1089 completed, 451 recruiting, 271 terminated, 252 unknown. 1096 Phase 2, 759 Phase 1, 287 Not applicable, 140 Phase 3, 47 Early Phase 1.
Follow this condition Literature Review of Sarcoma trials Research Report on Sarcoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Combination Immunotherapy Targeting Sarcomas Multiple sarcoma-specific CAR-T cells and sarcoma vaccines - Sarcoma, Osteoid Sarcoma | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 20 | 2027-07-01 | 2026-08-26 |
| Safety and Efficacy Evaluation of 4th Generation Safety-engineered CAR T Cells Targeting Sarcomas Sarcoma-specific CAR-T cells - Sarcoma, Osteoid Sarcoma | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 20 | 2027-06-01 | 2026-08-26 |
| A Phase 1/2 Study of CBX-12 in Children, Adolescents, or Young Adults With Solid Tumors That Have Come Back After Treatment or Are Difficult to Treat Archive Sample Retrieval, Biospecimen Collection, pH Low Insertion Peptide-exatecan Conjugate CBX-12 - Recurrent Childhood Ewing Sarcoma, Recurrent Childhood Malignant Solid Neoplasm | Phase 1 / Phase 2 | Not yet recruiting | Children's Oncology Group | 79 | 2027-05-07 | 2026-09-22 |
| Information-providing Chatbot ASCC (sarcoma-specific AI chatbot), Routine Clinical Care - Sarcoma | Not applicable | Not yet recruiting | The Hong Kong Polytechnic University | 78 | 2027-04-01 | 2026-04-01 |
| Doxorubicin With or Without DT-7012 in Advanced Soft Tissue Sarcoma DT-7012, Doxorubicin - Undifferentiated Pleomorphic Sarcoma (UPS), Dedifferentiated Liposarcoma (DDLPS) | Phase 2 | Not yet recruiting | Gustave Roussy, Cancer Campus, Grand Paris | 80 | 2027-02-01 | 2026-09-15 |
| RAPID: Phase 2 Platform Trial Of Promising Drugs For AYA Patients With R/R Ewing Sarcoma & DSRCT LX-101 - Ewing Sarcoma | Phase 2 | Not yet recruiting | M.D. Anderson Cancer Center | 120 | 2027-02-01 | 2026-08-24 |
| Combination of Avutometinib and Defactinib for Treatment of Relapsed, Refractory, Metastatic, or Unresectable Malignant Peripheral Nerve Sheath Tumor avutometinib capsule + defactinib tablet - MPNST (Malignant Peripheral Nerve Sheath Tumor) | Phase 2 | Not yet recruiting | Girish Dhall, MD | 23 | 2027-01-01 | 2026-08-04 |
| Bone Arches: Performance of Pseudo-scanner Sequences in Segmenting the Extent of the Tumour and in Planning Surgical Resection Using the CT Scan as a Reference Whole body MRI - Sarcoma | Not applicable | Not yet recruiting | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | 122 | 2027-01-01 | 2026-04-29 |
| Sarcoma and Intra-infusion Exercise for Better Outcomes Exercise - Sarcoma | Not applicable | Not yet recruiting | Kira Bloomquist | 16 | 2027-01-01 | 2026-08-25 |
| Tumor-Lymph Node Mapping ICG (Indocyanine Green) - Pediatric Solid Tumors, Rhabdomyosarcoma | Not yet recruiting | University of Rochester | 10 | 2026-12-13 | 2026-08-26 | |
| Acupuncture as add-on to G-CSF for Febrile Neutropenia-related Hospitalization in Doxorubicin-treated Patients With Sarcoma Acupuncture - Febrile Neutropenia, Sarcoma | Not applicable | Not yet recruiting | Shaare Zedek Medical Center | 60 | 2026-12-01 | 2026-04-29 |
| Paediatric Sarcoma, Hybrid Imaging & FAPI - Raising the Diagnostic Standard for Paediatric Sarcoma Patients, Combining Novel Radiotracer FAPI and Whole-body PET/MRI FAPI tracer - Sarcoma | Phase 2 | Not yet recruiting | Copenhagen University Hospital, Rigshospitalet | 40 | 2026-12-01 | 2026-10-06 |
| Treatment of Stage IV Cancer Patients With Multiple Patient-specific Mutated Cell Surface Proteins With Chimeric Antibodies Moonshot Antibodies - Soft Tissue Cancer | Phase 1 | Not yet recruiting | Centre hospitalier de l'Université de Montréal (CHUM) | 16 | 2026-12-01 | 2026-09-22 |
| Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma Doxorubicin - Sarcoma | Phase 2 | Recruiting | University of Colorado, Denver | 20 | 2026-12-01 | 2026-02-05 |
| Comparison of the Effects of Needle Biopsy Tract Resection and Non-resection on Recurrence Rate in Patients With Primary Extremity Sarcoma biopsy tract resection, biopsy tract non-resection - Primary, Sarcoma | Phase 2 | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 3300 | 2026-12-01 | 2026-07-14 |
| Low Dose, Reduced Frequency Nivolumab for the Treatment of Unresectable or Metastatic Cancer, AFFORD IO Trial Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging - Clinical Stage III Cutaneous Melanoma AJCC v8, Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8 | Phase 2 | Not yet recruiting | Fred Hutchinson Cancer Center | 50 | 2026-12-01 | 2026-09-17 |
| Testing the Anti-Cancer Drug, Brenetafusp (IMCF106C), in Rare Cancers Anti-PRAME T-cell Receptor/Anti-CD3 scFv Fusion Protein IMC-F106C, Biopsy Procedure, Biospecimen Collection - Metastatic Myxoid Liposarcoma, Metastatic Synovial Sarcoma | Phase 2 | Not yet recruiting | National Cancer Institute (NCI) | 42 | 2026-11-23 | 2026-09-25 |
| A Phase 1b, Open-Label Study Of REC-617, A Selective CDK7 Inhibitor, In Patients With Metastatic Or Unresectable RB1-Negative Leiomyosarcoma After Prior Systemic Therapy REC617 - Phase 1b, Open Label | Phase 1 | Recruiting | M.D. Anderson Cancer Center | 15 | 2026-10-19 | 2026-07-31 |
| Utidelone Capsules Combined With Doxorubicin for Advanced Soft Tissue Sarcoma UTD2 + tislelizumab + doxorubicin - Soft Tissue Sarcoma (STS), Utidelone | Phase 2 | Not yet recruiting | Beijing Biostar Pharmaceuticals Co., Ltd. | 49 | 2026-10-18 | 2026-09-25 |
| PROACT AYA: Preventing Overweight/Obesity-Associated Cardiotoxicity With Tirzepatide In Adolescent And Young Adult Cancer Survivors - A Phase 2 Single-Arm, Single-Center Feasibility Study Tirzepatide - Sarcoma,Soft Tissue | Phase 2 | Recruiting | M.D. Anderson Cancer Center | 30 | 2026-10-14 | 2026-10-20 |
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Osteosarcoma (469) · Sarcoma, Ewing (244) · Rhabdomyosarcoma (229) · Neoplasms (218) · Melanoma (212) · Neuroblastoma (206) · Breast Neoplasms (200) · Ovarian Neoplasms (192) · Liposarcoma (158) · Leiomyosarcoma (157) · Sarcoma, Kaposi (154) · Sarcoma, Synovial (133) · Neoplasm Metastasis (126) · Colorectal Neoplasms (120)
Neoplasms by Histologic Type (2469) · Neoplasms, Connective and Soft Tissue (2464) · Neoplasms (2257) · Neoplasms, Connective Tissue (898) · Neoplasms by Site (841) · Neoplasms, Nerve Tissue (608) · Neoplasms, Bone Tissue (600) · Neoplasms, Glandular and Epithelial (583) · Urogenital Diseases (563) · Neoplasms, Germ Cell and Embryonal (529) · Neuroectodermal Tumors (519) · Urogenital Neoplasms (468) · Female Urogenital Diseases (465) · Female Urogenital Diseases and Pregnancy Complications (465)
Doxorubicin (191) · Cyclophosphamide (127) · Ifosfamide (114) · Radiotherapy (102) · Gemcitabine (84) · Vincristine (70) · Filgrastim (66) · Etoposide (64) · pembrolizumab (60) · Irinotecan (55) · Magnetic Resonance Spectroscopy (55) · Cisplatin (53) · pazopanib (52) · Trabectedin (51) · Specimen Handling (49)
National Cancer Institute (NCI) (201) · Memorial Sloan Kettering Cancer Center (86) · M.D. Anderson Cancer Center (75) · Children's Oncology Group (71) · Peking University People's Hospital (37) · St. Jude Children's Research Hospital (31) · Dana-Farber Cancer Institute (26) · Washington University School of Medicine (26) · European Organisation for Research and Treatment of Cancer - EORTC (25) · Institut Bergonié (25) · Eli Lilly and Company (23) · Italian Sarcoma Group (23) · Mayo Clinic (23) · Centre Leon Berard (22) · University Health Network, Toronto (22)
United States (1449) · France (262) · China (220) · Canada (208) · Italy (166) · United Kingdom (164) · Germany (149) · Spain (135) · Australia (122) · Netherlands (90) · Belgium (75) · Poland (53) · Puerto Rico (53) · Switzerland (53) · Denmark (49)
Robert Yarchoan, M.D. (10) · Brigitte C Widemann, M.D. (8) · Robert Maki, MD, PhD (8) · Sandra D'Angelo, MD (8) · Seth Pollack (8) · AeRang Kim, MD, PhD (7) · David S Schrump, M.D. (7) · Ramya M Ramaswami, M.D. (7)
PMID 31401903, PMID 32827353, PMID 22682017, PMID 35115306, PMID 38603649, PMID 28391775, PMID 31553693, PMID 40341199, PMID 11323136, PMID 16000093, PMID 17290061, PMID 17822748, PMID 18378136, PMID 19451433, PMID 19556464, PMID 19949018, PMID 22002018, PMID 23450030, PMID 24504442, PMID 24618336, PMID 25209242, PMID 25421877, PMID 26378637, PMID 27567955, PMID 27621408, PMID 28295221, PMID 28988646, PMID 29033609, PMID 29343557, PMID 30262660, PMID 30477937, PMID 31000377, PMID 31013172, PMID 31575518, PMID 31838007, PMID 31957034, PMID 32002290, PMID 32154021, PMID 32192573, PMID 32269142, PMID 32713836, PMID 34416158, PMID 35135810, PMID 35709412, PMID 36995690, PMID 37740179, PMID 38524902, PMID 39122389, PMID 39796745, PMID 39863139
U10CA180886 (31), U10CA098543 (27), 2015 (17), 2023 (17), 2016 (15), P30CA015704 (13), 2009 (12), 2018 (11), P30CA008748 (10), P30CA033572 (10), 2017 (9), 2019 (9), 2025 (8), P30CA016672 (8), U01CA121947 (7)