21 completed. 21 Phase 1, 11 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 21 | Completed 21 |
| Phase 2 | 11 | Completed 11 |
Follow Endothelial Dysfunction: new trials by email Literature Review of Endothelial Dysfunction trials Research Report on Endothelial Dysfunction
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| COMP-4 Supplementation and Brachial Artery FMD COMP-4 - Aging, Endothelial Dysfunction | Phase 1 / Phase 2 | Completed | University of California, Los Angeles | 32 | 2023-06-01 | 2026-03-09 |
| A Trial to Evaluate the Effect of C21 on Endothelial Dysfunction in Subjects With Type 2 Diabetes C21 - Type2diabetes, Endothelial Dysfunction | Phase 1 | Completed | Vicore Pharma AB | 11 | 2023-03-31 | 2024-11-12 |
| Study of Safety and Tolerability of EO2002 in the Treatment of Corneal Edema EO2002, EO2002 low dose, EO2002 mid dose - Corneal Edema, Corneal Endothelial Dysfunction | Phase 1 | Completed | Emmecell | 42 | 2021-06-22 | 2025-03-05 |
| Investigation of the Effects of Dietary Nitrate and Sex on COVID-19 Vaccine Induced Vascular Dysfunction in Healthy Men and Women (DiNOVasc-COVID-19) COVID-19 vaccine, Concentrate beetroot Juice, Nitrate-deplete beetroot juice - Cardiovascular Diseases, Endothelial Dysfunction | Phase 1 | Completed | Queen Mary University of London | 42 | 2021-05-10 | 2026-09-25 |
| A Phase 1/ Phase 2 Study of TTHX1114(NM141) TTHX1114(NM141), Vehicle (placebo) - Corneal Endothelial Dystrophy, Fuchs Endothelial Corneal Dystrophy | Phase 1 / Phase 2 | Completed | Trefoil Therapeutics, Inc. | 22 | 2020-08-19 | 2023-10-30 |
| Wild Blueberries and Cardiovascular Health in Middle-aged/Older Men and Postmenopausal Women Blueberry Powder, Placebo Powder - Hypertension, Aging | Phase 1 / Phase 2 | Completed | Colorado State University | 60 | 2020-01-01 | 2026-10-30 |
| Subarachnoid Hemorrhage and Soluble Epoxide Hydrolase Inhibition Trial GSK2256294, Placebo - Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia | Phase 1 / Phase 2 | Completed | Oregon Health and Science University | 20 | 2018-05-02 | 2021-01-22 |
| Effects of Carbon Monoxide Breathing on Blood Vessel Function Carbon Monoxide - Endothelial Dysfunction | Phase 1 | Completed | Cedars-Sinai Medical Center | 9 | 2017-06-23 | 2019-04-01 |
| CD36 in Nutrient Delivery and Its Dysfunction Sildenafil Citrate in G allele carrier, Sildenafil Citrate in non G allele carrier - Insulin Resistance, Endothelial Dysfunction | Phase 1 / Phase 2 | Completed | Vanderbilt University Medical Center | 26 | 2017-01-01 | 2022-11-30 |
| N-acetylcysteine to Reduce Oxidative Stress and Improve Endothelial Function in HIV-infected Older Adults PharmaNAC (N-acetylcysteine), Matching placebo - HIV, Endothelial Dysfunction | Phase 1 / Phase 2 | Completed | Indiana University | 24 | 2013-10-01 | 2016-02-08 |
| Impact of Oranges on Cardiovascular Health Citrus supplement, Placebo - Blood Pressure, Endothelial Dysfunction | Phase 1 / Phase 2 | Completed | University of Leeds | 25 | 2013-06-01 | 2014-04-01 |
| Effect of Proton Pump Inhibitors on Endothelial Function Lansoprazole, Placebo - Endothelial Dysfunction | Phase 1 | Completed | Stanford University | 21 | 2013-03-01 | 2022-08-23 |
| Effects of Trans-Resveratrol in Endothelial Function in Hypertensive Patients Trans-resveratrol, Placebo - Endothelial Dysfunction | Phase 1 | Completed | Hospital Universitario Pedro Ernesto | 24 | 2013-01-01 | 2015-11-30 |
| Effect of Vitamin D Supplementation on Endothelial Function in Obese Adolescents Vitamin D3 - Obesity, Endothelial Dysfunction | Phase 1 | Completed | Mayo Clinic | 19 | 2012-11-01 | 2016-05-02 |
| Effects of Dietary Nitrate on Age-related Vascular Function Nitrate, Placebo - Endothelial Dysfunction | Phase 1 / Phase 2 | Completed | Heinrich-Heine University, Duesseldorf | 20 | 2012-10-01 | 2013-12-09 |
| Cocoa Flavanols in Renal Disease Cocoa - End Stage Renal Disease, Endothelial Dysfunction | Phase 1 / Phase 2 | Completed | Klinik für Kardiologie, Pneumologie und Angiologie | 22 | 2011-08-01 | 2013-11-13 |
| Impact of Smoking Cessation and γ-Tocopherol to Restore Vascular Endothelial Function Nicotine Replacement Therapy (NRT), Gamma-Tocopherol, Placebo - Endothelial Dysfunction | Phase 1 / Phase 2 | Completed | University of Connecticut | 67 | 2011-01-01 | 2015-01-21 |
| Assessment of Coronary Plaque Composition Using Optical Coherence Tomography Optical Coherence Tomography (C7 XR Dragonfly ) - Coronary Atherosclerosis, Endothelial Dysfunction | Phase 1 | Completed | Mayo Clinic | 41 | 2010-10-01 | 2016-10-03 |
| Autonomic Nervous System and Nitric Oxide Interactions Trimethaphan, Placebo - Endothelial Dysfunction | Phase 1 | Completed | Vanderbilt University | 21 | 2010-06-01 | 2018-02-28 |
| Assessment of Coronary Plaque Composition LipiScan/LipiScan IVUS - Coronary Atherosclerosis, Endothelial Dysfunction | Phase 1 | Completed | Mayo Clinic | 39 | 2010-01-01 | 2019-03-05 |
Showing 20 of 21. Sign in to see all of them.
Cardiovascular Diseases (3) · Atherosclerosis (2) · Corneal Dystrophy, Posterior Polymorphous, 1 (2) · Coronary Artery Disease (2) · Fuchs' Endothelial Dystrophy (2) · Hypertension (2) · COVID-19 (1) · Coitus (1) · Corneal Edema (1) · Coronary Vasospasm (1) · Insulin Resistance (1) · Kidney Failure, Chronic (1) · Multiple Endocrine Neoplasia Type 1 (1) · Obesity (1) · Smoking Cessation (1)
Vascular Diseases (5) · Cardiovascular Diseases (4) · Arterial Occlusive Diseases (3) · Arteriosclerosis (3) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (3) · Genetic Diseases, Inborn (3) · Pathological Conditions, Signs and Symptoms (3) · Behavior (2) · Corneal Diseases (2) · Corneal Dystrophies, Hereditary (2) · Coronary Disease (2) · Eye Diseases (2) · Eye Diseases, Hereditary (2) · Heart Diseases (2) · Myocardial Ischemia (2)
Acetylcysteine (1) · COVID-19 Vaccines (1) · Carbon Monoxide (1) · Chocolate (1) · Cholecalciferol (1) · Corn Oil (1) · Dental Occlusion (1) · Lansoprazole (1) · N-((4-cyano-2-(trifluoromethyl)phenyl)methyl)-3-((4-methyl-6-(methylamino)-1,3,5-triazin-2-yl)amino)cyclohexanecarboxamide (1) · Nicotine (1) · Nicotine Replacement Therapy (1) · Nitrates (1) · Resveratrol (1) · Sildenafil Citrate (1) · Tobacco Use Cessation Devices (1)
Mayo Clinic (3) · Azienda Ospedaliera San Camillo Forlanini (1) · Cedars-Sinai Medical Center (1) · Colorado State University (1) · Emmecell (1) · Heinrich-Heine University, Duesseldorf (1) · Hospital Universitario Pedro Ernesto (1) · Indiana University (1) · Klinik für Kardiologie, Pneumologie und Angiologie (1) · Oregon Health and Science University (1) · Queen Mary University of London (1) · Stanford University (1) · Trefoil Therapeutics, Inc. (1) · University of California, Los Angeles (1) · University of Connecticut (1)
United States (14) · Germany (2) · United Kingdom (2) · Italy (1) · Sweden (1)
Abdurrahman M Sweidan (1) · Amir Lerman, MD (1) · Cyndya Shibao, MD (1) · Mischie Nicolae Alexandru, MD (1) · Nazzaro Marco, MD (1) · Nicholas Leeper, MD (1) · Noelia Kunzevitzky (1) · Rajiv Gulati, MD (1) · Richard S Bruno, PhD, RD (1) · Ronald Victor, MD (1) · Ross Martini, MD (1) · Samir K Gupta, MD, MS (1) · Seema Kumar, MD (1) · Sriram V. Eleswarapu, MD PhD (1) · Thomas M Tremblay, RN BSN (1)
PMID 23359371, PMID 24075893, PMID 25361769, PMID 25578927, PMID 25835348, PMID 26273791, PMID 26485680, PMID 27893465, PMID 30764644, PMID 32576603, PMID 33035428, PMID 34873674, PMID 37715222, PMID 37916745, PMID 39503770
2023 (1), UL1TR000135 (1)