8 completed, 3 withdrawn, 2 recruiting, 2 unknown. 9 Phase 1, 9 Phase 2, 3 Phase 3.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase 3 Trial Evaluating the Safety & Efficacy of IMNN-001 Administered in Combination w/ Standard NACT & Adjuvant Chemotherapy in Newly Diagnosed Patients w/ Advanced EOC, Fallopian Tube or Primary Peritoneal Cancer IMNN-001 (IL-12 Plasmid Formulated with PEG-PEI-Cholesterol Lipopolymer), Paclitaxel, Carboplatin - Epithelial Ovarian Cancer, Ovarian Cancer | Phase 3 | Recruiting | Imunon | 500 | 2025-07-09 | 2026-10-05 |
| Study to Evaluate the Safety & Immunogenicity of IMNN-101 Administered in Healthy Adults Previously Vaccinated Against SARS-CoV-2 IMNN-101 - SARS CoV 2 Infection | Phase 1 / Phase 2 | Completed | Imunon | 24 | 2024-06-04 | 2025-07-23 |
| Phase II IMNN-001 (Also Known as GEN-1) on SLL With BEV and NACT, Newly Diagnosed Advanced Ovarian, Fallopian Tube or Primary Peritoneal Cancer Paclitaxel, Carboplatin, Bevacizumab - Ovarian Cancer, Fallopian Tube Cancer | Phase 1 / Phase 2 | Recruiting | Imunon | 30 | 2023-02-10 | 2026-10-05 |
| PanDox: Targeted Doxorubicin in Pancreatic Tumours Focused Ultrasound, Doxorubicin, ThermoDox - Pancreatic Ductal Adenocarcinoma, Pancreatic Cancer Stage IV | Phase 1 | Withdrawn | University of Oxford | 2021-06-16 | 2023-04-12 | |
| Study of IMNN-001 (Also Known as GEN-1) With NACT for Treatment of Ovarian Cancer (OVATION 2) IMNN-001, Carboplatin, Paclitaxel - Epithelial Ovarian Cancer, Fallopian Tube Cancer | Phase 1 / Phase 2 | Active not recruiting | Imunon | 130 | 2018-09-05 | 2026-05-04 |
| Heat-Activated Target Therapy of Local-Regional Relapse in Breast Cancer Patients ThermoDox (Thermally Sensitive Liposomal Doxorubicin), Radiation Therapy, Superficial Hyperthermia - Breast Cancer | Phase 2 | Withdrawn | Imunon | 2017-03-01 | 2022-04-07 | |
| Study of Safety & Biological Activity of IP IMNN-001 (also Known As GEN-1) with Neoadjuvant Chemo in Ovarian Cancer IMNN-001 - Epithelial Ovarian Cancer, Fallopian Tube Cancer | Phase 1 | Completed | Imunon | 18 | 2015-09-01 | 2024-10-02 |
| Targeted Chemotherapy Using Focused Ultrasound for Liver Tumours ThermoDox® (LTLD), Focused Ultrasound of Target Liver Tumour, Pre-LTLD Biopsy of Target Liver Tumour - Liver Tumour | Phase 1 | Completed | University of Oxford | 10 | 2014-07-01 | 2019-07-22 |
| Study of ThermoDox With Standardized Radiofrequency Ablation (RFA) for Treatment of Hepatocellular Carcinoma (HCC) ThermoDox, Dummy infusion - Hepatocellular Carcinoma | Phase 3 | Completed | Imunon | 554 | 2014-06-01 | 2024-08-20 |
| Phase 1/2 Study of ThermoDox With Approved Hyperthermia in Treatment of Breast Cancer Recurrence at the Chest Wall ThermoDox in combination with Microwave Hyperthermia (heat) - Breast Cancer | Phase 1 / Phase 2 | Completed | Imunon | 17 | 2013-02-01 | 2017-01-30 |
| MRI Guided High Intensity Focused Ultrasound (HIFU) and ThermoDox for Palliation of Painful Bone Metastases High Intensity Focused Ultrasound (HIFU) in combination with ThermoDox - Painful Bone Metastases, Breast Carcinoma | Phase 2 | Withdrawn | Imunon | 2012-07-01 | 2017-02-07 | |
| Phase 2 Study of Thermodox as Adjuvant Therapy With Thermal Ablation (RFA) in Treatment of Metastatic Colorectal Cancer(mCRC) Lyso-Thermosensitive Liposomal Doxorubicin, 5% Dextrose Solution, ThermoDox - Colon Cancer Liver Metastasis | Phase 2 | Terminated | Imunon | 2 | 2011-09-01 | 2022-10-13 |
| Phase 3 Study of ThermoDox With Radiofrequency Ablation (RFA) in Treatment of Hepatocellular Carcinoma (HCC) ThermoDox, 5% Dextrose Solution - Hepatocellular Carcinoma | Phase 3 | Completed | Imunon | 701 | 2008-05-01 | 2024-05-03 |
| A Study of ThermoDox™ in Combination With Radiofrequency Ablation (RFA) in Primary and Metastatic Tumors of the Liver ThermoDox - Hepatocellular Carcinoma, Liver Neoplasms | Phase 1 | Completed | Imunon | 30 | 2007-02-01 | 2019-02-07 |
| Liposomal Doxorubicin and Thermal Therapy in Treating Patients With Prostate Cancer pegylated liposomal doxorubicin hydrochloride, hyperthermia treatment - Prostate Cancer | Phase 1 | Completed | Imunon | 2003-03-01 | 2013-05-30 | |
| Combination Chemotherapy With or Without Microwave Thermotherapy Before Surgery in Treating Women With Locally Advanced Breast Cancer cyclophosphamide, doxorubicin hydrochloride, conventional surgery - Breast Cancer | Phase 2 | Unknown | Imunon | 2001-08-01 | 2013-12-19 | |
| Microwave Thermotherapy in Treating Women With Stage I or Stage II Breast Cancer conventional surgery, neoadjuvant therapy, thermal ablation therapy - Breast Cancer | Phase 2 | Unknown | Imunon | 2001-08-01 | 2013-11-06 |
Breast Neoplasms (5) · Carcinoma, Hepatocellular (4) · Fallopian Tube Neoplasms (4) · Liver Neoplasms (4) · Carcinoma, Ovarian Epithelial (3) · Adenocarcinoma (2) · Neoplasms (2) · Ovarian Neoplasms (2) · Bone Neoplasms (1) · COVID-19 (1) · Carcinoma (1) · Carcinoma, Non-Small-Cell Lung (1) · Colonic Neoplasms (1) · Digestive System Diseases (1) · Digestive System Neoplasms (1)
Carboplatin (3) · Doxorubicin (3) · Paclitaxel (3) · GEN-1 (2) · Neoadjuvant Therapy (2) · Bevacizumab (1) · Cyclophosphamide (1) · Diathermy (1) · Hot Temperature (1) · Radiotherapy (1) · liposomal doxorubicin (1) · niraparib (1) · olaparib (1)
United States (13) · Canada (3) · Italy (3) · United Kingdom (3) · China (2) · Hong Kong (2) · Malaysia (2) · Philippines (2) · South Korea (2) · Taiwan (2) · Thailand (2) · Czechia (1) · Germany (1) · Israel (1) · Japan (1)
Nicholas Borys, M.D. (2) · William E. Gannon, MD (2) · Amir Jazaeri, MD (1) · Catherine Van Doren, RN (1) · Chen Min Hua, MD (1) · Douglas Faller, MD (1) · Mark Middleton (1) · Mark R Middleton, PhD, FRCP (1) · Nicholas Borys, MD (1) · Pietro Gabriele, M.D. (1) · Premal H Thaker, M.D. (1) · Premal H. Thaker, M.D (1) · Premal Thaker, M.D. (1) · Ricardo Lencioni, MD (1) · Riccardo Lencioni, M.D. (1)
PMID 36608308, PMID 25144817, PMID 30001990, PMID 30644817, PMID 34210826, PMID 37741968, PMID 40461366
2014 (1)