31 completed, 9 terminated, 8 recruiting, 8 unknown. 38 Phase 2, 12 Phase 1, 12 Phase 3.
Follow Floxuridine: new trials by email Literature Review of Floxuridine trials Research Report on Floxuridine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| CCR5 Targeting Leronlimab in Combination With Hepatic Arterial Infusion Floxuridine and Systemic Therapy for the Treatment of Colorectal Cancer Liver Metastases, CHAMP Trial Biopsy Procedure, Biospecimen Collection, Computed Tomography - Metastatic Colorectal Carcinoma, Metastatic Malignant Neoplasm in the Liver | Phase 1 | Not yet recruiting | City of Hope Medical Center | 36 | 2027-05-06 | 2026-09-25 |
| Hepatic Artery Infusion Pump Chemotherapy for Liver Metastases From Resected Pancreatic and Duodenal Adenocarcinoma Hepatic Artery Infusion Pump (HAIP), Floxuridine (FUDR) - Pancreas Cancer With Hepatic Metastase, Pancreas Adenocarcinoma | Recruiting | AdventHealth | 10 | 2026-11-01 | 2026-09-29 | |
| Induction Treatment for Initially Unresectable Colorectal Liver Metastases: Combined Hepatic Arterial Infusion Pump Therapy With Systemic Therapy Intra arterial infusion Floxuridine (FUDR) combined with systemic therapy, Hepatic arterial infusion pump (HAIP), Systemic therapy (standard of care) - Colorectal Neoplasms, Floxuridine | Phase 3 | Recruiting | The Netherlands Cancer Institute | 306 | 2024-11-21 | 2025-03-04 |
| Additional Chemotherapy Administered Directly Into the Liver Using a Chemo Pump in Patients With Bile Duct Cancer Inside the Liver Treatable by Surgery Hepatic Arterial Infusion Pump chemotherapy with floxuridin - Intrahepatic Bile Duct Cancer, Intrahepatic Cholangiocarcinoma (Icc) | Phase 2 | Recruiting | Erasmus Medical Center | 40 | 2024-11-20 | 2026-09-23 |
| Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial Bevacizumab, Capecitabine, Cetuximab - Metastatic Colorectal Carcinoma, Metastatic Malignant Neoplasm in the Liver | Phase 3 | Recruiting | ECOG-ACRIN Cancer Research Group | 408 | 2024-04-10 | 2026-09-24 |
| HAI-Floxuridine, or SIRT, Combined With Gemox For Patients With Intra-Hepatic Cholangiocarcinoma Not Amenable to Resection (TOMCAT) Floxuridine, Selective Internal Radiation Therapy (SIRT) - Intrahepatic Cholangiocarcinoma, Chemotherapy Effect | Phase 2 | Recruiting | Oslo University Hospital | 39 | 2024-02-13 | 2026-02-02 |
| PDS01ADC in Combination With Hepatic Artery Infusion Pump (HAIP) and Systemic Therapy for Subjects With Metastatic Colorectal Cancer, Intrahepatic Cholangiocarcinoma, or Metastatic Adrenocortical Carcinoma Dexamethasone, PDS01ADC, Intera 3000 Hepatic Artery Infusion Pump (HAIP) - Metastatic Colorectal Cancer (Mcrc), Intrahepatic Cholangiocarcinoma (Icc) | Phase 2 | Recruiting | National Cancer Institute (NCI) | 70 | 2022-10-24 | 2026-10-16 |
| FUDR/Oxaliplatin HAI Plus Irinotecan vs. FOLFOXIRI Chemotherapy in Treating Initially Unresectable CRCLM Irinotecan, Oxaliplatin HAI, Floxuridine - Metastatic Colorectal Cancer, Liver Metastases | Phase 3 | Terminated | Sun Yat-sen University | 92 | 2021-12-31 | 2023-02-16 |
| HAI-Floxuridine, or Liver-Tx, Combined With 2nd Line Chemotherapy Versus 2nd Line Chemotherapy Alone for Patients With Colorectal Liver Metastases and Heavy Tumour Burden. Floxuridine, Liver Transplantation - Colorectal Cancer, Liver Metastases | Phase 2 | Terminated | Oslo University Hospital | 39 | 2021-08-23 | 2026-10-22 |
| Gemcitabine and Oxaliplatin Chemotherapy With or Without a Floxuridine and Dexamethasone Pump in People With Cholangiocarcinoma That Cannot Be Removed With Surgery Gemcitabine, Oxaliplatin, Dexamethasone - Intrahepatic Cholangiocarcinoma | Phase 2 | Recruiting | Memorial Sloan Kettering Cancer Center | 164 | 2021-05-07 | 2026-10-22 |
| mFOLFIRINOX Followed by Hepatic Arterial Infusion of Floxuridine and Dexamethasone With Systemic mFOLFIRI for Unresectable Liver-dominant Intrahepatic Cholangiocarcinoma Dexamethasone, Floxuridine, Implanted Medical Device - Liver and Intrahepatic Bile Duct Carcinoma, Stage III Intrahepatic Cholangiocarcinoma AJCC v8 | Phase 2 | Terminated | OHSU Knight Cancer Institute | 5 | 2021-04-28 | 2026-06-25 |
| A Study of the Use of the Medtronic Pump and Codman Catheter to Give Chemotherapy to Patients With Colorectal Carcinoma or Cholangiocarcinoma Medtronic pump and Codman catheter, Floxuridine (FUDR), Gemcitabine - Colorectal Cancer, Cholangiocarcinoma | Phase 2 | Unknown | Benaroya Research Institute | 100 | 2020-11-25 | 2020-12-21 |
| Hepatic Arterial Infusion Pump Chemotherapy Combined With Systemic Chemotherapy (PUMP-IT) Floxuridine, Tricumed IP2000V infusion pump - Colorectal Neoplasms | Phase 2 / Phase 3 | Unknown | The Netherlands Cancer Institute | 31 | 2020-09-09 | 2020-09-17 |
| Hepatic Artery Infusion Pump Chemotherapy With Floxuridine and Dexamethasone in Combination With Systemic Chemotherapy for Patients With Colorectal Cancer Metastatic to the Liver Codman 3000 constant flow pump catheter, Panitumumab, FUDR-Dex - Colorectal Cancer, Liver Metastases | Phase 2 | Completed | National Cancer Institute (NCI) | 24 | 2019-06-24 | 2026-08-28 |
| Hepatic Artery Infusional Floxuridine to Treat Pancreatic Cancer Liver Metastases Floxuridine (FUDR), Hepatic Artery Infusion Pump, Heparinized Saline - Pancreatic Adenocarcinoma, Liver Metastases | Phase 2 | Active not recruiting | Corewell Health West | 14 | 2019-02-05 | 2026-07-16 |
| A Study of the Use of the Medtronic Pump and Codman Catheter to Give Chemotherapy to Patients With Colorectal Carcinoma or Cholangiocarcinoma Medtronic pump and Codman catheter, Floxuridine (FUDR), Gemcitabine - Colorectal Cancer, Cholangiocarcinoma | Phase 2 | Completed | Memorial Sloan Kettering Cancer Center | 35 | 2018-10-18 | 2026-02-06 |
| Adjuvant Systemic Chemotherapy With or Without HAI-FUDR in Patients With Resected CRLM FUDR, Oxaliplatin, Leucovorin - Colorectal Cancer, Liver Metastases | Phase 3 | Terminated | Sun Yat-sen University | 92 | 2018-05-28 | 2024-01-22 |
| A Study of Systemic Chemotherapy With CPT-11 Plus HAI (FUDR+L-OHP) in Patients With Initially Unresectable CRCLM Irinotecan, Oxaliplatin, Floxuridine - Colo-rectal Cancer, Liver Metastases | Phase 2 | Completed | Sun Yat-sen University | 60 | 2018-02-01 | 2023-02-15 |
| Study of Chemotherapy With or Without Hepatic Arterial Infusion for Patients With Unresectable Metastatic Colorectal Cancer to the Liver Floxuridine (FUDR), Irinotecan (CPT-11), FLUOROURACIL - Colorectal Adenocarcinoma Metastatic to the Liver | Phase 2 | Withdrawn | Memorial Sloan Kettering Cancer Center | 2017-02-28 | 2019-05-21 | |
| Alternating Systemic and Hepatic Artery Infusion Therapy As Adjuvant Treatment After Resection of Liver Metastases From Colorectal Cancer Floxuridine (FUDR),Dexamethasone (DXM), Heparin in combination with Oxaliplatin and Capecitabine (CapeOX) or in combination with Oxaliplatin and Leucovorin and 5-FU (mFOLFOX6), Oxaliplatin and Capecitabine (CapeOX) or Oxaliplatin and Leucovorin and 5-FU (mFOLFOX6) - Resected Liver Metastases From Colorectal Cancer | Phase 2 / Phase 3 | Unknown | Ye Xu | 432 | 2015-09-01 | 2015-08-20 |
Showing 20 of 61. Sign in to see all of them.
Colorectal Neoplasms (30) · Colonic Neoplasms (19) · Rectal Neoplasms (17) · Neoplasm Metastasis (16) · Cholangiocarcinoma (10) · Stomach Neoplasms (9) · Carcinoma, Hepatocellular (4) · Liver Neoplasms (4) · Neoplasms (4) · Esophageal Neoplasms (3) · Pancreatic Neoplasms (3) · Adenocarcinoma Of Esophagus (2) · Appendiceal Neoplasms (2) · Bile Duct Neoplasms (2) · Cirrhosis, Familial, with Pulmonary Hypertension (2)
Memorial Sloan Kettering Cancer Center (16) · National Cancer Institute (NCI) (6) · NYU Langone Health (4) · City of Hope Medical Center (3) · Sun Yat-sen University (3) · University of Miami (3) · Alliance for Clinical Trials in Oncology (2) · National Institutes of Health Clinical Center (CC) (2) · Oslo University Hospital (2) · The Netherlands Cancer Institute (2) · AdventHealth (1) · Benaroya Research Institute (1) · Corewell Health West (1) · ECOG-ACRIN Cancer Research Group (1) · Erasmus Medical Center (1)
United States (46) · China (7) · Netherlands (4) · Norway (2) · Australia (1) · Canada (1) · Italy (1) · Peru (1) · Puerto Rico (1)
Nancy E. Kemeny, MD (5) · Andrea Cercek, MD (3) · Bach Ardalan, MD (3) · David Paul Kelsen, MD (2) · Franco Muggia, MD (2) · Jonathan M Hernandez, M.D. (2) · Nancy Kemeny, MD (2) · William Jarnagin, MD (2) · Andrea E Wahner Hendrickson (1) · Bas Groot Koerkamp, MD, PhD (1) · Elliot Newman, MD (1) · Franco M. Muggia, MD (1) · G. Paul Wright, MD (1) · Garrett Nash, MD, MPH (1) · H. Richard Alexander, Jr. (1)
PMID 40812353, PMID 11913730, PMID 12782596, PMID 16009951, PMID 16399443, PMID 16505413, PMID 19233901, PMID 20048179, PMID 21258083, PMID 21677464, PMID 24646562, PMID 26010778, PMID 33214446, PMID 38608150, PMID 38989414, PMID 39644535, PMID 42143303, PMID 42365236
P30CA016087 (2), P30CA033572 (2), 2019 (1), 2023 (1), P30CA008748 (1), P30CA015083 (1), P30CA016672 (1), P50CA136393 (1), U01CA069912 (1), U10CA012027 (1), U10CA025224 (1), U10CA031946 (1), U10CA180820 (1), UM1CA186686 (1), UM1CA186691 (1)