7 completed, 2 unknown, 1 recruiting. 3 Phase 3, 1 Not applicable, 1 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 3 | Completed 2, Recruiting 1 |
| Not applicable | 1 | Completed 1 |
| Phase 1 | 1 | Completed 1 |
| Phase 2 | 1 | Completed 1 |
Follow Acanthamoeba Keratitis: new trials by email Literature Review of Acanthamoeba Keratitis trials Research Report on Acanthamoeba Keratitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Retrospective Chart Review of Patients With Acanthamoeba Keratitis Who Have Received 0.8 mg/mL Polihexanide as Part of the "Medicines in Special Situations" (Medicamentos en Situaciones Especiales) Program in Spain. PHMB 0.08% - Acanthamoeba Keratitis | Completed | SIFI SpA | 23 | 2025-10-30 | 2026-06-22 | |
| Retrospective Chart Review of Patients With Acanthamoeba Keratitis Who Have Received 0.8 mg/ml Polihexanide Acanthamoeba Keratitis | Completed | SIFI SpA | 40 | 2024-09-30 | 2025-10-01 | |
| Parasitic Ulcer Treatment Trial Polyhexamethylene biguanide (PHMB), Topical corticosteroid, Topical placebo - Acanthamoeba Keratitis | Phase 3 | Recruiting | Jeremy Keenan, MD, MPH | 232 | 2024-07-01 | 2026-10-01 |
| Acanthamoeba and Artificial Intelligence Acanthamoeba Keratitis, Artificial Intelligence | Unknown | IRCCS Ospedale San Raffaele | 151 | 2024-05-01 | 2024-05-10 | |
| Rose Bengal Electromagnetic Activation With Green Light for Infection Reduction Moxifloxacin Ophthalmic, Chlorhexidine Gluconate, Natamycin - Acanthamoeba Keratitis, Fungal Keratitis | Phase 3 | Completed | University of California, San Francisco | 330 | 2022-08-03 | 2026-09-03 |
| Parasitic Ulcer Treatment Trial Pilot Chlorhexidine, Povidone-Iodine, Prednisolone Sodium Phosphate - Acanthamoeba Keratitis | Phase 2 | Completed | University of California, San Francisco | 49 | 2018-01-01 | 2026-05-07 |
| Polihexanide (PHMB) Eye Drops in Patients Affected by Acanthamoeba Keratitis PHMB 0.08%, Propamidine 0.1%, placebo - Acanthamoeba Keratitis | Phase 3 | Completed | SIFI SpA | 135 | 2017-08-13 | 2023-08-22 |
| Ultrahigh-resolution Optical Coherence Tomography Imaging of the Anterior Eye Segment Structures Ultrahigh resolution Spectral Domain OCT - Meibomian Gland Dysfunction, Cataract | Not applicable | Completed | Medical University of Vienna | 14 | 2017-07-12 | 2025-05-23 |
| Safety and Tolerability of Preservative-free Polyhexamethylene Biguanide (PHMB) Ophthalmic Solution in Healthy Subjects 0.04% PHMB, 0.06% PHMB, 0.08% PHMB - Acanthamoeba Keratitis | Phase 1 | Completed | SIFI SpA | 90 | 2015-11-01 | 2017-02-09 |
| Retrospective Study of Acanthamoebic Keratitis During the Past 10 Years no intervention - Acanthamoeba Keratitis | Unknown | National Taiwan University Hospital | 100 | 2014-01-01 | 2016-05-09 |
Aniridia (1) · Cataract (1) · Corneal Ulcer (1) · Glaucoma (1) · Keratitis (1) · Meibomian Gland Dysfunction (1)
Amebiasis (10) · Corneal Diseases (10) · Eye Diseases (10) · Eye Infections (10) · Eye Infections, Parasitic (10) · Infections (10) · Parasitic Diseases (10) · Protozoan Infections (10) · Keratitis (9) · Congenital Abnormalities (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · Eye Abnormalities (1) · Eye Diseases, Hereditary (1) · Eyelid Diseases (1) · Genetic Diseases, Inborn (1)
polihexanide (3) · Adrenal Cortex Hormones (1) · Chlorhexidine (1) · Corneal Cross-Linking (1) · Hypromellose Derivatives (1) · Natamycin (1) · Povidone-Iodine (1) · Rose Bengal (1) · chlorhexidine gluconate (1) · dibrompropamidine (1) · prednisolone phosphate (1)
SIFI SpA (4) · University of California, San Francisco (2) · IRCCS Ospedale San Raffaele (1) · Jeremy Keenan, MD, MPH (1) · Medical University of Vienna (1) · National Taiwan University Hospital (1)
India (3) · Brazil (2) · Italy (2) · United Kingdom (2) · Austria (1) · Poland (1) · Spain (1) · Taiwan (1) · United States (1)
Gerami Seitzman, MD (1) · Jennifer Rose-Nussbaumer, MD (1) · Jeremy D Keenan, MD (1) · Jeremy Keenan, MD, MPH (1) · John Dart, MD (1) · Karl Knutsson, MD (1) · Nicole Varnado, MPH (1) · Tom Lietman, MD (1) · Wei-Li Chen, MD,PHD (1)
PMID 33239413, PMID 37802392, PMID 39011096, PMID 39192339, PMID 41561665, PMID 41914638, PMID 42141248, PMID 42348235
UG1EY028518 (1), UG1EY033284 (1)