15 completed, 7 unknown, 5 terminated, 3 recruiting. 33 Phase 2, 10 Phase 1, 4 Phase 3.
Follow Ischemic Heart Disease: new trials by email Literature Review of Ischemic Heart Disease trials Research Report on Ischemic Heart Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Exploratory Study of ADR-002K for Heart Failure Patients With Ischemic Heart Disease Who Undergo CABG Mesenchymal stem cell, Placebo - Ischemic Heart Disease | Phase 2 | Recruiting | Rohto Pharmaceutical Co., Ltd. | 50 | 2026-04-28 | 2026-06-09 |
| Chaigui Longmu Ejiao Paste for Ischemic Heart Disease Standard Western medicine treatment + Chaigui Longmu Ejiao Paste, Placebo Comparator: Standard Western medicine treatment + Chaigui Longmu Paste without Ejiao - Ischemic Heart Disease | Phase 2 | Not yet recruiting | Longhua Hospital | 60 | 2026-03-08 | 2026-03-17 |
| Endocardial Delivery for Myocardial Regeneration Using Allogeneic iPSC-derived Cardiomyocyte Spheroids for HF With Systolic Dysfunction (EMERALD Study) HS-005 - Heart Failure, Ischemic Heart Failure | Phase 1 / Phase 2 | Recruiting | Heartseed Inc. | 14 | 2026-01-19 | 2026-10-22 |
| Single or Repeated Intravenous Administration of umbiliCAl Cord Mesenchymal sTrOmal Cells in Ischemic Cardiomyopathy umbilical cord-derived mesenchymal stromal cells (UC-MSCs) - Ischemic Heart Disease | Phase 2 | Recruiting | Roberto Bolli | 60 | 2024-03-04 | 2026-05-13 |
| Polyamine Treatment in Elderly Patients With Coronary Artery Disease Spermidine, Placebo - Ischemic Heart Disease, Myocardial Infarction | Phase 2 | Completed | University of Aarhus | 187 | 2024-01-01 | 2026-07-01 |
| A Study of iPS Cell-derived Cardiomyocyte Spheroids (HS-001) in Patients With Heart Failure (LAPiS Study) HS-001 CS, HS-001-D needle, HS-001-D Adaptor - Heart Failure, Ischemic Heart Disease | Phase 1 / Phase 2 | Completed | Heartseed Inc. | 10 | 2022-04-19 | 2026-10-22 |
| A Study of Flurpiridaz (18F) Injection for PET Imaging for Assessment of MPI Quality Using HPLC and SPE Manufacturing Processes Flurpiridaz (18F) Injection - Coronary Artery Disease (CAD), Ischemic Heart Disease | Phase 2 | Completed | GE Healthcare | 38 | 2022-01-27 | 2023-08-01 |
| Allogeneic Mesenchymal Human Stem Cell Infusion Therapy for Endothelial DySfunctiOn in Diabetic Subjects With Symptomatic Ischemic Heart Disease. (ACESO-IHD) 100 million Allogeneic Mesenchymal Human Stem Cells, Placebo - Diabetes Mellitus, Ischemic Heart Disease | Phase 1 / Phase 2 | Completed | Joshua M Hare | 26 | 2021-08-16 | 2026-06-16 |
| Ozone Therapy in Refractory Ischemic Heart Disease. Ozone, Oxygen - Ischemic Heart Disease | Phase 2 / Phase 3 | Terminated | Bernardino Clavo, MD, PhD | 1 | 2020-02-26 | 2022-04-04 |
| Serial Infusions of Allogeneic Mesenchymal Stem Cells in Cardiomyopathy Patients With Left Ventricular Assist Device Human Allogeneic Mesenchymal Bone Marrow Cells (aMBMC), Placebo - Ischemic Heart Disease, Non-ischemic Cardiomyopathy | Phase 2 | Terminated | Medstar Health Research Institute | 4 | 2019-05-03 | 2022-02-02 |
| The Cardioprotective Effects of Adding Ozone To Cardioplegic Solution in Adult Cardiac Surgery Ozone, Cardioplegic Solutions - Ischemic Heart Disease | Phase 2 / Phase 3 | Unknown | Assiut University | 40 | 2019-04-01 | 2019-03-19 |
| The Randomized OPTIMAL-ACT Trial Unfractionated heparin - Coronary Artery Disease, Ischemic Heart Disease | Phase 2 | Completed | Mayo Clinic | 180 | 2019-02-08 | 2023-04-04 |
| Sequential Treatment of Extra-Corporeal Shock Wave Combined With aUtologous Bone marRow Mesenchymal Stem Cells on Patients With ischEmic Heart Disease : the S-CURE Study CSWT+BMMSCs, CSWT+Sham operation - Ischemic Heart Disease | Phase 1 / Phase 2 | Unknown | Shanghai 10th People's Hospital | 120 | 2018-04-03 | 2019-08-28 |
| Safety and Efficacy Study of Gene Therapy for Acute Myocardial Infarction in Korea Stage 1-Low dose VM202RY, Stage 1-Middle dose VM202RY, Stage 1-High dose VM202RY - Ischemic Heart Disease, Acute Myocardial Infarction | Phase 2 | Withdrawn | Helixmith Co., Ltd. | 2018-01-25 | 2025-09-25 | |
| Rituximab in Patients With Acute ST-elevation Myocardial Infarction Study RiTUXimab Injection - Ischemic Heart Disease, Myocardial Infarction | Phase 1 / Phase 2 | Completed | Papworth Hospital NHS Foundation Trust | 24 | 2017-06-01 | 2021-09-14 |
| Low Dose Interleukin-2 in Patients With Stable Ischaemic Heart Disease and Acute Coronary Syndromes Proleukin, Placebo Injection - Ischemic Heart Disease | Phase 1 / Phase 2 | Completed | Cambridge University Hospitals NHS Foundation Trust | 41 | 2017-05-11 | 2021-09-14 |
| The New Pharmaceutical Composition Containing Botulinum Toxin to Treat Atrial Fibrillation Pharmaceutical composition containing botulinum toxin, 0.9% normal saline, Coronary artery bypass grafting - Atrial Fibrillation, Ischemic Heart Disease | Phase 2 | Unknown | Meshalkin Research Institute of Pathology of Circulation | 180 | 2016-09-01 | 2016-12-05 |
| Epicardial Fat Pads Ablation During Coronary Surgery Coronary artery bypass grafting, Epicardial ganglionated plexi ablation, implantable loop recorder - Atrial Fibrillation, Ischemic Heart Disease | Phase 2 | Unknown | Meshalkin Research Institute of Pathology of Circulation | 264 | 2016-06-01 | 2016-12-06 |
| GS-6615 in Adults With Chronic Stable Angina and Coronary Artery Disease GS-6615, Placebo - Ischemic Heart Disease | Phase 2 | Withdrawn | Gilead Sciences | 2015-05-01 | 2015-06-08 | |
| BioFreedom US IDE Feasibility Trial BioFreedom drug coated coronary stent - Ischemic Heart Disease, Stable Angina | Phase 2 / Phase 3 | Unknown | Biosensors Europe SA | 72 | 2014-08-01 | 2015-04-01 |
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Myocardial Ischemia (33) · Heart Failure (6) · Coronary Artery Disease (5) · Myocardial Infarction (3) · Angina, Stable (2) · Angina, Unstable (2) · Atrial Fibrillation (2) · Cardiovascular Diseases (2) · Coronary Disease (2) · Heart Diseases (2) · Inflammation (2) · Adenoviridae Infections (1) · Angina Pectoris (1) · Atherosclerosis (1) · Cardiomyopathy, Dilated (1)
Vascular Diseases (33) · Cardiovascular Diseases (31) · Heart Diseases (31) · Pathological Conditions, Signs and Symptoms (8) · Pathologic Processes (6) · Arterial Occlusive Diseases (5) · Arteriosclerosis (5) · Coronary Disease (4) · Signs and Symptoms (4) · Chest Pain (3) · Endocrine System Diseases (3) · Infarction (3) · Ischemia (3) · Necrosis (3) · Neurologic Manifestations (3)
Coronary Artery Bypass (2) · Ozone (2) · Adenosine (1) · Cardioplegic Solutions (1) · Cell- and Tissue-Based Therapy (1) · Dipyridamole (1) · Fluid Therapy (1) · Growth Hormone (1) · Heparin (1) · Hepatocyte Growth Factor (1) · Human Growth Hormone (1) · Injections (1) · Natriuretic Peptide, Brain (1) · Oxygen (1) · Polyamines (1)
Heartseed Inc. (2) · Helixmith Co., Ltd. (2) · Meshalkin Research Institute of Pathology of Circulation (2) · Adenobio N.V (1) · Assiut University (1) · Bernardino Clavo, MD, PhD (1) · Biosensors Europe SA (1) · Cambridge University Hospitals NHS Foundation Trust (1) · Cook MyoSite (1) · Copenhagen University Hospital, Rigshospitalet (1) · Federico II University (1) · Forest Laboratories (1) · GE Healthcare (1) · Genzyme, a Sanofi Company (1) · Gilead Sciences (1)
United States (7) · China (3) · France (3) · Japan (3) · South Korea (3) · United Kingdom (3) · Belgium (2) · Denmark (2) · Italy (2) · Russia (2) · Canada (1) · Germany (1) · Spain (1) · Switzerland (1)
Antonio Cittadini, MD (1) · Bernardino Clavo, MD, PhD (1) · Celestina Amador, MD, PhD (1) · Corrado Vassanelli, MD (1) · E Gordon DePuey, MD (1) · Flavio Ribichini, MD (1) · Francois Tranquart, MD, PhD (1) · Gibong Kim, MD, PhD (1) · Henrik Wiggers, DMSC PHD MD (1) · Hung Q. Ly, MD (1) · Janusz Lipiecki, Dr (1) · Jens Kastrup, MD DMSc (1) · Joseph Cheriyan, MBCHB, MA, FRCP (1)
PMID 19377384, PMID 21531233, PMID 23492671, PMID 30224390, PMID 33783498, PMID 37184744, PMID 38319239, PMID 39163570, PMID 41168834, PMID 41397478, PMID 42000692
2014 (1), 2018 (1), R01HL134558 (1)