Comparing Tear Proteomics Profile in Dry Eye Disease pre-and Post-treatment With Low Level Light Therapy

NCT07329712 — Recruiting, 30 participants, Singapore National Eye Centre

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Registry	NCT07329712
Status	Recruiting
Study type	Observational
Enrollment	30 (Estimated)
Sponsor	Singapore National Eye Centre (Other gov)
Conditions	Dry Eye, Meibomian Gland Dysfunction (Disorder)
Dates	start 2025-11-05, primary completion 2026-12-31 (estimated), completion 2027-12-31 (estimated), first posted 2026-01-09, last updated 2026-01-09
Locations	1 site in Singapore

-Summary

The purpose of this research study is to understand the mechanism of action of low level light therapy and also potentially yield markers associated with good treatment response. Low-level light therapy is light-based treatment delivered through advance eye-light device. This therapy uses light energy to provide energy to the meibomian gland cells to slow down age-ing, improve tear stability and reduce inflammation.

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+Arms and interventions

Arm	Type	Interventions	Description
Patients undergoing low level light therapy

+Outcome measures

Primary outcomes

Comparing tear proteomics profile in dry eye disease pre-and post-treatment with low level light therapy [Baseline visit and Post Baseline visit 3 months (+3 weeks).]: Aim 1: Tear proteomic profile of MGD patients with DED pre- and post-treatment with LLLT will be profiled Aim 2: Baseline tear cytokine levels will be measured using the novel Olink 500-plex technology in DED patients with MGD undergoing LLLT

+Eligibility

Sex: All, ages: 21 Years to any

Inclusion Criteria:

1. Must be eligible for, and have consented for low level light therapy
2. Must not have presented to the clinic for an acute eye problem such as visual loss or painful eye
3. Ability to give informed consent.
4. Age more or equals to 21 years old.

Exclusion Criteria:

1. Patients who are unable to or decline to give consent.
2. Age less than 21 years old.
3. Patients who presented to the clinic for an acute eye problem such as visual loss or painful eye.
4. Patients not suitable for low level lighttherapy:

   * Pregnant
   * Fitted with pacemakers, metal, electrical, acoustic prosthetics
   * Epilepsy, cardiac rhythm or frequency disorders
   * Fever, thrombophlebitis or acute phlebitis of the legs, large-sized varicose veins, or venous surgery within 2 months
   * Uncontrolled hypertension or severe diabetes
   * Open wounds on eyelid or skin
   * Evolving cancer or hepatitis
   * Blood anticoagulant or coagulation defect

+Locations (1)

Facility	City	Country	Status
Singapore Eye Research Insititute	Singapore	Singapore	Recruiting

+Investigators

Louis Tong, PhD, Principal investigator, Singapore Eye Research Institute