16 unknown, 12 completed, 1 not yet recruiting, 1 recruiting. 13 Phase 2, 9 Phase 4, 6 Phase 3, 4 Not applicable, 3 Phase 1.
Follow Trimetazidine: new trials by email Literature Review of Trimetazidine trials Research Report on Trimetazidine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Trimetazidine on Coronary Flow in Transthyretin Cardiac Amyloidosis Trimetazidine - Transthyretin Cardiac Amyloidosis | Phase 2 | Not yet recruiting | Fábio Fernandes | 20 | 2027-01-01 | 2026-10-23 |
| Effect of Trimetazidine on Endothelin-1 and Clinical Outcomes of Patients With Diabetic Peripheral Neuropathy Trimetazidine Dihydrochloride Tablets - Diabetic Peripheral Neuropathic Pain (DPN) | Phase 1 / Phase 2 | Recruiting | Sara Refaat Azab Metry | 60 | 2026-08-01 | 2026-08-31 |
| "The Effect of Trimetazidine on the Clinical Outcome of Acute Ischemic Stroke Patients" Trimetazidine - Acute Ischemic Stroke | Phase 3 | Completed | Ain Shams University | 60 | 2024-09-01 | 2025-09-08 |
| Trimetazidine Efficacy in Attenuating Paclitaxel-Induced Peripheral Neuropathy Trimetazidine, Placebo - Peripheral Neuropathy Due to Chemotherapy | Phase 1 / Phase 2 | Completed | Minia University | 60 | 2024-06-23 | 2025-03-30 |
| Benefits of Trimetazidine in MASLD Patients Trimetazidine, Conventional therapy, Placebo - Metabolic Associated Fatty Liver Disease | Phase 2 | Completed | October 6 University | 60 | 2023-12-10 | 2025-07-11 |
| Allopurinol and Trimetazidine as a Preventive of Acute Kidney Injury in PCI Patients Trimetazidine 35 mg, Allopurinol 300 MG, Normal saline - AKI - Acute Kidney Injury | Phase 4 | Unknown | Beni-Suef University | 124 | 2022-09-19 | 2023-01-19 |
| Efficacy of Trimetazidine in Diabetic Patients Trimetazidine Dihydrochloride, Placebo - Diabetes Mellitus, Type 2, Diabetic Cardiomyopathies | Phase 2 | Unknown | Ain Shams University | 60 | 2022-09-18 | 2022-09-27 |
| The Effects of TMZ on Diabetic Nephropathy Trimetazidine - Diabetic Nephropathies | Phase 2 | Unknown | Tongji Hospital | 150 | 2022-01-01 | 2021-12-07 |
| The Effect of Trimetazidine on Mitochondrial Function, Myocardial Performance, and Invasive Hemodynamics in Patients Diagnosed With Wild-Type Transthyretin Cardiac Amyloidosis Trimetazidine, Placebo - Transthyretin Amyloid Cardiopathy, Mitochondrial Pathology | Phase 4 | Completed | Steen Hvitfeldt Poulsen | 24 | 2021-10-01 | 2024-04-25 |
| Targeting Metabolic Flexibility in Amyotrophic Lateral Sclerosis (ALS) Trimetazidine Dihydrochloride - Amyotrophic Lateral Sclerosis, Motor Neuron Disease | Phase 2 | Completed | The University of Queensland | 21 | 2021-06-29 | 2023-07-20 |
| Effect of Trimetazidine on Radiotherapy-induced Heart Damage. Trimetazidine - Cardiotoxicity | Phase 2 / Phase 3 | Unknown | Peking University Third Hospital | 80 | 2021-06-25 | 2021-06-25 |
| Efficacy and Safety of Wen Xin Granules for the Treatment of Unstable Angina Pectoris Wen Xin granule, Clopidogrel Hydrogen Sulfate 75 MG Oral Tablet, Atorvastatin Calcium - Coronary Heart Disease, Unstable Angina | Phase 4 | Unknown | Guang'anmen Hospital of China Academy of Chinese Medical Sciences | 502 | 2021-03-01 | 2021-01-25 |
| Metoprolol and Trimetazidine for Coronary Heart Disease With Angina Metoprolol Succinate Sustained-Release Tablets, Trimetazidine, Routine Drug Therapy - Coronary Heart Disease (CHD) | Not applicable | Completed | Shiyan City Renmin Hospital | 102 | 2021-02-01 | 2025-07-20 |
| Prevention of Acute Myocardial Injury by Trimetazidine in Patients Hospitalized for COVID-19 Trimetazidine - Acute Respiratory Distress Syndrome, Covid19 | Phase 2 | Unknown | Ministry of Health, Brazil | 80 | 2020-12-10 | 2021-02-21 |
| Effects of Yangxinshi Pills on the Exercise Tolerance Compared With Trimetazidine in Patients After PCI Yangxinshi, Trimetazidine, Yangxinshi mimic - Percutaneous Coronary Intervention | Phase 4 | Completed | Shenyang Northern Hospital | 681 | 2019-08-01 | 2025-09-10 |
| Cardiac Metabolic Modulator Treatment for Improvement of Diastolic Function in Patients With Coronary Heart Disease Trimetazidine - Coronary Heart Disease, Diastolic Dysfunction | Phase 4 | Unknown | China National Center for Cardiovascular Diseases | 226 | 2019-03-25 | 2019-03-25 |
| Effect of Trimetazidine on the Improvement of Coronary Microvascular Dysfunction in Patients With INOCA(Ischemia and no Obstructive Coronary Artery Disease) Trimetazidine - Patients With INOCA(Ischemia and no Obstructive Coronary Artery Disease) Who Have Coronary Microvascular Dysfunction | Not applicable | Unknown | Shanghai 10th People's Hospital | 10 | 2019-03-01 | 2018-10-25 |
| TRimetazidine for acUte on Chronic Liver Failure STudy Trimetazidine - Acute-On-Chronic Liver Failure | Phase 1 | Suspended | Martin Pharmaceuticals | 30 | 2018-11-28 | 2021-03-04 |
| Trimetazidine in Myocardial Injury After Percutaneous Coronary Intervention in Patients With Angina and Diabetes trimetazidine, Placebo Oral Tablet - Diabetes Mellitus, Angina, Unstable | Phase 3 | Unknown | University of Sao Paulo General Hospital | 120 | 2018-10-01 | 2018-10-24 |
| Trimetazidine as an Adjunct to Enhance Clopidogrel Response. Trimetazidine - Platelet Dysfunction Due to Drugs | Phase 2 | Completed | The University of The West Indies | 24 | 2018-07-01 | 2019-12-02 |
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Coronary Artery Disease (4) · Coronary Disease (3) · Diabetes Mellitus (3) · Angina, Unstable (2) · Diabetes Mellitus, Type 2 (2) · Acute Kidney Injury (1) · Acute-On-Chronic Liver Failure (1) · Amyotrophic Lateral Sclerosis (1) · Atrial Fibrillation (1) · Brain Edema (1) · COVID-19 (1) · Cardiomyopathy, Hypertrophic (1) · Cardiotoxicity (1) · Cardiovascular Diseases (1) · Coronavirus Infections (1)
Ain Shams University (2) · Jun Li (2) · The First Affiliated Hospital of Zhengzhou University (2) · Beni-Suef University (1) · China National Center for Cardiovascular Diseases (1) · Chinese PLA General Hospital (1) · Clinical Hospital Center Zemun (1) · Fábio Fernandes (1) · Guang'anmen Hospital of China Academy of Chinese Medical Sciences (1) · IRCCS San Raffaele (1) · Martin Pharmaceuticals (1) · Minia University (1) · Ministry of Health, Brazil (1) · National Research Center for Preventive Medicine (1) · October 6 University (1)
China (6) · Egypt (6) · Brazil (3) · United Kingdom (2) · Australia (1) · Austria (1) · Belgium (1) · Chile (1) · Denmark (1) · France (1) · Germany (1) · Indonesia (1) · Netherlands (1) · Serbia (1) · Spain (1)
Jie Wang, MD (2) · Ahmed Mostafa Abd-Elaziz, Lecturer (1) · Ammar Al-Chalabi, MB ChB, PhD (1) · Asmaa N. Iqbal Ahmed, Demonstrator (1) · Dai Yun Chen, MD (1) · Dan Zhu, doctor (1) · Eman M. Sadek, Lecturer (1) · Engy A. Wahsh, Asst. Prof. (1) · Fatma M. Mady, Professor (1) · Felipe Gallego Lima, MD (1) · Frederik Steyn, PhD (1) · Giuseppe Marazzi, MD (1) · Hadeer Safwat Hassan Zaki, Doctor (1) · Hary Sakti Muliawan, MD,PhD (1)
PMID 20432394, PMID 20531008, PMID 20681275, PMID 22019563, PMID 23303884, PMID 27480425, PMID 27847338, PMID 22719784, PMID 23173251, PMID 26142341, PMID 26972437, PMID 27491230, PMID 29444778, PMID 30725091, PMID 31292901, PMID 34767131, PMID 34774099, PMID 39566404, PMID 39814796, PMID 41704280