20 unknown. 20 Phase 2, 4 Phase 3, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 20 | Unknown 20 |
| Phase 3 | 4 | Unknown 4 |
| Phase 1 | 2 | Unknown 2 |
Follow Heart Valve Diseases: new trials by email Literature Review of Heart Valve Diseases trials Research Report on Heart Valve Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of Edoxaban in Patients With Atrial Fibrillation and Mitral Stenosis Edoxaban, Warfarin - Mitral Valve Stenosis, Atrial Fibrillation | Phase 2 | Unknown | Sung-Hwan Kim | 240 | 2022-05-20 | 2022-09-14 |
| Effect of Dapagliflozin on Myocardial and Renal Function Following Aortic Valve Stenosis Intervention SGLT2 inhibitor, Placebo - Aortic Stenosis, Left Ventricle Hypertrophied | Phase 2 / Phase 3 | Unknown | University of Aarhus | 106 | 2022-02-12 | 2022-02-15 |
| Open Label RCT for Chronic Severe AR : Entresto vs. CCB/ARB Sacubitril-valsartan, Amlodipine-losartan - Aortic Valve Insufficiency | Phase 2 | Unknown | Samsung Medical Center | 100 | 2022-01-12 | 2022-01-28 |
| Role of Perhexiline in Hypertrophic Cardiomyopathy Perhexiline, Placebo - Hypertrophic Cardiomyopathy | Phase 2 | Unknown | Flinders University | 60 | 2020-12-01 | 2021-03-11 |
| The Safety and Effectiveness of Transcatheter Aortic Valve Raplacemet in Intermediate Risk Patients With Bicuspid Aortic Stenosis TAVR, SAVR - Aortic Valve Disease | Phase 2 | Unknown | China National Center for Cardiovascular Diseases | 300 | 2018-02-01 | 2018-01-11 |
| Decalcification of the Aortic Valve by Vitamin K2 (Menaquinone-7) Vitamin K2 (Menaquinone 7) + Vitamin D3 - Aortic Valve Disease | Phase 2 | Unknown | Hopital St. Georges, Ajaltoun | 150 | 2018-01-02 | 2019-08-09 |
| PCSK9 Inhibitors in the Progression of Aortic Stenosis PCSK9 Inhibitor [EPC], Placebos - Aortic Valve Stenosis | Phase 2 | Unknown | Seoul National University Hospital | 140 | 2017-06-01 | 2017-02-13 |
| Bicuspid Aortic Valve Stenosis and the Effect of vItamin K2 on Calciummetabolism on 18F-NaF PET/MRI Vitamin K2, Placebo - Aortic Valve Stenosis, Bicuspid Aortic Valve | Phase 2 | Unknown | Maastricht University Medical Center | 44 | 2016-08-01 | 2018-03-22 |
| Protection by Remote Ischemic Preconditioning During Transcatheter Aortic Valve Implantation Remote ischemic preconditioning (RIPC), Placebo - Aortic Valve Stenosis | Phase 2 | Unknown | University Hospital, Essen | 100 | 2013-09-01 | 2016-11-02 |
| TranScatheter Aortic Valve RepLacement System US Feasibility Trial Transcatheter aortic valve replacement - Aortic Valve Stenosis | Phase 2 | Unknown | Direct Flow Medical, Inc. | 30 | 2013-08-01 | 2016-10-31 |
| CArdiac Desynchronization In Obstructive HCM, CARDIO-HCM Biventricular pacing, No Pacing - Hypertrophic Obstructive Cardiomyopathy (HOCM) | Phase 2 | Unknown | Hospital Clinic of Barcelona | 80 | 2013-06-01 | 2016-10-20 |
| Multi-center Trial of Percutaneous Pulmonary Valve Implantation With Venus-p Venues-P Valve - Pulmonary Regurgitation, Tetralogy of Fallot | Phase 2 / Phase 3 | Unknown | Shanghai Zhongshan Hospital | 44 | 2013-05-01 | 2015-10-29 |
| Trimetazidine Therapy in Hypertrophic Cardiomyopathy Trimetazidine, Placebo capsule - Hypertrophic Cardiomyopathy | Phase 2 | Unknown | University College, London | 90 | 2012-04-01 | 2013-02-28 |
| Bosentan for Severe Mitral Valve Dysfunction BOSENTAN - SECONDARY PULMONARY HYPERTENSION, MITRAL STENOSIS | Phase 1 / Phase 2 | Unknown | General Hospital of Chalkida | 10 | 2010-12-01 | 2011-01-28 |
| Myocardial Protection With Perhexiline in Left Ventricular Hypertrophy Perhexiline, Placebo marked PEXSIG - Myocardial Reperfusion Injury, Cardiac Output, Low | Phase 2 / Phase 3 | Unknown | University Hospital Birmingham | 220 | 2009-10-01 | 2011-08-11 |
| Value of Oral Phytate (InsP6) in the Prevention of Progression of the Cardiovascular Calcifications Phytine (phytate), Placebo - Heart Valve Disease, Aortic Stenosis | Phase 2 / Phase 3 | Unknown | Hospital Universitari Son Dureta | 250 | 2009-08-01 | 2010-05-26 |
| Dynamic Annuloplasty System With Activation for the Treatment of Mitral Regurgitation Dynamic Annuloplasty Ring (with option to adjust off-pump) - Mitral Valve Regurgitation | Phase 2 | Unknown | MiCardia Corporation | 130 | 2008-12-01 | 2009-01-30 |
| Statin Therapy in Asymptomatic Aortic Stenosis fluvastatin - Aortic Valve Stenosis | Phase 2 | Unknown | University of Leipzig | 100 | 2003-01-01 | 2010-01-14 |
| Cardiac Operation Under Totally Endoscope and Cardiopulmonary Bypass (CPB) cardiac operation with totally endoscopic method - Congenital Heart Defects, Heart Valve Diseases | Phase 1 / Phase 2 | Unknown | Xijing Hospital | 800 | 2000-01-01 | 2009-06-16 |
| CHANCE - Candesartan in Hypertrophic Cardiomyopathy candesartan - Hypertrophic Cardiomyopathy | Phase 2 | Unknown | Charles University, Czech Republic | 2007-02-02 |
Aortic Valve Stenosis (8) · Cardiomyopathy, Hypertrophic (4) · Aortic Valve Disease (2) · Heart Failure (2) · Hypertrophy, Left Ventricular (2) · Mitral Valve Stenosis (2) · Aortic Valve Insufficiency (1) · Atrial Fibrillation (1) · Bicuspid Aortic Valve Disease (1) · Cardiac Output, Low (1) · Constriction, Pathologic (1) · Heart Defects, Congenital (1) · Hypertrophy (1) · Mitral Valve Insufficiency (1)
Cardiovascular Diseases (20) · Heart Diseases (20) · Aortic Valve Disease (13) · Ventricular Outflow Obstruction (8) · Cardiomyopathies (5) · Pathological Conditions, Signs and Symptoms (5) · Aortic Stenosis, Subvalvular (4) · Aortic Valve Stenosis (4) · Pathological Conditions, Anatomical (4) · Cardiovascular Abnormalities (3) · Congenital Abnormalities (3) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (3) · Cardiomegaly (2) · Heart Defects, Congenital (2)
Perhexiline (2) · Vitamin K 2 (2) · Bosentan (1) · Cardiac Resynchronization Therapy (1) · Cardiac Surgical Procedures (1) · Cholecalciferol (1) · Fluvastatin (1) · Phytic Acid (1) · Sodium-Glucose Transporter 2 Inhibitors (1) · Transcatheter Aortic Valve Replacement (1) · Trimetazidine (1) · Warfarin (1) · amlodipine-losartan drug combination (1) · candesartan (1) · edoxaban (1)
Charles University, Czech Republic (1) · China National Center for Cardiovascular Diseases (1) · Direct Flow Medical, Inc. (1) · Flinders University (1) · General Hospital of Chalkida (1) · Hopital St. Georges, Ajaltoun (1) · Hospital Clinic of Barcelona (1) · Hospital Universitari Son Dureta (1) · Maastricht University Medical Center (1) · MiCardia Corporation (1) · Samsung Medical Center (1) · Seoul National University Hospital (1) · Shanghai Zhongshan Hospital (1) · Sung-Hwan Kim (1) · University College, London (1)
Germany (3) · South Korea (3) · China (2) · Netherlands (2) · Spain (2) · United Kingdom (2) · Australia (1) · Canada (1) · Czechia (1) · Denmark (1) · Greece (1) · Lebanon (1) · United States (1)
Bas Kietselaer, M.D. PhD (1) · Dinghua Yi, MD (1) · Domeinco Pagano, MD FRCS (1) · E. Murat Tuzcu, MD (1) · Eun Kyoung Kim, MD, PhD (1) · Eva Kottenberg, MD (1) · Gerd Heusch, MD, PhD (1) · Gerhard Schuler, Professor (1) · Guillem Frontera, MD (1) · Heinz Jakob, MD (1) · Joseph Selvanayagam (1) · Junbo Ge, M.D. (1)