45 recruiting. 45 Phase 2, 7 Phase 1, 5 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 45 | Recruiting 45 |
| Phase 1 | 7 | Recruiting 7 |
| Phase 3 | 5 | Recruiting 5 |
Follow Heart Failure: new trials by email Literature Review of Heart Failure trials Research Report on Heart Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of EDG-15400 in Adults With Heart Failure With Preserved Ejection Fraction (EQUINOX-HFpEF) EDG-15400 25 mg, Placebo to match EDG-15400 25 mg or 50 mg, EDG-15400 50 mg - Heart Failure With Preserved Ejection Fraction | Phase 2 | Recruiting | Edgewise Therapeutics, Inc. | 90 | 2026-08-25 | 2026-10-13 |
| Midodrine in Heart Failure With Reduced Ejection Fraction With Hypotension Midodrine Oral Tablet - Heart Failure With Reduced Ejection Fraction, Hypotension | Phase 2 / Phase 3 | Recruiting | Ottawa Heart Institute Research Corporation | 56 | 2026-08-07 | 2026-09-08 |
| A Trial of CRD-4730 in HFrEF CRD-4730, Placebo - Heart Failure With Reduced Ejection Fraction (HFrEF) | Phase 2 | Recruiting | Cardurion Pharmaceuticals, Inc. | 525 | 2026-07-15 | 2026-08-06 |
| A Study of Metformin to Improve Cardiac Function After LVAD Implantation Metformin Hydrochloride, Placebo - Heart Failure, Left Ventricular Assist Device | Phase 1 / Phase 2 | Recruiting | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 108 | 2026-07-01 | 2026-09-02 |
| Comparative Study on the Mode of Action of Vicadrostat and Spironolactone on Protein Profiles and Renal Hemodynamic Effects (COMPARE-VS) vicadrostat / empagliflozin combination 1, Spironolactone (drug) - CKD, Cardiovascular Diseases | Phase 2 | Recruiting | University Medical Center Groningen | 100 | 2026-05-12 | 2026-05-29 |
| Sodium-Glucose Cotransporter-2 Inhibitor for Patients With Acute Cardiorenal Syndrome Dapagliflozin 10mg Tab, Placebo - Heart Failure, Acute Kidney Injury | Phase 2 | Recruiting | Yale University | 130 | 2026-03-05 | 2026-03-13 |
| Swedish Cardiac And Renal Failure Study-1 Eplerenone - HFrEF - Heart Failure With Reduced Ejection Fraction, Chronic Kidney Disease | Phase 2 | Recruiting | Karolinska Institutet | 40 | 2026-02-01 | 2026-02-24 |
| Endocardial Delivery for Myocardial Regeneration Using Allogeneic iPSC-derived Cardiomyocyte Spheroids for HF With Systolic Dysfunction (EMERALD Study) HS-005 - Heart Failure, Ischemic Heart Failure | Phase 1 / Phase 2 | Recruiting | Heartseed Inc. | 14 | 2026-01-19 | 2026-10-22 |
| PET Myocardial Fatty-acid Metabolic Imaging With XTR003 Injection and 18F-FDG to Assess Myocardial Viability in Ischemic Cardiomyopathy Fasting XTR003/¹⁸F-FDG PET myocardial metabolic imaging, Glucose-loaded ¹⁸F-FDG PET Myocardial Metabolic Imaging - Ischemic Cardiomyopathy, Heart Failure | Phase 2 | Recruiting | Sinotau Pharmaceutical Group | 40 | 2025-12-18 | 2026-03-02 |
| Inhaled Milrinone and Epoprostenol for the Prevention of Difficult Cardiac Pulmonary Bypass Separation Combined Epoprostenol Sodium & Milrinone, Normal saline - Right Heart Failure, Right Ventricular Dysfunction | Phase 2 | Recruiting | Montreal Heart Institute | 141 | 2025-12-10 | 2026-06-25 |
| the Clinical Outcome of Empagliflozin in Pediatric Heart Failure Patients Empagliflozin (EMPA), Standard medical treatment - Heart Failure | Phase 2 | Recruiting | Ain Shams University | 60 | 2025-12-01 | 2026-07-09 |
| 18F-mFBG Imaging for Myocardial Sympathetic Innervation 18F-metaFluorobenzylguanidine, Rubidium-82 - Heart Failure, Ischemic Cardiomyopathy | Phase 2 | Recruiting | Innervate Radiopharmaceuticals LLC (Formerly: Illumina Radiopharmaceuticals LLC) | 20 | 2025-11-05 | 2026-07-01 |
| Feasibility Trial for a Right Ventricular Failure Platform Trial Empagliflozin, Ranolazine - Pulmonary Hypertension, Right Ventricular Dysfunction | Phase 2 | Recruiting | University of Alberta | 30 | 2025-07-15 | 2026-10-15 |
| A Research Study Comparing CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Reduced/Mildly Reduced Ejection Fraction and Left Ventricular Hypertrophy CDR132L, Placebo - Heart Failure | Phase 2 | Recruiting | Novo Nordisk A/S | 200 | 2025-06-30 | 2026-03-11 |
| A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy CDR132L, Placebo - Heart Failure | Phase 2 | Recruiting | Novo Nordisk A/S | 200 | 2025-06-27 | 2026-10-05 |
| A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF) Placebo, Low Dose PF-07328948, Medium Dose PF-07328948 - Heart Failure | Phase 2 | Recruiting | Pfizer | 620 | 2025-06-19 | 2026-10-23 |
| COgnitioN With VERiciGuat Evaluation in Heart Failure Vericiguat - Heart Failure, Cognitive Impairment | Phase 2 | Recruiting | University of Alberta | 120 | 2025-06-03 | 2026-08-25 |
| Safety and Efficacy of FAP iCDC in End-stage Dilated Cardiomyopathy FAP immunosuppressive CAR-DC - Dilated Cardiomyopathy (DCM), Heart Failure | Phase 1 / Phase 2 | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 43 | 2025-04-22 | 2026-07-14 |
| Effect of Xenon on Brain Injury After Aneurysmal Subarachnoid Hemorrhage Xenon, air/oxygen - Subarachnoid Hemorrhage, Aneurysmal, Cerebral Injury | Phase 2 | Recruiting | Turku University Hospital | 160 | 2025-04-22 | 2025-05-01 |
| Peritoneal Ultrafiltration in Cardio Renal Syndrome. PolyCore (Polydextrin, L-Carnitine, D-xylitol) - Congestive Heart Failure | Phase 1 / Phase 2 | Recruiting | Iperboreal Pharma Srl | 84 | 2025-04-16 | 2025-05-16 |
Showing 20 of 45. Sign in to see all of them.
Breast Neoplasms (3) · Cardiomyopathy, Dilated (3) · Cardiovascular Diseases (3) · Inflammation (3) · Ventricular Dysfunction, Left (3) · Ventricular Dysfunction, Right (3) · Acute Kidney Injury (2) · Coronary Artery Disease (2) · Acute Coronary Syndrome (1) · Albuminuria (1) · Arrhythmogenic Right Ventricular Dysplasia (1) · Brain Injuries (1) · Brain Ischemia (1) · Cardio-Renal Syndrome (1)
Heart Diseases (45) · Cardiovascular Diseases (42) · Pathological Conditions, Signs and Symptoms (8) · Pathologic Processes (7) · Vascular Diseases (7) · Ventricular Dysfunction (6) · Cardiomyopathies (5) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (5) · Female Urogenital Diseases (5) · Female Urogenital Diseases and Pregnancy Complications (5) · Male Urogenital Diseases (5) · Urogenital Diseases (5) · Urologic Diseases (5) · Kidney Diseases (4) · Neoplasms (4)
empagliflozin (3) · Spironolactone (2) · Valsartan (2) · dapagliflozin (2) · vericiguat (2) · (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(methylthio)tetrahydro-2H-pyran-3,4,5-triol (1) · Ado-Trastuzumab Emtansine (1) · Carnitine (1) · Carvedilol (1) · Colchicine (1) · Contraceptives, Oral (1) · Eplerenone (1) · Heparin (1) · Metformin (1) · Metolazone (1)
Novo Nordisk A/S (2) · University Medical Centre Ljubljana (2) · University of Alberta (2) · Yale University (2) · Ain Shams University (1) · Baylor Research Institute (1) · Cardiac Success (1) · Cardurion Pharmaceuticals, Inc. (1) · Chulalongkorn University (1) · Cytokinetics (1) · Edgewise Therapeutics, Inc. (1) · Heartseed Inc. (1) · Hospices Civils de Lyon (1) · Hospital de Clinicas de Porto Alegre (1) · Innervate Radiopharmaceuticals LLC (Formerly: Illumina Radiopharmaceuticals LLC) (1)
United States (19) · Canada (8) · United Kingdom (5) · Brazil (4) · China (4) · Germany (4) · Japan (4) · Poland (4) · Spain (4) · France (3) · Netherlands (3) · South Korea (3) · Sweden (3) · Czechia (2) · Finland (2)
Abay Baigenzhin, Prof Dr (1) · Abinet Aklilu, MD (1) · Ambarish Pandey, MD (1) · Amy Mottl, MD, MPH (1) · Andrew Rosenbaum (1) · Bojan Vrtovec, MD, PhD (1) · Caroline Ozment, MD (1) · Darryl Leong, PhD. MBBSm (1) · Edoardo Gronda, MD (1) · Ian Paterson, MD (1) · Ify Mordi, MBChB, MD (1) · Jason Weatherald, MD,MSc,FRCPC (1)
PMID 11082382, PMID 11606352, PMID 12456409, PMID 14639158, PMID 15999045, PMID 16236968, PMID 16547439, PMID 17400468, PMID 17566702, PMID 18378625, PMID 19559822, PMID 19794327, PMID 22578975, PMID 26978207, PMID 27378592, PMID 28526144, PMID 28598920, PMID 29169472, PMID 31585674, PMID 32682511, PMID 34596223, PMID 37337295, PMID 37979797, PMID 38916717, PMID 39382091, PMID 40193211, PMID 40334814, PMID 42202318, PMID 7574953, PMID 8103681, PMID 9201062, PMID 9288373
2025 (2), 2019 (1), 2023 (1), I01CX002045 (1), K23DK142042 (1), R61HL167848 (1)