18 completed, 6 terminated, 3 unknown, 3 withdrawn. 9 Phase 2, 8 Phase 3, 7 Phase 4, 3 Not applicable, 3 Phase 1.
Follow this drug Literature Review of Prochlorperazine trials Research Report on Prochlorperazine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Prochlorperazine Maleate Versus Placebo for the Prophylaxis of Acute Mountain Sickness Prochlorperazine Maleate, Placebo - Acute Mountain Sickness | Phase 2 | Completed | University of Colorado, Denver | 57 | 2024-08-05 | 2024-09-19 |
| Intranasal Ketorolac Trial Ketorolac, Prochlorperazine, Diphenhydramine - Headache, Migraine | Phase 2 | Terminated | Washington University School of Medicine | 41 | 2024-01-01 | 2026-01-16 |
| Melphalan on Disease Burden Measured by Next Generation Sequencing Before AHCT (Autologous Hematopoietic Cell Transplant) for Multiple Myeloma Evomela, Next Generation Sequencing, Prochlorperazine - Multiple Myeloma | Early Phase 1 | Withdrawn | Koen van Besien | 2023-09-01 | 2024-04-02 | |
| Intravenous Fluids in Pediatric Migraine 1/2 maintenance fluids, Ketorolac, Diphenhydramine - Migraine, Migraine in Children | Not applicable | Unknown | Dayton Children's Hospital | 134 | 2023-06-27 | 2023-12-26 |
| Efficacy of Prophylactic Treatment of Oral Prochlorperazine for Acute Mountain Sickness Immediate descent from altitude., Diphenhydramine, Prochlorperazine 10 mg - AMS, Acute Mountain Sickness | Phase 4 | Completed | CHRISTUS Health | 30 | 2021-05-20 | 2024-05-28 |
| Olanzapine for the Prevention of Chemotherapy Induced Nausea and Vomiting in Gynecologic Oncology Patients Ondansetron, Dexamethasone, Neurokinin-1 Receptor Antagonist (NK1-RA) - Gynecologic Cancer | Phase 3 | Terminated | University of Michigan Rogel Cancer Center | 62 | 2020-12-28 | 2025-06-18 |
| Paracervical Injection for Headache in the Emergency Department Paracervical injection, prochlorperazine and diphenhydramine.(Standard Treatment) - Headache Disorders, Primary, Pain Management | Phase 2 | Terminated | Christian Fromm, MD | 19 | 2020-09-15 | 2024-08-01 |
| Magnesium Versus Prochlorperazine Versus Metoclopramide for Migraines Magnesium Sulfate, Metoclopramide 10mg, Prochlorperazine (Compazine) Injection - Migraine, Headache | Phase 3 | Completed | Wake Forest University Health Sciences | 157 | 2019-08-23 | 2024-10-08 |
| SPG Block for Acute Pediatric Migraine Lidocaine topical, Prochlorperazine Injection - Migraine in Children, Sphenopalatine Neuralgia | Phase 3 | Unknown | Newark Beth Israel Medical Center | 72 | 2019-06-06 | 2021-11-17 |
| Treatment of Refractory Nausea and Vomiting in Patients With Breast Cancer Dexamethasone, Laboratory Biomarker Analysis, Netupitant/Palonosetron Hydrochloride - Breast Carcinoma | Phase 3 | Completed | University of Rochester NCORP Research Base | 1363 | 2018-04-19 | 2025-09-25 |
| Designing Optimal Prevention and Management of Postoperative Nausea and Emesis for Patients Undergoing Laparoscopic Sleeve Gastrectomy Aprepitant 80 mg Oral Capsule, scopolamine transdermal, Total intravenous anesthesia - Post-operative Nausea and Vomiting, Laparoscopic Sleeve Gastrectomy | Phase 4 | Completed | Stony Brook University | 83 | 2017-08-28 | 2024-02-14 |
| Intravenous Fluids in Benign Headaches Trial Normal Saline 5mL, Normal Saline 20mL/kg, Prochlorperazine 0.15 mg/kg up to 10 mg IV - Headache | Phase 4 | Completed | University Medical Center of Southern Nevada | 58 | 2017-05-16 | 2024-06-06 |
| E7 TCR T Cells for Human Papillomavirus-Associated Cancers E7 TCR cells, Aldesleukin, Fludarabine - Papillomavirus Infections, Cervical Intraepithelial Neoplasia | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 224 | 2017-01-27 | 2026-03-09 |
| The CHECK Trial: A Comparison of Headache Treatment in the Emergency Department: Compazine Versus Ketamine Compazine, Ketamine - Headache | Phase 3 | Terminated | Mike O'Callaghan Military Hospital | 5 | 2016-08-01 | 2024-03-04 |
| Buccal Prochlorperazine Versus Intravenous Prochlorperazine for Migraine Headaches, a RCT Prochlorperazine - Migraine Disorders | Phase 3 | Unknown | Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center | 80 | 2016-04-01 | 2018-01-05 |
| The CHECK Trial: A Comparison of Headache Treatment in the ED: Compazine Versus Ketamine Prochlorperazine, Ketamine, Diphenhydramine - Headache | Phase 4 | Completed | University Medical Center of Southern Nevada | 54 | 2016-03-17 | 2017-12-11 |
| Family Intervention in Recent Onset Schizophrenia Treatment (FIRST) Caregiver psycho-education and skills training, Caregiver support available at the study site, Paliperidone palmitate - Schizophrenia | Completed | Janssen Scientific Affairs, LLC | 296 | 2015-07-24 | 2019-01-23 | |
| Hydromorphone Versus Prochlorperazine + Diphenhydramine for Acute Migraine Hydromorphone, Prochlorperazine, Diphenhydramine - Migraine | Phase 4 | Completed | Montefiore Medical Center | 127 | 2015-03-01 | 2018-08-31 |
| Bupivacaine for Benign Headache in the ED 0.5% bupivacaine, Standard Care - Benign Headache | Phase 2 | Terminated | Wake Forest University Health Sciences | 23 | 2013-10-01 | 2022-07-14 |
| TRC102 and Temozolomide for Relapsed Solid Tumors and Lymphomas TRC102, CT scan, Lomotil - Lymphomas, Solid Tumors | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 93 | 2013-07-12 | 2024-05-08 |
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Migraine Disorders (11) · Headache (8) · Vomiting (5) · Nausea (4) · Altitude Sickness (2) · Breast Neoplasms (2) · Emergencies (2) · Lymphoma (2) · Agnosia (1) · Breast Neoplasms, Male (1) · Burkitt Lymphoma (1) · Carcinoma in Situ (1) · Colonic Neoplasms (1) · Facial Neuralgia (1) · Headache Disorders, Primary (1)
National Cancer Institute (NCI) (4) · Montefiore Medical Center (2) · University Medical Center of Southern Nevada (2) · Wake Forest University Health Sciences (2) · Albert Einstein Healthcare Network (1) · Australasian Leukaemia and Lymphoma Group (1) · CHRISTUS Health (1) · Christian Fromm, MD (1) · Dayton Children's Hospital (1) · Emory University (1) · Gary Morrow (1) · Janssen Scientific Affairs, LLC (1) · Joseph Roscoe (1) · Koen van Besien (1) · Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center (1)
United States (29)
Alice P Chen, M.D. (2) · Benjamin W Friedman, MD, MS (2) · Adam Sivitz, MD (1) · Aimee Rolston (1) · Andrew Grigg, Professor (1) · Carey Nichols, MD (1) · Christian Fromm, MD (1) · Christopher Pitotti, MD (1) · Daniel A Spyker, MD (1) · Daniel T Wu, MD (1) · David Tanen, MD (1) · Elan Small, MD (1) · Frank Gutierrez, MD (1) · Gary R. Morrow, PhD, MS (1)
PMID 11535479, PMID 12598264, PMID 12764341, PMID 14633551, PMID 15107371, PMID 16198982, PMID 17157685, PMID 18006188, PMID 18387702, PMID 18534808, PMID 18958996, PMID 20045576, PMID 21880111, PMID 22915657, PMID 23567060, PMID 23574119, PMID 23936605, PMID 24127709, PMID 24180163, PMID 24224624, PMID 25024303, PMID 25366551, PMID 25817884, PMID 29033296, PMID 29046364, PMID 29089172, PMID 2915441, PMID 29748435, PMID 30125215, PMID 32620543, PMID 33528788, PMID 33558725, PMID 34363617, PMID 34432874, PMID 35436231, PMID 35882475, PMID 36302173, PMID 39574186, PMID 7486359, PMID 9707750
R01CA200579 (1), U10CA037420 (1), UG1CA189961 (1)