10 completed, 4 unknown, 3 recruiting. 10 Not applicable, 2 Phase 2, 1 Early Phase 1, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 10 | Completed 6, Unknown 3, Recruiting 1 |
| Phase 2 | 2 | Completed 2 |
| Early Phase 1 | 1 | Recruiting 1 |
| Phase 1 | 1 | Completed 1 |
Follow Limb Ischemia: new trials by email Literature Review of Limb Ischemia trials Research Report on Limb Ischemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparison of Aspirin Alone Versus Low-Dose Rivaroxaban Plus Aspirin in Chronic Limb-Threatening Ischemia Aspirin tablet, Low-Dose Rivaroxaban Plus Aspirin, - Limb Ischemia | Early Phase 1 | Recruiting | King Edward Medical University | 78 | 2026-06-01 | 2026-09-22 |
| Feasibility and Clinical Utility of Paired Non-Invasive Hemodynamic and Tissue Oximetry Monitoring to Detect Limb Ischemia in Lithotomy-Positioned Surgeries Lower-Extremity Perfusion Monitoring - Neuropathy;Peripheral, Limb Ischemia | Recruiting | The University of Texas Health Science Center, Houston | 30 | 2026-01-29 | 2026-05-14 | |
| The Effect of Emotional Freedom Technique on Patients Receiving Preventive Foot Care Emotional freedom technique - Limb Injury, Limb Ischemia | Not applicable | Completed | Bitlis Eren University | 60 | 2025-04-15 | 2026-02-25 |
| Nanofat Grafting as a Method of Treating Critical Limb Ischemia nano-fat grafting in chronic limb ischaemia, sham comparator - Limb Ischemia | Not applicable | Unknown | Center of New Medical Technologies | 40 | 2024-04-20 | 2024-04-10 |
| Continuous Compartment Pressure Monitoring for Compartment Syndrome in VA-ECMO Patients MY01 + Standard of Care, 14-Gauge Slit Catheter + Standard of Care, Standard of Care - Compartment Syndrome of Leg, Extracorporeal Membrane Oxygenation Complication | Not applicable | Recruiting | Johns Hopkins University | 6 | 2024-01-02 | 2025-12-24 |
| Chemical Analysis of Limb Microfluidics Microdialysis catheter + biosensor - Limb Ischemia, Compartment Syndrome of Leg | Unknown | Imperial College London | 12 | 2023-02-01 | 2023-09-26 | |
| Pragmatic Randomized Trial for Arterial Catheters in the Critical Care Environment Restricted-use of arterial catheter, Standard-use of arterial catheter - Mechanical Ventilation Complication, Arterial Thrombosis | Not applicable | Completed | Dartmouth-Hitchcock Medical Center | 700 | 2022-10-17 | 2024-02-26 |
| Comorbidity Screening and Referral by Prosthetists Standard-of-Care, Clinical Screening - Limb Ischemia, Low Back Pain | Not applicable | Completed | University of Delaware | 70 | 2022-06-09 | 2025-12-31 |
| Evaluation of Online Tool (E-TOOL SCS) in Spinal Cord Stimulaion Failed Back Surgery Syndrome, Limb Ischemia | Completed | Istituti Clinici Scientifici Maugeri SpA | 80 | 2021-07-13 | 2026-03-18 | |
| Safety and Efficacy of Allogeneic Adipose Tissue Mesenchymal Stem Cells in Diabetic Patients With Critical Limb Ischemia High dose allogeneic mesenchymal stromal cells, Low dose allogeneic mesenchymal stromal cells, Placebos - Limb Ischemia, Diabetic Foot | Phase 2 | Completed | Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz | 90 | 2021-01-11 | 2025-04-27 |
| Combined Management in ALI ( Image Guided Thrombectomy With Open Transfemoral Access ) thrombectomy and PTA - Limb Ischemia | Not applicable | Unknown | Assiut University | 100 | 2020-12-01 | 2020-11-13 |
| Digital Variance Angiography in Diagnostic Angiographies for Effective Radiation Dose Reduction Diagnostic Angiography (DSA or DVA based on randomization result) - Peripheral Arterial Disease, Peripheral Artery Disease | Not applicable | Completed | Kinepict Health Ltd. | 114 | 2020-04-21 | 2021-09-13 |
| Characteristics and Prognosis of Patients With Critical Ischemia at High Risk of Amputation Managed by Endovascular Bypass: a Retrospective Study of 15 Patients Limb Ischemia | Completed | Fondation Hôpital Saint-Joseph | 15 | 2019-05-15 | 2019-10-03 | |
| Remote Ischemic Preconditioning During Lower Limb Revascularization RIPC, Control - Ischemic Preconditioning, Acute Kidney Injury | Not applicable | Completed | University of Messina | 50 | 2018-01-15 | 2021-10-04 |
| Complex Endovascular Approach to Treatment of Patients With Aneurysm of Popliteal Artery Combined endovascular approach (EVAR), Standard optimal therapy (OPT) - Aneurysm; Popliteal Artery, Limb Ischemia | Not applicable | Unknown | Charles University, Czech Republic | 30 | 2016-08-01 | 2017-02-02 |
| Model System for Transient Forearm Blood Vessel Dysfunction Limb Ischemia, Acetylcholine - Limb Ischemia, Ischemic Preconditioning | Phase 1 / Phase 2 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 6 | 2007-03-26 | 2022-08-09 |
| Hematopoietic Stem Cell Transplantation for the Treatment of Limb Ischemia and Diabetic Neuropathy Hematopoietic stem cell transplantation - Limb Ischemia, Diabetic Neuropathy | Not applicable | Completed | Hospital Universitario Dr. Jose E. Gonzalez | 20 | 2006-03-01 | 2008-08-08 |
Chronic Limb-Threatening Ischemia (2) · Compartment Syndromes (2) · Neuritis (2) · Peripheral Arterial Disease (2) · Acute Kidney Injury (1) · Aneurysm (1) · Anxiety Disorders (1) · Back Pain (1) · Complex Regional Pain Syndromes (1) · Depression (1) · Diabetes Complications (1) · Diabetic Foot (1) · Diabetic Neuropathies (1) · Failed Back Surgery Syndrome (1) · Hypotension (1)
Cardiovascular Diseases (8) · Vascular Diseases (8) · Pathological Conditions, Signs and Symptoms (6) · Pathologic Processes (5) · Arterial Occlusive Diseases (4) · Arteriosclerosis (4) · Atherosclerosis (4) · Nervous System Diseases (4) · Neuromuscular Diseases (4) · Peripheral Nervous System Diseases (4) · Peripheral Vascular Diseases (4) · Diabetes Mellitus (3) · Endocrine System Diseases (3) · Behavior (2) · Chronic Disease (2)
Standard of Care (2) · Acetylcholine (1) · Aspirin (1) · Biosensing Techniques (1) · Hematopoietic Stem Cell Transplantation (1) · Rivaroxaban (1) · Thrombectomy (1)
Assiut University (1) · Bitlis Eren University (1) · Center of New Medical Technologies (1) · Charles University, Czech Republic (1) · Dartmouth-Hitchcock Medical Center (1) · Fondation Hôpital Saint-Joseph (1) · Hospital Universitario Dr. Jose E. Gonzalez (1) · Imperial College London (1) · Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz (1) · Istituti Clinici Scientifici Maugeri SpA (1) · Johns Hopkins University (1) · Kinepict Health Ltd. (1) · King Edward Medical University (1) · National Heart, Lung, and Blood Institute (NHLBI) (1) · The University of Texas Health Science Center, Houston (1)
United States (5) · Italy (2) · Czechia (1) · France (1) · Hungary (1) · Mexico (1) · Pakistan (1) · Russia (1) · Spain (1) · Turkey (Türkiye) (1) · United Kingdom (1)
Alberto Noto, MD, PhD (1) · Babar Shafiq, MD, MSPT (1) · David Feller-Kopman, MD (1) · Fernando J Lavalle, MD (1) · Jaclyn M Sions, PhD, DPT (1)