84 completed, 43 unknown, 32 recruiting, 25 terminated. 81 Phase 2, 55 Not applicable, 45 Phase 3, 40 Phase 1, 3 Early Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Trial of Pembrolizumab With Chemotherapy or Chemoradiotherapy in Participants From India With Different Types of Cancer (MK-3475-G44/KEYNOTE-G44) Pembrolizumab, Cisplatin, 5-Fluorouracil - Neoplasm Malignant, Gastric Neoplasms | Phase 4 | Not yet recruiting | Merck Sharp & Dohme LLC | 150 | 2026-11-06 | 2026-09-03 |
| Single FrAction Interstitial BreaSt BracHytherApy Partial Breast Irradiation - Breast Cancer | Phase 2 | Not yet recruiting | Virginia Commonwealth University | 134 | 2026-09-01 | 2026-06-18 |
| PSMA PET-Staged Comprehensive Progression-Directed Radiotherapy for Limited Progression in Prostate Cancer Comprehensive Progression-Directed Radiotherapy - Oligoprogressive Prostate Cancer, Metastatic Prostate Cancer | Recruiting | Affidea Nu-med Center of Oncological DIagnostics and Therapy | 1000 | 2026-06-26 | 2026-09-17 | |
| Focal Radiation Therapy (HDR-Brachytherapy) for the Treatment of Prostate Cancer Biopsy Procedure, Biospecimen Collection, High-Dose Rate Brachytherapy - Prostate Adenocarcinoma, Stage I Prostate Cancer American Joint Committee on Cancer (AJCC) v8 | Not applicable | Recruiting | Jonsson Comprehensive Cancer Center | 45 | 2026-05-11 | 2026-05-22 |
| Retinoblastoma Consolidation in Egyptians transpupillary thermotherapy, Cryotherapy, Brachytherapy - Retinoblastoma | Not yet recruiting | Assiut University | 150 | 2026-05-01 | 2026-04-15 | |
| Hypofractionated Radiotherapy for the Treatment of Locally Advanced Cervical Cancer in Uganda Hypofractionated Radiation Therapy, Conventional Fractionated Radiotherapy, Cisplatin - Cervical Cancer, Cervix Cancer | Phase 2 | Recruiting | Uganda Cancer Institute | 278 | 2026-03-11 | 2026-03-27 |
| A Study to Evaluate the Safety, Tolerability, Preliminary Efficacy of KRC-01 KRC-01, External Beam Radiation Therapy, cisplatin - Cervical Cancer | Phase 1 | Recruiting | Kortuc, Inc. | 70 | 2026-03-01 | 2026-04-08 |
| Iparomlimab/Tuvonralimab Injection Plus CCRT in LACC Iparomlimab/Tuvonralimab, Cisplatin, Brachytherapy and External Beam Radiotherapy - LOCALLY ADVANCED CERVICAL CANCERS | Phase 2 | Recruiting | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 30 | 2025-11-11 | 2025-12-01 |
| Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer Biospecimen Collection, Brachytherapy, Carboplatin - Locally Advanced Cervical Adenocarcinoma, Locally Advanced Cervical Adenosquamous Carcinoma | Phase 3 | Recruiting | National Cancer Institute (NCI) | 336 | 2025-11-05 | 2026-10-22 |
| MRI-guided Locoregional SBRT Prostate Program Brachytherapy + SBRT - Prostate Cancer | Not applicable | Enrolling by invitation | Clinica Universidad de Navarra, Universidad de Navarra | 40 | 2025-10-01 | 2026-04-29 |
| MRI-guided Brachytherapy and Salvage SBRT Program Brachytherapy and MR-Guided SBRT - Prostate Cancer (Post Prostatectomy) | Not applicable | Not yet recruiting | Clinica Universidad de Navarra, Universidad de Navarra | 29 | 2025-10-01 | 2025-08-20 |
| Brachytherapy With Radiotherapy and Immunotherapy: Guided HDR Trial in Esophageal Squamous Cell Carcinoma Nivolumab (240 mg), Brachytherapy - Esophageal Cancer, Esophageal Squamous Cell Carcinoma | Phase 2 | Recruiting | National Taiwan University Hospital | 60 | 2025-09-01 | 2025-09-03 |
| Biological Drivers of Cervical Cancer and Side Effects From Radiation Therapy Brachytherapy - Cervical Cancer | Recruiting | University of California, San Diego | 20 | 2025-08-04 | 2025-08-13 | |
| Neoadjuvant High Dose Rate Brachytherapy Prior to Radical Prostatectomy in Patients With Prostate Cancer Brachytherapy - Prostate Cancer (Adenocarcinoma) | Phase 1 / Phase 2 | Recruiting | The Methodist Hospital Research Institute | 29 | 2025-08-01 | 2026-03-09 |
| External Beam Radiation Therapy and Brachytherapy With Chemotherapy and Immunotherapy for the Treatment of Stage IVB Cervical Cancer Bevacizumab, Biospecimen Collection, Brachytherapy - Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma | Phase 1 / Phase 2 | Recruiting | Jonsson Comprehensive Cancer Center | 35 | 2025-07-29 | 2026-08-12 |
| Hypofractionated Radiochemotherapy Cisplatin, intensity modulated radiation therapy (IMRT), high-dose-rate (HDR) brachytherapy - Uterine Cervix Cancer | Phase 2 | Recruiting | Denise Fabian | 20 | 2025-06-26 | 2026-07-30 |
| Short-Course Radiotherapy Combined with Intracavitary Brachytherapy Followed by Pucotenlimab, Bevacizumab, Oxaliplatin, and Trifluridine/Tipiracil (TAS-102) for Total Neoadjuvant Therapy of Microsatellite Stable (MSS) Locally Advanced Low Rectal Cancer Pucotenlimab, Bevacizumab, Oxaliplatin - Rectal Adenocarcinoma | Phase 2 | Not yet recruiting | Sir Run Run Shaw Hospital | 33 | 2025-04-01 | 2025-03-12 |
| A Clinical Study of Pelvic Concurrent Chemoradiotherapy Combined with CT-guided Intracavitary Brachytherapy with Adaptive Simultaneous Dose Escalation for Locally Advanced Cervical Cancer Brachytherapy and CT-guided online adaptive external beam pelvic radiotherapy are delivered on the same day - Locally Advanced Cervical Cancer | Not applicable | Not yet recruiting | Peking University Third Hospital | 20 | 2025-03-15 | 2025-03-18 |
| Single High-dose Brachytherapy for Giant Osteosarcoma Masses brachytherapy - Osteosarcoma | Phase 2 | Not yet recruiting | Shanghai Jiao Tong University Affiliated Sixth People's Hospital | 16 | 2024-08-30 | 2024-08-07 |
| Serplulimab Plus Chemoradiotherapy for Stage III-IVA Cervical Cancer Serplulimab, Cisplatin, Carboplatin - Cervical Cancer | Phase 2 | Active not recruiting | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 240 | 2024-05-01 | 2024-05-17 |
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Uterine Cervical Neoplasms (75) · Prostatic Neoplasms (55) · Breast Neoplasms (16) · Neoplasms (12) · Endometrial Neoplasms (11) · Sarcoma (10) · Vaginal Neoplasms (8) · Esophageal Neoplasms (6) · Liver Neoplasms (5) · Lung Neoplasms (5) · Radiation Injuries (5) · Uterine Neoplasms (5) · Adenocarcinoma (4) · Carcinoma, Ductal, Breast (4) · Glioblastoma (4)
National Cancer Institute (NCI) (12) · Gynecologic Oncology Group (10) · Radiation Therapy Oncology Group (9) · Jonsson Comprehensive Cancer Center (7) · St. Jude Children's Research Hospital (5) · Mayo Clinic (4) · Memorial Sloan Kettering Cancer Center (4) · Peking University Third Hospital (4) · Washington University School of Medicine (4) · Albert Einstein College of Medicine (3) · Center for Molecular Medicine (3) · Clinica Universidad de Navarra, Universidad de Navarra (3) · Merck Sharp & Dohme LLC (3) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (3) · The Methodist Hospital Research Institute (3)
United States (131) · Canada (26) · China (24) · France (12) · United Kingdom (10) · Germany (9) · India (6) · Netherlands (6) · Poland (6) · Spain (6) · Brazil (5) · Israel (5) · Italy (5) · Japan (5) · Puerto Rico (5)
Jyoti S Mayadev (3) · Alan C Lee (2) · Albert J Chang (2) · Carien L. Creutzberg, MD, PhD (2) · Dennis Yi-Shin Kuo (2) · Joan L. Walker, MD (2) · Mack Roach, MD (2) · Martin King, MD, PhD (2) · Stanley E. Order, MD, ScD, FACR (2) · Thomas M. Pisansky, MD (2) · Vratislav Strnad, MD (2) · ALison R Calkins, MD (1) · Aaron H Wolfson, MD, FACR (1)
PMID 21444871, PMID 15863167, PMID 16230678, PMID 16289906, PMID 16446334, PMID 16531618, PMID 16531619, PMID 16815535, PMID 16889823, PMID 17084549, PMID 17118317, PMID 17159027, PMID 17337065, PMID 17340591, PMID 17398031, PMID 17482376, PMID 17620582, PMID 18035213, PMID 18294778, PMID 18299147, PMID 18313521, PMID 19010522, PMID 19070889, PMID 19118701, PMID 19224552, PMID 19231103, PMID 19463342, PMID 19509178, PMID 19546404, PMID 19893425, PMID 20004966, PMID 20044066, PMID 20206777, PMID 20375833, PMID 20572040, PMID 20646289, PMID 21480204, PMID 21724195, PMID 21840137, PMID 21872277, PMID 21892091, PMID 22176868, PMID 22307061, PMID 22330999, PMID 22665534, PMID 23091096, PMID 23411385, PMID 23603369, PMID 23826842, PMID 23849695
U10CA180868 (10), U10CA027469 (9), P30CA013330 (3), P30CA015083 (3), P30CA043703 (2), P30CA138292 (2), 2008 (1), 2015 (1), 2018 (1), 2019 (1), D43TW009759 (1), P30CA016672 (1), P30CA072720 (1), P30CA168524 (1), U01CA062502 (1)