15 completed, 4 unknown, 3 recruiting, 2 withdrawn. 8 Phase 1, 7 Phase 2, 6 Not applicable, 2 Phase 3, 1 Early Phase 1.
Follow Hypoxic Ischemic Encephalopathy: new trials by email Literature Review of Hypoxic Ischemic Encephalopathy trials Research Report on Hypoxic Ischemic Encephalopathy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Real World Outcomes of Intranasal MuSE Exosomes and Stem Cells in Neurological Regenerative Therapy Traumatic Brain Injury, Cerebral Palsy | Enrolling by invitation | Healing Hope International | 36 | 2026-06-01 | 2026-04-09 | |
| Intensive Multimodal Neurorehabilitation Targeting Neuroplasticity in Pediatric Neurodevelopmental and Chromosomal Disorders Neurodevelopmental Disorders, Neurodevelopmental Disorders (NDD) | Recruiting | Healing Hope International | 100 | 2026-03-01 | 2026-03-25 | |
| The HIEnome Study: Genome Sequencing for Perinatal HIE Genome sequencing - Hypoxic Ischemic Encephalopathy of Newborn, Hypoxic Ischemic Encephalopathy | Not applicable | Recruiting | Baylor College of Medicine | 25 | 2025-05-15 | 2026-10-01 |
| Radiological Evaluation of Hypoxic Ischemic Encephalopathy MRI brain, MSCT brain, Transcranial Ultrasound - Hypoxic Ischemic Encephalopathy | Unknown | Assiut University | 48 | 2023-12-10 | 2023-12-07 | |
| Melatonin as a Neuroprotective Therapy in Neonates With HIE Undergoing Hypothermia Melatonin, Magnetic Resonance Imaging, Pharmacokinetics - Hypoxic Ischemic Encephalopathy | Early Phase 1 | Recruiting | University of Florida | 70 | 2016-11-09 | 2026-06-29 |
| Intra-operative Feed Back on Traction Force During Vacuum Extraction: Safe Vacuum Extraction Alliance Vacuum extraction intelligent system - Hypoxic Ischemic Encephalopathy, Neonatal Convulsions | Not applicable | Completed | Karolinska Institutet | 800 | 2016-04-01 | 2019-03-07 |
| Clinical Utility of Serum Biomarkers for the Management of Neonatal Hypoxic Ischemic Encephalopathy (Control Levels) blood sample - Hypoxic Ischemic Encephalopathy | Completed | University of Florida | 39 | 2016-03-01 | 2018-06-21 | |
| Targeted Temperature Management After In-Hospital Cardiac Arrest Arctic Sun®, Arcticgel™, Conventional antipyretic treatment - Hypoxic Ischemic Encephalopathy | Not applicable | Unknown | Asan Medical Center | 60 | 2016-01-01 | 2016-06-29 |
| Neuroprotective Effect of Autologous Cord Blood Combined With Therapeutic Hypothermia Following Neonatal Encephalopathy Autologous cord blood, Hypothermia - Hypoxic Ischemic Encephalopathy, Cerebral Infarction | Phase 1 / Phase 2 | Withdrawn | Children's Hospital of Fudan University | 2015-09-08 | 2023-12-29 | |
| Reno-protective Effect of Brain Cooling in Newborn With Hypoxia Therapeutic hypothermia - Hypoxic Ischemic Encephalopathy | Completed | Mansoura University Children Hospital | 30 | 2015-09-01 | 2018-04-03 | |
| Umbilical Cord Milking for Neonates With Hypoxic Ischemic Encephalopathy Umbilical Cord Milking - Hypoxic Ischemic Encephalopathy, Umbilical Cord Milking | Not applicable | Completed | Thomas Jefferson University | 101 | 2014-12-01 | 2017-12-18 |
| Umbilical Cord Derived Mesenchymal Stem Cells Therapy in Hypoxic Ischemic Encephalopathy mesenchymal stem cells - Hypoxic Ischemic Encephalopathy | Phase 1 | Unknown | Hebei Medical University | 10 | 2013-09-01 | 2013-10-14 |
| Efficacy of Erythropoietin to Improve Survival and Neurological Outcome in Hypoxic Ischemic Encephalopathy erythropoietin Beta, Placebo - Hypoxic Ischemic Encephalopathy | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 120 | 2013-03-28 | 2025-11-20 |
| Topiramate in Neonates Receiving Whole Body Cooling for Hypoxic Ischemic Encephalopathy Topiramate, Placebo - Hypoxic Ischemic Encephalopathy | Phase 1 / Phase 2 | Terminated | Kristin R Hoffman | 34 | 2013-02-01 | 2024-06-11 |
| Darbe Administration in Newborns Undergoing Cooling for Encephalopathy Darbepoetin alfa, Placebo - Hypoxic Ischemic Encephalopathy | Phase 1 / Phase 2 | Completed | University of Utah | 30 | 2012-09-01 | 2024-07-23 |
| California Transport Cooling Trial Device (servo-regulated cooling), Control (standard practice) - Hypoxic Ischemic Encephalopathy | Not applicable | Completed | Stanford University | 101 | 2012-09-01 | 2014-12-08 |
| Magnetic Resonance Imaging and Spectroscopy Biomarkers of Neonatal Hypoxic Ischemic Encephalopathy Hypoxic Ischemic Encephalopathy | Completed | University Children's Hospital, Zurich | 59 | 2011-09-01 | 2019-09-25 | |
| Autologous Cord Blood Cells for Brain Injury in Term Newborns Autologous cord blood - Hypoxic Ischemic Encephalopathy | Phase 1 | Completed | National University Hospital, Singapore | 2 | 2011-09-01 | 2017-01-26 |
| MRI Thermal Imaging of Infants Undergoing Cooling for Hypoxic Ischemic Encephalopathy(HIE) mRI - Hypoxic Ischemic Encephalopathy | Withdrawn | Vanderbilt University | 2010-05-01 | 2015-06-03 | ||
| Safety and Efficacy of Topiramate in Neonates With Hypoxic Ischemic Encephalopathy Treated With Hypothermia Topiramate in newborns with hypoxic ischemic encephalopathy treated with therapeutic hypothermia - Hypoxic Ischemic Encephalopathy | Phase 2 | Completed | Meyer Children's Hospital IRCCS | 64 | 2010-02-01 | 2013-12-13 |
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Hypoxia-Ischemia, Brain (26) · Asphyxia Neonatorum (3) · Cerebral Palsy (3) · Brain Injuries, Traumatic (2) · Hypothermia (2) · Acute Kidney Injury (1) · Alzheimer Disease (1) · Asphyxia (1) · Autism Spectrum Disorder (1) · Autistic Disorder (1) · Brain Injuries (1) · Cerebral Infarction (1) · Chromosome Aberrations (1) · Developmental Disabilities (1) · DiGeorge Syndrome (1)
Brain Diseases (26) · Brain Ischemia (26) · Cardiovascular Diseases (26) · Central Nervous System Diseases (26) · Cerebrovascular Disorders (26) · Hypoxia (26) · Hypoxia, Brain (26) · Pathological Conditions, Signs and Symptoms (26) · Signs and Symptoms (26) · Signs and Symptoms, Respiratory (26) · Vascular Diseases (26) · Nervous System Diseases (25) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (4) · Wounds and Injuries (4) · Brain Damage, Chronic (3)
Hypothermia, Induced (3) · Cool-Down Exercise (2) · Topiramate (2) · Ascorbic Acid (1) · Blood Specimen Collection (1) · Darbepoetin alfa (1) · Endothelium-Dependent Relaxing Factors (1) · Ibuprofen (1) · Magnetic Resonance Spectroscopy (1) · Melatonin (1) · Parturition (1) · Pharmacokinetics (1) · Umbilical Cord Clamping (1)
Healing Hope International (2) · University of Florida (2) · Vanderbilt University (2) · Al-Azhar University (1) · Asan Medical Center (1) · Assistance Publique - Hôpitaux de Paris (1) · Assiut University (1) · Baylor College of Medicine (1) · Children's Hospital of Fudan University (1) · Hebei Medical University (1) · Karolinska Institutet (1) · Kristin R Hoffman (1) · Mansoura University Children Hospital (1) · Medical University of South Carolina (1) · Meyer Children's Hospital IRCCS (1)
United States (9) · Egypt (3) · China (2) · India (2) · France (1) · Italy (1) · Mexico (1) · Singapore (1) · South Korea (1) · Sweden (1) · Switzerland (1) · Zambia (1)
Ahmed Elsayed, MD (1) · Balraj Guhan, MD (1) · Baoyong Yan, Doctor (1) · Cheo Lian Yeo, MBBS (1) · Dorothea D Jenkins, MD (1) · Dr. Glen Cronett, PhD/MD (1) · Dr. Tina Casoglos-Adamopoulos, OT, OTD, BCP (1) · Elwyn Chomba, MBChB, DCH, MRCP (1) · Jiun Lee, MBBS (1) · Juliana Patkai, MD, PhD (1) · Jun Zhang, Master (1) · Krisa Van Meurs, M.D. (1) · Kristin R Hoffman, MD (1) · Laila Abd-Rabboh, MD (1) · Lina Zhang, Master (1)
PMID 24524452, PMID 15607598, PMID 15607599, PMID 20385632, PMID 22805873, PMID 22950861, PMID 23897243, PMID 25558833, PMID 25684087, PMID 31561395, PMID 33637058
R01NS038062 (1), U01HD043464 (1)