9 completed, 7 unknown, 3 not yet recruiting, 2 active not recruiting. 25 Phase 2, 7 Phase 1, 4 Phase 3.
Follow Hyperthermia: new trials by email Literature Review of Hyperthermia trials Research Report on Hyperthermia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Mild-Intensity Whole Body Hyperthermia (WBH) for Major Depressive Disorder Tocilizumab, Placebo, Whole-Body Hyperthermia - Major Depressive Disorder | Phase 2 | Suspended | Massachusetts General Hospital | 35 | 2026-12-01 | 2025-11-13 |
| A Study Comparing Whole-Body Heat Treatment Plus Systemic Therapy to Systemic Therapy Alone, for Advanced Pancreatic Cancer Whole-body hyperthermia, Standard-of-Care Systemic therapy - Pancreatic Ductal Adenocarcinoma (mPDAC), Metastatic Pancreatic Ductal Adenocarcinoma (PDAC) | Phase 2 / Phase 3 | Not yet recruiting | ElmediX | 95 | 2026-10-01 | 2026-07-17 |
| Feasibility of Total Neoadjuvant Treatment With HYPErthermia in Patients With High-risk Extremity and Trunk Soft Tissue Sarcoma (TNT-HYPE) Doxorubicin, Ifosfamide, Dacarbazine - Sarcoma,Soft Tissue | Phase 2 | Recruiting | Swiss Cancer Institute | 24 | 2025-10-27 | 2025-12-30 |
| Hyperthermia Combined With Immune Checkpoint Inhibitors in the Treatment of Advanced Gastrointestinal Malignancies With Liver Metastases Hyperthermia, Immunotherapy - Gastrointestinal Cancer, Immunotherapy | Phase 2 | Not yet recruiting | China Medical University, China | 40 | 2025-08-15 | 2025-08-12 |
| Hyperthermia Enhanced Re-irradiation of Loco-regional Recurrent Tumors loco-regional hyperthermia - Recurrent Cancer, Prostate Cancer | Phase 2 | Not yet recruiting | Charite University, Berlin, Germany | 110 | 2024-05-10 | 2023-12-26 |
| Clinical Application of Near-infrared Whole Body Heat Shock Multimodal Technique in Treatment of Castration-resistant Prostate Cancer Immunotherapy, Targeted therapy, Hyperthermia - Metastatic Castration-resistant Prostate Cancer (CRPC) | Phase 2 | Recruiting | Pengyuan Liu | 60 | 2024-01-01 | 2024-02-08 |
| Intranasal Cocaine and Temperature Regulation During Exercise Cocaine, Lidocaine - Hyperthermia, Cocaine Use | Phase 1 / Phase 2 | Completed | University of Texas Southwestern Medical Center | 27 | 2023-09-01 | 2025-07-14 |
| Neoadjuvant Concomitant Modulated Electro-hyperthermia in HER2-negative Breast Cancer Oncotherm EHY-2030, Paclitaxel, Carboplatin - HER2-negative Breast Cancer | Phase 2 / Phase 3 | Active not recruiting | Semmelweis University | 71 | 2023-02-20 | 2026-05-15 |
| Heat Therapy, Functional Capacity, and Vascular Health in Older Adults Home-based leg heat therapy, Home-based sham therapy - Aging Well, Walking, Difficulty | Phase 1 / Phase 2 | Completed | University of North Texas Health Science Center | 21 | 2022-11-03 | 2026-06-05 |
| Assessment of Growth Factors Levels Associated with Wound Healing After Soft Tissue Crown Lengthening single intervention by Sirolase ® lower power diode laser 970 ± 15 nm (0.5 watts) continuous emission, power =3 watts, fiber 320 μm, single intervention by electrosurgical unit which was kept 38 watts rms ± 5%. The working frequency was adjusted to 1.5 MHz ± 5%. - Gingival Overgrowth | Phase 2 | Completed | Al-Azhar University | 80 | 2021-10-03 | 2025-02-04 |
| Hyperthermia Combined With Immune Checkpoint Inhibitor Therapy for Advanced Gastrointestinal Tumours Water-filtered infrared A radiation whole-body hyperthermia (HECKEL 3000MT-4T, Germany), tislelizumab (BeiGene, China) combined with PD-1 inhibitor - Gastrointestinal Tumor | Phase 1 / Phase 2 | Completed | Pengyuan Liu | 18 | 2020-06-01 | 2023-09-05 |
| SBRT Combined With PD-1 Inhibitor and Thoracic Hyperthermia for Advanced NSCLC SBRT combined with PD-1 inhibitors and thoracic hyperthermia - Stereotactic Body Radiation Therapy; PD-1 Inhibitor; Hyperthermia; NSCLC | Phase 2 | Unknown | First People's Hospital of Hangzhou | 63 | 2020-01-20 | 2022-08-30 |
| Aggressive Antipyretics for Fever Reduction in CNS Malaria Acetaminophen, Ibuprofen, placebo for acetaminophen - Malaria, Seizures | Phase 2 | Completed | University of Rochester | 256 | 2019-01-07 | 2024-03-05 |
| Efficacy of Bromocriptine For Fever Reduction in Acute Neurologic Injury Bromocriptine 5 MG, Acetaminophen 650 MG - Subarachnoid Hemorrhage, Subdural Hematoma | Phase 1 / Phase 2 | Completed | University of California, San Francisco | 47 | 2018-11-30 | 2021-06-24 |
| Hypofractionated Radiotherapy With Hyperthermia in Unresectable or Marginally Resectable Soft Tissue Sarcomas Hypofractionated radiotherapy, Hyperthermia - Sarcoma, Alveolar Soft Part Sarcoma | Phase 2 | Unknown | Maria Sklodowska-Curie National Research Institute of Oncology | 30 | 2018-06-01 | 2021-02-01 |
| Perioperative Systemic Therapy for Isolated Resectable Colorectal Peritoneal Metastases Perioperative systemic therapy, Perioperative CAPOX-bevacizumab, Perioperative FOLFOX-bevacizumab - Colorectal Neoplasm, Colorectal Cancer | Phase 2 / Phase 3 | Active not recruiting | Koen Rovers | 358 | 2017-06-01 | 2026-03-24 |
| Concurrent Hyperthermia and Chemoradiotherapy in LAPC: Phase II Study Chemoradiotherapy (CTRT), Thermochemoradiotherapy (CTRTHT) - Cancer Pancreas | Phase 2 | Unknown | Kantonsspital Aarau | 78 | 2017-01-01 | 2017-08-01 |
| Combination of Hyperthermia and Concurrent Chemoradiotherapy (CCRT) for Recurrent Head and Neck Cancer Radiation, Hyperthermia; Thermotron RF-8, Cisplatin - Recurrent Head and Neck Cancer | Phase 2 | Unknown | Shin Kong Wu Ho-Su Memorial Hospital | 45 | 2015-09-01 | 2020-07-28 |
| Hyperthermia and Proton Therapy in Unresectable Soft Tissue Sarcoma Hyperthermia and Proton Beam - Soft Tissue Sarcoma | Phase 1 / Phase 2 | Unknown | Kantonsspital Aarau | 26 | 2014-02-01 | 2015-09-02 |
| Surgery and Heated Chemotherapy for Adrenocortical Carcinoma Cisplatin, Cytoreductive surgery, sodium thiosulfate - Adrenocortical Carcinoma, Peritoneal Carcinomatosis | Phase 2 | Completed | National Cancer Institute (NCI) | 11 | 2013-04-12 | 2019-07-30 |
Showing 20 of 25. Sign in to see all of them.
Sarcoma (4) · Fever (3) · Rectal Neoplasms (3) · Cerebral Hemorrhage (2) · Pancreatic Neoplasms (2) · Peritoneal Neoplasms (2) · Adrenocortical Carcinoma (1) · Anus Neoplasms (1) · Brain Injuries, Traumatic (1) · Breast Neoplasms (1) · Camurati-Engelmann Syndrome (1) · Carcinoma, Non-Small-Cell Lung (1) · Carcinoma, Squamous Cell (1) · Colonic Neoplasms (1)
Body Temperature Changes (25) · Heat Stress Disorders (25) · Pathological Conditions, Signs and Symptoms (25) · Signs and Symptoms (25) · Wounds and Injuries (25) · Neoplasms (15) · Neoplasms by Site (12) · Digestive System Diseases (8) · Digestive System Neoplasms (7) · Neoplasms by Histologic Type (6) · Pathologic Processes (6) · Gastrointestinal Diseases (5) · Gastrointestinal Neoplasms (4) · Intestinal Diseases (4) · Intestinal Neoplasms (4)
Diathermy (7) · Immune Checkpoint Inhibitors (3) · Radiotherapy (3) · Acetaminophen (2) · Cisplatin (2) · Fluorouracil (2) · Immunotherapy (2) · tislelizumab (2) · AC protocol (1) · Bromocriptine (1) · Capecitabine (1) · Carboplatin (1) · Chemoradiotherapy (1) · Cocaine (1) · Cytoreduction Surgical Procedures (1)
Kantonsspital Aarau (2) · National Cancer Institute (NCI) (2) · Pengyuan Liu (2) · Al-Azhar University (1) · Charite University, Berlin, Germany (1) · China Medical University, China (1) · ElmediX (1) · First People's Hospital of Hangzhou (1) · Koen Rovers (1) · Maria Sklodowska-Curie National Research Institute of Oncology (1) · Massachusetts General Hospital (1) · Medical University of Vienna (1) · Semmelweis University (1) · Shin Kong Wu Ho-Su Memorial Hospital (1) · Swiss Cancer Institute (1)
United States (7) · China (3) · Germany (3) · Switzerland (3) · Belgium (2) · Austria (1) · Egypt (1) · Hungary (1) · Malawi (1) · Netherlands (1) · Poland (1) · Spain (1) · Taiwan (1) · Zambia (1)
Alexandra R Brandt-Kerkhof, MD (1) · Andrea Holzer, MD (1) · Arend G Aalbers, MD (1) · Bing Xia, MD (1) · Cornelis J Punt, MD, PhD (1) · Eino B van Duyn, MD, PhD (1) · Emanuel Stutz, MD (1) · Fred Rincon, MD, MSc (1) · Gretchen L Birbeck, MD (1) · Ignace H de Hingh, MD, PhD (1) · Jeremy L Davis, M.D. (1) · Judy H Ch'ang, MD (1) · Jun Chen (1)
PMID 29162142, PMID 30463745, PMID 31023318, PMID 31772984, PMID 33528867, PMID 33741467, PMID 33805731, PMID 34009291, PMID 36316704, PMID 38640099, PMID 38857015, PMID 39920700, PMID 42372745
2016 (1), R01NS102176 (1)