12 completed, 4 recruiting, 4 terminated, 1 enrolling by invitation. 15 Not applicable, 2 Phase 4, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 15 | Completed 8, Terminated 3, Recruiting 2, Enrolling by invitation 1, Not yet recruiting 1 |
| Phase 4 | 2 | Completed 2 |
| Phase 3 | 1 | Completed 1 |
Follow Fundoplication: new trials by email Literature Review of Fundoplication trials Research Report on Fundoplication
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Preoperative Predictors of Symptom Improvement After Laparoscopic Fundoplication Laparoscopic Nissen fundoplication, Laparoscopic Toupet fundoplication - Gastroesophageal Reflux Disease, Hiatal Hernia | Recruiting | Minia University | 470 | 2026-09-20 | 2026-09-22 | |
| A Blinded Randomized Clinical Study of RefluxStop™ Compared With Nissen Fundoplication in the Treatment of GERD RefluxStop™ implantation, Nissen fundoplication - GERD (Gastroesophageal Reflux Disease) | Not applicable | Not yet recruiting | Implantica CE Reflux Ltd. | 200 | 2025-08-01 | 2025-06-04 |
| Laparoscopic Management of Gastroesophageal Reflux Disease in Children fundoplication - Gastric Function Disorder | Not applicable | Recruiting | Tanta University | 36 | 2025-03-01 | 2026-07-16 |
| Nissen Versus Dor Hiatal Hernia Repair Nissen fundoplication, Dor fundoplication - Hiatal Hernia, Paraesophageal Hernia | Not applicable | Recruiting | Kuopio University Hospital | 150 | 2025-02-07 | 2025-02-19 |
| Fundoplication in Laparoscopic PEH Repair Based on FLIP Laparoscopic paraesophageal hernia repair without fundoplication - Paraesophageal Hernia | Not applicable | Enrolling by invitation | The Foundation for Surgical Innovation and Education | 260 | 2023-02-22 | 2024-11-27 |
| Post-Market Registry for the Evaluation of RefluxStop in GERD Treatment RefluxStop implantation, Nissen fundoplication - Gastroesophageal Reflux Disease (GERD) | Recruiting | Implantica CE Reflux Ltd. | 2500 | 2023-02-20 | 2025-04-01 | |
| TuLip : Role of the Tumor Environment in Cancer-related Fat Loss Nissen Fundoplication, cholecystectomy - Cancer, Cachexia | Not applicable | Terminated | Université Catholique de Louvain | 5 | 2022-11-16 | 2024-05-09 |
| Health, Economic Analysis and Clinical Aspects of Patients With Neurological Disabilities in Enteral Nutrition With Dedicated Formula. The Role of Nissen's Fundoplication in the Management of Gastroesophageal Reflux Nissen fundoplication, Enteral nutrition - Gastro-Esophageal Reflux, Fundoplication | Unknown | Bambino Gesù Hospital and Research Institute | 360 | 2021-11-01 | 2021-10-22 | |
| LINX Reflux Management System or Fundoplication Clinical Study in Patients With Hiatal Hernia >3 cm LINX Reflux Management System, Fundoplication - Hiatal Hernia Large, Gastro Esophageal Reflux | Terminated | Foregut Research Foundation | 336 | 2021-01-14 | 2026-02-09 | |
| Registry of Outcomes From AntiReflux Surgery Laparoscopic Fundoplication, LINX Antireflux - Gastroesophageal Reflux Disease, Hiatal Hernia | Completed | The Heartburn Foundation | 1941 | 2016-05-01 | 2026-08-07 | |
| Treatment of IPF With Laparoscopic Anti-Reflux Surgery Surgery - Idiopathic Pulmonary Fibrosis, Gastroesophageal Reflux | Not applicable | Completed | University of California, San Francisco | 58 | 2013-12-01 | 2021-10-25 |
| Influence of Wrap Fixation Technique on the Results of Fundoplication Nissen Fundoplication with wrap fixation, Nissen Fundoplication without wrap fixation - Gastro Oesophageal Reflux Disease | Not applicable | Completed | Grubnik Volodymyr | 138 | 2012-11-01 | 2020-04-06 |
| A Randomized Trial of Medical and Surgical Treatments for Patients With GERD Symptoms That Are Refractory to Proton Pump Inhibitors Nissen fundoplication, baclofen, Desipramine - GERD | Phase 3 | Completed | VA Office of Research and Development | 366 | 2012-08-13 | 2020-01-22 |
| Comparative Anti-Reflux Procedures in Neurologically Impaired Children Fundoplication, Gastrojejunal (GJ) feeding tube - Gastroesophageal Reflux, Nervous System Diseases | Not applicable | Completed | University of Utah | 3 | 2011-01-01 | 2013-10-21 |
| The Role of Anti-Reflux Surgery for Gastroesophageal Reflux Disease in Premature Infants With Bronchopulmonary Dysplasia Fundoplication - Gastroesophageal Reflux Disease, Bronchopulmonary Dysplasia | Phase 4 | Completed | The University of Texas Health Science Center, Houston | 2 | 2009-06-01 | 2014-12-11 |
| vMII for Measurement of Oesophageal Bolus Transport and Reflux Heller's Myotomy, Nissen Fundoplication, domperidone or esomeprazole (Conservative management) - Achalasia, GORD | Not applicable | Terminated | Guy's and St Thomas' NHS Foundation Trust | 140 | 2007-11-01 | 2009-08-03 |
| Clinical Trial Comparing Open and Laparoscopic Nissen Fundoplication in Children Nissen fundoplication - Gastroesophageal Reflux | Not applicable | Completed | Johns Hopkins University | 68 | 2005-11-01 | 2018-08-01 |
| Is Laparoscopic Fundoplication Better Than Open Fundoplication in Children ? Fundoplication - Gastroesophageal Reflux | Not applicable | Terminated | Oslo University Hospital | 88 | 2003-01-01 | 2012-03-12 |
| Nissen and Gastroplasty in Gastroesophageal Reflux Disease (GERD) Nissen, Gastropexy - Gastroesophageal Reflux Disease, Hiatal Hernia | Phase 4 | Completed | G. Hatzikosta General Hospital | 90 | 2002-01-01 | 2009-03-31 |
| Comparison of Total and Partial Fundoplication During Surgery of Patients With Gastroesophageal Reflux Disease Nissen, Toupét - Reflux, Gastroesophageal | Not applicable | Completed | Karolinska Institutet | 460 | 2001-11-01 | 2018-10-29 |
Showing 20 of 23. Sign in to see all of them.
Gastroesophageal Reflux (19) · Hernia, Hiatal (6) · Barrett Esophagus (2) · Deglutition Disorders (2) · Bronchopulmonary Dysplasia (1) · Cachexia (1) · Esophageal Achalasia (1) · Esophagitis (1) · Esophagitis, Peptic (1) · Heartburn (1) · Idiopathic Pulmonary Fibrosis (1) · Laryngopharyngeal Reflux (1) · Neoplasms (1) · Nervous System Diseases (1) · Recurrence (1)
Implantica CE Reflux Ltd. (2) · Bambino Gesù Hospital and Research Institute (1) · Federal University of São Paulo (1) · Foregut Research Foundation (1) · G. Hatzikosta General Hospital (1) · Grubnik Volodymyr (1) · Guy's and St Thomas' NHS Foundation Trust (1) · Johns Hopkins University (1) · Karolinska Institutet (1) · Kuopio University Hospital (1) · Minia University (1) · Oslo University Hospital (1) · Region Skane (1) · Tanta University (1) · The Foundation for Surgical Innovation and Education (1)
United States (8) · Italy (3) · Egypt (2) · Germany (2) · Norway (2) · Switzerland (2) · Austria (1) · Belgium (1) · Brazil (1) · Finland (1) · Greece (1) · Sweden (1) · United Kingdom (1)
Anders Thorell, professor (1) · Benoit Navez, Professor (1) · Christy M Dunst, MD (1) · Evangelos C. Tsimoyiannis, M.D. chairman (1) · Francisco Farah, MD (1) · Ganesh Raghu, MD (1) · Harold R Collard, MD (1) · Kevin J Anstrom, PhD (1) · Kristin Bjornland, MD, PhD (1) · KuoJen Tsao, M.D. (1) · Mark Fox, MD (1) · Michelle L DeOliveira, MD (1) · Paul M Colombani, MD (1) · Pauline Djerf, Md (1)
PMID 18235928, PMID 19960205, PMID 26518379, PMID 30100404, PMID 30840057, PMID 31124989, PMID 31618539, PMID 35915187, PMID 38570069
1UM1HL119089 (1)