17 completed, 12 not yet recruiting, 10 recruiting, 9 unknown. 24 Not applicable, 5 Phase 4, 1 Early Phase 1, 1 Phase 1.
Follow ICU: new trials by email Literature Review of ICU trials Research Report on ICU
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Prospective Multicenter Registry Study of Sedation and Analgesia in Critically Ill Patients Not applicable- observational study - Sedation, Analgesia Assessment | Enrolling by invitation | Beijing Chao Yang Hospital | 2000 | 2027-01-01 | 2026-10-21 | |
| Evolution of Sleep in Intensive Care Unit Patients Sleep monitoring using Sleepscan®, Actigraphy - ICU, Sleep Deprivation | Not applicable | Not yet recruiting | Centre Hospitalier Universitaire de Saint Etienne | 40 | 2026-12-01 | 2026-10-09 |
| reALIGNing Circadian Rhythm and Promoting Sleep in the Intensive Care Unit Sleep chronobundle, Control - Sleep, Circadian Dysregulation | Early Phase 1 | Not yet recruiting | University of Alberta | 50 | 2026-11-30 | 2026-10-21 |
| Transcutaneous Auricular Stimulation Targeting Enteral Feeding Intolerance Transcutaneous auricular vagus nerve stimulation - Enteral Feeding Intolerance, ICU | Not applicable | Not yet recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 60 | 2026-10-08 | 2026-10-02 |
| External Validation of the FedHist Dynamic Early Warning Model for Mortality Risk in Critically Ill Patients: A Prospective Multicenter Study Risk of mortality - ICU | Not yet recruiting | Southeast University, China | 23579 | 2026-10-01 | 2026-09-17 | |
| BURN-ASV Trial: Adaptive Support Ventilation in Severe Burn Injury Adaptive Support Ventilation (ASV), Conventional Lung-Protective Mechanical Ventilation - Burn, Mechanical Ventilation | Not applicable | Not yet recruiting | Ukrainian Society of Regional Anesthesia and Pain Therapy | 100 | 2026-09-23 | 2026-06-29 |
| Effects of Melatonin on Sleep Architecture of Critically Ill Patients in the ICU Melatonin - Critical Illness, ICU | Phase 4 | Not yet recruiting | Rutgers, The State University of New Jersey | 30 | 2026-09-01 | 2026-07-13 |
| EAA-Guided AN69-oXiris and PMX-HP Therapy in Septic Patients Adsorptive Hemofilter for Continuous Renal Replacement Therapy, Polymyxin B-Immobilized Hemoperfusion Cartridge - Hemoperfusion, Sepsis | Not applicable | Enrolling by invitation | Kyoung Moo Im | 50 | 2026-08-11 | 2026-08-26 |
| The Effect of Early Intervention on the Incidence of Posttraumatic Stress Disorder After Intensive Care Hospitalization Due to Sepsis Psychiatric interview - PTSD - Post Traumatic Stress Disorder, Sepsis | Not applicable | Recruiting | Barzilai Medical Center | 60 | 2026-07-01 | 2026-07-17 |
| Case-Based Learning for Bedside Lung Ultrasound Teaching in ICU Case-Based Learning (CBL), Traditional lecture-based teaching - Medical Education, ICU | Not applicable | Not yet recruiting | First Affiliated Hospital of Wannan Medical College | 106 | 2026-07-01 | 2026-05-18 |
| Functional Inspiratory Versus Expiratory Muscle Electrical Stimulation on Weaning Outcomes in Mechanically Ventilated Patients Inspiratory muscle functional electrical stimulation by Flexistem Digital electrical muscle stimulator, Expiratory muscle functional electrical stimulation by Flexistem Digital electrical muscle stimulator, Early rehabilitation program - Icu | Not applicable | Not yet recruiting | Beni-Suef University | 48 | 2026-06-15 | 2026-06-03 |
| What Are the Predictors of Acute Kidney Injury in Children Admitted to Pediatrics Intensive Care Unit at Assiut University Children Hospital? Clinical and laboratory assessment - AKI, ICU | Not yet recruiting | Assiut University | 100 | 2026-05-01 | 2026-04-08 | |
| Eye-Tracking Interactive Agent in Non-verbal ICU Patients eye-tracking interactive agent, conventional techniques - Eye Tracking, ICU | Not applicable | Not yet recruiting | Shanghai Zhongshan Hospital | 54 | 2026-04-01 | 2026-02-24 |
| Association Between Dynamic Prealbumin Trajectories and Prognosis in Critically Ill Patients No Intervention: Observational Cohort - ICU, Critical Illness | Not yet recruiting | The First Hospital of Jilin University | 500 | 2026-03-15 | 2026-02-17 | |
| Machine Learning Prediction of Mortality After Prone Positioning in ARDS Prone Position Ventilation - Acute Respiratory Distress Syndrome (ARDS), Prone Position Ventilation | Completed | Shanghai Zhongshan Hospital | 358 | 2026-03-01 | 2026-08-14 | |
| Trial on the Impact of Indirect Calorimetry-Guided Nutritional Support on Patient-Centered Outcomes in Critically Ill Patients - The OPTICal Study Indirect Calorimetry Group, Control Group - Formula-Based Group - Critical Illness, ICU | Not applicable | Recruiting | HEIDEGGER CP | 356 | 2026-01-01 | 2026-05-19 |
| Establishment of Reference Limits for Blood Lactate Levels in Intensive Care Patients With a Particular Focus on Age and Sex Lactate, Sepsis | Active not recruiting | Uppsala University | 16000 | 2025-11-06 | 2026-05-13 | |
| Applying the ADDIE Model to Develop a Multimedia Program to Enhance Chemotherapy Knowledge and Self-Efficacy Among Intensive Care Unit Nurses Interactive multimedia education - Nurse, Self-Efficacy | Not applicable | Enrolling by invitation | National Cheng-Kung University Hospital | 50 | 2025-11-01 | 2025-12-08 |
| Influenza A-associated Pulmonary Aspergillosis in Patients Admitted to the Intensive Care Unit in China IPA and non-IPA groups - ICU, Invasive Pulmonary Aspergillosis | Completed | Jianfeng Xie | 542 | 2025-11-01 | 2026-01-09 | |
| The HIgh-fidelity Hydraulic couPling Upper-arm Cuff Assessment of Limits, Safety, and Effectiveness (HIPULSE) Trial (Cardiac Output Study) Philips Advanced Monitoring Cuff (AMC) - ICU, Pulmonary Artery Catheter (PAC) | Recruiting | Philips Clinical & Medical Affairs Global | 75 | 2025-10-28 | 2026-02-27 |
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Critical Illness (10) · Delirium (5) · Sepsis (4) · COVID-19 (3) · Agnosia (2) · Burns (2) · Accidental Injuries (1) · Acute Kidney Injury (1) · Alzheimer Disease (1) · Asthma (1) · Brain Diseases (1) · Brain Injuries, Traumatic (1) · Cerebral Hemorrhage (1) · Chronic Pain (1) · Chronobiology Disorders (1)
Pathological Conditions, Signs and Symptoms (24) · Pathologic Processes (17) · Disease Attributes (13) · Nervous System Diseases (9) · Neurologic Manifestations (9) · Signs and Symptoms (9) · Infections (8) · Lung Diseases (8) · Respiratory Tract Diseases (8) · Mental Disorders (7) · Neurobehavioral Manifestations (7) · Neurocognitive Disorders (5) · Confusion (4) · Inflammation (4) · Systemic Inflammatory Response Syndrome (4)
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Nanfang Hospital, Southern Medical University (3) · Duke University (2) · Shanghai Zhongshan Hospital (2) · The First Hospital of Jilin University (2) · University of Birmingham (2) · Akdeniz University (1) · Alexis FERRE (1) · Ankara University (1) · Assistance Publique - Hôpitaux de Paris (1) · Assiut University (1) · Australian and New Zealand Intensive Care Research Centre (1) · Barzilai Medical Center (1) · Basilea Pharmaceutica (1) · Beijing Chao Yang Hospital (1) · Beni-Suef University (1)
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PMID 38063184, PMID 21406514, PMID 26398070, PMID 27311311, PMID 28132075, PMID 31408142, PMID 33661521, PMID 33709318, PMID 34463700, PMID 35799302, PMID 36645531, PMID 36856550, PMID 37356618, PMID 37438060, PMID 38190699, PMID 40341100, PMID 40803734, PMID 41281994, PMID 41577060, PMID 42624606
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