24 completed, 19 unknown, 5 recruiting, 4 not yet recruiting. 23 Phase 2, 15 Phase 3, 7 Phase 1, 7 Phase 4, 4 Not applicable.
Follow avatrombopag: new trials by email Literature Review of avatrombopag trials Research Report on avatrombopag
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Assess the Tolerability of Ianalumab (VAY736) With Investigator's Choice Thrombopoietin Receptor Agonist (IC TPO-RA) in Patients With Primary Immune Thrombocytopenia (ITP) ianalumab, thrombopoietin receptor agonist (TPO-RA) - Primary Immune Thrombocytopenia (ITP), Primary Evans Syndrome (ES) | Phase 2 | Recruiting | Novartis Pharmaceuticals | 164 | 2026-08-04 | 2026-10-22 |
| A Study of Avatrombopag in Adults With Aplastic Anemia Who Did Not Respond to, Cannot Receive, or Had Return of Disease After Standard Treatment Avatrombopag 20 mg Oral Tablet - Aplastic Anemia | Phase 2 / Phase 3 | Not yet recruiting | Swedish Orphan Biovitrum | 26 | 2026-07-31 | 2026-08-26 |
| Avatrombopag Combined With All-trans Retinoic Acid in the Treatment of Primary Immune Thrombocytopenia Avatrombopag+All trans retinoic acid, Avatrombopag - ITP - Immune Thrombocytopenia | Phase 2 / Phase 3 | Not yet recruiting | Institute of Hematology & Blood Diseases Hospital, China | 248 | 2025-12-01 | 2025-12-12 |
| The Holistic Study Avatrombopag, Rituximab (Arm B) - Thrombocytopenia Purpura | Phase 3 | Not yet recruiting | Ostfold Hospital Trust | 220 | 2025-09-15 | 2025-09-09 |
| Exploring the Efficacy, Safety of a Modified Starting Dosage of Avatrombopag in Immune Throbocytopenia (ITP) - a Pilot Study Avatrombopag 20 mg Oral Tablet - ITP - Immune Thrombocytopenia | Phase 4 | Recruiting | Al-Mustansiriyah University | 25 | 2025-06-08 | 2025-08-21 |
| Efficacy and Safety of Avatrombopag in the Treatment of Thrombocytopenia After Haplo-HSCT avatrombopag, Placebo - Thrombocytopenia, Stem Cell Transplant Complications | Phase 2 / Phase 3 | Unknown | Peking University People's Hospital | 142 | 2024-05-13 | 2024-10-01 |
| Avatrombopag in the Treatment of Pediatric Immune Thrombocytopenia Avatrombopag - Immune Thrombocytopenia, Treatment | Phase 2 | Recruiting | Institute of Hematology & Blood Diseases Hospital, China | 60 | 2024-03-01 | 2025-02-24 |
| Efficacy and Safety of Avatrombopag vs. Avatrombopag Combined With rhTPO in the Treatment of SAA Avatrombopag, Avatrombopag +rhTPO - Anemia, Aplastic | Phase 2 | Unknown | Institute of Hematology & Blood Diseases Hospital, China | 60 | 2024-02-01 | 2024-02-12 |
| Avatrombopag vs. Placebo for CIT in GI Malignancies Avatrombopag, Matching Placebo - Gastrointestinal Cancer, Gastrointestinal Neoplasms | Phase 2 | Completed | Hanny Al-Samkari, MD | 49 | 2023-11-01 | 2026-08-31 |
| CsA+ATG+AVA vs. CsA+AVA for the Treatment of Newly-diagnosed SAA in the Elderly Ciclosporin, Avatrombopag, Anti-Human Thymocyte Immunoglobulin, Rabbit - Aplastic Anemia | Phase 4 | Completed | Peking Union Medical College Hospital | 86 | 2023-09-15 | 2025-04-30 |
| Efficacy and Safety of CsA+AVA in the Treatment of NSAA in the Elderly Ciclosporin, Avatrombopag - Aplastic Anemia | Phase 2 | Unknown | Peking Union Medical College Hospital | 30 | 2023-08-17 | 2023-12-08 |
| Avatrombopag for HCC Patients With Thrombocytopenia Who Intend to Undergo TACE and/or HAIC Avatrombopag - Thrombocytopenia, Hepatocellular Carcinoma | Phase 2 | Unknown | Second Affiliated Hospital of Guangzhou Medical University | 30 | 2023-08-14 | 2023-09-14 |
| Decitabine for Poor Graft Function Post Allo-HSCT Decitabine, Granulocyte Colony-Stimulating Factor, Thrombopoietin Receptor Agonist - Poor Graft Function | Phase 3 | Not yet recruiting | The First Affiliated Hospital of Soochow University | 76 | 2023-07-01 | 2023-06-18 |
| Avatrombopag for Platelet Recovery Post-UCBT in Patients With Bone Marrow Failure Disease Avatrombopag - Platelet Recovery After Umbilical Cord Blood Transplantation | Recruiting | Anhui Provincial Hospital | 40 | 2023-05-04 | 2024-12-31 | |
| Avatrombopag for the Treatment of Thrombocytopenia After Donor Hematopoietic Stem Cell Transplant Avatrombopag - Platelet Disorder | Phase 2 | Withdrawn | Ayman Saad | 2022-12-01 | 2021-12-09 | |
| Avatrombopag Combined With IST as First-line Treatment for SAA avatrombopag - Severe Aplastic Anemia | Phase 2 | Unknown | Institute of Hematology & Blood Diseases Hospital, China | 53 | 2022-11-10 | 2023-02-09 |
| Efficacy and Safety of Avatrombopag Combined With IST for the Treatment of HAAA and SAA With Abnormal Liver Function Avatrombopag 20 MG Oral Tablet - Aplastic Anemia | Not applicable | Unknown | Institute of Hematology & Blood Diseases Hospital, China | 39 | 2022-06-28 | 2022-10-07 |
| Evaluation of Avatrombopag for the Treatment of Thrombocytopenia in Japanese Adults With Chronic ITP Avatrombopag Oral Tablet - Immune Thrombocytopenia | Phase 3 | Completed | Sobi, Inc. | 19 | 2022-06-15 | 2026-06-03 |
| Efficacy and Safety of CSA and Avatrombopag for the Treatment of SAA in the Elderly Avatrombopag - Severe Aplastic Anemia | Not applicable | Unknown | Institute of Hematology & Blood Diseases Hospital, China | 80 | 2022-06-01 | 2022-06-27 |
| The Safety and Efficacy Study of Avatrombopag Switch in TPO-RA Refractory AA avatrombopag - Refractory Aplastic Anemia | Not applicable | Unknown | Institute of Hematology & Blood Diseases Hospital, China | 39 | 2022-06-01 | 2022-08-26 |
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Thrombocytopenia (25) · Purpura, Thrombocytopenic, Idiopathic (18) · Anemia, Aplastic (9) · Blood Platelet Disorders (2) · Carcinoma, Hepatocellular (2) · Evans Syndrome (2) · Liver Diseases (2) · Acute-On-Chronic Liver Failure (1) · Bone Marrow Failure Disorders (1) · Connective Tissue Diseases (1) · Disease (1) · End Stage Liver Disease (1) · Fibrosis (1) · Gastrointestinal Neoplasms (1) · Hepatitis (1)
Eisai Inc. (15) · Institute of Hematology & Blood Diseases Hospital, China (9) · Sobi, Inc. (7) · Peking Union Medical College Hospital (4) · Shanghai Zhongshan Hospital (2) · Swedish Orphan Biovitrum (2) · The First Affiliated Hospital of Soochow University (2) · Al-Mustansiriyah University (1) · Anhui Provincial Cancer Hospital (1) · Anhui Provincial Hospital (1) · Ayman Saad (1) · Chinese PLA General Hospital (1) · Eisai Co., Ltd. (1) · Hanny Al-Samkari, MD (1) · Hvidovre University Hospital (1)
China (26) · United States (22) · Germany (4) · Poland (4) · Australia (3) · Belgium (3) · Czechia (3) · France (3) · Hungary (3) · Italy (3) · Japan (3) · Russia (3) · Spain (3) · Ukraine (3) · United Kingdom (3)
Franklin Johnson (3) · Joe McIntosh (2) · Lei Zhang, MD (2) · Pei-Ran Ho, MD (2) · Alireza Manhuchehri (1) · Ayman Saad, MB/BCH (1) · Gerald A Soff, MD (1) · Gerald Soff, MD (1) · Gina Pastino (1) · Haitao Haitao, Prof (1) · Hanny Al-Samkari, MD (1) · Jian Zhou, MD PhD (1) · Lei Ye, doctor (1) · Lei Zhang, M.D. (1)
PMID 30504345, PMID 18379007, PMID 24802775, PMID 28423296, PMID 29778606, PMID 32047671, PMID 10758304, PMID 12506176, PMID 15254053, PMID 17825602, PMID 19446902, PMID 22762314, PMID 24613543, PMID 26568159, PMID 27688097, PMID 28219216, PMID 30191972, PMID 30262561, PMID 32876852, PMID 35134259, PMID 35371427, PMID 36238568, PMID 37318085, PMID 40101243, PMID 40392465, PMID 40418942, PMID 40828490, PMID 41411046