8 completed, 6 unknown, 3 terminated, 2 active not recruiting. 22 Phase 3, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 22 | Completed 8, Unknown 6, Terminated 3, Active not recruiting 2, Recruiting 2, Not yet recruiting 1 |
| Phase 2 | 4 | Active not recruiting 2, Not yet recruiting 1, Terminated 1 |
Follow Hyperthermia: new trials by email Literature Review of Hyperthermia trials Research Report on Hyperthermia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study Comparing Whole-Body Heat Treatment Plus Systemic Therapy to Systemic Therapy Alone, for Advanced Pancreatic Cancer Whole-body hyperthermia, Standard-of-Care Systemic therapy - Pancreatic Ductal Adenocarcinoma (mPDAC), Metastatic Pancreatic Ductal Adenocarcinoma (PDAC) | Phase 2 / Phase 3 | Not yet recruiting | ElmediX | 95 | 2026-10-01 | 2026-07-17 |
| Modulated Electro-Hyperthermia in Combination With Multimodal Therapy for Locally Advanced Rectal Cancer Hyperthermia - Locally Advanced Rectal Carcinoma | Phase 3 | Recruiting | Shih-Kai Hung | 126 | 2025-09-23 | 2026-01-28 |
| Electrosurgical Modes for Endoscopic Submucosal Dissection in Peroral Endoscopic Esophageal Myotomy endoscopic submucosal dissection using SPRAY COAG mode, endoscopic submucosal dissection using Precisect mode - Achalasia, Achalasia Cardia | Phase 3 | Recruiting | Cairo University | 52 | 2024-03-16 | 2025-05-13 |
| Neoadjuvant Concomitant Modulated Electro-hyperthermia in HER2-negative Breast Cancer Oncotherm EHY-2030, Paclitaxel, Carboplatin - HER2-negative Breast Cancer | Phase 2 / Phase 3 | Active not recruiting | Semmelweis University | 71 | 2023-02-20 | 2026-05-15 |
| Randomised Clinical Trial in Treatment Modalities for Cutaneous Leishmaniasis Caused by Leishmania Tropica, in Pakistan drug: miltefosine with thermotherapy - Old World Cutaneous Leishmaniasis | Phase 3 | Completed | Medecins Sans Frontieres, Netherlands | 645 | 2022-10-07 | 2026-07-30 |
| Effectiveness, Safety and Feasibility of HECT-CL, in Quetta, Pakistan HECT-CL - Cutaneous Leishmaniases | Phase 3 | Terminated | Medecins Sans Frontieres, Netherlands | 56 | 2017-10-04 | 2019-01-16 |
| Perioperative Systemic Therapy for Isolated Resectable Colorectal Peritoneal Metastases Perioperative systemic therapy, Perioperative CAPOX-bevacizumab, Perioperative FOLFOX-bevacizumab - Colorectal Neoplasm, Colorectal Cancer | Phase 2 / Phase 3 | Active not recruiting | Koen Rovers | 358 | 2017-06-01 | 2026-03-24 |
| Treatment of Postpartum Hemorrhage With Misoprostol: Fever Study Misoprostol - Postpartum Hemorrhage | Phase 3 | Completed | Gynuity Health Projects | 635 | 2015-09-01 | 2017-04-24 |
| Effects of Deep Regional Hyperthermia in Patients With Anal Carcinoma Treated by Standard Radiochemotherapy Irradiation, Mitomycin C, 5-Fluorouracil - Anal Carcinoma | Phase 3 | Unknown | University of Erlangen-Nürnberg Medical School | 118 | 2014-12-01 | 2017-08-11 |
| Modulated Electro-Hyperthermia Plus Chemo-radiation for Locally Advanced Cervical Cancer Patients in South Africa Modulated electro-hyperthermia, External beam radiation, Cisplatin - Cervical Cancer | Phase 3 | Unknown | Jeffrey Kotzen | 236 | 2014-01-09 | 2017-11-07 |
| Comparing the Effectiveness of Combined Hyperthermia and External Beam Radiation (EBRT) Versus EBRT Alone in Treating Patients With Painful Bone Metastases Hyperthermia, External-beam radiotherapy - All Type of Cancers With Bony Metastasis | Phase 3 | Unknown | Shin Kong Wu Ho-Su Memorial Hospital | 152 | 2013-07-01 | 2016-10-13 |
| A Randomized, Sham Device Controlled, Single Blinded Trial of Portable Transcutaneous Electrical Nerve Stimulation and Heat Therapy Machine in Women With Dysmenorrhea I RUNE, sham - Dysmenorrhea | Phase 3 | Unknown | Seoul National University Hospital | 118 | 2012-08-01 | 2013-03-15 |
| Hyperthermia European Adjuvant Trial Gemcitabine + Cisplatin + regional hyperthermia, Gemcitabine + Capecitabine - Resected Pancreatic Adenocarcinoma | Phase 3 | Unknown | Klinikum der Universitaet Muenchen, Grosshadern | 336 | 2012-03-01 | 2017-11-17 |
| Randomized Study of Combination Chemotherapy With or Without Focused Microwave Thermotherapy Before Surgery in Treating Women With Large Breast Cancer Tumors Focused Microwave Thermotherapy, Chemotherapy (control) - Breast Cancer | Phase 3 | Unknown | Medifocus, Inc. | 238 | 2010-11-01 | 2015-09-24 |
| Laparoscopic Cholecystectomy And Capacitive Coupling - Coag Versus Blend Mode Causing Thermal Injury at Port Site Skin Covidien Triad monopolar generator - Intraoperative Complications, Thermal Injury | Phase 3 | Completed | University of Colorado, Denver | 40 | 2010-11-01 | 2013-03-25 |
| Dantrolene for Treatment of Hyperthermia in Subarachnoidal Hemorrhage (SAH) Dantrolene, Placebo - Hyperthermia | Phase 2 / Phase 3 | Terminated | Medical University of Vienna | 34 | 2008-05-01 | 2011-05-12 |
| Optimal Application Dose of Superficial Hyperthermia Hyperthermal treatment - Tumors | Phase 3 | Completed | Universitätsmedizin Mannheim | 17 | 2008-01-01 | 2021-09-29 |
| A Trial of Two Electrosurgical Conizations: Histopathological Analysis of Excision Margins SWETZ, LLETZ cone - Cervical Intraepithelial Neoplasia | Phase 3 | Completed | Oswaldo Cruz Foundation | 164 | 2008-01-01 | 2015-07-23 |
| Efficacy and Safety of Miltefosine or Thermotherapy for Cutaneous Leishmaniasis in Colombia. Miltefosine, Thermotherapy, Glucantime® - Cutaneous Leishmaniasis | Phase 3 | Completed | Universidad de Antioquia | 437 | 2006-06-01 | 2019-01-16 |
| Debulking and Chemotherapy With or Without Intraperitoneal Chemotherapy to Treat Peritoneal Carcinomatosis Cytoreductive surgery, Continuous hyperthermic peritoneal perfusion (HIPEC/CHPP) - Gastrointestinal Neoplasm | Phase 3 | Completed | National Cancer Institute (NCI) | 30 | 2003-01-01 | 2012-11-22 |
Showing 20 of 22. Sign in to see all of them.
Leishmaniasis, Cutaneous (3) · Neoplasms (3) · Breast Neoplasms (2) · Neoplasms by Site (2) · Uterine Cervical Dysplasia (2) · Anus Neoplasms (1) · Appendiceal Neoplasms (1) · Breast Diseases (1) · Carcinoma (1) · Colonic Neoplasms (1) · Colorectal Neoplasms (1) · Dysmenorrhea (1) · Esophageal Achalasia (1) · Gastrointestinal Neoplasms (1)
Body Temperature Changes (22) · Heat Stress Disorders (22) · Pathological Conditions, Signs and Symptoms (22) · Signs and Symptoms (22) · Wounds and Injuries (22) · Neoplasms (9) · Neoplasms by Site (7) · Digestive System Diseases (6) · Digestive System Neoplasms (5) · Female Urogenital Diseases and Pregnancy Complications (5) · Gastrointestinal Diseases (5) · Skin Diseases (5) · Skin and Connective Tissue Diseases (5) · Urogenital Diseases (5) · Female Urogenital Diseases (4)
Diathermy (3) · Drug Therapy (2) · Hyperthermia, Induced (2) · miltefosine (2) · AC protocol (1) · Brachytherapy (1) · Capecitabine (1) · Carboplatin (1) · Cisplatin (1) · Conization (1) · Cytoreduction Surgical Procedures (1) · Dantrolene (1) · Doxorubicin (1) · Fluorouracil (1) · Gemcitabine (1)
Medecins Sans Frontieres, Netherlands (2) · Oswaldo Cruz Foundation (2) · Cairo University (1) · ElmediX (1) · Gynuity Health Projects (1) · Jeffrey Kotzen (1) · Klinikum der Universitaet Muenchen, Grosshadern (1) · Koen Rovers (1) · Medical Enterprises Europe B.V. (1) · Medical University of Vienna (1) · Medifocus, Inc. (1) · National Cancer Institute (NCI) (1) · Semmelweis University (1) · Seoul National University Hospital (1) · Shih-Kai Hung (1)
Germany (3) · United States (3) · Austria (2) · Belgium (2) · Brazil (2) · Netherlands (2) · Pakistan (2) · Taiwan (2) · Argentina (1) · Canada (1) · Colombia (1) · Egypt (1) · Hungary (1) · Israel (1) · Italy (1)
Alexandra R Brandt-Kerkhof, MD (1) · Alfred A Witjes, MD PhD (1) · Andrea Holzer, MD (1) · Ans Baeyes, PhD (1) · Arend G Aalbers, MD (1) · Beverly Winikoff, MD, MPH (1) · Carrie A Minnaar, Msc (1) · Cornelis J Punt, MD, PhD (1) · Eino B van Duyn, MD, PhD (1) · Guillermo Carroli, MD (1) · Ignace H de Hingh, MD, PhD (1) · Ilana Dzuba, MPH (1) · Jeffrey A Kotzen, MBBCH (1) · Jill Durocher (1)
PMID 22594858, PMID 23739984, PMID 23740007, PMID 25516462, PMID 25783647, PMID 26340453, PMID 26803476, PMID 30390114, PMID 31023318, PMID 31216321, PMID 32180481, PMID 33528867, PMID 34009291, PMID 36657324, PMID 42372745
2008 (1), 2016 (1)