204 completed, 64 terminated, 36 unknown, 25 recruiting. 247 Phase 2, 71 Phase 1, 34 Not applicable, 32 Phase 3, 26 Phase 4.
Follow Antilymphocyte Serum: new trials by email Literature Review of Antilymphocyte Serum trials Research Report on Antilymphocyte Serum
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Conditioning Regimen Containing Low-Dose ATG for the Treatment of AA Receiving sUCBT Anti-Thymocyte Globulin (Rabbit) (Thymoglobulin®) - Aplastic Anaemia | Phase 2 | Not yet recruiting | Anhui Provincial Hospital | 59 | 2027-08-01 | 2026-10-21 |
| CD45RA-depleted CD19-CAR T Cell Consolidation After TCRαβ+/CD19 B Cell-depleted Haploidentical Hematopoietic Cell Transplantation for Relapsed/Refractory CD19+ ALL and Lymphoma Anti-Thymocyte Globulin (Rabbit), Cyclophosphamide, Fludarabine - Relapsed Pediatric ALL, Hematopoietic Cell Transplantation | Phase 1 | Recruiting | St. Jude Children's Research Hospital | 70 | 2026-10-03 | 2026-08-28 |
| TLI- and ATG-Enabled Minimization Protocol in Liver Transplantation Anti-Thymocyte Globulin, ATG (Rabbit), Total lymphoid irradiation - Liver Failure | Phase 1 / Phase 2 | Recruiting | Stanford University | 12 | 2026-09-01 | 2026-10-07 |
| A Study of VABu Conditioning Regimen in Allo-HSCT for AML Patients Venetoclax, Azacitidine (AZA), Decitabine 20 mg/m²/day for 5 days - Leukemia, Myeloid, Acute(AML), Hematopoietic Stem Cell Transplantation (HSCT) | Not applicable | Not yet recruiting | The First Affiliated Hospital of Soochow University | 42 | 2026-08-01 | 2026-08-19 |
| Population PK-guided ATG Dosing for Haploidentical Hematopoietic Stem Cell Transplantation Anti-Thymocyte Globulin (ATG) - Hematopoietic Stem Cell Transplantation | Phase 3 | Recruiting | Daihong Liu | 324 | 2026-08-01 | 2026-10-14 |
| Platform Trial to Delay Stage 3 Diabetes: Comparing Teplizumab With ATG Antithymocyte Globulin (ATG), Teplizumab - Type 1 Diabetes Mellitus | Phase 2 | Recruiting | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 60 | 2026-07-29 | 2026-09-09 |
| A Study Comparing Siplizumab With Rabbit Anti-Thymocyte Globulin to Help the Body Accept a Kidney Transplant Siplizumab, Rabbit anti-thymocyte globulin - Renal Transplant Failure and Rejection | Phase 2 | Recruiting | Nefro Avillion Clinical Development, LLC | 120 | 2026-06-29 | 2026-10-06 |
| A Study to Investigate the Efficacy and Safety of Frexalimab Versus Tacrolimus in Adults Undergoing Kidney Transplantation Frexalimab, Tacrolimus, rabbit anti-thymocyte globulin - Kidney Transplant Rejection | Phase 2 / Phase 3 | Recruiting | Sanofi | 526 | 2026-03-13 | 2026-10-13 |
| A Randomized Phase 1/2 Trial of Low Dose Anti-thymocyte Globulin (ATG) With Subsequent Adalimumab or Verapamil in New Onset Type 1 Diabetes Anti-thymocyte globulin (ATG), verapamil extended-release capsule, Adalimumab - Type 1 Diabetes, New Onset | Phase 1 / Phase 2 | Recruiting | City of Hope Medical Center | 120 | 2026-03-10 | 2026-10-16 |
| Individualized Application of Anti-Thymocyte Globulin(ATG)in Unrelated Donor Hematopoietic Stem Cell Transplantation Anti-Thymocyte Globulin - Hematopoietic Stem Cell Transplantation | Phase 4 | Recruiting | Daihong Liu | 324 | 2025-12-01 | 2026-06-15 |
| Precision Administration of Anti-thymocyte Globulin With or Without Verapamil Anti-thymocyte globulin (ATG), verapamil extended release capsule, Placebo - Type 1 Diabetes | Phase 2 | Recruiting | University of Florida | 60 | 2025-11-12 | 2025-11-26 |
| Haplo-Cord HSCT for AML/MDS haplo-cord HSCT, Fludarabine, Cytarabine, Busulfan, Antithymocyte Globulin (ATG), Melphalan, Cyclophosphamide (CTX) - MDS (Myelodysplastic Syndrome), AML (Acute Myeloid Leukemia) | Not applicable | Recruiting | Fujian Medical University Union Hospital | 82 | 2025-10-20 | 2026-06-10 |
| Tolerance Through Mixed Chimerism (Sip-Tego) Combined Kidney/Bone Marrow Transplant, Donation of Kidney / Bone Marrow, Conditioning Regimen (Rituxan, Siplizumab (or ATGAM), Cyclophosphamide, Tegoprubart) - Kidney Failure, Transplant Recipient (Kidney) | Early Phase 1 | Active not recruiting | Tatsuo Kawai, MD, PhD | 12 | 2025-05-31 | 2026-09-25 |
| Population PK-guided ATG Dosing in Haplo-HSCT Anti Thymocyte Globulin - Hematopoietic Stem Cell Transplantation | Phase 2 | Recruiting | Chinese PLA General Hospital | 63 | 2025-05-10 | 2026-08-28 |
| A Reduced-Intensity Conditioning Regimen (Cyclophosphamide, Pentostatin, Anti-thymocyte Globulin) Followed by Haploidentical Hematopoietic Stem Cell Transplant for the Treatment of Patients With Refractory or Recurrent Severe Aplastic Anemia Anti-Thymocyte Globulin, Biospecimen Collection, Bone Marrow Aspirate - Recurrent Severe Aplastic Anemia, Refractory Severe Aplastic Anemia | Phase 1 | Recruiting | City of Hope Medical Center | 6 | 2024-11-15 | 2026-01-05 |
| Pilot Study of Memory-like Natural Killer (ML NK) Cells After TCRαβ T Cell Depleted Haploidentical Transplant in AML Rabbit Anti thymocyte globulin, Busulfan, Fludarabine - AML, Childhood, Aml | Phase 1 / Phase 2 | Recruiting | Washington University School of Medicine | 68 | 2024-11-15 | 2026-08-24 |
| Diabetes Islet Preservation Immune Treatment Anti-Thymocyte Globulin (ATG), Interleukin 2, Exenatide - Diabetes Mellitus, Type 1, Hypoglycemia | Phase 1 / Phase 2 | Withdrawn | Camillo Ricordi and Jay Skyler | 2024-06-01 | 2026-01-15 | |
| Advancing Transplantation Outcomes in Children Sirolimus, Belatacept, Mycophenolate Mofetil - Kidney Transplant | Phase 2 | Recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 200 | 2024-05-22 | 2026-10-23 |
| Combination of ATG-based Conditioning Regimen and PTCy for GVHD Prevention in Allo-HSCT After PD-1 Blockade Cyclophosphamid - Graft-versus-host Disease, Hematological Malignancies | Phase 2 | Unknown | Beijing 302 Hospital | 22 | 2024-02-28 | 2024-02-20 |
| A Study of TCD601 in de Novo Renal Transplant Recipients TCD601, belatacept, ATG - Renal Transplantation | Phase 2 | Completed | ITB-Med LLC | 76 | 2023-12-28 | 2026-05-05 |
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Myelodysplastic Syndromes (107) · Leukemia (94) · Leukemia, Myeloid, Acute (86) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (71) · Lymphoma (65) · Leukemia, Lymphocytic, Chronic, B-Cell (61) · Lymphoma, Non-Hodgkin (56) · Multiple Myeloma (55) · Hodgkin Disease (51) · Leukemia, Myeloid, Chronic-Phase (48) · Myeloproliferative Disorders (47) · Leukemia, Myeloid, Accelerated Phase (45) · Lymphoma, Follicular (43) · Lymphoma, Large B-Cell, Diffuse (42) · Lymphoma, Mantle-Cell (42)
M.D. Anderson Cancer Center (37) · Masonic Cancer Center, University of Minnesota (22) · Fred Hutchinson Cancer Center (19) · National Institute of Allergy and Infectious Diseases (NIAID) (16) · Memorial Sloan Kettering Cancer Center (10) · Stanford University (10) · Asan Medical Center (8) · Roswell Park Cancer Institute (8) · Case Comprehensive Cancer Center (7) · National Heart, Lung, and Blood Institute (NHLBI) (7) · St. Jude Children's Research Hospital (7) · University of California, San Francisco (7) · Chinese PLA General Hospital (6) · Genzyme, a Sanofi Company (6) · Columbia University (5)
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Robert Lowsky (5) · Daihong Liu, Doctor (4) · Richard Burt, MD (4) · Wen-Kai Weng (4) · Asad Bashey, MD, PhD (3) · Barbara Jean Bambach, MD (3) · Kenneth G. Lucas, MD (3) · Kyoo H. Lee, MD (3) · Leona Holmberg (3) · Margaret MacMillan, MD (3) · Michael Pulsipher, MD (3) · Philip L. McCarthy, MD (3) · Richard E. Champlin, MD (3) · Thomas G. Martin, MD (3)
PMID 21403127, PMID 22430088, PMID 25310303, PMID 18997171, PMID 19179301, PMID 22055111, PMID 26869630, PMID 30012675, PMID 34724566, PMID 37341189, PMID 15814548, PMID 16192477, PMID 16468960, PMID 17093248, PMID 17910637, PMID 18035553, PMID 18418404, PMID 18424759, PMID 18431244, PMID 18497677, PMID 18557726, PMID 18769450, PMID 19066739, PMID 19167681, PMID 19286996, PMID 19423725, PMID 19528536, PMID 19714613, PMID 19843296, PMID 20107229, PMID 20236866, PMID 20383216, PMID 20528878, PMID 20595516, PMID 20674758, PMID 20946966, PMID 21401720, PMID 21508125, PMID 21523798, PMID 21586746, PMID 21606164, PMID 21663651, PMID 21715313, PMID 21816832, PMID 21874061, PMID 21976674, PMID 22002488, PMID 22056644, PMID 22544699, PMID 23234514
P30CA016672 (4), P30CA015704 (3), P30CA043703 (3), U10HL069294 (3), 2008 (2), 2009 (2), 2019 (2), P01CA100265 (2), P01CA148600 (2), P01HL036444 (2), P30CA008748 (2), P30CA016086 (2), P30CA033572 (2), P30CA036727 (2), U10CA031946 (2)