18 completed, 5 unknown, 3 not yet recruiting, 2 recruiting. 13 Not applicable, 3 Phase 3, 3 Phase 4, 1 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 13 | Completed 5, Unknown 5, Not yet recruiting 3 |
| Phase 3 | 3 | Completed 2, Recruiting 1 |
| Phase 4 | 3 | Completed 1, Recruiting 1, Terminated 1 |
| Phase 1 | 1 | Completed 1 |
| Phase 2 | 1 | Completed 1 |
Follow Lacrimal Duct Obstruction: new trials by email Literature Review of Lacrimal Duct Obstruction trials Research Report on Lacrimal Duct Obstruction
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Outcomes of Stentless Dacryocystorhinostomy in Primary Acquired Nasolacrimal Duct Obstruction. Stentless Endoscopic Dacryocystorhinostomy - Nasolacrimal Duct Obstruction, Epiphora | Not applicable | Not yet recruiting | Assiut University | 40 | 2027-01-01 | 2026-09-30 |
| Outcomes of Early Lacrimal Probing Versus Lacrimal Sac Massage in Infants With Congenital Nasolacrimal Duct Obstruction naslacrimal duct probing - Lacrimal Duct Obstruction | Not applicable | Not yet recruiting | Hany Mahmoud,MD | 50 | 2026-06-01 | 2026-05-18 |
| Portable Endoscopic Camera System Using Modified Action Camera for Endoscopic Sinunasal Examination Modified Portable Endoscopic Camera - Nasolacrimal Duct Obstruction, Nasolacrimal Tract Obstruction | Completed | University of Arkansas | 22 | 2025-12-16 | 2026-08-11 | |
| Effect of Standardized Lacrimal Sac Massage Compared With Probing for Congenital Lacrimal Duct Obstruction tear duct probing, Lacrimal sac massage - Nasolacrimal Duct Obstruction | Not applicable | Not yet recruiting | Zhongshan Ophthalmic Center, Sun Yat-sen University | 160 | 2025-05-01 | 2025-04-11 |
| The Efficacy of Dexmedetomidine Versus Labetalol In Providing Controlled Hypotension In Dacryocystorhinostomy SurgeryA Comparative Randomized Prospective Study Dexmedetomidine, Labetalol - Nasolacrimal Duct Obstruction | Not applicable | Unknown | Sohag University | 50 | 2024-03-30 | 2024-04-04 |
| Amniotic Membrane for Dacryocystorhinostomy Dacryocystorhinostomy and amniotic membrane, Conventional dacryocystorhinostomy - Nasolacrimal Duct Obstruction, Dacryocystorhinostomy | Not applicable | Completed | Instituto de Oftalmología Fundación Conde de Valenciana | 22 | 2024-01-01 | 2026-09-04 |
| Artificial Tears to Prevent Nasolacrimal Duct Obstruction in Patients Treated With Radioactive Iodine for Thyroid Cancer Artificial Tears Methylcellulose - Nasolacrimal Duct Obstruction, Thyroid Cancer | Phase 3 | Recruiting | Vanderbilt University Medical Center | 100 | 2023-08-21 | 2025-10-28 |
| Examination of Lacrimal Sac and Nasal Mucosa Preparations Taken in Dacryocystorhinostomy Surgery of Patients With Nasolacrimal Duct Obstruction and Comparison of Clinical Groups With Each Other Dacryocystitis, Dacryocystitis; Chronic | Completed | Uludag University | 78 | 2023-05-15 | 2025-02-05 | |
| Closed Dacryointubation vs Bicanalicular Intubation for Proximal Tear Duct Obstruction Bicanalicular intubation, Closed dacryointubation - Lacrimal Duct Obstruction, Lacrimal Apparatus Diseases | Not applicable | Completed | Instituto de Oftalmología Fundación Conde de Valenciana | 31 | 2021-07-01 | 2024-05-31 |
| Self-retaining Bicanalicular Intubation Stent Versus Bicanalicular Silicone Tube for Management of Canalicular Obstruction Self-retaining bicanalicular intubation stent - Canalicular Obstruction | Not applicable | Unknown | Minia University | 40 | 2021-02-01 | 2021-02-24 |
| Does Topical Ophthalmic Proparacaine 0.5% Prior to Probing and Irrigation Decrease Pain? Proparacaine Hydrochloride ophthalmic solution, USP 0.5%, Balanced salt solution - Epiphora, Dacryostenosis | Phase 4 | Recruiting | Louisiana State University Health Sciences Center in New Orleans | 145 | 2020-06-30 | 2022-12-23 |
| Does Topical Ophthalmic Anesthetic Prior to Probing and Irrigation Decrease Pain? Proparacaine Hydrochloride ophthalmic solution, USP 0.5%, Balanced salt solution - Epiphora, Dacryostenosis | Phase 4 | Terminated | Corewell Health East | 2 | 2020-06-30 | 2023-01-19 |
| Clinical Study of Lacrimal Drainage Obstruction Diseases Using Dacryoendoscopy Dacryoendoscopic-assisted laser dacryoplasty with silicone intubation - Lacrimal Duct Obstruction | Not applicable | Completed | Tianjin Eye Hospital | 522 | 2019-11-01 | 2023-11-28 |
| Long Term Effectiveness of Dacryocystorinostomy With and Without Bicanalicular Intubation dacryocystorinostomy - Lacrimal Duct Obstruction | Not applicable | Completed | University Hospital Ostrava | 120 | 2019-07-01 | 2022-12-07 |
| Low Temperature Plasma Ablation Combined Lacrimal Duct Catheterization in the Treatment of Lacrimal Duct Obstructive Low temperature plasma lacrimal duct obstruction ablation combined with lacrimal duct catheterization, YAG lacrimal duct laser combined with lacrimal duct catheter - Lacrimal Duct Obstruction | Not applicable | Unknown | Second Affiliated Hospital, Zhejiang University, School of Medicine | 180 | 2018-10-10 | 2021-06-29 |
| Nasolacrimal Duct Obstruction retrospective analyis - Eye Diseases, Lacrimal Duct Obstruction | Completed | Medical University of Vienna | 625 | 2018-07-03 | 2021-06-23 | |
| A Feasibility Study to Develop a Protocol for Functional Lacrimal Magnetic Resonance Imaging MRI scanning - Lacrimal Duct Obstruction, Lacrimal Stenosis | Not applicable | Completed | Brighton and Sussex University Hospitals NHS Trust | 15 | 2018-06-13 | 2022-03-25 |
| Safety, Tolerability and Preliminary Efficacy of Unilateral Latanoprost-loaded Punctual Plug -EXP-LP drug delivery system, XALATAN® - Glaucoma, Ocular Hypertension | Not applicable | Unknown | Shaare Zedek Medical Center | 40 | 2018-06-01 | 2017-11-28 |
| Color Doppler Ultrasound in Lacrimal Sac Space-occupying Lesions CDU and CT-DCG or CT examination - Dacryocystitis; Chronic, Lacrimal Sac Space-occupying Lesions | Completed | Wenzhou Medical University | 21 | 2018-01-01 | 2022-08-15 | |
| Risk and Importance of Peroperative Nasal Hemorrhage in the Treatment of Lacrimal Duct Obstruction in Young Children "pushed" mono-canaliculonasal intubation - Lacrimal Duct Obstruction | Completed | Fondation Ophtalmologique Adolphe de Rothschild | 108 | 2015-09-02 | 2019-12-11 |
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Lacrimal Apparatus Diseases (7) · Dacryocystitis (4) · Bronchiolitis Obliterans Syndrome (2) · Ectropion (1) · Eye Diseases (1) · Glaucoma (1) · Medullary cystic kidney disease 1 (1) · Ocular Hypertension (1) · Thyroid Neoplasms (1)
Eye Diseases (28) · Lacrimal Apparatus Diseases (22) · Bronchial Diseases (2) · Bronchiolitis (2) · Bronchiolitis Obliterans (2) · Bronchitis (2) · Graft vs Host Disease (2) · Immune System Diseases (2) · Lung Diseases (2) · Lung Diseases, Obstructive (2) · Organizing Pneumonia (2) · Respiratory Tract Diseases (2) · Endocrine Gland Neoplasms (1) · Endocrine System Diseases (1) · Eyelid Diseases (1)
Dacryocystorhinostomy (2) · Hanks Balanced Salt Solution (2) · proxymetacaine (2) · Dexmedetomidine (1) · Drug Delivery Systems (1) · Labetalol (1) · Latanoprost (1) · Magnetic Resonance Imaging (1) · Mitomycin (1)
Jaeb Center for Health Research (3) · University Hospital Ostrava (3) · Instituto de Oftalmología Fundación Conde de Valenciana (2) · Assiut University (1) · Brighton and Sussex University Hospitals NHS Trust (1) · Corewell Health East (1) · Fondation Ophtalmologique Adolphe de Rothschild (1) · Hany Mahmoud,MD (1) · Kuopio University Hospital (1) · Louisiana State University Health Sciences Center in New Orleans (1) · Medical University of Vienna (1) · Minia University (1) · Second Affiliated Hospital, Zhejiang University, School of Medicine (1) · Shaare Zedek Medical Center (1) · Sohag University (1)
United States (8) · China (4) · Czechia (3) · Mexico (2) · Austria (1) · Canada (1) · Egypt (1) · Finland (1) · France (1) · Israel (1) · Turkey (Türkiye) (1) · United Kingdom (1)
David I. Silbert, M.D. (2) · Michael X. Repka, M.D. (2) · Ahmed M Elshafei (1) · Amr A Mohrmed, I (1) · Austin M Pharo, MD (1) · Brian Costin, MD (1) · Dianne M Schlachter, MD (1) · Hany Mahmoud (1) · Ishay Attar, CEO (1) · Julian D Perry, MD (1) · Katherine A. Lee, M.D., Ph.D. (1) · Omar Solyman, MD (1) · Pavel Kominek, MD,PhD,MBA (1) · Pavel Kominek, doc,MD,PhD,MBA (1)
PMID 19433712, PMID 21399724, PMID 22607109, PMID 22972069, PMID 23229693, PMID 23420235, PMID 23881267, PMID 24170283, PMID 24568978, PMID 25383466, PMID 25533656, PMID 39486803, PMID 42593819
U10EY011751 (3)