12 completed, 6 unknown, 1 active not recruiting, 1 recruiting. 22 Phase 1, 7 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 22 | Completed 12, Unknown 6, Active not recruiting 1, Recruiting 1, Suspended 1, Terminated 1 |
| Phase 2 | 7 | Completed 4, Unknown 3 |
Follow Hyperthermia: new trials by email Literature Review of Hyperthermia trials Research Report on Hyperthermia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Thermotherapy for Head and Neck Cancer Patients Thermotherapy, Radiotherapy, Concurrent chemoradiation - Head and Neck Cancer, Oropharyngeal Carcinoma | Phase 1 | Recruiting | Erasmus Medical Center | 30 | 2026-09-01 | 2026-09-02 |
| Thermotherapy for Locally Advanced Head and Neck Cancer Thermotherapy, radiotherapy - Head and Neck Cancer, Oropharyngeal Carcinoma | Phase 1 | Active not recruiting | Erasmus Medical Center | 2 | 2025-05-01 | 2026-09-02 |
| Heat Therapy in Type 2 Diabetes Heat therapy, Sham - Type 2 Diabetes | Phase 1 | Unknown | Purdue University | 24 | 2024-09-03 | 2024-09-19 |
| Intranasal Cocaine and Temperature Regulation During Exercise Cocaine, Lidocaine - Hyperthermia, Cocaine Use | Phase 1 / Phase 2 | Completed | University of Texas Southwestern Medical Center | 27 | 2023-09-01 | 2025-07-14 |
| A New Heat Therapy Device for Home-based Leg Heating in Patients With Lower-extremity Peripheral Artery Disease Home-based leg heat therapy - Peripheral Arterial Disease, Intermittent Claudication | Phase 1 | Completed | Purdue University | 6 | 2023-05-30 | 2025-08-15 |
| Heat Therapy, Functional Capacity, and Vascular Health in Older Adults Home-based leg heat therapy, Home-based sham therapy - Aging Well, Walking, Difficulty | Phase 1 / Phase 2 | Completed | University of North Texas Health Science Center | 21 | 2022-11-03 | 2026-06-05 |
| Leg Heat Therapy in Elderly Individuals Sham device, Leg heat therapy device - Aging, Muscle Weakness | Phase 1 | Completed | Purdue University | 24 | 2022-09-05 | 2024-07-10 |
| Image-guided Targeted Doxorubicin Delivery With Hyperthermia to Optimize Loco-regional Control in Breast Cancer LTLD, MR-HIFU induced hyperthermia, Cyclophosphamide - Metastatic Breast Cancer, Breast Cancer | Phase 1 | Unknown | UMC Utrecht | 12 | 2021-03-01 | 2021-02-17 |
| Hyperthermia Combined With Immune Checkpoint Inhibitor Therapy for Advanced Gastrointestinal Tumours Water-filtered infrared A radiation whole-body hyperthermia (HECKEL 3000MT-4T, Germany), tislelizumab (BeiGene, China) combined with PD-1 inhibitor - Gastrointestinal Tumor | Phase 1 / Phase 2 | Completed | Pengyuan Liu | 18 | 2020-06-01 | 2023-09-05 |
| Efficacy of Bromocriptine For Fever Reduction in Acute Neurologic Injury Bromocriptine 5 MG, Acetaminophen 650 MG - Subarachnoid Hemorrhage, Subdural Hematoma | Phase 1 / Phase 2 | Completed | University of California, San Francisco | 47 | 2018-11-30 | 2021-06-24 |
| Moderate Whole Body Hyperthermia for Patients Undergoing Re-irradiation for Head and Neck Cancer -Influence on the Tumor Microenvironment Moderate whole body hyperthermia using water-filtered IR-A-radiation - Head and Neck Neoplasms, Recurrence Tumor | Phase 1 | Completed | Charite University, Berlin, Germany | 10 | 2018-07-01 | 2020-05-05 |
| Hyperthermia and Proton Therapy in Unresectable Soft Tissue Sarcoma Hyperthermia and Proton Beam - Soft Tissue Sarcoma | Phase 1 / Phase 2 | Unknown | Kantonsspital Aarau | 26 | 2014-02-01 | 2015-09-02 |
| A Phase 1 Trial of Perfusion Induced Systemic Hyperthermia (PISH) Over Multiple Cycles for Terminal Ovarian Cancer ThermalCore Hyperthermia System - Ovarian Cancer | Phase 1 | Suspended | ThermalCore Inc | 20 | 2013-08-01 | 2017-07-21 |
| Complementary and Alternative Medicine Sauna Detoxification Study: Phase I Sauna Detoxification Protocol, Observation Sessions - Hyperthermia | Phase 1 | Terminated | Bastyr University | 1 | 2013-07-01 | 2015-04-17 |
| Safety and Feasibility Study of Targeted Temperature Management After ICH Normothermia, Hypothermia - Intracerebral Hemorrhage | Phase 1 / Phase 2 | Unknown | Thomas Jefferson University | 50 | 2013-01-01 | 2015-08-05 |
| Neoadjuvant Chemoradiation With 5-FU(or Capecitabine) and Oxaliplatin Combined With Hyperthermia in Rectal Cancer Radiotherapy, Hyperthermia, 5-Fluorouracil - Rectal Cancer | Phase 1 / Phase 2 | Unknown | University of Erlangen-Nürnberg Medical School | 59 | 2012-09-01 | 2017-08-11 |
| Sauna Detoxification Study: Pilot Feasibility This protocol will utilize a sauna as the primary method of detoxification. - Hyperthermia | Phase 1 | Completed | Bastyr University | 10 | 2011-11-01 | 2012-10-30 |
| Are Sutures Required in Total Abdominal Hysterectomy? A Randomised Control Trial Performing abdominal hysterectomy using gyrus electrocoagulation forceps - Total Abdominal Hysterectomy | Phase 1 | Unknown | Southern Health | 60 | 2007-09-01 | 2007-08-08 |
| A Study of ThermoDox™ in Combination With Radiofrequency Ablation (RFA) in Primary and Metastatic Tumors of the Liver ThermoDox - Hepatocellular Carcinoma, Liver Neoplasms | Phase 1 | Completed | Imunon | 30 | 2007-02-01 | 2019-02-07 |
| A Phase I Study of Isolated Hepatic Portal and Arterial Perfusion (IHP) With Escalating Dose Melphalan for Primary or Metastatic Unresectable Cancers of the Liver Isolated hepatic portal and arterial perfusion, Melphalan - Liver Neoplasms, Neoplasm Metastasis | Phase 1 | Completed | National Cancer Institute (NCI) | 30 | 1997-09-01 | 2008-03-04 |
Showing 20 of 22. Sign in to see all of them.
Head and Neck Neoplasms (3) · Liver Neoplasms (3) · Neoplasm Metastasis (3) · Squamous Cell Carcinoma of Head and Neck (3) · Cerebral Hemorrhage (2) · Hypopharyngeal Neoplasms (2) · Laryngeal Neoplasms (2) · Mouth Neoplasms (2) · Oropharyngeal Neoplasms (2) · Sarcoma (2) · Brain Injuries, Traumatic (1) · Breast Neoplasms (1) · Carcinoma, Ductal, Breast (1) · Carcinoma, Hepatocellular (1)
Body Temperature Changes (22) · Heat Stress Disorders (22) · Pathological Conditions, Signs and Symptoms (22) · Signs and Symptoms (22) · Wounds and Injuries (22) · Neoplasms (11) · Neoplasms by Site (11) · Neoplasms by Histologic Type (7) · Pathologic Processes (7) · Carcinoma (5) · Digestive System Diseases (5) · Neoplasms, Glandular and Epithelial (5) · Cardiovascular Diseases (4) · Digestive System Neoplasms (4) · Vascular Diseases (4)
Diathermy (5) · Melphalan (3) · Radiotherapy (3) · Hyperthermia, Induced (2) · Acetaminophen (1) · Bromocriptine (1) · Capecitabine (1) · Cocaine (1) · Cyclophosphamide (1) · Floxuridine (1) · Fluorouracil (1) · Immune Checkpoint Inhibitors (1) · Leucovorin (1) · Lidocaine (1) · Oxaliplatin (1)
National Cancer Institute (NCI) (3) · Purdue University (3) · Bastyr University (2) · Erasmus Medical Center (2) · Charite University, Berlin, Germany (1) · Imunon (1) · Kantonsspital Aarau (1) · Pengyuan Liu (1) · Southern Health (1) · ThermalCore Inc (1) · Thomas Jefferson University (1) · UMC Utrecht (1) · University of California, San Francisco (1) · University of Erlangen-Nürnberg Medical School (1) · University of North Texas Health Science Center (1)
United States (14) · Netherlands (3) · Germany (2) · Australia (1) · China (1) · Switzerland (1)
Michiel Kroesen, MD, Dr. (2) · Britt BM Suelmann, MD (1) · Fred Rincon, MD, MSc (1) · Jan Winetz, MD (1) · Jason Allen, N.D., MPH (1) · Jason Allen, ND, MPH (1) · Judy H Ch'ang, MD (1) · Jun Chen (1) · Marziya Kadir, MBBS (1) · Niloy R Datta, MD, DNB (1) · Oliver Ott, MD (1) · Sebastian Zschaeck, MD (1)
PMID 31772984, PMID 33243800, PMID 33626457, PMID 33805731
R00AT004711 (2), 2015 (1), P30DK097512 (1)