6 completed, 2 recruiting, 2 terminated, 1 not yet recruiting. 11 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 11 | Completed 6, Recruiting 2, Terminated 2, Not yet recruiting 1 |
Follow Ketosis: new trials by email Literature Review of Ketosis trials Research Report on Ketosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure Ketone Monoester (KE) - Acute Heart Failure (AHF), Cardiogenic Shock | Phase 4 | Recruiting | Institute for Clinical and Experimental Medicine | 12 | 2026-04-04 | 2026-04-14 |
| Can the Addition of Pioglitazone to SGLT2 Inhibitor in Type 1 Diabetic Patients Amplify the Decrease in HbA1c and Prevent the Increase in Plasma Ketone Concentration? Dapagliflozin (DAPA), Pioglitazone 45 mg, Placebo - Type 1 Diabetes | Phase 4 | Not yet recruiting | Dasman Diabetes Institute | 60 | 2025-09-15 | 2025-08-29 |
| Modeling Ketosis-Prone Diabetes Remission Via Diverse Mechanisms of Glucotoxicity Continuous Glucose Monitoring, Insulin - Ketosis Prone Diabetes | Phase 4 | Recruiting | Emory University | 12 | 2025-01-23 | 2026-06-15 |
| 0.9% Saline Versus Balanced Solutions in Severe Diabetic Ketoacidosis Sodium chloride 0.9% (SC), Ringer lactate (RL) - Metabolic Ketoacidosis, Ketoacidemia | Phase 4 | Completed | Tunis University | 92 | 2022-11-01 | 2024-04-12 |
| Ketone Monitoring in T1D: Effect of SGLT2i During Usual Care and With Insulin Deficiency SGLT2 inhibitor, Biosense Breath Ketone Analyzer - Diabetes Mellitus, Type 1 | Phase 4 | Completed | Washington University School of Medicine | 21 | 2022-10-14 | 2025-02-21 |
| Early Basal Insulin Administration in Adult Diabetic Ketoacidosis Management Early Glargine, Late Glargine, IV insulin infusion - Diabetic Ketoacidosis, Type 1 Diabetes | Phase 4 | Terminated | The Cleveland Clinic | 39 | 2020-10-01 | 2022-09-21 |
| Double Blinded Randomized Control Trial of Types of IVF in Children With DKA Normal saline, Lactated Ringers - Diabetic Ketoacidosis | Phase 4 | Terminated | State University of New York at Buffalo | 53 | 2018-09-01 | 2024-08-06 |
| Metabolic Responses of Dapagliflozin vs Sitagliptin in T2DM Patients Inadequately Controlled With Insulin Therapy Dapagliflozin 10 mg, Sitagliptin 100mg - Type 2 Diabetes, Ketonemia | Phase 4 | Completed | The University of Hong Kong | 60 | 2017-08-16 | 2021-04-29 |
| Early Glargine (Lantus) in DKA Management in Children With Type 1 Diabetes Glargine, Continuous Glucose Monitor (Abbott FreeStyle Libre Pro) - Diabetic Ketoacidosis, Type 1 Diabetes Mellitus | Phase 4 | Completed | University of Colorado, Denver | 61 | 2017-07-21 | 2022-05-10 |
| Dosage Reduction and Acute Glycemic Complications in People With Type 2 Diabetes Who Fast During Ramadan Metformin and Glimepiride (Low Dosage), Metformin and Vildagliptin (Low Dosage), Metformin and Insulin Glargine U100 (Low Dosage) - Diabetes Mellitus, Type 2 | Phase 4 | Completed | University of Jordan | 687 | 2017-02-14 | 2020-02-11 |
| Basal Insulin in the Management of Patients With Diabetic Ketoacidosis (DKA) insulin glargine+ glulisine, NPH + Regular insulin - Diabetic Ketoacidosis | Phase 4 | Completed | Emory University | 74 | 2007-12-01 | 2018-09-26 |
Diabetic Ketoacidosis (7) · Diabetes Mellitus, Type 1 (5) · Diabetes Mellitus, Type 2 (4) · Hypoglycemia (2) · Fasting (1) · Heart Failure (1) · Hyperglycemia (1) · Hyperglycemic Hyperosmolar Nonketotic Coma (1) · Insulin Resistance (1) · Shock, Cardiogenic (1)
Acid-Base Imbalance (11) · Acidosis (11) · Metabolic Diseases (11) · Nutritional and Metabolic Diseases (11) · Diabetes Mellitus (10) · Endocrine System Diseases (10) · Diabetes Complications (7) · Glucose Metabolism Disorders (7) · Autoimmune Diseases (5) · Immune System Diseases (5) · Behavior (1) · Cardiovascular Diseases (1) · Diabetic Coma (1) · Feeding Behavior (1)
Insulin (3) · Insulin Glargine (3) · dapagliflozin (3) · Ringer's Lactate (2) · Sodium Chloride (2) · Continuous Glucose Monitoring (1) · Fluid Therapy (1) · Metformin (1) · Pioglitazone (1) · Saline Solution (1) · Sitagliptin Phosphate (1) · Sodium-Glucose Transporter 2 Inhibitors (1) · Vildagliptin (1) · glimepiride (1) · insulin glulisine (1)
Emory University (2) · Dasman Diabetes Institute (1) · Institute for Clinical and Experimental Medicine (1) · State University of New York at Buffalo (1) · The Cleveland Clinic (1) · The University of Hong Kong (1) · Tunis University (1) · University of Colorado, Denver (1) · University of Jordan (1) · Washington University School of Medicine (1)
United States (6) · Czechia (1) · Hong Kong (1) · Jordan (1) · Kuwait (1) · Qatar (1) · Saudi Arabia (1) · Tunisia (1)
Ahlem Trifi (1) · Amanda B Hassinger, MD, MS (1) · Ayman A. Zayed, MD (1) · Fahd Al-Mulla, MD, PhD (1) · Guillermo Umpierrez, MD (1) · Janet B McGill, MD (1) · Kathryn Tan, MD (1) · Mohamed Abu-Farha, PhD (1) · Muhammed Abdul Ghani, MD, PhD (1) · Priyathama Vellanki, MD, MS (1) · Rebecca Ohman-Hanson (1) · Sidney Jones, MD (1)
PMID 19366972, PMID 34305809, PMID 39974120, PMID 40234173, PMID 40260699