8 recruiting, 5 not yet recruiting, 2 completed, 1 active not recruiting. 6 Not applicable, 1 Phase 1, 1 Phase 2, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 6 | Recruiting 4, Completed 1, Not yet recruiting 1 |
| Phase 1 | 1 | Not yet recruiting 1 |
| Phase 2 | 1 | Not yet recruiting 1 |
| Phase 4 | 1 | Recruiting 1 |
Follow Heart Failure - NYHA II - IV: new trials by email Literature Review of Heart Failure - NYHA II - IV trials Research Report on Heart Failure - NYHA II - IV
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Mitral Valve Edge-to-Edge Repair in Patients With Exercise-Induced Severe Mitral Regurgitation Guideline-Directed Medical Therapy (GDMT), Mitral valve TEER - Heart Failure - NYHA II - IV, Mitral Regurgitation Functional | Not applicable | Recruiting | Jena University Hospital | 246 | 2026-09-16 | 2026-10-05 |
| Cor360: Clinician-Facing Broad-Spectrum Cardiac Phenotyping and Risk Assessment Using COR® Wearable ECG to Inform Outcomes-Oriented Care Pathways COR Wearable ECG Monitoring, Cor360 Clinician-Facing Decision-Aid Reporting - Cardiovascular Diseases, Cardiovascular Diseases Risk | Enrolling by invitation | Peerbridge Health, Inc | 1000 | 2026-08-20 | 2026-08-21 | |
| AI-Optimized Single-Feature Recognition Model for Heart Failure Cardiac Sound, Heart Failure - NYHA II - IV | Recruiting | Vivalink | 50 | 2026-07-16 | 2026-07-21 | |
| REstoration of SYNChronous Cardiac Function Due to Physiologic cArdiac Pacing Modalities With Clinical Endpoints Physiologic cardiac resynchronization using conduction system pacing and selective LV lead optimization. - Heart Failure - NYHA II - IV, Left Bundle Branch Area Pacing | Not yet recruiting | University of Pecs | 50 | 2026-06-29 | 2026-07-10 | |
| Ted Rogers Understanding of Exacerbations in Heart Failure 2: Monitor Heart Failure, Heart Failure - NYHA II - IV | Recruiting | University Health Network, Toronto | 360 | 2026-06-16 | 2026-07-06 | |
| Evaluation of Liver Stiffness Performance, by FibroScan®, to Detect Elevated Central Venous Pressure (CVP) FibroScan, Right-sided Heart Catheterization, Transthoracic echocardiography - Heart Failure, Heart Failure - NYHA II - IV | Not applicable | Recruiting | Echosens | 149 | 2026-04-23 | 2026-09-23 |
| Urine Sodium-Driven Diuretic Adjustment Strategy in Acute Decompensated Heart Failure Furosemide intravenous solution - Heart Failure, Heart Failure - NYHA II - IV | Phase 4 | Recruiting | Lakeland Regional Health Systems, Inc. | 600 | 2026-04-01 | 2026-04-09 |
| Safety and Effectiveness of Left Bundle Branch Area Pacing Versus Conventional Cardiac Resynchronization Therapy in Heart Failure CRT-D with a Quadripolar LV lead, CRT-D with INGEVITY+ pace/sense lead - Heart Failure - NYHA II - IV | Not applicable | Recruiting | Boston Scientific Corporation | 850 | 2025-10-22 | 2026-10-05 |
| Cardiovascular Performance and Exercise Response in Patients With Persistent or Permanent Atrial Fibrillation and Heart Failure Pre and Post Cardioversion or Pace and Ablate Atrial Fibrillation (AF), Heart Failure - NYHA II - IV | Not yet recruiting | Habib Khan | 40 | 2025-10-01 | 2025-10-03 | |
| Effects of a 20-Minute Mindfulness-Based Breathing Exercise on Dyspnea, Fatigue, and Sleep Quality in Patients With Heart Failure 20-minute mindfulness-based breathing exercise, Control (Standard treatment) - Heart Failure, Heart Failure - NYHA II - IV | Not applicable | Not yet recruiting | Firat University | 72 | 2025-08-15 | 2025-07-01 |
| Low Dose Radiotherapy for Heart Failure Radiation Therapy - Heart Failure - NYHA II - IV | Phase 1 / Phase 2 | Not yet recruiting | Hospital do Coracao | 10 | 2025-07-14 | 2025-06-25 |
| Remote Monitoring of Cardiac Mechanics in Heart Failure Patients Continuous monitroing - Heart Failure, Heart Failure - NYHA II - IV | Recruiting | Aalborg University | 200 | 2025-06-11 | 2026-01-16 | |
| Peripheral Drivers of Heart Failure Progression - The Prospective PEDAL-HF Study Heart Failure network care - Heart Failure - NYHA II - IV | Not applicable | Recruiting | University of Leipzig | 1000 | 2024-11-28 | 2026-05-06 |
| Calibration of AlgoRithm for Detection of Cardiac Decompensation Via Parametric Objects (CARDCOP) Heart Failure - NYHA II - IV | Not yet recruiting | University Hospital, Brest | 640 | 2024-11-01 | 2024-10-28 | |
| An Optimization Pilot to Optimize An Early Palliative Care Intervention for Advanced Heart Failure UPHOLDS (Utilizing Palliative Care for Heart Failure Optimized using Lay Navigators to Decrease Suffering) - Chronic Illness, Heart Failure - NYHA II - IV | Not applicable | Completed | University of Alabama at Birmingham | 32 | 2024-08-15 | 2026-09-22 |
| Effect of Genetic Polymorphism on the Clinical Outcome to SGLT2 Inhibitors in Heart Failure Patients SGLT2 inhibitor (Dapagliflozin 10mg) - Heart Failure - NYHA II - IV, Cardiac Fibrosis | Active not recruiting | Ain Shams University | 200 | 2023-11-22 | 2025-03-30 | |
| Dual-Source Computed Tomography to Improve Prediction of Response to Cardiac Resynchronization Therapy Randomization of Pre-knowledge of CT coronary venography - Heart Failure - NYHA II - IV, Wide QRS Complex | Completed | Massachusetts General Hospital | 38 | 2009-02-01 | 2022-10-03 |
Heart Failure (8) · Arrhythmias, Cardiac (1) · Atrial Fibrillation (1) · Bundle-Branch Block (1) · Cardiac Conduction System Disease (1) · Cardiovascular Diseases (1) · Chronic Disease (1) · Death, Sudden, Cardiac (1) · Edema (1) · Epilepsy (1) · Fatigue (1) · Heart Arrest (1) · Myocardial Ischemia (1) · Primary Dysautonomias (1) · Sleep Apnea, Obstructive (1)
Heart Diseases (10) · Cardiovascular Diseases (9) · Pathological Conditions, Signs and Symptoms (5) · Pathologic Processes (4) · Arrhythmias, Cardiac (2) · Dyssomnias (2) · Nervous System Diseases (2) · Signs and Symptoms (2) · Sleep Disorders, Intrinsic (2) · Sleep Wake Disorders (2) · Apnea (1) · Autonomic Nervous System Diseases (1) · Brain Diseases (1) · Cardiac Conduction System Disease (1) · Central Nervous System Diseases (1)
Furosemide (1) · Radiotherapy (1) · Sodium-Glucose Transporter 2 Inhibitors (1) · dapagliflozin (1)
Aalborg University (1) · Ain Shams University (1) · Boston Scientific Corporation (1) · Echosens (1) · Firat University (1) · Habib Khan (1) · Hospital do Coracao (1) · Jena University Hospital (1) · Lakeland Regional Health Systems, Inc. (1) · Massachusetts General Hospital (1) · Peerbridge Health, Inc (1) · University Health Network, Toronto (1) · University Hospital, Brest (1) · University of Alabama at Birmingham (1) · University of Leipzig (1)
United States (6) · Germany (3) · France (2) · Brazil (1) · Canada (1) · China (1) · Denmark (1) · Egypt (1) · Hungary (1) · Poland (1)
Anas Bizanti, MD (1) · Andrew Lurie, DO (1) · Bassem Zarif, MD (1) · Chris McIntosh, PhD (1) · Christian Schulze, Prof. Dr. (1) · Heather Ross, MD (1) · Jagmeet P Singh, MD, PhD (1) · Maximilian Spieker, PD Dr. (1) · Sandeep Gulati, PhD (1) · Yasbanoo Moayedi, MD (1)
K23HL098370 (1), R00NR019854 (1)