15 completed, 6 unknown, 2 recruiting, 1 not yet recruiting. 9 Phase 4, 7 Not applicable, 4 Phase 3, 3 Phase 2.
Follow hydroquinone: new trials by email Literature Review of hydroquinone trials Research Report on hydroquinone
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Oral Tranexamic Acid Plus Triple Combination vs Triple Combination Alone in Melasma Oral tranexamic acid + triple combination cream (fluocinolone acetonide + hydroquinone + tretinoin), Triple combination cream (fluocinolone acetonide + hydroquinone + tretinoin) alone - Melasma, Melasma (Facial Melasma) | Phase 4 | Not yet recruiting | Combined Military Hospital Abbottabad | 128 | 2026-07-15 | 2026-07-28 |
| Comparison of Efficacy of Topical Westerhoff Formula Cream Vs Topical 4% Hydroquinone for the Treatment of Melasma Triple combination cream, Hydroquinone 4% Cream - Melasma (Facial Melasma) | Phase 4 | Completed | Pak Emirates Military Hospital | 50 | 2025-07-18 | 2026-04-02 |
| COMPARISON OF A COSMETIC SERUM AND 4% HYDROQUINONE FOR TREATING MELASMA OVER 84 DAYS Depigmenting Cosmetic Serum (Applied Morning and Evening) - Healthy, Melasma (Facial Melasma) | Not applicable | Recruiting | Laboratoire Dermatologique ACM | 40 | 2025-06-23 | 2025-08-20 |
| Comparison of Efficacy of Metformin Gel 30% vs Triple Combination Cream (Hydroquinone 4%, Flucinolone Acetonide 0.01%, Tretinoin 0.025%) in Treatment of Melasma in Tertiary Care Hospital Karachi Metformin gel, 30%, Triple combination cream (hydroquinone 2% + tretinoin 0.025% + fluocinolone acetonide 0.01%), Broad-spectrum sunscreen (SPF ≥30) - Melasma | Not applicable | Completed | Jinnah Postgraduate Medical Centre | 34 | 2025-02-01 | 2026-01-21 |
| EFFICACY and TOLERABILITY of TESTED FORMULA VS. HYDROQUINONE 4% in the TREATMENT of FACIAL MELASMA Experimental: Group TP, Active Comparator: Group HQ: Hydroquinone 4% - Melasma | Not applicable | Completed | Cosmetique Active International | 109 | 2023-08-17 | 2025-01-22 |
| To Evaluate the Effectiveness of Topical Eflornithine 9.58% + Hydroquinone 4% + Fluocinolone 0.01% as Compared to Topical Tretinoin 0.05% + Hydroquinone 4% + Fluocinolone 0.01% for the Treatment of Melasma Eflornithine 9.58% + Hydroquinone 4% + Fluocinolone 0.01% cream, Tretinoin 0.05% + hydroquinone 4% + fluocinolone 0.01% cream - Melasma, Melasma (Facial Melasma) | Phase 2 | Completed | National Skin Centre | 30 | 2023-06-06 | 2026-11-05 |
| Comparison Of Efficacy Of Combination Of TAM Formula Vs Kligman Formula For Melasma. TAM formula (hydroquinone 2%, tretinoin 0.05% and 5% vitamin C), Kligman formula (hydroquinone 4%, fluocinolone acetonide 0.01% and tretinoin 0.05%) - Melasma | Phase 2 | Unknown | Jinnah Postgraduate Medical Centre | 122 | 2022-08-01 | 2023-08-28 |
| Outcomes of Biological Therapy on Rheumatoid Arthritis Biological Drug - Rheumatoid Arthritis | Unknown | Sohag University | 200 | 2022-06-01 | 2022-03-21 | |
| A Study to Assess Efficacy of Supporting Properties and Safety of ARTNEO in Patients With Knee Osteoarthritis ARTNEO, Artra - Osteoarthritis, Osteo Arthritis Knee | Not applicable | Completed | NPO Petrovax | 70 | 2022-03-21 | 2025-06-03 |
| A Clinical Study to Evaluate the Effect of Facial Serum Q69 in Moderating the Appearance of Mild to Moderate Melasma Cosmetic facial serum Q69, 2% Hydroquinone - Melasma | Not applicable | Completed | Unilever R&D | 96 | 2021-09-06 | 2022-11-01 |
| Prospective Evaluation of Topical Almond Oil vs Hydroquinone Almond Oil, Hydroquinone Topical - Skin Pigmentation | Phase 4 | Recruiting | University of California, Davis | 50 | 2021-07-01 | 2026-09-14 |
| Efficacy and Safety of Using Combination of 755-nm Picosecond Alexandrite Laser and 2% Hydroquinone Compared With 2% Hydroquinone Alone for the Treatment of Melasma: a Randomized Split-face Controlled Trial 755-nm picosecond alexandrite laser with topical 2% hydroquinone, topical 2% hydroquinone - Melasma | Not applicable | Unknown | Mahidol University | 20 | 2020-10-01 | 2020-10-23 |
| Comparison of Topical Silymarin With Hydroquinone in the Treatment of Melasma Hydroquinone 4% Cream, silymarin 0.7% cream - Melasma | Phase 2 | Completed | Islamabad Medical and Dental College | 92 | 2019-07-15 | 2020-02-12 |
| Evaluation of Hexyresorcinol vs Hydroquinone for Photoaging Hexylresourcinol, Hydroquinone - Photoaging | Not applicable | Completed | Sytheon Ltd. | 32 | 2019-07-01 | 2020-07-10 |
| Oral and Topical Tranexamic Acid for the Treatment of Melasma Oral Tranexamic Acid, 5% topical tranexamic acid, 4% hydroquinone - Melasma, Chloasma | Phase 3 | Unknown | Centro Dermatológico Dr. Ladislao de la Pascua | 120 | 2018-08-01 | 2018-07-16 |
| Oral Tranexamic Acid and Topical Hydroquinone in the Treatment of Melasma Tranexamic Acid Oral Product, Hydroquinone 4% Cream, Sunscreen - Melasma | Phase 3 | Completed | Fakultas Kedokteran Universitas Indonesia | 50 | 2016-03-16 | 2018-11-26 |
| Efficacy and Safety of a 4% Hydroquinone Cream for the Treatment of Melasma Hydroquinone, Placebo - Facial Melasma | Phase 3 | Completed | Mesoestetic Pharma Group S.L. | 17 | 2014-03-01 | 2019-09-30 |
| Evaluation of an Herbal-Based De-Pigmenting System Herbal depigmenting agent (Epionce), Hydroquinone - Melasma, Hyperpigmentation | Phase 4 | Completed | Sadick Research Group | 28 | 2013-10-01 | 2015-11-18 |
| Clinical Trial of Hydroquinone Versus Miconazol in Melasma Miconazole, Hydroquinone - Melasma | Phase 4 | Unknown | Universidad Autonoma de San Luis Potosí | 60 | 2011-10-01 | 2014-12-02 |
| Efficacy and Safety of ARTRA (Glucosamine Plus Chondroitin Sulfate Combination) in Treatment of Chronic Low Back Pain ARTRA - Low Back Pain | Completed | Unipharm, Inc. | 10000 | 2010-07-01 | 2013-11-21 |
Showing 20 of 25. Sign in to see all of them.
Melanosis (19) · Hyperpigmentation (2) · Pigmentation Disorders (2) · Arthritis, Rheumatoid (1) · Facies (1) · Low Back Pain (1) · Osteoarthritis (1) · Osteoarthritis, Knee (1)
Galderma R&D (3) · Jinnah Postgraduate Medical Centre (2) · Callender Center for Clinical Research (1) · Catalysis SL (1) · Centro Dermatológico Dr. Ladislao de la Pascua (1) · Combined Military Hospital Abbottabad (1) · Cosmetique Active International (1) · Fakultas Kedokteran Universitas Indonesia (1) · Islamabad Medical and Dental College (1) · Laboratoire Dermatologique ACM (1) · Mahidol University (1) · Mesoestetic Pharma Group S.L. (1) · NPO Petrovax (1) · National Skin Centre (1) · Pak Emirates Military Hospital (1)
United States (7) · Pakistan (4) · Mexico (2) · Russia (2) · Brazil (1) · China (1) · Cuba (1) · Egypt (1) · Mauritius (1) · Singapore (1) · Spain (1) · Thailand (1)
Ronald W Gottschalk, MD (2) · Alfredo Abreu Daniel, PhD (1) · Ali Amar, MBBS, FCPS, CHPE (1) · Amalia Reyes-Herrera, M.D. (1) · Bertha Torres-Alvarez, M.D. (1) · Gurkirpal Singh, MD (1) · Juan P Castanedo-Cazares, M.D. (1) · Neil S Sadick, MD (1) · Raja Sivamani, MD (1) · Raja Sivamani, MD MS AP (1)
PMID 20398959, PMID 24746304, PMID 25184917, PMID 25396122, PMID 31354327, PMID 31502392, PMID 32649234, PMID 33849384, PMID 35357753, PMID 36345697, PMID 36502500, PMID 38192412, PMID 38896402, PMID 39369111, PMID 40586974