3 completed, 3 recruiting, 2 active not recruiting, 1 enrolling by invitation. 11 Phase 3, 7 Phase 2.
Follow Ketosis: new trials by email Literature Review of Ketosis trials Research Report on Ketosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of Ketones on Brain Energetics and Alcohol Consumption in Alcohol Use Disorder Kenetik, magnetic resonance imaging scan, Alcohol bar lab - Alcohol Use Disorder, Ketosis | Phase 2 / Phase 3 | Recruiting | University of Pennsylvania | 60 | 2026-12-01 | 2026-10-21 |
| Effects of Ketone Supplementation on Alcohol Withdrawal and Brain Metabolism in Alcohol Use Disorder ketone supplement "D-beta-hydroxybutryric acid and R-1,3 butanediol" 12g of ketones,, magnetic resonance imaging session, Placebo beverage - Alcohol Use Disorder, Alcohol Withdrawal | Phase 2 / Phase 3 | Recruiting | University of Pennsylvania | 30 | 2025-08-01 | 2026-11-05 |
| Effects of Ketone Supplement and Alcohol on Brain Metabolism Kenetik, Alcohol beverage - Ketosis, Alcohol Drinking | Phase 2 / Phase 3 | Active not recruiting | University of Pennsylvania | 60 | 2025-05-13 | 2026-10-14 |
| REAMBERIN® 1.5% in Rehydration Therapy of Diabetic Ketoacidosis Reamberin, Placebo - Diabetic Ketoacidosis | Phase 2 / Phase 3 | Recruiting | POLYSAN Scientific & Technological Pharmaceutical Company | 312 | 2025-05-01 | 2025-06-24 |
| Balanced Multi-Electrolyte Solution Versus Saline Trial for Diabetic KetoAcidosis Plasma-Lyte 148, 0.9% sodium chloride - Diabetic Ketoacidosis | Phase 3 | Completed | The George Institute | 547 | 2024-03-14 | 2026-10-05 |
| Effects of Ketone Supplementation on Acute Alcohol Withdrawal Kenetik; Ketone Concentrate, Isocaloric dextrose placebo - Alcohol Use Disorder, Alcohol Withdrawal | Phase 2 / Phase 3 | Enrolling by invitation | University of Pennsylvania | 50 | 2024-03-11 | 2026-04-06 |
| Effect of Nutritional Ketosis on Alcohol Metabolism Ketone Supplement, Control Diet, Ketogenic diet - Ketoses, Metabolic, Ketogenic Dieting | Phase 2 / Phase 3 | Active not recruiting | University of Pennsylvania | 23 | 2024-02-29 | 2026-04-07 |
| Exogenous Ketones for Acutely Decompensated HEart Failure 25g Ketone monoester without added salts, Placebo - Acute Heart Failure, Low Cardiac Output Syndrome | Phase 3 | Unknown | Institute for Clinical and Experimental Medicine | 24 | 2020-12-02 | 2021-01-06 |
| Randomized Control Trial of Fluid Therapy for Pediatric Diabetic Ketoacidosis 0.45% saline replacement fluid, 0.9% saline replacement fluid, 0.45% saline intravenous fluid - Cerebral Edema, Diabetic Ketoacidosis | Phase 3 | Completed | University of California, Davis | 1389 | 2010-11-01 | 2018-06-25 |
| Internet Administration of the Modified Atkins Diet for Adults With Intractable Epilepsy Dietary management of seizures - Epilepsy | Phase 3 | Completed | Johns Hopkins University | 30 | 2007-02-01 | 2015-09-02 |
| AC-1204 Long-term Efficacy Response Trial (ALERT Protocol) caprylic triglyceride, long-chain triglyceride - Alzheimer's Disease | Phase 2 / Phase 3 | Withdrawn | Cerecin | 2012-12-04 |
Alcoholism (3) · Diabetic Ketoacidosis (3) · Alcohol Drinking (2) · Alcoholic Intoxication (1) · Alzheimer Disease (1) · Brain Edema (1) · Cardiac Output, Low (1) · Epilepsy (1) · Seizures (1)
Acid-Base Imbalance (11) · Acidosis (11) · Metabolic Diseases (11) · Nutritional and Metabolic Diseases (11) · Mental Disorders (5) · Alcohol-Related Disorders (4) · Chemically-Induced Disorders (4) · Substance-Related Disorders (4) · Brain Diseases (3) · Central Nervous System Diseases (3) · Diabetes Complications (3) · Diabetes Mellitus (3) · Endocrine System Diseases (3) · Nervous System Diseases (3)
Ethanol (3) · Alcoholic Beverages (1) · Diet, Ketogenic (1) · Ketones (1) · Magnetic Resonance Spectroscopy (1) · Plasma-lyte 148 (1) · Reamberin (1) · Saline Solution (1) · Sodium Chloride (1) · Sunflower Oil (1) · maltodextrin (1) · tricaprylin (1)
University of Pennsylvania (5) · Cerecin (1) · Institute for Clinical and Experimental Medicine (1) · Johns Hopkins University (1) · POLYSAN Scientific & Technological Pharmaceutical Company (1) · The George Institute (1) · University of California, Davis (1)
United States (8) · Australia (1) · Czechia (1) · Russia (1)
Corinde Wiers, Ph.D. (4) · Corinde E Wiers, Ph.D. (1) · Eric H Kossoff, MD (1) · Henry Kranzler, MD (1) · Kyle Kampman, MD (1) · Mildred Farmer, MD (1) · Nathan Kuppermann, MD, MPH (1) · Nicole S Glaser, MD (1) · Tatiana Kharitonova, MD, PhD (1)
R21AA031088 (2), R01AA031570 (1), R21AA031337 (1), U01HD062417 (1)