82 completed, 39 recruiting, 24 unknown, 17 terminated. 88 Not applicable, 29 Phase 2, 15 Phase 1, 11 Phase 3, 1 Early Phase 1.
Follow Deafness: new trials by email Literature Review of Deafness trials Research Report on Deafness
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| 24-Month Trial of NPI-001 for the Preservation of Photoreceptors in Retinitis Pigmentosa Associated With Usher Syndrome N-acetylcysteine amide, Placebo - Retinitis Pigmentosa (RP), Usher Syndrome | Phase 3 | Not yet recruiting | Nacuity Pharmaceuticals, Inc. | 80 | 2026-12-01 | 2026-07-01 |
| A 24-Month Trial of NPI-001 for the Preservation of Photoreceptors in Retinitis Pigmentosa Associated With Usher Syndrome Placebo, NPI-001 - Retinitis Pigmentosa (RP), Usher Syndrome | Phase 3 | Recruiting | Nacuity Pharmaceuticals, Inc. | 80 | 2026-10-23 | 2026-11-10 |
| SENSE-Brain Health Pro for Older Adults With Sensory Loss Brain Health Pro - Vision and Hearing Loss, Vision Impairment | Not applicable | Not yet recruiting | Université de Montréal | 300 | 2026-10-15 | 2026-10-05 |
| Study to Evaluate the Long-Term Safety of Ultevursen in Participants With Retinitis Pigmentosa (RP) Due to Mutations in Exon 13 of the USH2A Gene No intervention, will not receive any active study intervention, Intravitreal Injection of Ultevursen - Retinitis Pigmentosa (RP), Usher Syndrome Type 2 | Phase 2 | Not yet recruiting | Laboratoires Thea | 81 | 2026-10-05 | 2026-09-01 |
| Improving Cochlear Implant Outcomes Through Modeling and Programming Strategies Based on Human Inner Ear Pathology Everyday Clinical Listening Program (Control), ENI-Based Experimental Program 1, ENI-Based Experimental Program 2 - Deafness | Not applicable | Recruiting | Massachusetts Eye and Ear Infirmary | 45 | 2026-10-01 | 2026-10-09 |
| Retrospective Analysis of Performance and Safety of MED-EL Cochlear Implants. Cochlear implantation - Severe to Profound Hearing Loss | Not yet recruiting | MED-EL Elektromedizinische Geräte GesmbH | 700 | 2026-10-01 | 2026-09-09 | |
| Cognitive Processing of Natural Sequences in Humans and Artificial Intelligence (AI) Hearing Disorders and Deafness | Not yet recruiting | Institut Pasteur | 700 | 2026-09-01 | 2026-07-31 | |
| Evaluation of the Effectiveness of a Rehabilitation Program for Hearing and Communication Disorders in Elderly People in Nursing Homes. use of hearing rehabilitation device - Deafness | Not applicable | Not yet recruiting | University Hospital, Toulouse | 40 | 2026-09-01 | 2026-05-19 |
| SPI-1005 for Prevention and Treatment of Chemotherapy Induced Hearing Loss SPI-1005 Low Dose, SPI-1005 Middle Dose, SPI-1005 High Dose - Lung Cancer, Head and Neck Cancer | Phase 2 | Withdrawn | Sound Pharmaceuticals, Incorporated | 2026-06-01 | 2026-06-03 | |
| Open-label Study of SKY-GJB2 in Pediatric Subjects With GJB2-mediated Hearing Loss SKY-GJB2 - GJB2-mediated Hearing Loss, GJB2 Gene Mutation | Phase 1 / Phase 2 | Recruiting | Skylark Bio Inc. | 10 | 2026-05-28 | 2026-08-27 |
| Observational Study to Investigate the Short-term Effects of Transcorneal Electrical Stimulation on Visual Performance Transcorneal Electrical Stimulation using the OkuStim System - Retinitis Pigmentosa (RP), Usher Syndrome | Recruiting | Okuvision GmbH | 30 | 2026-04-20 | 2026-05-01 | |
| Language Development in Children With Cochlear Implants and Speech-language Therapy Interventions Speech-language therapy (observed standard care) - Severe to Profound Prelingual Hearing Loss | Recruiting | Assistance Publique - Hôpitaux de Paris | 60 | 2026-04-17 | 2026-05-28 | |
| OSIA System Bilateral Implantation Efficacy Evaluation in Children With Ear Aplasia Audiological tests, Speech, Spatial and Qualities of Hearing Scale - Deafness Caused by High Grade Microtia or Ear Atresia | Not applicable | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 12 | 2026-04-01 | 2026-02-13 |
| ListenFuture-Listening for Their Future: Deaf and Hard-of-Hearing Adolescents Hearing Disorders and Deafness | Recruiting | Heikki Löppönen | 256 | 2026-03-01 | 2026-02-25 | |
| Characterization and Contribution of Genome-wide DNA Methylation (DNA Methylation Episignatures) in Rare Diseases With Prenatal Onset Methylation analysis - Rare Fetal Genetic Diseases, Congenital Malformation | Recruiting | Assistance Publique - Hôpitaux de Paris | 63 | 2026-02-26 | 2026-03-27 | |
| Does Recessive Optic Atrophy Due to WFS1 Exist? analyse study - Wolfram Syndrome 1, Optic Atrophies, Hereditary | Not yet recruiting | Hôpital Necker-Enfants Malades | 45 | 2026-02-01 | 2026-01-13 | |
| Cisplatin-induced Cochlear and Vestibular Damage in Head and Neck Cancer Ototoxic Hearing Loss, Ototoxicity, Drug-Induced | Recruiting | Simon Jäger | 55 | 2026-01-20 | 2026-10-20 | |
| Extended Reality Vocational Training for Hearing Impaired Interactive 360-degree Virtual Reality Vocational Training - Hearing Impairment, Deafness | Not applicable | Completed | King Salman Center for Disability Research | 48 | 2026-01-03 | 2026-06-10 |
| Comparative Analysis of Hearing Outcomes: Robotic vs. Manual Insertion of Cochlear Implants IotaSoft Robotic Insertion System, Manual Cochlear Implant Insertion - Sensorineural Hearing Loss, Bilateral Hearing Loss | Not applicable | Not yet recruiting | AdventHealth | 32 | 2026-01-01 | 2026-01-02 |
| Mechanisms of Fecal Incontinence in Wolfram Syndrome Retrospective case-control analysis - Wolfram Syndrome, Fecal Incontinence | Not yet recruiting | Hôpital Necker-Enfants Malades | 20 | 2025-12-20 | 2025-12-31 |
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Hearing Loss (65) · Usher Syndromes (33) · Retinitis Pigmentosa (27) · Hearing Loss, Sensorineural (25) · Hearing Disorders (17) · Wolfram Syndrome (12) · Ear Diseases (11) · Diabetes Mellitus (10) · Hearing Loss, Conductive (10) · Retinal Diseases (10) · Vision Disorders (8) · Hearing Loss, Mixed Conductive-Sensorineural (7) · Otorhinolaryngologic Diseases (7) · Eye Diseases (6)
Nervous System Diseases (196) · Neurologic Manifestations (196) · Sensation Disorders (195) · Otorhinolaryngologic Diseases (191) · Pathological Conditions, Signs and Symptoms (189) · Ear Diseases (187) · Signs and Symptoms (187) · Hearing Disorders (181) · Hearing Loss (133) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (61) · Abnormalities, Multiple (58) · Congenital Abnormalities (58) · Eye Diseases (53) · Genetic Diseases, Inborn (53) · Blindness (52)
Cochlear Implants (5) · Acetylcysteine (4) · Cochlear Implantation (4) · Intravitreal Injections (4) · Surveys and Questionnaires (3) · Ankle Brachial Index (2) · D-JNKI-1 (2) · Educational Status (2) · Genotype (2) · Hearing Aids (2) · Magnetic Resonance Spectroscopy (2) · Speech Therapy (2) · Telemedicine (2) · Valproic Acid (2) · ebselen (2)
Assistance Publique - Hôpitaux de Paris (9) · University Hospital, Toulouse (9) · Hospices Civils de Lyon (6) · Laboratoires Thea (5) · Massachusetts Eye and Ear Infirmary (5) · National Institute on Deafness and Other Communication Disorders (NIDCD) (5) · Cochlear (4) · NYU Langone Health (4) · Oticon Medical (4) · Washington University School of Medicine (4) · CHU de Reims (3) · Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts (3) · Cochlear Bone Anchored Solutions (3) · East Carolina University (3) · Gallaudet University (3)
United States (81) · France (48) · Canada (17) · Netherlands (14) · Germany (12) · United Kingdom (10) · Australia (8) · Italy (6) · Switzerland (6) · Denmark (5) · Brazil (4) · China (4) · Spain (4) · Austria (3) · Hong Kong (3)
Thomas B Friedman, Ph.D. (3) · Claire M Bernstein, PhD (2) · Diane M Brewer, MA (2) · Jonathan Kil, MD (2) · Julie Arenberg (2) · Michio Hirano, MD (2) · Sarah Neuhaus, D.O. (2) · Aaron J Newman, PhD (1) · Aaron Newman, PhD (1) · Amy Lieberman, PhD (1) · Angelica Perez Fornos, PhD (1)
PMID 37552281, PMID 10547481, PMID 10590970, PMID 14576249, PMID 15064663, PMID 1555319, PMID 15715067, PMID 15978485, PMID 16504089, PMID 17329129, PMID 2069187, PMID 21340183, PMID 23604349, PMID 24705452, PMID 24975234, PMID 25073872, PMID 25634465, PMID 25790770, PMID 26025012, PMID 26199618, PMID 26366332, PMID 26604914, PMID 26635571, PMID 26742931, PMID 27459537, PMID 27857759, PMID 27898605, PMID 27904503, PMID 28692981, PMID 28716314, PMID 29270420, PMID 29714549, PMID 29718280, PMID 29914727, PMID 30050918, PMID 30358468, PMID 30837546, PMID 31119146, PMID 31215818, PMID 31530099, PMID 31533581, PMID 31620478, PMID 32039263, PMID 32231088, PMID 32231633, PMID 32573764, PMID 32576247, PMID 32885711, PMID 33388985, PMID 33546345
2018 (2), 1UG1EY033293 (1), 2023 (1), P30DK111024 (1), R01DC010075 (1), R01DC015272 (1), R01DC016901 (1), R01DC016957 (1), R01DK132090 (1), R01HD070855 (1), R01HD117137 (1), R21DC019458 (1), R21DK113487 (1), R44DC013467 (1), U54NS078059 (1)