24 completed, 6 recruiting, 3 active not recruiting, 3 unknown. 11 Not applicable, 6 Phase 1, 6 Phase 4, 5 Phase 2, 4 Phase 3.
Follow Corneal Edema: new trials by email Literature Review of Corneal Edema trials Research Report on Corneal Edema
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of EO2002 in Subjects With Corneal Edema Secondary to Corneal Endothelial Dysfunction 150K cells, 500K cells, Placebo - Corneal Edema, Fuchs | Phase 2 | Recruiting | Emmecell | 121 | 2026-10-01 | 2026-10-09 |
| EndoArt® Implantation in Subjects With Chronic Corneal Edema - US Study The EndoArt® (Corneal Artificial Endothelial layer) - Corneal Edema | Not applicable | Not yet recruiting | Eye-yon Medical | 123 | 2026-05-01 | 2026-03-13 |
| AURN001 Efficacy in Participants With Corneal Edema Secondary to Corneal Endothelial Dysfunction Combination Product: AURN001 + Y-27632, Placebo - Corneal Edema, Corneal Endothelial Dysfunction | Phase 3 | Active not recruiting | Aurion Biotech | 130 | 2026-02-19 | 2026-09-24 |
| PVEK Corneal Implant For Treatment of Corneal Edema Precise Vision Endothelial Keratoplasty (PVEK) Implant - Corneal Edema, Fuchs' Endothelial Dystrophy | Phase 1 | Recruiting | Precise Bio | 15 | 2025-09-16 | 2026-01-12 |
| Comparison of 5% Hypertonic Saline Versus 3% Hypertonic Saline in Resolution of Post-operative Corneal Edema. 5% Hypertonic Saline, 3% Hypertonic Saline - Corneal Edema | Not applicable | Completed | Muhammad Aamir Latif | 70 | 2025-06-01 | 2026-05-22 |
| The Effect of ROCK Inhibitors on Corneas of Patients With Glaucoma and Pseudophakic Bullous Keratopathy (PBK) Netarsudil 0.02%/latanoprost 0.005% fixed dose combination ophthalmic solution, Placebo - Pseudophakic Bullous Keratopathy, Glaucoma | Phase 2 / Phase 3 | Completed | University Hospital Dubrava | 50 | 2025-05-12 | 2026-09-09 |
| The Effect of Topical Rho-kinase Inhibitors on Corneas of Patients With Fuchs Endothelial Corneal Dystrophy Netarsudil 0.02% Ophthalmic Solution, artificial tear substitute - Fuchs Endothelial Corneal Dystrophy, Cataract | Enrolling by invitation | University Hospital Dubrava | 50 | 2025-04-01 | 2026-09-09 | |
| Study of Cryopreserved AURN001 in Subjects With Corneal Edema Secondary to Corneal Endothelial Dysfunction Cryopreserved AURN001 - Corneal Edema | Phase 2 | Active not recruiting | Aurion Biotech | 25 | 2024-09-16 | 2025-01-28 |
| Plasma Rich in Growth Factors in Corneal Endothelial Transplantation Endothelial keratoplasty, PRGF - Fuchs' Endothelial Dystrophy, Corneal Edema | Not applicable | Recruiting | University of Miami | 100 | 2024-07-15 | 2026-04-09 |
| Validation of the Use of Terahertz Scanning System on Corneal Scars and Corneal Edema THz scanning using THz Imaging system. - Corneal Diseases, Corneal Scars and Opacities | Recruiting | Singapore Eye Research Institute | 150 | 2024-07-01 | 2025-05-21 | |
| Evaluation of the Safety of Terahertz Scanning System on Corneas Terahertz (THz) scanning using THz Imaging system. - Corneal Diseases | Recruiting | Singapore Eye Research Institute | 5 | 2024-04-01 | 2025-05-16 | |
| A Phase 1/2 Study of AURN001 in Subjects With Corneal Edema Secondary to Corneal Endothelial Dysfunction (ABA-1) AURN001, Corneal Endothelial Cells, Y27632 - Corneal Edema, Corneal Endothelial Dysfunction | Phase 1 / Phase 2 | Completed | Aurion Biotech | 97 | 2023-10-18 | 2025-12-17 |
| Air Optix® Night and Day® Aqua Therapeutic Wear Lotrafilcon A contact lenses, Balafilcon A contact lenses - Bullous Keratopathy, Corneal Erosion | Completed | Alcon Research | 168 | 2023-09-26 | 2024-11-13 | |
| AONDA Therapeutic Indication Study I Lotrafilcon A contact lenses - Bullous Keratopathy, Corneal Erosion | Completed | Alcon Research | 55 | 2023-06-28 | 2023-07-20 | |
| Assessing eFficacy and Safety of DEXTENZA 0.4 mg inseRt, Following Cataract Surgery Dextenza 0.4Mg Ophthalmic Insert, Prednisolone Acetate 1% Oph Susp, Prolensa 0.07% Ophthalmic Solution - Corneal Edema, Corneal Defect | Phase 4 | Completed | Nicole Fram M.D. | 50 | 2023-06-01 | 2026-02-20 |
| Study to Assess Safety and Tolerability of Multiple Doses of EO2002 EO2002, Ripasudil - Corneal Edema, Corneal Endothelial Dystrophy | Phase 1 | Recruiting | Asociación para Evitar la Ceguera en México | 12 | 2022-11-08 | 2025-12-08 |
| The Belgian Endothelial Surgical Transplant of the Cornea UT-DSAEK, DMEK - Corneal Edema, Corneal Endothelial Disorder | Not applicable | Active not recruiting | University Hospital, Antwerp | 220 | 2022-08-10 | 2026-09-14 |
| A Safety and Efficacy Study of Corneal Injection for Endothelial Dysfunction Using Human Corneal Endothelial Cell Therapy in Subjects With Corneal Edema Secondary to Endothelial Dysfunction HCEC-1 - Corneal Edema | Phase 1 | Completed | Aurion Biotech | 22 | 2022-03-24 | 2024-08-19 |
| Loteprednol Etabonate 0.25% for Prevention of Cornea Transplant Rejection loteprednol etabonate 0.25% ophthalmic suspension - Corneal Endothelial Dystrophy, Corneal Edema | Phase 4 | Completed | Price Vision Group | 70 | 2021-11-23 | 2024-08-14 |
| EndoArt® Implantation in Subjects With Chronic Corneal Edema THE ENDOART® IMPLANTATION (Artificial Endothelial layer) - Corneal Edema | Not applicable | Completed | Eye-yon Medical | 52 | 2021-09-30 | 2024-08-28 |
Showing 20 of 38. Sign in to see all of them.
Fuchs' Endothelial Dystrophy (13) · Corneal Dystrophy, Posterior Polymorphous, 1 (4) · Eye Pain (3) · Cataract (2) · Corneal Diseases (2) · Corneal Dystrophies, Hereditary (2) · Entropion (2) · Glaucoma (2) · Bell Palsy (1) · Corneal Endothelial Cell Loss (1) · Corneal Endothelial Dystrophy 1 (1) · Corneal Injuries (1) · Corneal Ulcer (1) · Corneal dystrophy, Fuchs' endothelial, 1 (1)
Eye Diseases (38) · Corneal Diseases (36) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (15) · Eye Diseases, Hereditary (15) · Genetic Diseases, Inborn (15) · Corneal Dystrophies, Hereditary (13) · Pathological Conditions, Signs and Symptoms (5) · Signs and Symptoms (5) · Eye Manifestations (4) · Neurologic Manifestations (3) · Pain (3) · Eyelid Diseases (2) · Lens Diseases (2) · Nervous System Diseases (2) · Ocular Hypertension (2)
Calcium Dobesilate (3) · prednisolone acetate (3) · Descemet Stripping Endothelial Keratoplasty (2) · Dexamethasone (2) · Loteprednol Etabonate (2) · Ophthalmic Solutions (2) · Y 27632 (2) · netarsudil (2) · Brimonidine Tartrate (1) · Control Groups (1) · Corneal Transplantation (1) · Drug Implants (1) · Hyaluronic Acid (1) · Hypromellose Derivatives (1) · Intraocular Pressure (1)
Aurion Biotech (4) · Eye-yon Medical (4) · Nicole Fram M.D. (3) · Alcon Research (2) · Cornea Research Foundation of America (2) · Emmecell (2) · Singapore Eye Research Institute (2) · University Hospital Dubrava (2) · Aerie Pharmaceuticals (1) · Asociación para Evitar la Ceguera en México (1) · Cairo University (1) · Edward J. Holland (1) · Mayo Clinic (1) · Muhammad Aamir Latif (1) · Precise Bio (1)
United States (16) · Israel (5) · Germany (3) · Croatia (2) · El Salvador (2) · Mexico (2) · Singapore (2) · Armenia (1) · Belgium (1) · Brazil (1) · Canada (1) · Egypt (1) · France (1) · Georgia (1) · India (1)
Francis W Price, Jr., MD (2) · Nicole R Fram, M.D. (2) · Alfonso L Sabater, MD (1) · Anat Robinson, MD (1) · Anum Amin (1) · Bernard Duchesne, MD, PhD (1) · Carina Koppen, MD, PhD (1) · Edward J Holland, MD (1) · Eric D Donnenfeld, MD (1) · Francis W Price, Jr, MD (1) · Irit Bachar, Md (1) · Josip Pavan, MD, PhD (1) · Josip Pavan, prof.dr.sc. (1)
PMID 17996211, PMID 19298950, PMID 21704965, PMID 22357383, PMID 23018304, PMID 25015214, PMID 26020827, PMID 30367938, PMID 33014443, PMID 33892048, PMID 36327101, PMID 37714670, PMID 37733966