600 completed, 113 terminated, 109 unknown, 70 recruiting. 419 Phase 2, 243 Phase 4, 167 Phase 3, 147 Phase 1, 72 Not applicable.
Follow Tacrolimus: new trials by email Literature Review of Tacrolimus trials Research Report on Tacrolimus
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| CC-101 (f/k/a NR1) Neural Stem Cell Transplantation for Adults With Chronic Ischemic Stroke CC-101 (f/k/a NR1) Intracerebral Transplantation, Tacrolimus, Sham Surgical Control - Chronic Ischemic Stroke | Phase 2 | Not yet recruiting | Clarion Cells, Inc. | 36 | 2027-01-01 | 2026-07-17 |
| Total Marrow and Lymphoid Irradiation in Combination With Fludarabine and Melphalan as Conditioning for Allogeneic Peripheral Blood Stem Cell Hematopoietic Cell Transplant in Older Patients With Refractory and Relapsed Acute Myeloid Leukemia and High-risk Myelodysplastic Syndrome Biospecimen Collection, Bone Marrow Biopsy, Computed Tomography - Acute Myeloid Leukemia With Complex Karyotype, Myelodysplastic Chronic Myelomonocytic Leukemia | Phase 2 | Recruiting | City of Hope Medical Center | 35 | 2026-11-05 | 2026-10-08 |
| CSF-1R Inhibitor, Axatilimab, for Prevention of Acute and Chronic GVHD After HLA-Matched Related and Unrelated Donor Allogeneic Stem Cell Transplantation Hematopoietic Cell Transplantation, Cyclophosphamide, Tacrolimus - Graft -Versus-host-disease | Phase 2 | Not yet recruiting | Medical College of Wisconsin | 72 | 2026-11-01 | 2026-09-08 |
| Automated Total Marrow and Lymphoid Irradiation for Allogeneic Hematopoietic Cell Transplant VMAT-Based Total Marrow and Lymphoid Irradiation (TMLI), Fludarabine, Cyclophosphamide - Acute Myeloid Leukemia, Myeloproliferative Neoplasm | Phase 2 | Not yet recruiting | Stanford University | 30 | 2026-11-01 | 2026-09-30 |
| Intestinal & Multivisceral Transplantation for Unresectable Mucinous Carcinoma Peritonei (TRANSCAPE) Intestinal, Multivisceral or Modified Multivisceral Transplantation, Alemtuzumab, Tacrolimus - Secondary Malignant Neoplasm of Retroperitoneum, Secondary Malignant Neoplasm of Peritoneum | Phase 2 | Not yet recruiting | Case Comprehensive Cancer Center | 20 | 2026-11-01 | 2026-09-24 |
| Stem Cell Transplantation for Participants With Germline RUNX1 Associated Blood Cancers Cyclophosphamide, Busulfan, Fludarabine - Core Binding Factor Alpha Subunits, Hematologic Neoplasms | Phase 2 | Not yet recruiting | National Cancer Institute (NCI) | 102 | 2026-10-28 | 2026-10-23 |
| Study of Tegoprubart Efficacy and Safety Compared With Tacrolimus in Kidney Transplantation Tegoprubart, Tacrolimus - Kidney Transplant Rejection | Phase 3 | Not yet recruiting | Eledon Pharmaceuticals | 620 | 2026-10-01 | 2026-09-30 |
| A Phase 3 Study of Inebilizumab in Participants With Primary Membranous Nephropathy Inebilizumab, Tacrolimus - Glomerulonephritis, Membranous | Phase 3 | Recruiting | Amgen | 159 | 2026-10-01 | 2026-10-01 |
| Tacrolimus as Prophylaxis of Post-ERCP Pancreatitis Tacrolimus, NaCl (placebo) - Post-ERCP Pancreatitis | Phase 4 | Not yet recruiting | Amsterdam UMC, location VUmc | 520 | 2026-09-07 | 2026-08-24 |
| Biomarker-Guided Mycophenolate Mofetil Elimination in Low-Risk Older Adult Kidney Transplant Recipients Tacrolimus (Kidney transplant maintenance immunosuppression), Mycophenoate Mofetil, Prednisone (SOC arm) - Kidney Transplant Recipient | Early Phase 1 | Not yet recruiting | Virginia Commonwealth University | 20 | 2026-08-31 | 2026-09-08 |
| Everolimus bAsed caLcineurin inhibiTor frEe immunosuppRession oNe Year AfTer lIver transplantatiON (ALTERNATION) Everolimus, Tacrolimus or Cyclosporine - Liver Allograft, Liver Diseases | Phase 3 | Recruiting | Hannover Medical School | 150 | 2026-08-19 | 2026-10-05 |
| VEL-101 to Prevent Rejection After Kidney Transplantation Tacrolimus (TAC), VEL-101 - Transplantation, Kidney | Phase 2 | Recruiting | Veloxis Pharmaceuticals | 120 | 2026-08-18 | 2026-09-03 |
| Utilization of a Microdevice for Psoriasis and Atopic Dermatitis In situ cutaneous microdevice, Triamcinolone, 5-Fluorouracil - Psoriasis, Atopic Dermatitis | Phase 4 | Not yet recruiting | University of California, San Francisco | 10 | 2026-08-01 | 2026-06-03 |
| TACrolimus Targeted Immunosuppression Cessation in ALlogeneic HCT Tacrolimus, Early Tacrolimus Taper Strategy - GVHD, Hematopoietic Cell Transplantation (HCT) | Phase 1 | Recruiting | Stanford University | 50 | 2026-07-21 | 2026-08-17 |
| Emapalumab With Post-Transplant Cyclophosphamide, Tacrolimus and Mycophenolate Mofetil for the Prevention of Graft-versus-Host Disease After Donor Reduced-Intensity Hematopoietic Cell Transplant Biospecimen Collection, Busulfan, Computed Tomography - Acute Myeloid Leukemia, Graft Versus Host Disease | Phase 1 | Recruiting | City of Hope Medical Center | 15 | 2026-06-12 | 2026-07-01 |
| A Randomized Controlled Trial Comparing the Effectiveness and Safety of Topical Tacrolimus 0.03% Versus Crisaborole 2% in Patients With Mild to Moderate Atopic Dermatitis Over 8 Weeks Tacrolimus, Crisaborole 2% Top Oint - Atopic Dermatitis | Not applicable | Not yet recruiting | Foundation University Islamabad | 72 | 2026-06-01 | 2026-04-09 |
| Axatilimab Plus Standard of Care Therapy for the Prevention of Graft Versus Host Disease Following Allogeneic Hematopoietic Stem Cell Transplantation in Patients With Hematologic Cancer, ABRAXAS Trial Allogeneic Hematopoietic Stem Cell Transplantation, Axatilimab, Biospecimen Collection - Hematopoietic and Lymphatic System Neoplasm | Phase 2 | Withdrawn | Mayo Clinic | 2026-06-01 | 2026-09-03 | |
| A Phase 3 Study of Extended-release Tacrolimus in Subjects With Pulmonary Arterial Hypertension and Functional Limitations VI-0106, Placebo - Pulmonary Arterial Hypertension, Pulmonary Arterial Hypertension (PAH) | Phase 3 | Not yet recruiting | VIVUS LLC | 300 | 2026-05-29 | 2026-05-29 |
| A Study to Evaluate Axatilimab Versus Best Available Therapy in Pediatric Participants With Chronic Graft-Versus-Host Disease After at Least 2 Prior Lines of Systemic Therapy (AGAVE-256) INCA034176, Best available Treatment (BAT) - Chronic Graft-versus-host-disease | Phase 2 | Recruiting | Incyte Corporation | 60 | 2026-05-20 | 2026-10-09 |
| Cord Blood Transplantation in Children and Young Adults With Blood Cancer Cord Blood Units, Total Body Irradiation, Cyclophosphamide - Acute Myelogenous Leukemia, Acute Lymphoblastic Leukemia | Phase 2 | Recruiting | Memorial Sloan Kettering Cancer Center | 71 | 2026-04-28 | 2026-05-14 |
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Leukemia, Myeloid, Acute (126) · Myelodysplastic Syndromes (123) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (107) · Graft vs Host Disease (89) · Leukemia (86) · Hodgkin Disease (81) · Leukemia, Lymphocytic, Chronic, B-Cell (78) · Lymphoma (76) · Lymphoma, Non-Hodgkin (75) · Multiple Myeloma (75) · Myeloproliferative Disorders (58) · Lymphoma, Follicular (54) · Leukemia, Myeloid, Accelerated Phase (50) · Lymphoma, Large B-Cell, Diffuse (50) · Lymphoma, Mantle-Cell (50)
Astellas Pharma Inc (83) · M.D. Anderson Cancer Center (42) · Fred Hutchinson Cancer Center (35) · National Institute of Allergy and Infectious Diseases (NIAID) (34) · Novartis Pharmaceuticals (24) · City of Hope Medical Center (23) · National Cancer Institute (NCI) (17) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (16) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (14) · Veloxis Pharmaceuticals (13) · Medical College of Wisconsin (12) · Seoul National University Hospital (10) · Astellas Pharma Korea, Inc. (9) · Dana-Farber Cancer Institute (9) · Wyeth is now a wholly owned subsidiary of Pfizer (9)
United States (567) · Germany (86) · France (78) · Canada (73) · China (70) · Spain (62) · South Korea (55) · Italy (51) · United Kingdom (50) · Belgium (39) · Australia (33) · Netherlands (33) · Poland (33) · Brazil (32) · Czechia (31)
Mary Horowitz, MD (5) · Neal Flomenberg, MD (5) · Usama Gergis, MD (5) · Asad Bashey, MD, PhD (4)
PMID 36094829, PMID 23438305, PMID 29149958, PMID 34778952, PMID 35007144, PMID 35224732, PMID 40197799, PMID 16407509, PMID 19660021, PMID 19670189, PMID 22471345, PMID 32343796, PMID 32499241, PMID 35230699, PMID 36240296, PMID 39382091, PMID 39513526, PMID 10071354, PMID 10870982, PMID 11003346, PMID 11072057, PMID 11250374, PMID 11267411, PMID 12171484, PMID 12176626, PMID 12176628, PMID 12270445, PMID 12548508, PMID 12944064, PMID 14550808, PMID 14655180, PMID 14720063, PMID 14742989, PMID 14742990, PMID 15061852, PMID 15233820, PMID 15257060, PMID 15660173, PMID 15691272, PMID 15691277, PMID 15753371, PMID 15885236, PMID 15899725, PMID 15919463, PMID 16164651, PMID 16273116, PMID 16468960, PMID 16570006, PMID 16737942, PMID 16771810
P30CA015704 (14), P30CA033572 (10), 2009 (8), U10CA031946 (8), P01CA018029 (7), 2023 (6), P30CA016672 (6), 2008 (5), 2014 (5), 2025 (5), U01HL069294 (5), 2005 (4), P01CA015396 (4), P01CA078902 (4), P01HL036444 (4)