156 completed, 102 recruiting, 55 unknown, 30 not yet recruiting. 106 Phase 2, 77 Phase 1, 59 Not applicable, 50 Phase 3, 26 Early Phase 1.
Follow Myositis: new trials by email Literature Review of Myositis trials Research Report on Myositis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Investigate the Safety, Pharmacokinetics (PK), and Efficacy of Garetosmab in Children and Adolescents With Fibrodysplasia Ossificans Progressiva (FOP) garetosmab - Fibrodysplasia Ossificans Progressiva, FOP | Phase 3 | Not yet recruiting | Regeneron Pharmaceuticals | 18 | 2027-02-02 | 2026-10-20 |
| Teams Engaged in Accessible Mental Health Interventions for Lupus Erythematosus and Dermatomyositis Stress TEAM-LEADS - Lupus, Dermatomyositis, Juvenile | Not applicable | Not yet recruiting | Duke University | 25 | 2027-02-01 | 2026-05-27 |
| A Study to Understand How Nerandomilast Works in People With Active Idiopathic Inflammatory Myopathies Placebo, Nerandomilast - Idiopathic Inflammatory Myopathies | Phase 3 | Not yet recruiting | Boehringer Ingelheim | 270 | 2026-12-14 | 2026-10-29 |
| Study Investigating the Safety of Anti-CD19 CAR-T Cells Therapy Produced at Gustave Roussy for Adults With Severe and Refractory Systemic Autoimmune Rheumatic Diseases anti-CD19 CAR-T cells - Rheumatoid Arthritis (RA), Systemic Lupus Erythematosus (SLE) | Phase 1 | Not yet recruiting | Gustave Roussy, Cancer Campus, Grand Paris | 6 | 2026-12-01 | 2026-09-02 |
| Investigation of Type I Interferon Excess in Patients With Systemic Autoimmune Diseases and Genetic Type I Interferonopathies biological samples - Systememic Lupus Erythematosus, Systemic Sclerosis (SSc) | Not applicable | Not yet recruiting | Hospices Civils de Lyon | 120 | 2026-12-01 | 2026-09-24 |
| A Study to Learn About a Medicine Called PF-08154225 in Participants With Autoimmune Diseases PF-08154225 - Systemic Lupus Erythematosus, Rheumatoid Arthritis | Phase 1 / Phase 2 | Not yet recruiting | Pfizer | 54 | 2026-11-19 | 2026-10-01 |
| FAST for DM - Fatty Acid Supplementation Trial (FAST) for Dermatomyositis (DM) FISH OIL 500MG OMEGA-3 SOFT GEL MINIS, Placebo - Dermatomyositis (DM), Juvenile Dermatomyositis (JDM) | Phase 2 | Recruiting | National Institute of Environmental Health Sciences (NIEHS) | 3000 | 2026-11-11 | 2026-11-06 |
| Safety and Efficacy of Universal CAR-T Cells (UWD-CD19) Combined With Immunosuppressants in the Treatment of Refractory Autoimmune Diseases anti-CD19 CAR-T cells - Systemic Lupus Erthematosus, Systemic Sclerosis (SSc) | Phase 1 / Phase 2 | Not yet recruiting | Peking University Third Hospital | 9 | 2026-11-01 | 2026-09-23 |
| Emerging Indications for Hyperbaric Oxygen Treatment Hyperbaric oxygen treatment (HBOT), 100% Oxygen - Post-COVID-19 Condition, Ulcerative Colitis | Phase 4 | Not yet recruiting | Jay C. Buckey Jr. | 100 | 2026-11-01 | 2026-09-09 |
| Imaging Assessment of Swallowing and Speech Muscles in Inclusion Body Myositis IBM, Inclusion Body Myositis | Recruiting | Johns Hopkins University | 30 | 2026-11-01 | 2026-10-28 | |
| A Study of BMS-986553 in Participants With Refractory Autoimmune Diseases BMS-986553 - Systemic Lupus Erythematosus, Sjögren's Disease | Phase 1 | Not yet recruiting | Bristol-Myers Squibb | 60 | 2026-10-30 | 2026-10-14 |
| BAFF CAR-T Cells (LMY-922) for Treatment of Refractory Autoimmune Disease LMY-922 - Rheumatoid Arthritis (RA), Systemic Lupus Erthematosus (SLE) | Phase 1 | Not yet recruiting | Luminary Therapeutics | 94 | 2026-10-01 | 2026-07-28 |
| FT839 in Autoimmune Diseases FT839 - ANCA-Associated Vasculitis (AAV), Idiopathic Inflammatory Myositis (IIM) | Phase 1 / Phase 2 | Recruiting | Fate Therapeutics | 446 | 2026-10-01 | 2026-09-02 |
| Inflammatory Disease Biobank for Immunophenotyping and Cardiovascular Research Pericarditis, Tako-TSUBO Cardiomyopathy | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 300 | 2026-09-01 | 2026-08-10 | |
| CD19/BCMA-Targeted Universal CAR-T Cell Injection for the Treatment of Autoimmune Diseases RD06-05 CAR-T Cell Injection - SLE - Systemic Lupus Erythematosus, Systemic Sclerosis | Early Phase 1 | Not yet recruiting | Nanjing Bioheng Biotech Co., Ltd. | 30 | 2026-09-01 | 2026-07-16 |
| Anti-inflammation Treatment for Idiopathic Inflammatory Myopathies maraviroc (Selzentry, Celsentri) - Myositis | Phase 4 | Not yet recruiting | Chinese University of Hong Kong | 10 | 2026-09-01 | 2026-06-30 |
| Pain-Sleep in Rheumatic Disease Better Nights, Better Days for Youth - Rheumatic Diseases, Arthritis | Not applicable | Not yet recruiting | The Hospital for Sick Children | 43 | 2026-09-01 | 2026-08-20 |
| A Study to Test CRT-402 in Refractory Autoimmune Disease CRT-402 - Autoimmune Diseases, Systemic Lupus Erythematosus | Phase 1 / Phase 2 | Recruiting | Myeloid Therapeutics | 34 | 2026-08-26 | 2026-10-22 |
| Emapalumab MDA5 Rapidly Progressive Interstitial Lung Disease (RP-ILD) Study Emapalumab - Dermatomyositis, Dermatomyositis Sine Myositis | Phase 2 | Recruiting | University of Miami | 5 | 2026-07-23 | 2026-08-25 |
| The Aim of the Study is to Characterize Patients Exhibiting Muscular Atrophy and Weakness Who Require a Muscle Biopsy for Diagnosis (IBM vs Atypical MND), Through an Innovative Technique Which Enables the Evaluation of the Neuromuscular Junction Involvement in Each Condition Inclusion Body Myositis (IBM), Motor Neuron Disease, Amyotrophic Lateral Sclerosis | Active not recruiting | IRCCS San Raffaele | 30 | 2026-07-01 | 2026-09-01 |
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Dermatomyositis (181) · Lupus Erythematosus, Systemic (87) · Scleroderma, Systemic (84) · Polymyositis (73) · Myositis, Inclusion Body (65) · Arthritis, Rheumatoid (53) · Sjogren's Syndrome (42) · Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (40) · Autoimmune Diseases (40) · Scleroderma, Diffuse (28) · Arthritis, Juvenile (25) · Antiphospholipid Syndrome (23) · Myositis Ossificans (23) · Muscular Diseases (19)
Musculoskeletal Diseases (412) · Muscular Diseases (399) · Nervous System Diseases (393) · Neuromuscular Diseases (388) · Skin and Connective Tissue Diseases (269) · Skin Diseases (253) · Connective Tissue Diseases (252) · Immune System Diseases (148) · Polymyositis (114) · Autoimmune Diseases (106) · Joint Diseases (95) · Arthritis (88) · Rheumatic Diseases (80) · Cardiovascular Diseases (74)
Cyclophosphamide (13) · fludarabine (12) · Blood Specimen Collection (6) · Tacrolimus (6) · baricitinib (6) · Abatacept (5) · Exercise (5) · Methotrexate (5) · Palovarotene (5) · Rituximab (5) · tocilizumab (5) · tofacitinib (5) · Etanercept (4) · Interleukin-2 (4) · bimagrumab (4)
Assistance Publique - Hôpitaux de Paris (14) · National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) (10) · Novartis Pharmaceuticals (9) · Peking University People's Hospital (8) · Clementia Pharmaceuticals Inc. (7) · National Institute of Environmental Health Sciences (NIEHS) (7) · University Hospital, Strasbourg, France (7) · China Immunotech (Beijing) Biotechnology Co., Ltd. (6) · Karolinska Institutet (6) · Regeneron Pharmaceuticals (6) · University of Sao Paulo (6) · LMU Klinikum (5) · Pfizer (5) · RenJi Hospital (5) · The First Affiliated Hospital with Nanjing Medical University (5)
United States (179) · China (80) · France (75) · United Kingdom (43) · Germany (42) · Italy (36) · Spain (36) · Poland (30) · Japan (27) · Australia (26) · Canada (26) · Brazil (23) · Czechia (23) · Netherlands (22) · Sweden (19)
Zhanguo Li (5) · Adam I Schiffenbauer, M.D. (4) · Ingrid E Lundberg, MD, PhD (4) · Lisa G Rider, M.D. (4) · Rohit Aggarwal, MD (4) · Andrew L Mammen, M.D. (2) · Chester V. Oddis, MD (2) · Eloisa Bonfa, MD, PhD (2)
PMID 36526263, PMID 38059274, PMID 37957586, PMID 36583535, PMID 37156007, PMID 42542380, PMID 42770123, PMID 11744511, PMID 11846115, PMID 12610846, PMID 12835280, PMID 15917857, PMID 15942915, PMID 16267188, PMID 16415388, PMID 16849828, PMID 16899504, PMID 16900450, PMID 16914703, PMID 17265499, PMID 17284544, PMID 17407214, PMID 17557758, PMID 19362675, PMID 19454532, PMID 19494218, PMID 19819109, PMID 19927034, PMID 19962619, PMID 20843660, PMID 21540203, PMID 21688301, PMID 21859696, PMID 21876977, PMID 22003934, PMID 22089462, PMID 22227955, PMID 22298793, PMID 22733975, PMID 22859354, PMID 22908326, PMID 22931582, PMID 22949223, PMID 22992045, PMID 23070991, PMID 23123020, PMID 23124935, PMID 23139240, PMID 23434567, PMID 23525305
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