10 completed. 10 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 10 | Completed 10 |
Follow Hyponatremia: new trials by email Literature Review of Hyponatremia trials Research Report on Hyponatremia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of the SGLT2 Inhibitor Empagliflozin in Patients With Euvolemic and Hypervolemic Hyponatremia Empagliflozin 25 MG, Placebo - Hyponatremia, SIADH | Phase 4 | Completed | University Hospital, Basel, Switzerland | 113 | 2021-02-04 | 2026-09-22 |
| Early Sodium Intake in Preterm Newborns Sodium < 1mEq/kg/day, Sodium 5mEq/kg/day - Hyponatremia, Premature | Phase 4 | Completed | Hospital del Niño "Dr. Federico Gomez Santos" | 52 | 2018-03-30 | 2020-04-21 |
| Intravenous Fluids in Hospitalised Children Plasmalyte Glucos 50 mg/mL, 0.45% saline in 5% dextrose - Hypokalemia, Hyponatremia | Phase 4 | Completed | University of Oulu | 660 | 2016-10-03 | 2019-08-22 |
| Efficacy and Safety of Rapid Intermittent Compared With Slow Continuous Correction in Severe Hyponatremia Patients 3% hypertonic saline - Hyponatremia Symptomatic | Phase 4 | Completed | Seoul National University Hospital | 178 | 2016-08-01 | 2020-04-09 |
| Post Transjugular Intrahepatic Portosystemic Shunt (Tips) Albumine Infusion to Prevent Hepatic Encephalopathy Albumin - Hepatic Encephalopathy | Phase 4 | Completed | University of Roma La Sapienza | 20 | 2012-09-01 | 2013-12-17 |
| Tolvaptan in Hyponatremic Cancer Patients Tolvaptan, Placebo - Advanced Cancers | Phase 4 | Completed | M.D. Anderson Cancer Center | 52 | 2011-05-01 | 2020-09-23 |
| Effect of Midodrine and Albumine in the Prevention of Complications in Cirrhotic Patients Awaiting Liver Transplantation albumin, Midodrine, Placebo - Renal Failure, Hyponatremia | Phase 4 | Completed | Hospital Clinic of Barcelona | 199 | 2008-08-01 | 2016-08-18 |
| Pico-Salax Colonic Preparation Study: Quantifying Electrolyte and Volume Status Changes Pico-Salax - Hemodynamics, Hyponatremia | Phase 4 | Completed | Queen's University | 20 | 2008-07-01 | 2015-09-22 |
| A Study of Multiple Dosing Regimens of IV Conivaptan in Subjects With Euvolemic or Hypervolemic Hyponatremia Conivaptan, placebo - Hyponatremia, Euvolemia | Phase 4 | Completed | Cumberland Pharmaceuticals | 121 | 2007-01-01 | 2014-05-15 |
| Introduction of Hypo-osmolar ORS for Routine Use Hypo-osmolar ORS - Diarrhoea | Phase 4 | Completed | International Centre for Diarrhoeal Disease Research, Bangladesh | 75000 | 2002-12-01 | 2022-02-11 |
Fibrosis (2) · Hepatic Encephalopathy (2) · Renal Insufficiency (2) · Dehydration (1) · Diarrhea (1) · Edema (1) · Gastrointestinal Hemorrhage (1) · Hypernatremia (1) · Hypokalemia (1) · Hypovolemia (1) · Inappropriate ADH Syndrome (1) · Liver Failure (1) · Premature Birth (1) · Seizures (1)
Metabolic Diseases (10) · Nutritional and Metabolic Diseases (10) · Water-Electrolyte Imbalance (10) · Pathological Conditions, Signs and Symptoms (5) · Nervous System Diseases (4) · Brain Diseases (3) · Central Nervous System Diseases (3) · Digestive System Diseases (3) · Female Urogenital Diseases and Pregnancy Complications (3) · Hepatic Insufficiency (3) · Liver Diseases (3) · Pathologic Processes (3) · Urogenital Diseases (3) · Brain Diseases, Metabolic (2) · Female Urogenital Diseases (2)
Albumins (2) · Glucose (1) · Midodrine (1) · Pico-Salax (1) · Saline Solution, Hypertonic (1) · Serum Albumin, Human (1) · Sodium Chloride (1) · Sugars (1) · Tolvaptan (1) · conivaptan (1) · empagliflozin (1)
Cumberland Pharmaceuticals (1) · Hospital Clinic of Barcelona (1) · Hospital del Niño "Dr. Federico Gomez Santos" (1) · International Centre for Diarrhoeal Disease Research, Bangladesh (1) · M.D. Anderson Cancer Center (1) · Queen's University (1) · Seoul National University Hospital (1) · University Hospital, Basel, Switzerland (1) · University of Oulu (1) · University of Roma La Sapienza (1)
United States (2) · Bangladesh (1) · Canada (1) · Finland (1) · Germany (1) · India (1) · Israel (1) · Mexico (1) · Netherlands (1) · South Korea (1) · Spain (1) · Switzerland (1)
Abdulla K. Salahudeen, MD (1) · Art Wheeler, MD (1) · Ben D Valdes, MD (1) · Carlos Sanchez, MD (1) · Julie Refardt, MD (1) · Lawrence Hookey, MD (1) · Nur H Alam, MD (1) · Seon Ha Baek, PhD (1) · Terhi Tapiainen, MD (1)
PMID 24569125, PMID 28356136, PMID 30138685, PMID 33104176, PMID 33104189