102 completed, 33 unknown, 21 recruiting, 10 terminated. 40 Not applicable, 23 Phase 2, 17 Phase 1, 8 Phase 4, 6 Phase 3.
Follow Chromosome Aberrations: new trials by email Literature Review of Chromosome Aberrations trials Research Report on Chromosome Aberrations
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Randomized Study of ELVN-001 Versus Investigator-Selected TKI, in CP-CML Previously Treated With One or More TKIs ELVN-001, TKI - Chronic Myeloid Leukemia (CML), Chronic Myeloid Leukemia (CML) Philadelphia Chromosome Positive | Phase 3 | Not yet recruiting | Enliven Therapeutics | 450 | 2026-12-31 | 2026-10-29 |
| Study to Compare Traditional and Emerging Methods for Structural Variant Analysis in Prenatal, Postnatal, and Hematologic Samples Chromosome Aberrations, Aneuploidy | Recruiting | 4bases Italia Srl | 200 | 2026-09-22 | 2026-11-12 | |
| Pilot Study of Discarded Blastocysts Multiomics analysis - Infertility (IVF Patients) | Recruiting | Igenomix | 150 | 2026-03-14 | 2026-11-05 | |
| Intensive Multimodal Neurorehabilitation Targeting Neuroplasticity in Pediatric Neurodevelopmental and Chromosomal Disorders Neurodevelopmental Disorders, Neurodevelopmental Disorders (NDD) | Recruiting | Healing Hope International | 100 | 2026-03-01 | 2026-03-25 | |
| To Investigate if the Harvester® Improves Sperm Motility and Blastocyst Utilization (the Percent of Fertilized Eggs That Develop to the Point That They Are Able to be Transferred) in IVF Cycles. microfludics semen processing device - Infertility, Male Infertility | Not applicable | Active not recruiting | MotilityCount aps | 1600 | 2026-01-20 | 2026-01-27 |
| The ADVANCE (Assay Development and Validation for Pre-Natal and Obstetric Conditions) Study is the Largest U.S.-Based Prospective Study Demonstrating a Circulating Fetal Cell (CFC) Based Approach to Non-invasive Fetal Risk Assessment Pregnant Individuals, Aneuploidy | Recruiting | BillionToOne Inc. | 1000 | 2026-01-10 | 2026-10-15 | |
| Prenatal Genetics Chatbot Trial: Prenatal GENEie Prenatal GENEie Chatbot, In-person genetic counseling - Genetic Counseling | Not applicable | Not yet recruiting | Women and Infants Hospital of Rhode Island | 1470 | 2026-01-01 | 2025-07-28 |
| Evaluating the Status of Complex Aneuploidy to Locate Additional Transferrable Embryos Complex Aneuploidy, Chaotic Aneuploidy | Recruiting | Shady Grove Fertility Reproductive Science Center | 280 | 2025-11-01 | 2025-11-12 | |
| Prevalence of Translocation Phenotyping in Children With Down Syndrome and Their Parents No medical or experimental intervention will be administered - Translocation Down Syndrome, Chromosomal Abnormalities | Not yet recruiting | Assiut University | 230 | 2025-10-01 | 2025-09-16 | |
| Chromosomal Abnormalities in Patients With Congenital Heart Disease at Assiut University Children's Hospital Conventional Karyotyping - Congenital Heart Disease (CHD), Chromosomal Abnormalities | Not yet recruiting | Assiut University | 138 | 2025-10-01 | 2025-10-02 | |
| Study of Abnormally Fertilized Embryos Parental samples, PGT-A, TE rebiopsies and spent blastocyst media collection - Infertility (IVF Patients) | Recruiting | Igenomix | 300 | 2025-07-02 | 2026-08-21 | |
| Day-3 vs Day-5 Assisted Hatching: Impact on Blastocyst Morphology and PGT-A Outcomes Laser-Assisted Hatching - Infertility; In Vitro Fertilization; Embryo Development | Not applicable | Completed | Hoang Minh Ngan | 141 | 2025-06-14 | 2026-09-10 |
| Danish Prognostic Research on Embryonic Diagnostics Involving Chromosomal Testing. Aneuploidy | Recruiting | Christian Liebst Frisk Toft | 220 | 2025-04-22 | 2025-04-25 | |
| GEM: Impact of a Video Education Tool on Decisional Conflict Among Prenatal Patients Video Educational Tool Regarding Prenatal Genetics - Aneuploidy, Genetic Counseling | Not applicable | Active not recruiting | Women and Infants Hospital of Rhode Island | 140 | 2025-01-16 | 2025-09-18 |
| Embryo Assessment Utilizing Timelapse Imaging in Conjunction With Preimplantation Genetic Testing for Aneuploidy With Next Generation Sequencing Timelapse incubation and PGT - Infertility, Female, Infertility, Male | Enrolling by invitation | Gattaca Genomics | 2000 | 2025-01-01 | 2026-01-29 | |
| Microfluidic Chip vs Density Gradient Centrifugation on the Euploidy Rate of Pre-implantation Genetic Testing microfluidic chip, density gradient centrifugation - Infertility, Genetic Disease | Not applicable | Recruiting | Professor Ernest Hung-Yu Ng | 318 | 2024-11-01 | 2024-12-06 |
| Non-Euploid Embryo Transfer (NEET) Registry Infertility, Mosaicism | Recruiting | Inception Fertility Research Institute, LLC | 1000 | 2024-09-23 | 2026-08-14 | |
| Clinical and Genetic Aspects in Fetuses and Children With Sex Chromosome Disorders Sex Chromosome Disorders | Enrolling by invitation | University of Aarhus | 300 | 2024-09-01 | 2026-01-14 | |
| Translational Study of MSS, TP53 Mutation and Chromosome Instability Relationship in Endometrial Carcinoma Endometrial Neoplasms, TP53 Gene Mutation | Unknown | Peking Union Medical College Hospital | 110 | 2024-09-01 | 2024-07-26 | |
| A Study of Sovilnesib in Subjects With Ovarian Cancer Sovilnesib - High Grade Serous Adenocarcinoma of Ovary, Fallopian Tube Cancer | Phase 1 | Recruiting | Volastra Therapeutics, Inc. | 150 | 2024-04-04 | 2026-10-13 |
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Aneuploidy (70) · Philadelphia Chromosome (36) · Infertility (28) · Down Syndrome (24) · Leukemia, Myelogenous, Chronic, BCR-ABL Positive (24) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (17) · Trisomy 18 Syndrome (13) · Leukemia (12) · Trisomy 13 Syndrome (11) · Turner Syndrome (11) · Sex Chromosome Aberrations (10) · Chromosomal Instability (9) · Genetic Diseases, Inborn (9) · Trisomy (9)
Pathological Conditions, Signs and Symptoms (181) · Pathologic Processes (180) · Neoplasms (56) · Urogenital Diseases (56) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (53) · Hemic and Lymphatic Diseases (51) · Neoplasms by Histologic Type (46) · Congenital Abnormalities (40) · Hematologic Diseases (40) · Genital Diseases (36) · Genetic Diseases, Inborn (35) · Translocation, Genetic (35) · Chromosome Disorders (34) · Female Urogenital Diseases and Pregnancy Complications (33)
Imatinib Mesylate (14) · Blood Specimen Collection (6) · Dasatinib (6) · Cyclophosphamide (5) · bosutinib (5) · nilotinib (5) · Cytarabine (4) · fludarabine (4) · Daunorubicin (3) · Dexamethasone (3) · Methotrexate (3) · Vincristine (3) · 4-methyl-N-(3-(4-methylimidazol-1-yl)-5-trifluoromethylphenyl)-3-(4-pyrazin-2-ylpyrimidin-2-ylamino)benzamide (2) · Acetaminophen (2) · Azacitidine (2)
Novartis Pharmaceuticals (10) · Natera, Inc. (7) · Igenomix (6) · Sequenom, Inc. (6) · National Human Genome Research Institute (NHGRI) (5) · Nanfang Hospital, Southern Medical University (4) · ART Fertility Clinics LLC (3) · Cindy Cisneros (3) · Instituto Valenciano de Infertilidad, IVI VALENCIA (3) · M.D. Anderson Cancer Center (3) · National Cancer Institute (NCI) (3) · Pfizer (3) · Women and Infants Hospital of Rhode Island (3) · Applied Spectral Imaging Ltd. (2) · Assisting Nature (2)
United States (78) · Spain (21) · China (20) · France (18) · Italy (17) · Canada (16) · United Kingdom (13) · Germany (11) · Belgium (8) · India (8) · Netherlands (8) · South Korea (8) · Australia (7) · Sweden (7) · Taiwan (7)
Carmen Rubio, PhD (3) · Peer Dar, MD (2) · William A Gahl, M.D. (2) · Alexander Kolevzon, MD (1) · Alfonso Quintas-Cardama, MD (1) · Allan T Bombard, MD (1) · Andrea Biondi, MD (1) · Andreas Hochhaus, Professor, MD (1) · Ann C. Collier (1) · Antonio Capalbo, BSc PhD (1) · Arjun Pennathur, MD (1)
PMID 32898291, PMID 35235189, PMID 10405442, PMID 10417280, PMID 10453734, PMID 10598807, PMID 11134092, PMID 11203878, PMID 11531930, PMID 11839953, PMID 12547409, PMID 12794705, PMID 12820840, PMID 15315963, PMID 15540176, PMID 15671099, PMID 15704090, PMID 15760848, PMID 16007630, PMID 16344315, PMID 16765182, PMID 16814942, PMID 17157333, PMID 17535868, PMID 18039723, PMID 18082557, PMID 18223280, PMID 18765009, PMID 19560006, PMID 20020300, PMID 20093507, PMID 20375405, PMID 20627979, PMID 20723835, PMID 21147004, PMID 21310373, PMID 21519036, PMID 21865346, PMID 22005709, PMID 22036634, PMID 22281937, PMID 22371878, PMID 22464072, PMID 22551456, PMID 22617594, PMID 22742782, PMID 22865900, PMID 22898679, PMID 23116602, PMID 23215555
2005 (4), 2009 (2), 2008 (1), 2016 (1), 2019 (1), 2023 (1), K23NS070337 (1), M01RR001346 (1), P01CA148600 (1), R01HD111426 (1), R44HD062114 (1), U01HG006487 (1)