335 completed, 157 unknown, 63 recruiting, 46 not yet recruiting. 285 Not applicable, 123 Phase 2, 64 Phase 4, 52 Phase 3, 44 Phase 1.
Follow Pigmentation Disorders: new trials by email Literature Review of Pigmentation Disorders trials Research Report on Pigmentation Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Vitiligo Registry for Adults and Children in the UK Dermatologic Disease, Vitiligo | Not yet recruiting | The Royal Wolverhampton Hospitals NHS Trust | 30 | 2026-12-15 | 2026-09-15 | |
| Baseline Dermoscopic Vascular Score and Response to Oral Tranexamic Acid in Facial Melasma Tranexamic acid, Standardised sunscreen and emollient - Melasma | Phase 4 | Not yet recruiting | Allied Hospital Faisalabad | 128 | 2026-11-01 | 2026-10-19 |
| COMPARISON OF TOPICAL VITAMIN C VS NIACINAMIDE IN TREATMENT OF MELASMA Ascorbic acid, niacinamide - Melasma | Not applicable | Not yet recruiting | Pak Emirates Military Hospital | 100 | 2026-11-01 | 2026-10-22 |
| New Treatment in Melasma Tranexamic Acid - topical, Microneedling with Topical Tranexamic acid, Modified Kligman's Formula - Female, With | Not applicable | Not yet recruiting | Sohag University | 75 | 2026-10-18 | 2026-10-21 |
| Efficacy and Safety of Triple-Combination Cream Plus Microneedling Along With Tranexamic Acid Versus Platelet-Rich Plasma in the Treatment of Moderate-to-Severe Melasma: A Randomized Comparative Study Group B (Triple Combination Cream + Microneedling + Platelet-Rich Plasma) - Melasma (Facial Melasma) | Phase 4 | Active not recruiting | Bangladesh Medical University | 60 | 2026-10-13 | 2026-10-23 |
| Local Warming to Improve Pulse Oximetry Accuracy in Critically Ill Patients Protocolized Local Warming - Critical Illness, Low Peripheral Perfusion | Not applicable | Not yet recruiting | Vastra Gotaland Region | 240 | 2026-10-01 | 2026-09-25 |
| Chinese Multicenter Registry for Peutz-Jeghers Syndrome Peutz-Jeghers Syndrome | Not yet recruiting | First People's Hospital of Hangzhou | 1000 | 2026-10-01 | 2026-10-22 | |
| Foam Sclerotherapy With or Without Transdermal Laser for Reticular Veins and Telangiectasias Polidocanol foam sclerotherapy, Transdermal 1064 nm Nd:YAG Laser - Telangiectasias, Reticular Veins | Phase 4 | Recruiting | University of Sao Paulo | 70 | 2026-09-01 | 2026-10-05 |
| An Observational Study of Patients With Dermatologic Disease Vitiligo, Atopic Dermatitis | Not yet recruiting | Target PharmaSolutions, Inc. | 2000000 | 2026-09-01 | 2026-09-10 | |
| Mitochondrial Network Modulation Approach Using Hyperbaric Oxygen (HBO) Therapy and Nb-UVB for Treating Vitiligo OXYGENE MEDICINAL LIQUIDE AIR PRODUCTS MEDICAL - Vitiligo Vulgaris | Phase 2 / Phase 3 | Not yet recruiting | Centre Hospitalier Universitaire de Nice | 5 | 2026-09-01 | 2026-06-05 |
| Fractional CO2 Laser vs Dermabrasion With 5-Fluorouracil for Acquired Leukoderma Fractional CO2 Laser, Dermabrasion, 5-Fluorouracil - Leukoderma, Hypopigmentation | Not applicable | Not yet recruiting | Al-Azhar University | 16 | 2026-08-26 | 2026-09-24 |
| PPDTM CorEvitasTM Vitiligo Drug Safety and Effectiveness Registry for Adults & Adolescents Vitiligo | Recruiting | CorEvitas | 2500 | 2026-08-21 | 2026-08-26 | |
| Topical Metformin Versus Triple Regimen for Epidermal Melasma Topical 30% metformin cream, Topical Triple Regimen - Epidermal Melasma, Facial Hyperpigmentation | Phase 2 | Not yet recruiting | Combined Military Hospital, Pakistan | 104 | 2026-08-15 | 2026-08-21 |
| Clinical Efficacy and Mechanisms of a Topical Azone-Tranexamic Acid-Aloe Polysaccharide Gel in the Treatment of Melasma Ligustrazine - tranexamic acid - aloe polysaccharide composite gel - Melasma, Treatment of Stable Melasma | Not applicable | Not yet recruiting | The First Affiliated Hospital of Xinxiang Medical College | 10 | 2026-08-12 | 2026-04-14 |
| Efficacy and Safety Of Fractional Carbon Dioxide Laser Plus Topical Metformin In Treatment Of Acanthosis Nigricans Topical metformin - Acanthosis Nigricans | Phase 1 | Not yet recruiting | Al-Azhar University | 34 | 2026-08-10 | 2026-08-12 |
| A Phase III Clinical Study to Evaluate the Efficacy and Safety of MH004 Ointment in Non-segmental Vitiligo MH004 1.0% Ointment, MH004 Placebo Ointment - Vitiligo | Phase 3 | Recruiting | Minghui Pharmaceutical (Hangzhou) Ltd | 405 | 2026-08-04 | 2026-08-11 |
| Influence of Adjunctive Acids Use on Esthetic Outcomes of Gingival Melanin Depigmentation: A Periodontal-Operative Pilot Randomized Clinical Trial Citric acid - Gingival Pigmentation | Not applicable | Not yet recruiting | Dijlah University | 30 | 2026-08-01 | 2026-07-16 |
| Oral Tranexamic Acid Plus Triple Combination vs Triple Combination Alone in Melasma Oral tranexamic acid + triple combination cream (fluocinolone acetonide + hydroquinone + tretinoin), Triple combination cream (fluocinolone acetonide + hydroquinone + tretinoin) alone - Melasma, Melasma (Facial Melasma) | Phase 4 | Not yet recruiting | Combined Military Hospital Abbottabad | 128 | 2026-07-15 | 2026-07-28 |
| Efficacy Evaluation of a Cosmetic Product for Facial Hyperpigmentation Blancy Pro - Hyperpigmentation, Melasma (Facial Melasma) | Not applicable | Recruiting | Brainfarma Industria Química e Farmacêutica S/A | 40 | 2026-07-13 | 2026-09-16 |
| Microneedling-Assisted Metformin, Tranexamic Acid, and Modified Kligman's Formula for Melasma Metformin 30% Topical Lotion, Tranexamic Acid 0.5% Topical Solution, Modified Kligman's Formula - Melasma (Facial Melasma) | Phase 4 | Enrolling by invitation | Sameh Sarsik | 80 | 2026-07-10 | 2026-07-28 |
Showing 20 of 690. Sign in to see all of them.
Vitiligo (291) · Melanosis (170) · Hyperpigmentation (103) · Peutz-Jeghers Syndrome (22) · Psoriasis (20) · Skin Diseases (20) · Dermatitis, Atopic (19) · Acanthosis Nigricans (18) · Acne Vulgaris (18) · Piebaldism (18) · Albinism (17) · Alopecia Areata (16) · Lentigo (13) · Xeroderma Pigmentosum (12)
Skin and Connective Tissue Diseases (689) · Skin Diseases (670) · Hypopigmentation (331) · Hyperpigmentation (192) · Pathological Conditions, Signs and Symptoms (126) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (116) · Genetic Diseases, Inborn (108) · Pathologic Processes (95) · Nutritional and Metabolic Diseases (90) · Skin Diseases, Genetic (85) · Metabolic Diseases (84) · Neoplasms (70) · Melanosis (52) · Eye Diseases, Hereditary (51)
Tranexamic Acid (26) · hydroquinone (20) · Percutaneous Collagen Induction (18) · Phototherapy (12) · Tacrolimus (12) · Tretinoin (12) · Metformin (10) · Blood Specimen Collection (8) · Lasers, Excimer (8) · ruxolitinib (8) · Lasers (7) · Therapeutics (7) · afamelanotide (7) · Fluorouracil (6) · Dermabrasion (5)
Assiut University (27) · Cairo University (25) · Centre Hospitalier Universitaire de Nice (24) · Cosmetique Active International (13) · Henry Ford Health System (12) · Sohag University (12) · University Hospital, Bordeaux (11) · Cryonove Pharma (9) · Universidad Autonoma de San Luis Potosí (8) · Incyte Corporation (7) · National Human Genome Research Institute (NHGRI) (7) · Xijing Hospital (7) · Al-Azhar University (6) · Combined Military Hospital Abbottabad (6) · Kasr El Aini Hospital (6)
United States (210) · France (65) · Egypt (55) · China (51) · Pakistan (30) · Canada (26) · Brazil (21) · Netherlands (18) · Indonesia (15) · Italy (15) · Mexico (15) · United Kingdom (15) · South Korea (14) · Germany (13) · India (12)
Passeron Thierry, PhD (7) · Murad Alam, MD (5) · Andrew McGovern, MD (4) · Bertha Torres-Alvarez, MD (4) · Harvey Lui, MD, FRCPC (4) · Juan P Castanedo-Cazares, MD (4) · Kathleen Butler, MD (4) · Thierry Passeron, PhD (4) · Iltefat H Hamzavi, MD (3) · Iltefat Hamzavi, MD (3) · Jeffrey Kenkel, MD (3) · Wendy J Introne, M.D. (3)
PMID 25184917, PMID 41125994, PMID 20364383, PMID 23919018, PMID 25068546, PMID 25596811, PMID 28726212, PMID 29445374, PMID 30369044, PMID 30601885, PMID 32443482, PMID 36260792, PMID 40156697, PMID 10803620, PMID 11096382, PMID 12410698, PMID 12516826, PMID 15149497, PMID 15888156, PMID 16631967, PMID 17199653, PMID 17659004, PMID 17875874, PMID 18021205, PMID 18419607, PMID 19043850, PMID 19067714, PMID 19481375, PMID 19627411, PMID 19787413, PMID 20083690, PMID 20197747, PMID 20398959, PMID 20413357, PMID 20458532, PMID 20514787, PMID 20961233, PMID 20966063, PMID 20981308, PMID 21275943, PMID 21384391, PMID 21406109, PMID 21451378, PMID 21920241, PMID 21920242, PMID 22154461, PMID 22676819, PMID 22892471, PMID 23003920, PMID 23093467
2023 (4), 2025 (4), 2019 (3), 2018 (2), 2009 (1), 2016 (1), M01RR006022 (1), P30CA015704 (1), R01CA176828 (1), R33AR077495 (1), U01CA210170 (1), U54HL127672 (1), UM1CA154967 (1)