1093 completed, 500 unknown, 329 recruiting, 214 terminated. 782 Phase 2, 646 Not applicable, 360 Phase 1, 266 Phase 3, 23 Phase 4.
Follow Rectal Neoplasms: new trials by email Literature Review of Rectal Neoplasms trials Research Report on Rectal Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Improving Clinic Delivery of HIV-related Anal Health Services PEACHES 2.0 Implementation Strategies - HIV, Gonorrhea | Not applicable | Not yet recruiting | Albert Einstein College of Medicine | 8 | 2028-02-01 | 2026-10-13 |
| Application of Multimodal MRI in Histological Grading and Prognostic Assessment of Rectal Cancer intravoxel incoherent motion magnetic resonance imaging - Rectal Neoplasms, Prognosis | Not yet recruiting | Sichuan Cancer Hospital and Research Institute | 400 | 2027-11-01 | 2025-12-08 | |
| PET/MRI in Rectal Cancer Total Neo-adjuvant Therapy, 18FDG-PET/MRI scan - Rectal Cancer | Phase 2 | Not yet recruiting | AHS Cancer Control Alberta | 40 | 2027-05-01 | 2026-10-28 |
| A Bowel Management Program (Retrograde Rectal Enema) for the Treatment of Low Anterior Resection Syndrome in Rectal Cancer Patients Dietary Fiber, Enema Administration, Loperamide Hydrochloride - Low Anterior Resection Syndrome, Rectal Carcinoma | Not applicable | Recruiting | Ohio State University Comprehensive Cancer Center | 80 | 2027-02-15 | 2026-10-06 |
| Gemcitabine, Cisplatin, Nab-paclitaxel (GAP) and Cemiplimab for Locally Advanced Biliary Tract Cancer (BTC) Cemiplimab - Colon and Rectal Cancer | Phase 2 | Recruiting | Columbia University | 20 | 2027-01-01 | 2026-11-04 |
| COQ10 and Vitamin E for Off-Target Radiation Toxicity Coenzyme Q10 Cap/Tab, Vitamin E Cap/Tab - Prostate Cancer, Uterine Cancer | Phase 1 / Phase 2 | Not yet recruiting | University of Nebraska | 200 | 2026-12-01 | 2026-10-08 |
| Oral B-Complex Vitamin (B6, B9 and B12) Prevents Low Anterior Resection Syndrome in Rectal Cancer Patients With Hyperhomocysteinemia Oral B-Complex Vitamin (B6, B9 and B12), Placebo - Low Anterior Resection Syndrome, Hyperhomocysteinemia | Not applicable | Not yet recruiting | Qilu Hospital of Shandong University | 277 | 2026-12-01 | 2026-11-10 |
| Improving Colorectal Cancer Screening Uptake Through Education and Stool-Based Testing Outreach Colorectal Cancer Education Materials, Cologuard test kit, Fecal immunochemical test kit - Colorectal Cancer (CRC) Screening, CRC Screening | Not applicable | Not yet recruiting | Washington University School of Medicine | 200 | 2026-11-30 | 2026-11-05 |
| Single Versus Double Stapling and Two Purse-String Techniques in Rectal Cancer Surgery Double-Stapled Anastomosis, Single-Stapled Anastomosis With Intracorporeal Purse-String, Single-Stapled Anastomosis With Transanal Purse-String - Rectal Cancer | Not applicable | Recruiting | Alexandria University | 124 | 2026-11-05 | 2026-11-10 |
| A Study of Retifanlimab After Chemoradiation in People With Anal Cancer Retifanlimab - Anal Squamous Cell Carcinoma, Anal Cancer | Phase 2 | Recruiting | Memorial Sloan Kettering Cancer Center | 25 | 2026-11-04 | 2026-11-10 |
| Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates High Rare Dose Rectal Brachytherapy Boost - Rectal Adenocarcinoma, Rectal Cancer | Phase 2 | Recruiting | University of Colorado, Denver | 44 | 2026-11-01 | 2026-09-02 |
| A Prospective, Biomarker-Stratified Phase 2 Study: β-Hydroxybutyrate as a Predictive Biomarker for Short-Course Radiotherapy Followed by Chemotherapy Plus PD-1 Inhibitor Versus Chemotherapy Alone in Locally Advanced Rectal Cancer Short-course radiotherapy, Capecitabine, Oxaliplatin - Rectal Cancer, Radiotherapy | Phase 2 | Not yet recruiting | Tao Zhang | 144 | 2026-11-01 | 2026-10-06 |
| Swabs in Screening for HPV (SWISH) Self-collected anal swab - Anal Cancer, Human Papilloma Virus (HPV) | Not applicable | Not yet recruiting | Kirby Institute | 700 | 2026-11-01 | 2026-08-27 |
| Multidimensional Study Designed to Develop a Methodological Framework Based on MRI Data to Predict Pathological Complete Response (pCR) in Patients With Locally Advanced Rectal Cancer After Neoadjuvant Treatment questionnaire completion - Rectal Cancer, Chemoradiotherapy | Not yet recruiting | Institut du Cancer de Montpellier - Val d'Aurelle | 115 | 2026-11-01 | 2026-11-06 | |
| Adaptive Radiotherapy for Safe Hypofractionation Adaptive Hypofractionated Radiotherapy, Standard-of-care Radiotherapy - Cancer, Endometrial Cancer | Phase 2 | Not yet recruiting | Centre hospitalier de l'Université de Montréal (CHUM) | 264 | 2026-11-01 | 2026-10-29 |
| Dose-Escalated Short-Course Proton Therapy for Locally Advanced Rectal Cancer Intensity modulated proton therapy - Locally Advanced Rectal Cancer, Rectal Adenocarcinoma | Not applicable | Not yet recruiting | University of Aarhus | 30 | 2026-11-01 | 2026-10-29 |
| T1 Colorectal Cancer After Local Excision: Decision Between Surgery and Active Surveillance (T1LDA Trial) Additional surgery - Colorectal Cancer | Not applicable | Not yet recruiting | Tampere University Hospital | 500 | 2026-11-01 | 2026-10-28 |
| Combining DCSZ11 With Radiation and Chemotherapy as Neoadjuvant Treatment for pMMR Locally Advanced Rectal Cancer DCSZ11, Radiation, Capecitabine - Rectal Cancer | Phase 2 | Not yet recruiting | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 30 | 2026-11-01 | 2026-10-28 |
| Leveraging Digital Health Solutions to Collect Patient-Reported Outcomes in Rectal Cancer Quality of Life Surveys - Rectal Cancer, Non Metastatic Rectal Cancer | Not yet recruiting | University of California, San Francisco | 150 | 2026-10-31 | 2026-09-09 | |
| Modified Short-Course Radiotherapy Combined With Tislelizumab and CAPOX for pMMR/MSS Rectal Cancer node-sparing modified short-course radiotherapy, standard short-course radiotherapy - Rectal Cancer | Phase 3 | Not yet recruiting | Sir Run Run Shaw Hospital | 210 | 2026-10-25 | 2026-10-28 |
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Digestive System Diseases (2473) · Neoplasms by Site (2473) · Gastrointestinal Diseases (2472) · Digestive System Neoplasms (2469) · Rectal Diseases (2466) · Intestinal Diseases (2464) · Intestinal Neoplasms (2463) · Gastrointestinal Neoplasms (2432) · Neoplasms (2358) · Colorectal Neoplasms (1836) · Colonic Diseases (1024) · Pathological Conditions, Signs and Symptoms (442) · Pathologic Processes (363) · Anus Diseases (294) · Urogenital Diseases (290)
Fluorouracil (292) · Oxaliplatin (273) · Capecitabine (247) · Leucovorin (210) · Radiotherapy (157) · Irinotecan (152) · Bevacizumab (115) · Cetuximab (88) · Surgical Procedures, Operative (53) · Drug Therapy (50) · Radiation (50) · Folfox protocol (49) · Neoadjuvant Therapy (47) · Chemoradiotherapy (35) · Chemotherapy, Adjuvant (34)
National Cancer Institute (NCI) (104) · Memorial Sloan Kettering Cancer Center (56) · Sixth Affiliated Hospital, Sun Yat-sen University (39) · Alliance for Clinical Trials in Oncology (37) · Sun Yat-sen University (36) · M.D. Anderson Cancer Center (33) · Fudan University (28) · City of Hope Medical Center (27) · Fox Chase Cancer Center (18) · Case Comprehensive Cancer Center (17) · Sahlgrenska University Hospital (17) · Stanford University (17) · Washington University School of Medicine (16) · Amgen (15) · Roswell Park Cancer Institute (15)
United States (888) · China (394) · France (178) · United Kingdom (120) · Canada (107) · Italy (103) · Spain (93) · Germany (85) · Netherlands (74) · South Korea (72) · Sweden (72) · Denmark (66) · Belgium (62) · Australia (43) · Switzerland (42)
Leonard B. Saltz, MD (8) · Marwan Fakih, MD (7) · Norman Wolmark, MD (7) · Gina Brown (6) · Nancy E. Kemeny, MD (6) · Gina Brown, MD (5) · Hedy L. Kindler, MD (5) · Howard S. Hochster, MD (5) · Smitha Krishnamurthi, MD (5) · Sydney Welt, MD (5) · Aimery de Gramont, MD (4) · Antonino Spinelli, MD, PhD (4)
PMID 15496622, PMID 26187751, PMID 37310167, PMID 17976611, PMID 19269519, PMID 20106720, PMID 21596621, PMID 22529255, PMID 23008301, PMID 23395398, PMID 23578724, PMID 26049686, PMID 27432930, PMID 27602924, PMID 28223062, PMID 14616164, PMID 15894098, PMID 15927411, PMID 15997446, PMID 16099600, PMID 16971718, PMID 17042060, PMID 17401014, PMID 18316791, PMID 18430910, PMID 20065174, PMID 20354531, PMID 20797891, PMID 20956625, PMID 21494121, PMID 21550216, PMID 22067400, PMID 22070868, PMID 22434245, PMID 22591948, PMID 22770982, PMID 24440473, PMID 25623323, PMID 25651787, PMID 25822672, PMID 25830422, PMID 26156652, PMID 26189067, PMID 26808342, PMID 27480145, PMID 28190762, PMID 28453692, PMID 28594719, PMID 29067426, PMID 29234923
P30CA033572 (15), P30CA068485 (11), P30CA015083 (10), U10CA031946 (10), U10CA032102 (10), P30CA043703 (8), U01CA121947 (8), U10CA021115 (8), U10CA180820 (8), P30CA016672 (6), 2016 (5), 2018 (5), 2019 (5), 2025 (5), P30CA006927 (5)