | Not applicable | Not yet recruiting | Sohag University | 75 | 2026-10-18 | 2026-10-21 |
| Clinical Efficacy and Mechanisms of a Topical Azone-Tranexamic Acid-Aloe Polysaccharide Gel in the Treatment of Melasma Ligustrazine - tranexamic acid - aloe polysaccharide composite gel - Melasma, Treatment of Stable Melasma | Not applicable | Not yet recruiting | The First Affiliated Hospital of Xinxiang Medical College | 10 | 2026-08-12 | 2026-04-14 |
| Comparative Evaluation of Topical 30% Metformin and Kligman's Regimen in Women With Melasma Topical 30% metformin cream, Kligman's Regimen - Melasma (Facial Melasma), Melasma | Not applicable | Not yet recruiting | Foundation University Islamabad | 82 | 2026-07-01 | 2026-03-20 |
| Comparative Evaluation of Topical Metformin and Topical Tranexamic Acid in Melasma topical 3% tranexamic acid solution, Topical 30% metformin cream - Melasma | Not applicable | Not yet recruiting | Foundation University Islamabad | 70 | 2026-07-01 | 2026-03-27 |
| Efficacy and Safety of a Combined Topical Formula Versus Placebo in Patients With Melasma Topical azelaic acid 12% plus tranexamic acid 5%, Placebo topical formulation - Melasma | Not applicable | Completed | University of Guadalajara | 40 | 2026-06-12 | 2026-07-27 |
| A Clinical Study to Evaluate the Efficacy in Improving Dark Spots After 8 Weeks of Use of Facial Sunscreens in Adult Participants Sunscreen untinted, Sunscreen tinted - Post-inflammatory Hyperpigmentation, Melasma | Not applicable | Recruiting | Kenvue Brands LLC | 152 | 2026-06-02 | 2026-07-01 |
| Comparative Efficacy of Intralesional Tranexamic Acid Versus Mandelic Acid Peel in the Treatment of Melasma Mandelic Acid Peel, Intralesional Tranexamic Acid - Melasma | Not applicable | Not yet recruiting | Combined Military Hospital Abbottabad | 120 | 2026-05-01 | 2026-05-28 |
| Evaluation of Efficacy and Tolerabilty of MelaB3 Serum in Combination of 35% Glycolic Acid Peeling Compared to 35% Glycolic Acid Peeling Alone in Various Hyperpigmentation Conditions Glycolic acid peel alone, MelaB3 serum - Hyperpigmentation, Melasma | Not applicable | Not yet recruiting | Cosmetique Active International | 80 | 2026-03-04 | 2026-02-24 |
| Secretome TGF Beta 3 Concentrated secretome Injection 3 mL, Concentrated secretome Injection 3 mL with addition of TGF Beta 3 - Melasma | Not applicable | Not yet recruiting | Universitas Indonesia | 34 | 2026-02-14 | 2025-08-22 |
| Injectable Platelet-Rich Fibrin Versus Intradermal Tranexamic Acid for Melasma Injectable Platelet-Rich Fibrin, Tranexamic acid 100 mg/mL (Kapron) - Melasma, Facial Melasma | Not applicable | Recruiting | Kasr El Aini Hospital | 21 | 2026-02-01 | 2026-04-22 |
| Microfocused Ultrasound for Facial Pigmentary Diseases and Rosacea Microfocused Ultrasound Treatment, Sham Microfocused Ultrasound Stimulation - Melasma, Rosacea | Not applicable | Active not recruiting | Xiangya Hospital of Central South University | 200 | 2025-10-01 | 2026-06-30 |
| Efficacy and Safety of a Combined Serum Containing Melasyl™, 10% Niacinamide, Hyaluronic Acid, and HEPES a combination serum containing Melasyl™, 10% Niacinamide, Hyaluronic Acid, and HEPES, 2% hydroquinone cream - Melasma, Post-acne Hyperpigmentation | Not applicable | Not yet recruiting | Dr.dr.Irma Bernadette, SpKK (K) | 68 | 2025-09-15 | 2025-08-13 |
| A 4-week Study Investigating Two Targeted Brightening Serum (A and B) Versus 4% Hydroquinone in Women With Mild to Severe Full-face Hyperpigmentation Facial Cleanser, Facial Moisturizer, Sunscreen SPF 55 - Hyperpigmentation, Melasma | Not applicable | Completed | Revision Skincare | 18 | 2025-08-11 | 2026-06-12 |
| Comparative Efficacy of Resveratrol 1 % Gel and Trichloroacetic Acid 20% in Treatment of Melasma: A Split-face Study resveratrol 1 % gel, TCA20% - Melasma | Not applicable | Not yet recruiting | Assiut University | 41 | 2025-07-22 | 2025-07-11 |
| Comparative Effects Of Trichloroacetic Chemical Peel And Fractional Laser 35% TCA combined with croton oil peel, Isolate 35% TCA peel, Erbium-YAG laser - Melasma, Acne Scars - Mixed Atrophic and Hypertrophic | Not applicable | Active not recruiting | Jose Roberto Cortelli | 120 | 2025-06-02 | 2026-05-19 |
| Azelaic Acid 20% vs Hydroquinone 4% in Epidermal Melasma Topical Azelaic Acid 20% Cream, Topical 4% hydroquinone cream - Melasma, Melasma (Facial Melasma) | Not applicable | Completed | Gujranwala medical college District Headquarters Hospital, Gujranwala | 146 | 2025-05-04 | 2026-01-08 |
| Comparison of Effectiveness and Safety of Triple Combination Cream of Fucinolone Acetonide 0.01%, Hydroquinone 4%, Tretinoin 0.05% with Mometasone Furoate 0.1%, Hydroquinone 4%, Tretinoin 0.05% in the Treatment of Melasma Triple combination cream - Melasma | Not applicable | Not yet recruiting | Universitas Indonesia | 56 | 2025-02-17 | 2025-01-17 |
| Comparison of Efficacy of Metformin Gel 30% vs Triple Combination Cream (Hydroquinone 4%, Flucinolone Acetonide 0.01%, Tretinoin 0.025%) in Treatment of Melasma in Tertiary Care Hospital Karachi Metformin gel, 30%, Triple combination cream (hydroquinone 2% + tretinoin 0.025% + fluocinolone acetonide 0.01%), Broad-spectrum sunscreen (SPF ≥30) - Melasma | Not applicable | Completed | Jinnah Postgraduate Medical Centre | 34 | 2025-02-01 | 2026-01-21 |
| Clinical Evaluation and Study of the Efficacy of a Centella Asiatica-Infused Facial Mask on Discosmetic Dermatosis Face mask containing Centella sinensis - Rosacea, Acne | Not applicable | Not yet recruiting | Nanjing First Hospital, Nanjing Medical University | 30 | 2025-01-08 | 2025-01-08 |
Showing 20 of 69. Sign in to see all of them.
Melanosis (69) · Hyperpigmentation (9) · Rosacea (3) · Acne Vulgaris (2) · Facies (2) · Pigmentation Disorders (2) · Dermatitis, Seborrheic (1) · Exanthema (1) · Hypertrophy (1) · Lentigo (1) · Margins of Excision (1) · Neovascularization, Pathologic (1) · Vitiligo (1)
Skin Diseases (69) · Skin and Connective Tissue Diseases (69) · Pigmentation Disorders (67) · Hyperpigmentation (60) · Pathological Conditions, Signs and Symptoms (7) · Pathologic Processes (5) · Acneiform Eruptions (2) · Disease Attributes (2) · Sebaceous Gland Diseases (2) · Dermatitis (1) · Hypopigmentation (1) · Metaplasia (1) · Morphological and Microscopic Findings (1) · Pathological Conditions, Anatomical (1) · Skin Diseases, Eczematous (1)
Tranexamic Acid (6) · hydroquinone (4) · Lasers, Solid-State (3) · Laser Therapy (2) · Niacinamide (2) · Saline Solution (2) · Tretinoin (2) · azelaic acid (2) · Ascorbic Acid (1) · Control Groups (1) · Cysteamine (1) · Gels (1) · HEPES (1) · Hyaluronic Acid (1) · Lasers (1)
Centre Hospitalier Universitaire de Nice (4) · Cosmetique Active International (4) · Cynosure, Inc. (3) · CynosureLutronic (3) · Dr.dr.Irma Bernadette, SpKK (K) (3) · Universitas Indonesia (3) · Assiut University (2) · Foundation University Islamabad (2) · Fujian Medical University Union Hospital (2) · Kasr El Aini Hospital (2) · Northwestern University (2) · Second Affiliated Hospital of Xi'an Jiaotong University (2) · Sohag University (2) · Allergan (1) · Benev Company, Inc. (1)
United States (16) · China (9) · Egypt (6) · Indonesia (6) · Pakistan (6) · Brazil (5) · France (4) · Mexico (2) · Canada (1) · Germany (1) · India (1) · Italy (1) · Japan (1) · Slovenia (1) · Taiwan (1)
Kari Larson, MBA (2) · Murad Alam, MD (2) · Patricia Krantz (2) · Ali Amar, MBBS, FCPS(dermatology), CHPE (1) · Chang-Cheng Chang, M.D., Ph. D. (1) · Claire Deloche-Bensmain, PhD (1) · David J Goldberg, MD (1) · Elizabeth Makino (1) · Gang Wang, Prof (1) · Hanan Ahmed, Professor (1) · Heather Woolery-Lloyd, MD (1) · Henry Hin-Lee Chan, M.D., Ph.D (1) · Kei Negishi, M.D., Ph.D (1) · Khadija Qenawi, Doctor (1)
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