6 completed, 5 recruiting, 4 unknown, 2 enrolling by invitation. 14 Not applicable, 2 Phase 2, 2 Phase 4, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 14 | Completed 6, Recruiting 4, Unknown 2, Enrolling by invitation 1, Suspended 1 |
| Phase 2 | 2 | Enrolling by invitation 1, Recruiting 1 |
| Phase 4 | 2 | Unknown 2 |
| Phase 3 | 1 | Recruiting 1 |
Follow Ketones: new trials by email Literature Review of Ketones trials Research Report on Ketones
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ketogenic Dietary Intervention to Improve Response to Immunotherapy in Patients With Metastatic Melanoma and Metastatic Kidney Cancer Best Practice, Biospecimen Collection, Computed Tomography - Clinical Stage IV Cutaneous Melanoma AJCC v8, Metastatic Cutaneous Melanoma | Not applicable | Suspended | Ohio State University Comprehensive Cancer Center | 60 | 2025-11-17 | 2026-05-26 |
| Ketone and Hawthorn Extract Supplementation in Congestive Heart Failure Hawthorn supplement, Ketones, Placebo Control - Congestive Heart Failure(CHF) | Not applicable | Enrolling by invitation | Thomas Jefferson University | 45 | 2025-11-15 | 2025-11-18 |
| Effects of Ketone Supplementation on Alcohol Withdrawal and Brain Metabolism in Alcohol Use Disorder ketone supplement "D-beta-hydroxybutryric acid and R-1,3 butanediol" 12g of ketones,, magnetic resonance imaging session, Placebo beverage - Alcohol Use Disorder, Alcohol Withdrawal | Phase 2 / Phase 3 | Recruiting | University of Pennsylvania | 30 | 2025-08-01 | 2026-11-05 |
| Chronic Exogenous Ketosis in HFpEF Exogenous Ketone Drink, Placebo - Heart Failure With Preserved Ejection Fraction (HFPEF), Heart Failure With Normal Ejection Fraction | Phase 2 | Enrolling by invitation | Duke University | 20 | 2025-07-28 | 2026-10-14 |
| Exogenous Ketone Supplementation in Females with Polycystic Ovary Syndrome Ketone, Water - PCOS | Not applicable | Recruiting | McGill University | 60 | 2025-01-20 | 2025-01-22 |
| BHB & CAR-T for Lymphomas R-1,3-Butanediol - Large B-cell Lymphoma | Not applicable | Recruiting | Abramson Cancer Center at Penn Medicine | 5 | 2025-01-07 | 2026-02-23 |
| The Effect of Butanediol Ingestion on Skeletal Muscle Angiogenesis in Hypoxia Normoxic recovery and placebo (NPL), Normoxic recovery and ketones (NKE), Hypoxic recovery and placebo (HPL) - Ketosis, Hypoxia | Not applicable | Completed | KU Leuven | 15 | 2024-07-01 | 2024-09-19 |
| Well-Formulated Ketogenic Diet Polycystic Kidney Disease Ketogenic Diet, Ketone/Glucose Monitoring, CGM/CKM - Polycystic Kidney Disease | Not applicable | Recruiting | Ohio State University | 20 | 2024-06-01 | 2026-11-03 |
| Use of Ketosis in Modulating Metabolic Pathways in Bipolar Disorder Glucose, Ketones - Bipolar Disorder, Bipolar Disorder Type 1 | Not applicable | Recruiting | Stony Brook University | 100 | 2024-01-26 | 2026-04-15 |
| Ketogenic Intervention in Depression Ketogenic Diet, NIH Toolbox, gradCPT - Depression, Ketosis | Not applicable | Completed | Ohio State University | 30 | 2023-02-20 | 2025-05-29 |
| Ketones and Muscle Protein Synthesis Ketone, Ketone + Protein, Protein - Ketosis, Regulation of Muscle Protein Synthesis | Not applicable | Completed | McGill University | 36 | 2020-09-21 | 2021-05-18 |
| Ketone Supplementation in Adolescents Post-Concussion Ketone, Placebo - Concussion, Mild, Concussion, Severe | Not applicable | Completed | University of Alabama at Birmingham | 5 | 2020-03-20 | 2022-05-10 |
| Ketone Supplementation and Exercise Performance 10 km time trial, 30s Wingate, Ketone - Ketosis, Exercise Performance | Not applicable | Unknown | Western University, Canada | 20 | 2019-09-01 | 2019-07-23 |
| Exogenous Ketone Supplementation and Exercise Performance 20 km time trial, Wingate test, Ketone/Caffeine - Ketonemia, Ketosis | Not applicable | Unknown | Western University, Canada | 20 | 2019-05-15 | 2019-10-02 |
| Impact of Exogenous Ketones on Indices of Keto-Adaptation in Obese Subjects on Weight Reducing Diets. Diet, Blood Draw, Ketone/Glucose Monitoring - Ketogenic Diet, Weight Loss | Not applicable | Completed | Ohio State University | 37 | 2018-07-05 | 2024-12-19 |
| Dynamic Connectivity Under Metabolic Constraints Ketones, Glucose - Insulin Resistance, Healthy | Phase 4 | Unknown | Stony Brook University | 80 | 2015-06-19 | 2019-09-27 |
| Dynamic Connectivity Under Metabolic Constraints Ketones, Glucose - Insulin Resistance, Healthy | Phase 4 | Unknown | Massachusetts General Hospital | 80 | 2015-06-19 | 2023-01-12 |
| Ketones Influence on Glucose Metabolism in Brain. A Human Positron Emission Tomography (PET) Study ketone, placebo - Ketone Body Metabolism, Brain Metabolism | Not applicable | Completed | University of Aarhus | 9 | 2015-03-01 | 2016-01-18 |
Ketosis (8) · Insulin Resistance (3) · Heart Failure (2) · Motor Activity (2) · Alcoholism (1) · Bipolar Disorder (1) · Brain Concussion (1) · Bronchiolitis Obliterans Syndrome (1) · Carcinoma, Renal Cell (1) · Depression (1) · Heart Failure, Diastolic (1) · Hypoxia (1) · Melanoma (1) · Polycystic Kidney Diseases (1) · Polycystic Ovary Syndrome (1)
Ohio State University (3) · McGill University (2) · Stony Brook University (2) · Western University, Canada (2) · Abramson Cancer Center at Penn Medicine (1) · Duke University (1) · KU Leuven (1) · Massachusetts General Hospital (1) · Ohio State University Comprehensive Cancer Center (1) · Thomas Jefferson University (1) · University of Aarhus (1) · University of Alabama at Birmingham (1) · University of Pennsylvania (1)
United States (12) · Canada (4) · Belgium (1) · Denmark (1)
Andrew B Newberg, MD (1) · Charlotte Usselman, Ph.D (1) · Corinde Wiers, Ph.D. (1) · Elise Chong, MD (1) · Jeff Volek, PhD (1) · Lilianne Mujica-Parodi, PhD (1) · Lilianne R Mujica-Parodi, Ph.D. (1) · Mads Svart, MD (1) · Marium Husain, MD, MPH (1) · Peter Lemon, PhD (1) · Peter WR Lemon, PhD (1) · Senthil Selvaraj, MD (1) · Tyler A Churchward-Venne, Ph.D. (1)
PMID 25275931, PMID 30327354, PMID 33074729, PMID 36248655, PMID 36629058, PMID 36963874, PMID 38215886
R21AA031337 (1)