173 completed, 69 recruiting, 48 unknown, 29 not yet recruiting. 255 Not applicable, 27 Phase 2, 23 Phase 3, 22 Phase 1, 7 Phase 4.
Follow this condition Literature Review of Heat Stress Disorders trials Research Report on Heat Stress Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Work Design Interventions for Older Workers During Consecutive Days in the Heat Standard work pace, Additional rest breaks - Hyperthermia, Fatigue; Heat | Not applicable | Not yet recruiting | State University of New York at Buffalo | 32 | 2028-09-01 | 2026-06-30 |
| Work Design Interventions for Heat Resilience Standard work pace, Reduced-pace work, Increased-pace work - Hyperthermia, Fatigue; Heat | Not applicable | Not yet recruiting | State University of New York at Buffalo | 32 | 2027-09-01 | 2026-06-30 |
| A Prospective Study of Concurrent Hyperthermia, Chemotherapy and Radiotherapy in Borderline and Locally Advanced Pancreatic Cancer (PANHEAT) Hyperthermia plus neoadjuvant chemotherapy/radiotherapy Arm Description: Hyperthermia plus neoadjuvant chemotherapy (mFOLFIRINOX/nab Paclitaxel) followed by a) surgically resectable: Hyp - Borderline and Locally Advanced Pancreatic Cancer | Not applicable | Not yet recruiting | Fernando Pessoa Canarias University | 60 | 2027-03-31 | 2026-09-24 |
| Hyperthermia in Patients With Chronic Primary Pain - Effects on Thermoregulation, Somatosensory System and Movement Evoked Pain serial whole body hyperthermia - Hyperthermia, Chronic Primary Pain | Not applicable | Not yet recruiting | Bern University of Applied Sciences | 60 | 2026-12-01 | 2026-09-30 |
| Mild-Intensity Whole Body Hyperthermia (WBH) for Major Depressive Disorder Tocilizumab, Placebo, Whole-Body Hyperthermia - Major Depressive Disorder | Phase 2 | Suspended | Massachusetts General Hospital | 35 | 2026-12-01 | 2025-11-13 |
| Multi-site Feasibility of an Integrated Treatment for the Biology and Experience of Depression: The MULTIBED Study Cognitive Behavioral Therapy (CBT), Whole-Body Hyperthermia - Major Depressive Disorder | Not applicable | Not yet recruiting | University of California, San Francisco | 60 | 2026-12-01 | 2026-10-13 |
| TECAR Therapy in Chronic Back Pain TECAR Therapy plus Hi-EMS, Tecar therapy alone - Chronic Low-back Pain (cLBP), Non Specific Chronic Low Back Pain | Not applicable | Not yet recruiting | University of Hartford | 37 | 2026-10-19 | 2026-09-15 |
| Indoor Overheating and Physiological Strain in Older Adults With COPD Simulated indoor thermal environment - Chronic Obstructive Pulmonary Disease (COPD), Heat Stress | Not applicable | Not yet recruiting | University of Ottawa | 18 | 2026-10-13 | 2026-10-05 |
| Efficacy of Electric Fans in Children During Heat Waves Simulated exposure to indoor overheating without fans, Simulated exposure to indoor overheating with fans - Heat Stress, Physiological Stress | Not applicable | Recruiting | University of Ottawa | 60 | 2026-10-02 | 2026-10-07 |
| Progressive Heat Exposure and Physiological Strain Constant Heat Exposure, Progressively Increasing Heat Exposure - Body Temperature Changes, Heat Stress | Not applicable | Not yet recruiting | University of Ottawa | 14 | 2026-10-01 | 2026-09-29 |
| Intratumoral Targeted Hyperthermia Therapy (THT) for Cutaneous Metastatic Melanoma Targeted Hyperthermia Therapy - Cutaneous Metastatic Melanoma | Not applicable | Not yet recruiting | Sona Nanotech Inc | 10 | 2026-10-01 | 2026-04-24 |
| A Study Comparing Whole-Body Heat Treatment Plus Systemic Therapy to Systemic Therapy Alone, for Advanced Pancreatic Cancer Whole-body hyperthermia, Standard-of-Care Systemic therapy - Pancreatic Ductal Adenocarcinoma (mPDAC), Metastatic Pancreatic Ductal Adenocarcinoma (PDAC) | Phase 2 / Phase 3 | Not yet recruiting | ElmediX | 95 | 2026-10-01 | 2026-07-17 |
| Rapid Cool: Heat Stroke Treatment Recirculated water, Phoenix protocol - Hyperthermia | Not applicable | Not yet recruiting | State University of New York at Buffalo | 20 | 2026-09-21 | 2026-08-04 |
| Thermotherapy for Head and Neck Cancer Patients Thermotherapy, Radiotherapy, Concurrent chemoradiation - Head and Neck Cancer, Oropharyngeal Carcinoma | Phase 1 | Recruiting | Erasmus Medical Center | 30 | 2026-09-01 | 2026-09-02 |
| Hyperthermia Safety Study Uses Temperature Management System to Gently Raise Participant's Body Temperature to a Fever-range Level in a Controlled Setting. Hyperthermia - Safety Study | Not applicable | Enrolling by invitation | Marc Abreu | 20 | 2026-09-01 | 2026-09-21 |
| Exercise Intensity and Heat Responses in Children and Youth Low-Intensity Exercise in the Heat, Moderate-Intensity Exercise in the Heat, Vigorous-Intensity Exercise in the Heat - Body Temperature Changes, Heat Stress | Not applicable | Enrolling by invitation | University of Ottawa | 12 | 2026-07-21 | 2026-08-24 |
| Ambient Temperature and Thermoregulation During Exercise in Children and Youth Exercise at 22°C, Exercise at 26°C, Exercise at 31°C - Body Temperature Changes, Heat Stress | Not applicable | Recruiting | University of Ottawa | 12 | 2026-07-19 | 2026-08-24 |
| Temperature Optimization in Afebrile Septic PatienTs External Warming - Sepsis, Temperature | Not applicable | Recruiting | Matt Harmon | 50 | 2026-07-17 | 2026-09-21 |
| Consecutive Occupational Heat Exposure With and Without Overnight Cooling Simulated occupational heat exposure with recovery at recommended indoor temperature limit, Simulated occupational heat exposure with recovery in an overheated indoor environment - Body Temperature Changes, Heat Stress | Not applicable | Recruiting | University of Ottawa | 10 | 2026-06-24 | 2026-10-05 |
| Working in the Heat at Simulated Altitude: Effects of Normobaric Hypoxia on Physiological Strain Simulated Occupational heat exposure under normoxic conditions, Simulated Occupational heat exposure under hypoxic conditions - Body Temperature Changes, Heat Stress | Not applicable | Recruiting | University of Ottawa | 20 | 2026-06-17 | 2026-07-14 |
Showing 20 of 363. Sign in to see all of them.
Hyperthermia (254) · Motor Activity (30) · Heat Stroke (20) · Body Temperature Changes (14) · Depression (12) · Hypothermia (12) · Dehydration (10) · Neoplasms (10) · Breast Neoplasms (8) · Sleep Initiation and Maintenance Disorders (8) · Diabetes Mellitus (7) · Fatigue (7) · Fever (7) · Psychological Well-Being (7)
Wounds and Injuries (361) · Pathological Conditions, Signs and Symptoms (276) · Signs and Symptoms (266) · Body Temperature Changes (248) · Neoplasms (56) · Pathologic Processes (51) · Neoplasms by Site (46) · Behavior (45) · Nervous System Diseases (30) · Digestive System Diseases (26) · Female Urogenital Diseases and Pregnancy Complications (25) · Urogenital Diseases (25) · Skin and Connective Tissue Diseases (24) · Skin Diseases (23)
Diathermy (40) · Radiotherapy (13) · Hyperthermia, Induced (11) · Exercise (10) · Electrosurgery (6) · Cisplatin (5) · Drug Therapy (5) · Electrocoagulation (4) · Fluorouracil (4) · Hot Temperature (4) · Radiation (4) · Acetaminophen (3) · Brachytherapy (3) · Cryotherapy (3) · Cytoreduction Surgical Procedures (3)
University of Ottawa (30) · University of Texas Southwestern Medical Center (12) · State University of New York at Buffalo (11) · University of Connecticut (9) · Aditi Bunker (7) · Medtronic Surgical Technologies (7) · National Cancer Institute (NCI) (6) · Clinical Laserthermia Systems AB (5) · First Hospital of China Medical University (5) · University of Erlangen-Nürnberg Medical School (5) · Universität Duisburg-Essen (5) · Aga Khan University (4) · Penn State University (4) · Petros Dinas (4) · Second Affiliated Hospital, Zhejiang University, School of Medicine (4)
United States (118) · Canada (42) · Germany (21) · China (19) · Pakistan (10) · Netherlands (9) · Switzerland (9) · Israel (8) · Brazil (7) · France (7) · Greece (7) · Mexico (7) · United Kingdom (7) · Spain (6) · Egypt (5)
Glen P Kenny, PhD (18) · Collin Tukuitonga, Sir. Dr. (5) · Ronald J Sigal, MD, MPH (5) · Douglas Casa, PhD (3) · Riana R Pryor, PhD (3) · W. Larry Kenney, Ph.D. (3) · Xinghua Gao (3) · Abhay Gupta, MD (2) · Amit Druyan, M.D (2) · Andreas Flouris (2) · Ashley E Mason, PhD (2) · Beverly Winikoff, MD, MPH (2) · Christopher T Minson, PhD (2) · Collin Tukuitonga (2) · Douglas J Casa, PhD (2)
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R00AT004711 (2), R01AG069005 (2), 2008 (1), 2015 (1), 2016 (1), K23GM129630 (1), OT2HL158287 (1), P20GM103418 (1), P20TW013028 (1), P30DK097512 (1), R01AG073634 (1), R01AG089307 (1), R01AT013214 (1), R01DK146310 (1), R01ES035910 (1)