11 completed, 6 unknown, 2 terminated, 1 recruiting. 20 Phase 1, 10 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 20 | Completed 11, Unknown 6, Terminated 2, Recruiting 1 |
| Phase 2 | 10 | Completed 6, Unknown 2, Recruiting 1, Terminated 1 |
Follow Ischemic Heart Disease: new trials by email Literature Review of Ischemic Heart Disease trials Research Report on Ischemic Heart Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Endocardial Delivery for Myocardial Regeneration Using Allogeneic iPSC-derived Cardiomyocyte Spheroids for HF With Systolic Dysfunction (EMERALD Study) HS-005 - Heart Failure, Ischemic Heart Failure | Phase 1 / Phase 2 | Recruiting | Heartseed Inc. | 14 | 2026-01-19 | 2026-10-22 |
| A Study of iPS Cell-derived Cardiomyocyte Spheroids (HS-001) in Patients With Heart Failure (LAPiS Study) HS-001 CS, HS-001-D needle, HS-001-D Adaptor - Heart Failure, Ischemic Heart Disease | Phase 1 / Phase 2 | Completed | Heartseed Inc. | 10 | 2022-04-19 | 2026-10-22 |
| Allogeneic Mesenchymal Human Stem Cell Infusion Therapy for Endothelial DySfunctiOn in Diabetic Subjects With Symptomatic Ischemic Heart Disease. (ACESO-IHD) 100 million Allogeneic Mesenchymal Human Stem Cells, Placebo - Diabetes Mellitus, Ischemic Heart Disease | Phase 1 / Phase 2 | Completed | Joshua M Hare | 26 | 2021-08-16 | 2026-06-16 |
| Effect of Human Umbilical Cord-derived Mesenchymal Stem Cells on Non-cardiac Surgery-induced Lung Injury human umbilical cord-derived mesenchymal stem cells, saline - Ischemic Heart Disease, Lung Injury | Phase 1 | Unknown | Shanghai East Hospital | 16 | 2021-08-01 | 2023-12-19 |
| Sequential Treatment of Extra-Corporeal Shock Wave Combined With aUtologous Bone marRow Mesenchymal Stem Cells on Patients With ischEmic Heart Disease : the S-CURE Study CSWT+BMMSCs, CSWT+Sham operation - Ischemic Heart Disease | Phase 1 / Phase 2 | Unknown | Shanghai 10th People's Hospital | 120 | 2018-04-03 | 2019-08-28 |
| Rituximab in Patients With Acute ST-elevation Myocardial Infarction Study RiTUXimab Injection - Ischemic Heart Disease, Myocardial Infarction | Phase 1 / Phase 2 | Completed | Papworth Hospital NHS Foundation Trust | 24 | 2017-06-01 | 2021-09-14 |
| Low Dose Interleukin-2 in Patients With Stable Ischaemic Heart Disease and Acute Coronary Syndromes Proleukin, Placebo Injection - Ischemic Heart Disease | Phase 1 / Phase 2 | Completed | Cambridge University Hospitals NHS Foundation Trust | 41 | 2017-05-11 | 2021-09-14 |
| Intraoperative Nasal Insulin Effect on Plasma and CSF Insulin Concentration and Blood Glucose Humulin R, Normal Saline - Ischemic Heart Disease, Aortic Aneurysm | Phase 1 | Unknown | Hiroaki Sato, MD., PhD. | 141 | 2016-09-01 | 2021-02-24 |
| Transplantation of Human Embryonic Stem Cell-derived Progenitors in Severe Heart Failure Human embryonic stem cell-derived CD15+ Isl-1+ progenitors - Ischemic Heart Disease | Phase 1 | Completed | Assistance Publique - Hôpitaux de Paris | 10 | 2013-05-27 | 2018-07-10 |
| In Vivo Tracking of USPIO Labeled MSC in the Heart USPIO labeled MSC injection - Ischemic Heart Disease | Phase 1 | Completed | Copenhagen University Hospital, Rigshospitalet | 5 | 2013-05-01 | 2018-08-29 |
| A Phase 1 Study to Assess the Safety,Tolerability, and Pharmacokinetics of GS-6615 in Healthy Subjects GS-6615, Placebo - Ischemic Heart Disease | Phase 1 | Completed | Gilead Sciences | 36 | 2013-05-01 | 2013-11-13 |
| Safety Study of Adenovirus Hepatocyte Growth Factor to Treat Ischemic Heart Disease Ad-HGF - Ischemic Heart Disease | Phase 1 / Phase 2 | Unknown | The First Affiliated Hospital with Nanjing Medical University | 40 | 2012-11-01 | 2013-08-20 |
| Stem Cell Injection to Treat Heart Damage During Open Heart Surgery Cell Therapy - Heart Disease, Ischemic Heart Disease | Phase 1 | Terminated | National Heart, Lung, and Blood Institute (NHLBI) | 24 | 2012-02-29 | 2018-07-05 |
| Autologous Cell Therapy for Ischemic Heart Failure AMDC - Ischemic Heart Disease | Phase 1 / Phase 2 | Terminated | Cook MyoSite | 9 | 2011-02-05 | 2021-07-01 |
| Effect of Remote Ischemic Preconditioning on Cognitive Function After Off-Pump Coronary Artery Bypass Graft remote ischemic preconditioning - Ischemic Heart Disease | Phase 1 | Unknown | Asan Medical Center | 270 | 2009-10-01 | 2009-08-06 |
| Effect of Remote Preconditioning in Patients Undergoing Off-pump Coronary Artery Bypass Graft Surgery remote ischemic preconditioning - Ischemic Heart Disease | Phase 1 | Completed | Seoul National University Hospital | 68 | 2009-03-01 | 2009-10-08 |
| VIVID - Valvular and Ventricular Improvement Via iCoapsys Delivery - Feasibility Study Percutaneous mitral valve repair - Mitral Valve Regurgitation, Left Ventricular Dysfunction | Phase 1 | Unknown | Myocor | 30 | 2008-01-01 | 2009-06-24 |
| Safety Study of Gene Therapy for Ischemic Heart Disease in Korea VM202-0.5 mg, VM202-1.0 mg, VM202-2.0 mg - Ischemic Heart Disease | Phase 1 / Phase 2 | Completed | Helixmith Co., Ltd. | 9 | 2007-01-01 | 2025-10-03 |
| A Randomized Clinical Trial of Adipose-derived Stem Cells in Treatment of Non Revascularizable Ischemic Myocardium Direct injection of ADRCs into the Left Ventricle, Direct injection of placebo into the Left Ventricle - Ischemic Heart Disease, Coronary Arteriosclerosis | Phase 1 | Completed | Cytori Therapeutics | 27 | 2007-01-01 | 2013-08-28 |
| The Effect of Mobilized Stem Cell by G-CSF and VEGF Gene Therapy in Patients With Stable Severe Angina Pectoris VEGF-A165 plasmid - Ischemic Heart Disease | Phase 1 / Phase 2 | Completed | Copenhagen University Hospital, Rigshospitalet | 48 | 2003-03-01 | 2011-08-05 |
Myocardial Ischemia (20) · Heart Diseases (4) · Heart Failure (4) · Coronary Artery Disease (2) · Myocardial Infarction (2) · Adenoviridae Infections (1) · Aortic Aneurysm (1) · Cardiomyopathy, Dilated (1) · Cardiovascular Diseases (1) · Coronary Disease (1) · Deafness, Autosomal Recessive 39 (1) · Diabetes Mellitus (1) · Inflammation (1) · Lung Injury (1) · Mitral Valve Insufficiency (1)
Vascular Diseases (20) · Cardiovascular Diseases (19) · Heart Diseases (16) · Arterial Occlusive Diseases (2) · Arteriosclerosis (2) · Infarction (2) · Ischemia (2) · Necrosis (2) · Pathologic Processes (2) · Pathological Conditions, Signs and Symptoms (2) · Aneurysm (1) · Aortic Diseases (1) · Cardiomegaly (1) · Cardiomyopathies (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1)
Cell- and Tissue-Based Therapy (1) · Insulin (1) · Rituximab (1) · Saline Solution (1) · Sodium Chloride (1) · aldesleukin (1) · eleclazine (1)
Copenhagen University Hospital, Rigshospitalet (2) · Heartseed Inc. (2) · Asan Medical Center (1) · Assistance Publique - Hôpitaux de Paris (1) · Cambridge University Hospitals NHS Foundation Trust (1) · Cook MyoSite (1) · Cytori Therapeutics (1) · Gilead Sciences (1) · Helixmith Co., Ltd. (1) · Hiroaki Sato, MD., PhD. (1) · Joshua M Hare (1) · Myocor (1) · National Heart, Lung, and Blood Institute (NHLBI) (1) · Papworth Hospital NHS Foundation Trust (1) · Seoul National University Hospital (1)
United States (4) · China (3) · South Korea (3) · Canada (2) · Denmark (2) · Japan (2) · United Kingdom (2) · France (1) · Netherlands (1) · Spain (1)
Jens Kastrup, MD DMSc (2) · Alexander M Milstein, MD (1) · Elizabeth Layug, MD (1) · Emerson C Perin, MD, PhD (1) · Gibong Kim, MD, PhD (1) · Hung Q. Ly, MD (1) · In-Cheol Choi, professor (1) · Joseph Cheriyan, MBCHB, MA, FRCP (1) · Nikolaos Spilias, MD (1) · Pamela G Robey, Ph.D. (1) · Xiangrui Wang (1) · Yawei Xu, MD,PhD (1) · YunSeok Jeon, Professor (1)
PMID 18841094, PMID 22301846, PMID 24952864, PMID 29389360, PMID 30224390, PMID 30895515, PMID 31814830, PMID 33721199, PMID 33783498, PMID 37184744, PMID 38319239
R01HL134558 (1)