79 completed, 37 recruiting, 19 unknown, 15 not yet recruiting. 175 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 175 | Completed 79, Recruiting 37, Unknown 19, Not yet recruiting 15, Terminated 15, Withdrawn 6, Active not recruiting 3, Enrolling by invitation 1 |
Follow Hyperthermia: new trials by email Literature Review of Hyperthermia trials Research Report on Hyperthermia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Work Design Interventions for Older Workers During Consecutive Days in the Heat Standard work pace, Additional rest breaks - Hyperthermia, Fatigue; Heat | Not applicable | Not yet recruiting | State University of New York at Buffalo | 32 | 2028-09-01 | 2026-06-30 |
| Work Design Interventions for Heat Resilience Standard work pace, Reduced-pace work, Increased-pace work - Hyperthermia, Fatigue; Heat | Not applicable | Not yet recruiting | State University of New York at Buffalo | 32 | 2027-09-01 | 2026-06-30 |
| A Prospective Study of Concurrent Hyperthermia, Chemotherapy and Radiotherapy in Borderline and Locally Advanced Pancreatic Cancer (PANHEAT) Hyperthermia plus neoadjuvant chemotherapy/radiotherapy Arm Description: Hyperthermia plus neoadjuvant chemotherapy (mFOLFIRINOX/nab Paclitaxel) followed by a) surgically resectable: Hyp - Borderline and Locally Advanced Pancreatic Cancer | Not applicable | Not yet recruiting | Fernando Pessoa Canarias University | 60 | 2027-03-31 | 2026-09-24 |
| Hyperthermia in Patients With Chronic Primary Pain - Effects on Thermoregulation, Somatosensory System and Movement Evoked Pain serial whole body hyperthermia - Hyperthermia, Chronic Primary Pain | Not applicable | Not yet recruiting | Bern University of Applied Sciences | 60 | 2026-12-01 | 2026-09-30 |
| Multi-site Feasibility of an Integrated Treatment for the Biology and Experience of Depression: The MULTIBED Study Cognitive Behavioral Therapy (CBT), Whole-Body Hyperthermia - Major Depressive Disorder | Not applicable | Not yet recruiting | University of California, San Francisco | 60 | 2026-12-01 | 2026-10-13 |
| Rapid Cool: Heat Stroke Treatment Recirculated water, Phoenix protocol - Hyperthermia | Not applicable | Not yet recruiting | State University of New York at Buffalo | 20 | 2026-11-21 | 2026-11-03 |
| TECAR Therapy in Chronic Back Pain TECAR Therapy plus Hi-EMS, Tecar therapy alone - Chronic Low-back Pain (cLBP), Non Specific Chronic Low Back Pain | Not applicable | Not yet recruiting | University of Hartford | 37 | 2026-10-19 | 2026-09-15 |
| Progressive Heat Exposure and Physiological Strain Constant Heat Exposure, Progressively Increasing Heat Exposure - Body Temperature Changes, Heat Stress | Not applicable | Not yet recruiting | University of Ottawa | 14 | 2026-10-01 | 2026-09-29 |
| Intratumoral Targeted Hyperthermia Therapy (THT) for Cutaneous Metastatic Melanoma Targeted Hyperthermia Therapy - Cutaneous Metastatic Melanoma | Not applicable | Not yet recruiting | Sona Nanotech Inc | 10 | 2026-10-01 | 2026-04-24 |
| Hyperthermia Safety Study Uses Temperature Management System to Gently Raise Participant's Body Temperature to a Fever-range Level in a Controlled Setting. Hyperthermia - Safety Study | Not applicable | Enrolling by invitation | Marc Abreu | 20 | 2026-09-01 | 2026-09-21 |
| Temperature Optimization in Afebrile Septic PatienTs External Warming - Sepsis, Temperature | Not applicable | Recruiting | Matt Harmon | 50 | 2026-07-17 | 2026-09-21 |
| Consecutive Occupational Heat Exposure With and Without Overnight Cooling Simulated occupational heat exposure with recovery at recommended indoor temperature limit, Simulated occupational heat exposure with recovery in an overheated indoor environment - Body Temperature Changes, Heat Stress | Not applicable | Recruiting | University of Ottawa | 10 | 2026-06-24 | 2026-10-05 |
| Working in the Heat at Simulated Altitude: Effects of Normobaric Hypoxia on Physiological Strain Simulated Occupational heat exposure under normoxic conditions, Simulated Occupational heat exposure under hypoxic conditions - Body Temperature Changes, Heat Stress | Not applicable | Recruiting | University of Ottawa | 20 | 2026-06-17 | 2026-07-14 |
| Laboratory Heat Biomarker and Cooling Interventions Hand cooling table, Cooling bandana - Hyperthermia | Not applicable | Not yet recruiting | Stanford University | 30 | 2026-06-01 | 2026-06-01 |
| Home-Based Heat Therapy in Spinal Cord Injury to Improve Cardiovascular Health HEAT - Passive Heat Therapy, Sham (No Treatment) - SCI - Spinal Cord Injury | Not applicable | Recruiting | The University of Texas Health Science Center at San Antonio | 48 | 2026-03-24 | 2026-05-05 |
| The Effect of Heat Pads and Foam Rolling on Strength in Athletes. Heating Pad, Foam Roller - Healthy Participants | Not applicable | Active not recruiting | University of Redlands | 38 | 2026-02-01 | 2026-05-06 |
| More Representative Vaginal Temperature Measurements With a Hyperthermia Pelotte During Hyperthermia Treatments for Gynaecological Cancer. Pelotte - Gynaecologic Cancer | Not applicable | Recruiting | Dr. G.H. (Henrike) Westerveld | 27 | 2026-01-05 | 2026-09-25 |
| Heat Therapy During Reduced Physical Activity Sauna, Reduced Physical Activity - Physical Inactivity, Vascular Dysfunction | Not applicable | Recruiting | Brigham Young University | 60 | 2026-01-01 | 2026-09-29 |
| The Sarah Nanotechnology System for Treatment of Advanced Metastatic Solid Tumors Using Hyperthermia. The Sarah Nanotechnology System - intended to deliver thermal energy to malignant cells for the purpose of thermal destruction of these cells in patients with advanced metastatic solid tumors. - Metastatic Solid Tumors, Stage 4 Cancer | Not applicable | Recruiting | New Phase Ltd. | 12 | 2025-12-16 | 2026-05-15 |
| Adjunctive Effects of Heat vs Contrast Therapy With Otago Exercises on Patellofemoral Pain Syndrome Heat therapy+Otago exercise program, Contrast therapy+ Otago exercise program - Patello Femoral Pain Syndrome, Patello Femoral Syndrome | Not applicable | Completed | Lahore University of Biological and Applied Sciences | 40 | 2025-12-10 | 2026-08-27 |
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Heat Stress Disorders (24) · Motor Activity (13) · Hypothermia (8) · Body Temperature Changes (6) · Depression (6) · Pain (5) · Breast Neoplasms (4) · Fatigue (4) · Neoplasms (4) · Obesity (4) · Occupational Stress (4) · Peripheral Arterial Disease (4) · Dehydration (3) · Depressive Disorder, Major (3)
Pathological Conditions, Signs and Symptoms (175) · Signs and Symptoms (175) · Wounds and Injuries (174) · Body Temperature Changes (169) · Heat Stress Disorders (150) · Neoplasms (23) · Pathologic Processes (23) · Behavior (19) · Neoplasms by Site (19) · Neurologic Manifestations (17) · Infections (13) · Female Urogenital Diseases and Pregnancy Complications (12) · Nervous System Diseases (12) · Respiratory Tract Diseases (12) · Skin and Connective Tissue Diseases (12)
Diathermy (24) · Exercise (7) · Electrosurgery (6) · Hyperthermia, Induced (6) · Radiotherapy (6) · Cryotherapy (3) · Electrocoagulation (3) · Hot Temperature (3) · Brachytherapy (2) · CCP110 protein, human (2) · Cisplatin (2) · Cognitive Behavioral Therapy (2) · Hydrogen Peroxide (2) · Laser Therapy (2) · Solutions (2)
University of Ottawa (16) · State University of New York at Buffalo (10) · University of Texas Southwestern Medical Center (8) · Medtronic Surgical Technologies (7) · University of Connecticut (7) · Clinical Laserthermia Systems AB (5) · First Hospital of China Medical University (5) · Universität Duisburg-Essen (5) · Indiana University (3) · University of Erlangen-Nürnberg Medical School (3) · University of Malaga (3) · Brigham Young University (2) · National Heart, Lung, and Blood Institute (NHLBI) (2) · Sona Nanotech Inc (2) · Stanford University (2)
United States (63) · Canada (21) · Germany (12) · China (7) · Brazil (5) · Spain (4) · United Kingdom (4) · Italy (3) · South Korea (3) · Switzerland (3) · Egypt (2) · France (2) · Greece (2) · Mexico (2) · Nepal (2)
Glen P Kenny, PhD (9) · Douglas Casa, PhD (3) · Ronald J Sigal, MD, MPH (3) · Xinghua Gao (3) · Abhay Gupta, MD (2) · Ashley E Mason, PhD (2) · Gustav Dobos, Prof. MD (2) · Julie Parsonnet, MD (2) · Manimaran Ramani, MD (2) · Peter Naruns, MD (2) · Riana R Pryor, PhD (2) · Robert D Meade, PhD (2) · Robert J Lederman, M.D. (2) · Waldemar A Carlo, MD (2) · Aftab Ahmed Mirza Baig, MSAPT, PhD (1)
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