Hypopharyngeal Neoplasms: Clinical Trials

54 completed, 32 recruiting, 27 unknown, 12 active not recruiting. 58 Phase 2, 29 Not applicable, 28 Phase 1, 18 Phase 3, 4 Phase 4.

By phase and status

Phase	Trials	Status
Phase 2	58	Completed 20, Unknown 13, Recruiting 11, Active not recruiting 5, Terminated 5, Not yet recruiting 3, Withdrawn 1
Not applicable	29	Completed 13, Recruiting 4, Unknown 4, Terminated 3, Withdrawn 3, Active not recruiting 1, Not yet recruiting 1
Phase 1	28	Completed 11, Recruiting 6, Active not recruiting 3, Unknown 3, Terminated 2, Withdrawn 2, Not yet recruiting 1
Phase 3	18	Completed 8, Active not recruiting 3, Recruiting 3, Unknown 2, Not yet recruiting 1, Terminated 1
Phase 4	4	Completed 2, Active not recruiting 1, Recruiting 1
Early Phase 1	1	Recruiting 1

Follow Hypopharyngeal Neoplasms: new trials by email Literature Review of Hypopharyngeal Neoplasms trials Research Report on Hypopharyngeal Neoplasms

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Testing the Addition of an Anti-Cancer Drug, Camonsertib, to Radiation Therapy for Recurrent Head and Neck Squamous Cell Carcinoma Biospecimen Collection, Camonsertib, Computed Tomography - Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Recurrent Head and Neck Squamous Cell Carcinoma	Phase 1	Recruiting	National Cancer Institute (NCI)	39	2027-02-13	2026-09-03
Docetaxel and SX-682 in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma, Salivary Gland Carcinoma, and Advanced Prostate Cancer SX-682, DTX - Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma	Phase 1 / Phase 2	Recruiting	National Cancer Institute (NCI)	120	2026-10-29	2026-10-26
Ficerafusp Alfa, Pembrolizumab, and Stereotactic Body Radiotherapy (SBRT) for Head and Neck Squamous Cell Carcinoma (HNSCC) Hypofractionated Stereotactic Body Radiotherapy (SBRT), Pembrolizumab, Ficerafusp alfa - Head and Neck Squamous Cell Carcinoma, HPV-Negative Squamous Cell Carcinoma	Phase 1 / Phase 2	Not yet recruiting	Washington University School of Medicine	45	2026-09-30	2026-08-13
Intraoperative Methadone for the Management of Postoperative Pain in Patients With Head and Neck Cancers Electronic Health Record Review, Fentanyl, Laryngoscopy - Head and Neck Carcinoma, Hypopharyngeal Carcinoma	Phase 4	Recruiting	OHSU Knight Cancer Institute	58	2026-09-22	2026-10-05
Thermotherapy for Head and Neck Cancer Patients Thermotherapy, Radiotherapy, Concurrent chemoradiation - Head and Neck Cancer, Oropharyngeal Carcinoma	Phase 1	Recruiting	Erasmus Medical Center	30	2026-09-01	2026-09-02
Comparing Radiation Plus Cetuximab to Radiation Plus Chemotherapy in People With Head and Neck Cancer Who Cannot Receive Cisplatin Biospecimen Collection, Carboplatin, Cetuximab - Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8	Phase 3	Recruiting	NRG Oncology	454	2026-07-31	2026-08-17
A Machine Learning-Based Risk Prediction Model for Head and Neck Cancerous Lesions Hypopharyngeal Cancer, Laryngeal Cancer		Recruiting	The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School	3000	2026-04-30	2026-09-02
Neoadjuvant Chemotherapy Combined With Finotonlimab in the Treatment of Locally Advanced Hypopharyngeal Carcinoma Finolizumab, Albumin-Bound Paclitaxel /nab-Paclitaxel, Cisplatin - Hypopharyngeal Carcinoma	Phase 2	Recruiting	Eye & ENT Hospital of Fudan University	116	2025-12-22	2025-12-23
Oral Mucositis Management in Patients Receiving Radiation for Head and Neck Cancer: An Evaluation of a Barrier Based Treatment Gelclair Oral Mouth Rinse - Squamous Cell Carcinoma, Oropharyngeal Cancers	Phase 4	Active not recruiting	McMaster University	29	2025-12-15	2026-07-13
Clinical Treatments in Specialized Diseases of Laryngeal Carcinoma (LC) and Hypopharyngeal Carcinoma (HPC) routines - Glottic Carcinoma, Supraglottic Carcinoma		Recruiting	Eye & ENT Hospital of Fudan University	1000	2025-12-01	2025-12-04
Remote Audiometry to Monitor for Treatment-Related Hearing Loss in Patients With H&N SCC Receiving Cisplatin and/or Radiation Audiometric Test, Interview - Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Cutaneous Squamous Cell Carcinoma of the Head and Neck	Not applicable	Recruiting	Emory University	118	2025-08-25	2026-07-16
Neoadjuvant Treatment of Locally Advanced Hypopharyngeal Cancer With Adebrelimab Combined With TP Chemotherapy Regimen Adebrelimab+Albumin paclitaxel +Cisplatin - Locally Advanced Hypopharyngeal Cancer	Phase 2	Not yet recruiting	The First Affiliated Hospital of Xiamen University	34	2025-08-20	2025-08-22
Methotrexate, Erlotinib, and Celecoxib for the Treatment of Recurrent/Metastatic Head and Neck Cancer in a Rural Midwest United States Population Celecoxib, Erlotinib Hydrochloride, Imaging Procedure - Metastatic Oral Cavity Carcinoma, Recurrent Oral Cavity Carcinoma	Phase 2	Recruiting	Mayo Clinic	25	2025-08-07	2026-10-01
A Study of Sacituzumab Govitecan in Combination With Cetuximab in People With Head and Neck Squamous Cell Cancer (HNSCC) Sacituzumab Govitecan, Cetuximab - Squamous Cell Carcinoma of Head and Neck, Sinus Cancer	Phase 2	Recruiting	Memorial Sloan Kettering Cancer Center	40	2025-07-02	2026-02-19
Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck Cancer Best Practice, Biospecimen Collection, Cisplatin - Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8	Phase 2	Recruiting	NRG Oncology	98	2025-06-23	2026-08-17
TMV Vaccine Therapy Alone and With Pembrolizumab for the Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell Cancer Autologous Tumor Membrane Vesicles Vaccine, Biospecimen Collection, Computed Tomography - Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Metastatic Head and Neck Squamous Cell Carcinoma	Phase 1	Recruiting	Emory University	40	2025-05-08	2026-03-04
Thermotherapy for Locally Advanced Head and Neck Cancer Thermotherapy, radiotherapy - Head and Neck Cancer, Oropharyngeal Carcinoma	Phase 1	Active not recruiting	Erasmus Medical Center	2	2025-05-01	2026-09-02
Comparing Neoadjuvant Chemotherapy Combined With PD-1 Inhibitor Versus Neoadjuvant Chemotherapy in Locally Advanced Laryngeal and Hypopharyngeal Carcinoma Neoadjuvant Chemotherapy (NACT), Neoadjuvant and maintenance Tislelizumab, Concurrent chemo-radiotherapy (CCRT) - Laryngeal Carcinoma, Hypopharyngeal Carcinoma	Phase 3	Not yet recruiting	Fudan University	168	2025-04-28	2025-05-08
Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment Biospecimen Collection, Cetuximab, Computed Tomography - Metastatic Head and Neck Squamous Cell Carcinoma, Metastatic Hypopharyngeal Squamous Cell Carcinoma	Phase 3	Recruiting	National Cancer Institute (NCI)	158	2025-03-27	2026-10-26
Salvage Surgery in Recurrent Hypopharyngeal Carcinoma: an Observational Single-institutional Study From 1998 Hypopharyngeal Carcinoma		Active not recruiting	Fondazione IRCCS Policlinico San Matteo di Pavia	100	2025-03-18	2025-12-19

Showing 20 of 147. Sign in to see all of them.

Narrower conditions

Laryngeal Neoplasms (119)  ·  Oropharyngeal Neoplasms (100)  ·  Mouth Neoplasms (90)  ·  Head and Neck Neoplasms (67)  ·  Nasopharyngeal Neoplasms (47)  ·  Squamous Cell Carcinoma of Head and Neck (45)  ·  Carcinoma (26)  ·  Salivary Gland Neoplasms (26)  ·  Carcinoma, Non-Small-Cell Lung (19)  ·  Esophageal Neoplasms (17)  ·  Lung Neoplasms (17)  ·  Tongue Neoplasms (14)  ·  Small Cell Lung Carcinoma (13)  ·  Stomach Neoplasms (12)

Broader conditions

Otorhinolaryngologic Neoplasms (147)  ·  Pharyngeal Diseases (147)  ·  Stomatognathic Diseases (147)  ·  Neoplasms by Site (146)  ·  Otorhinolaryngologic Diseases (146)  ·  Pharyngeal Neoplasms (146)  ·  Neoplasms (142)  ·  Respiratory Tract Diseases (121)  ·  Respiratory Tract Neoplasms (120)  ·  Laryngeal Diseases (116)  ·  Mouth Diseases (94)  ·  Head and Neck Neoplasms (80)  ·  Neoplasms by Histologic Type (73)  ·  Neoplasms, Glandular and Epithelial (72)  ·  Nasopharyngeal Diseases (56)

Interventions

Cisplatin (29)  ·  Magnetic Resonance Spectroscopy (15)  ·  Radiotherapy (14)  ·  Specimen Handling (13)  ·  Cetuximab (11)  ·  Radiotherapy, Intensity-Modulated (11)  ·  pembrolizumab (11)  ·  Surgical Procedures, Operative (10)  ·  Docetaxel (9)  ·  Fluorouracil (9)  ·  Paclitaxel (9)  ·  1,2-diaminocyclohexaneplatinum II citrate (8)  ·  Platinum (8)  ·  Carboplatin (6)  ·  Radiation (6)

Sponsors

National Cancer Institute (NCI) (14)  ·  M.D. Anderson Cancer Center (7)  ·  Mayo Clinic (5)  ·  Emory University (4)  ·  Eye & ENT Hospital of Fudan University (4)  ·  Fudan University (4)  ·  Groupe Oncologie Radiotherapie Tete et Cou (4)  ·  Memorial Sloan Kettering Cancer Center (4)  ·  Dana-Farber Cancer Institute (3)  ·  ECOG-ACRIN Cancer Research Group (3)  ·  National Taiwan University Hospital (3)  ·  Roswell Park Cancer Institute (3)  ·  Sun Yat-sen University (3)  ·  Wake Forest University Health Sciences (3)  ·  Abramson Cancer Center at Penn Medicine (2)

Countries

United States (86)  ·  China (20)  ·  France (10)  ·  Canada (8)  ·  Taiwan (6)  ·  Switzerland (5)  ·  Germany (4)  ·  Netherlands (3)  ·  South Korea (3)  ·  United Kingdom (3)  ·  Belgium (2)  ·  Czechia (2)  ·  India (2)  ·  Italy (2)  ·  Australia (1)

Top investigators

Ching-Ting Tan, MD, PhD (2)  ·  Everett E. Vokes, MD (2)  ·  Jean Bourhis, PhD (2)  ·  Loren K Mell (2)  ·  Martin Mahoney, MD (2)  ·  Michiel Kroesen, MD, Dr. (2)  ·  Ming Zhang, PhD (2)  ·  Xiayun He, M.D. (2)  ·  Yu Wang, M.D. (2)  ·  Yvonne M Mowery (2)  ·  Aarti Bhatia (1)  ·  Amit Agrawal (1)  ·  Amol M Takalkar, MD, MS, MBA, FACNM (1)

Results publications

PMID 10924966, PMID 14511925, PMID 16849759, PMID 17293228, PMID 17709149, PMID 19380364, PMID 19643246, PMID 20403855, PMID 21266057, PMID 21775497, PMID 21831465, PMID 22241828, PMID 22252927, PMID 22319013, PMID 23199641, PMID 23341517, PMID 23541643, PMID 23733379, PMID 24821357, PMID 25965900, PMID 26062933, PMID 26611425, PMID 29346519, PMID 30850872, PMID 31178203, PMID 31536129, PMID 31705729, PMID 32417348, PMID 32479189, PMID 33004905, PMID 33300144, PMID 33989559, PMID 34611902, PMID 34791718, PMID 34841093, PMID 35998768, PMID 36447152, PMID 37142273, PMID 37230961, PMID 38416544, PMID 38739392, PMID 39551064, PMID 39868569, PMID 40404202, PMID 40692081, PMID 42498484

NIH funding

P30CA138292 (4), U10CA180820 (4), U10CA180868 (3), P30CA015083 (2), UM1CA186690 (2), 2008 (1), 2023 (1), K01AT004415 (1), K24DC022077 (1), P30CA006516 (1), P30CA006973 (1), P30CA014520 (1), P30CA016042 (1), P30CA016056 (1), P30CA016672 (1)