15 terminated. 15 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 15 | Terminated 15 |
Follow Headache Disorders, Primary: new trials by email Literature Review of Headache Disorders, Primary trials Research Report on Headache Disorders, Primary
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Acute Migraine Treatment in the ED With Gepants Rimegepant, Zavegepant - Migraine Headaches | Phase 4 | Terminated | Icahn School of Medicine at Mount Sinai | 9 | 2025-06-05 | 2026-04-29 |
| Tandem OnabotulinumtoxinA Galcanezumab Emerging Therapeutic Headache Elimination Research Study Galcanezumab, Placebo - Migraine | Phase 4 | Terminated | Diamond Headache Clinic | 2 | 2022-10-01 | 2023-09-29 |
| Evaluation of the Efficacy of Almotriptan and Ubrogepant for the Acute Treatment of Migraine Almotriptan 12.5 Mg Oral Tablet, Ubrogepant 50Mg Tab - Migraine With Aura, Migraine Without Aura | Phase 4 | Terminated | Messoud Ashina, MD | 8 | 2022-06-30 | 2025-05-31 |
| Evaluation of the Efficacy of Diclofenac Potassium and Rimegepant for the Acute Treatment of Migraine Diclofenac Potassium 50Mg/Pkt Oral Pwdr, Rimegepant 75 MG - Migraine With Aura, Migraine Without Aura | Phase 4 | Terminated | Danish Headache Center | 300 | 2022-05-05 | 2025-09-29 |
| Real World Effectiveness of Eptinezumab in Participants With Migraine Eptinezumab, Erenumab, Onabotulinumtoxin-A - Migraine | Phase 4 | Terminated | H. Lundbeck A/S | 32 | 2022-03-04 | 2024-05-29 |
| Fremanezumab, Migraine and Sleep Fremanezumab Prefilled Syringe [Ajovy] - Migraine Disorders, Sleep Disorder | Phase 4 | Terminated | Beth Israel Deaconess Medical Center | 22 | 2021-07-29 | 2026-02-27 |
| Therapy for Migraine Prevention in Children 6-11 Years of Age SPN-538, Placebo - Migraine Disorders, Headache Disorders | Phase 4 | Terminated | Supernus Pharmaceuticals, Inc. | 26 | 2020-07-14 | 2026-01-22 |
| Effect of Erenumab-aooe on Disability and Work Productivity in Employed Subjects With Episodic Migraine Placebo, Erenumab - Migraine | Phase 4 | Terminated | Amgen | 29 | 2019-12-04 | 2022-07-20 |
| RCT Evaluating Intranasal Fentanyl in the Pain Management of Children With Headaches Fentanyl, Salinex - Headaches | Phase 4 | Terminated | St. Justine's Hospital | 62 | 2016-01-01 | 2020-09-03 |
| Sphenopalatine Ganglion Nerve Block vs. Elavil for Treatment of Transformed Migraines SPG Block with 5% Lidocaine gel, Amitriptyline - Transformed Migraine, Chronic Daily Headache | Phase 4 | Terminated | Rutgers, The State University of New Jersey | 10 | 2014-05-01 | 2026-06-23 |
| Efficacy of Haloperidol vs. Metoclopramide for Treatment of Acute Headaches and Migraines in the Emergency Department Metoclopramide, Haloperidol, Normal Saline - Headache, Migraine | Phase 4 | Terminated | OhioHealth | 66 | 2014-02-01 | 2018-10-23 |
| Theramine® in the Prevention of Migraine Headache Theramine (medical food/old drug), Placebo (l-alanine) - Migraine Headaches | Phase 4 | Terminated | Vincent Martin, MD | 31 | 2013-11-01 | 2016-05-05 |
| Prochlorperazine Versus Acetaminophen, Aspirin, and Caffeine for the Treatment of Acute Migraine Aspirin, Acetaminophen, Caffeine pills, Prochlorperazine 10mg - Migraine Headaches | Phase 4 | Terminated | Albert Einstein Healthcare Network | 93 | 2010-11-01 | 2020-03-18 |
| A Double-Blind Placebo-Controlled Trial of Rozerem in Migraine Headaches ramelteon - Migraine Headache | Phase 4 | Terminated | Charlottesville Neuroscience | 4 | 2006-10-01 | 2012-02-10 |
| A Double-Blind, Placebo-Controlled Study Examining the Use of Topiramate in the Treatment of Cluster Headache Topiramate - Cluster Headache | Phase 4 | Terminated | Thomas Jefferson University | 60 | 2004-09-01 | 2009-01-23 |
Migraine Disorders (12) · Headache (2) · Headache Disorders (2) · Migraine with Aura (2) · Migraine without Aura (2) · Cluster Headache (1) · Emergencies (1) · Epilepsy, Temporal Lobe (1) · Sleep Wake Disorders (1) · Vascular Headaches (1)
Brain Diseases (15) · Central Nervous System Diseases (15) · Nervous System Diseases (15) · Headache Disorders (13) · Pathological Conditions, Signs and Symptoms (4) · Neurologic Manifestations (3) · Signs and Symptoms (3) · Migraine Disorders (2) · Pain (2) · Cardiovascular Diseases (1) · Cerebrovascular Disorders (1) · Disease Attributes (1) · Epilepsies, Partial (1) · Epilepsy (1)
erenumab (3) · galcanezumab (2) · rimegepant sulfate (2) · Acetaminophen (1) · Alanine (1) · Amitriptyline (1) · Aspirin (1) · Botulinum Toxins, Type A (1) · Diclofenac (1) · Diphenhydramine (1) · Fentanyl (1) · Haloperidol (1) · Metoclopramide (1) · Prochlorperazine (1) · Saline Solution (1)
Albert Einstein Healthcare Network (1) · Amgen (1) · Beth Israel Deaconess Medical Center (1) · Charlottesville Neuroscience (1) · Danish Headache Center (1) · Diamond Headache Clinic (1) · H. Lundbeck A/S (1) · Icahn School of Medicine at Mount Sinai (1) · Messoud Ashina, MD (1) · OhioHealth (1) · Rutgers, The State University of New Jersey (1) · St. Justine's Hospital (1) · Supernus Pharmaceuticals, Inc. (1) · Thomas Jefferson University (1) · Vincent Martin, MD (1)
United States (12) · Denmark (2) · Canada (1)
Messoud Ashina, Prof. (2) · Christopher Lloyd, D.O. (1) · Christopher P Rhyne, MD (1) · Gianpiera Ceresoli-Borroni, PhD (1) · Jonathan Schimmel (1) · Kenneth Deitch, DO (1) · Patricia J Shipley, MD (1) · Sait Ashina, MD (1) · Serge Gouin (1) · Vincent Martin, MD (1) · William B Young, MD (1)