57 completed, 26 recruiting, 20 unknown, 5 terminated. 44 Not applicable, 19 Phase 2, 12 Phase 1, 8 Phase 3, 5 Phase 4.
Follow Corneal Dystrophies, Hereditary: new trials by email Literature Review of Corneal Dystrophies, Hereditary trials Research Report on Corneal Dystrophies, Hereditary
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Partial Range Of Field IOLs in DMEK-Enabled Procedures combined cataract and lamellar endothelial keratoplasty - Cataract, Fuchs Endothelial Corneal Dystrophy | Not applicable | Not yet recruiting | Universitair Ziekenhuis Brussel | 10 | 2026-10-01 | 2026-08-25 |
| Safety and Efficacy Study of GEB-101 Injection in Subjects With TGFBI-related Corneal Dystrophy GEB-101 Injection - Hereditary Corneal Dystrophy, Corneal Abnormality | Phase 1 / Phase 2 | Not yet recruiting | GenEditBio Limited | 30 | 2026-10-01 | 2026-09-10 |
| Study of EO2002 in Subjects With Corneal Edema Secondary to Corneal Endothelial Dysfunction 150K cells, 500K cells, Placebo - Corneal Edema, Fuchs | Phase 2 | Recruiting | Emmecell | 121 | 2026-10-01 | 2026-10-09 |
| Postoperative CCT in FECD vs. Non-FECD Fuchs Endothelial Corneal Dystrophy, Cataract (Post-operative Cataract Surgery Follow-up) | Not yet recruiting | Vienna Hospital Association | 98 | 2026-07-20 | 2026-08-10 | |
| Effect of Descemet Membrane Polishing in Fuchs Endothelial Corneal Dystrophy Fuchs Polishing - Fuchs Endothelial Corneal Dystrophy | Not applicable | Recruiting | Centre Hospitalier Universitaire de Saint Etienne | 20 | 2026-05-21 | 2026-05-26 |
| Effect of Donor Diabetes and Other Factors on Corneal Transplant Endothelial Cell Loss and Success at 5 Years Descemet membrane endothelial keratoplasty - Fuchs Endothelial Corneal Dystrophy, Corneal Endothelial Decompensation | Not applicable | Enrolling by invitation | Case Western Reserve University | 570 | 2025-12-03 | 2026-02-27 |
| Assessment of Corneal Endothelial Function Following Hypoxic Stress Wearing of contact lens - Fuchs' Endothelial Corneal Dystrophy | Phase 1 / Phase 2 | Withdrawn | Massachusetts Eye and Ear Infirmary | 2025-12-01 | 2026-03-02 | |
| Influence of Supine Positioning on the Outcomes After Descemet Membrane Endothelial Keratoplasty (DMEK) Duration of Supine Positioning - Fuchs Endothelial Corneal Dystrophy, Descemet Membrane Endothelial Keratoplasty (DMEK) | Not applicable | Recruiting | University Hospital Heidelberg | 102 | 2025-10-02 | 2026-01-28 |
| PVEK Corneal Implant For Treatment of Corneal Edema Precise Vision Endothelial Keratoplasty (PVEK) Implant - Corneal Edema, Fuchs' Endothelial Dystrophy | Phase 1 | Recruiting | Precise Bio | 15 | 2025-09-16 | 2026-01-12 |
| DT-168 in Keratoplasty Patients With Fuchs Endothelial Corneal Dystrophy DT-168 - Fuchs Endothelial Corneal Dystrophy, Fuchs | Phase 2 | Recruiting | Design Therapeutics, Inc. | 70 | 2025-07-30 | 2026-09-28 |
| Microsurgical Robot-assisted Corneal Transplant Robot-assisted keratoplasty - Corneal Dystrophy | Not applicable | Recruiting | CHU de Reims | 10 | 2025-06-06 | 2025-06-26 |
| The Effect of Topical Rho-kinase Inhibitors on Corneas of Patients With Fuchs Endothelial Corneal Dystrophy Netarsudil 0.02% Ophthalmic Solution, artificial tear substitute - Fuchs Endothelial Corneal Dystrophy, Cataract | Enrolling by invitation | University Hospital Dubrava | 50 | 2025-04-01 | 2026-09-09 | |
| Brillouin Microscopy Used to Evaluate Corneal Mechanical Properties Brillouin optical scanning system (Intelon Optics) (BOSS) - Map Dot Fingerprint Dystrophy, Post-penetrating Keratoplasty | Not applicable | Not yet recruiting | Vienna Institute for Research in Ocular Surgery | 100 | 2025-04-01 | 2025-04-06 |
| The Effects of Ripasudil in Patients With FED Undergoing Femtosecond Laser Assisted Cataract Surgery Ripasudil, Placebo - Fuchs' Endothelial Dystrophy, Cataract | Phase 3 | Recruiting | Singapore Eye Research Institute | 120 | 2025-03-01 | 2025-01-29 |
| Trial Comparing Cataract Surgery With Triple-DMEK in Patients With Cataract and Fuchs Endothelial Corneal Dystrophy Intervention group /arm 1 (Cataract surgery alone), Control group /arm 2: Corneal transplantation as Descemet Membrane Endothelial Keratoplasty (DMEK) in combination with cataract surgery (triple-DMEK) - Cataract Surgery, Cataract and Fuchs Endothelial Corneal Dystrophy | Not applicable | Recruiting | University of Cologne | 120 | 2025-01-24 | 2025-02-21 |
| Comparison of Outcomes Between Femtosecond Laser-Assisted and Conventional Phacoemulsification in Fuchs Endothelial Corneal Dystrophy Patients With Cataracts Fuchs Endothelial Corneal Dystrophy, Cataract | Recruiting | Eye & ENT Hospital of Fudan University | 120 | 2025-01-01 | 2025-06-17 | |
| Analysis of the Genotype/Phenotype Relationship in the Fuchs' Corneal Endothelial Dystrophy in France Genotyping, Histology, Collection of data - Corneal Dystrophies | Recruiting | Centre Hospitalier Universitaire de Saint Etienne | 500 | 2024-08-08 | 2026-05-06 | |
| The OPTIMISE Study Fluorometholone 0.1% Oph Susp, Dexamethasone 0.1% ophthalmic suspension, Stop steroids - Pseudophakic Bullous Keratopathy, Fuchs' Endothelial Dystrophy | Phase 4 | Recruiting | Maastricht University Medical Center | 342 | 2024-07-29 | 2025-10-06 |
| Plasma Rich in Growth Factors in Corneal Endothelial Transplantation Endothelial keratoplasty, PRGF - Fuchs' Endothelial Dystrophy, Corneal Edema | Not applicable | Recruiting | University of Miami | 100 | 2024-07-15 | 2026-04-09 |
| National Ophthalmic Genotyping and Phenotyping Network (eyeGENE (Registered Trademark)), Stage 3 - Expansion of DNA and Data Repositories for Rare Inherited Ophthalmic Diseases Inherited Ophthalmic Diseases, Hypopigmentation Disorder | Recruiting | National Eye Institute (NEI) | 1000 | 2024-07-12 | 2026-06-09 |
Showing 20 of 120. Sign in to see all of them.
Fuchs' Endothelial Dystrophy (92) · Corneal Edema (15) · Cataract (13) · Keratoconus (13) · Corneal Diseases (11) · Corneal Dystrophy, Posterior Polymorphous, 1 (8) · Corneal Opacity (4) · Corneal Ulcer (4) · Corneal Endothelial Cell Loss (3) · Corneal endothelial dystrophy type 2 (3) · Keratitis, Herpetic (3) · Retinal Detachment (3) · Diabetes Mellitus (2) · Entropion (2)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (120) · Eye Diseases, Hereditary (120) · Genetic Diseases, Inborn (120) · Eye Diseases (119) · Corneal Diseases (109) · Lens Diseases (13) · Eye Infections (6) · Infections (6) · Keratitis (6) · Pathological Conditions, Signs and Symptoms (6) · Retinal Diseases (6) · Nervous System Diseases (5) · Signs and Symptoms (5) · DNA Virus Infections (4)
K-115 (7) · Descemet Stripping Endothelial Keratoplasty (6) · Ophthalmic Solutions (5) · netarsudil (4) · Corneal Transplantation (3) · Cataract Extraction (2) · Drug Implants (2) · Phacoemulsification (2) · Tomography, Optical Coherence (2) · Acetylcysteine (1) · Amphotericin B (1) · Anti-Inflammatory Agents (1) · BID protein, human (1) · Blood Specimen Collection (1) · Control Groups (1)
Centre Hospitalier Universitaire de Saint Etienne (5) · Centre Hospitalier Régional Metz-Thionville (4) · Cornea Research Foundation of America (4) · Massachusetts Eye and Ear Infirmary (4) · Oregon Health and Science University (4) · Kowa Research Institute, Inc. (3) · Maastricht University Medical Center (3) · Alcon Research (2) · Case Western Reserve University (2) · Centre Hospitalier Universitaire de Besancon (2) · Emmecell (2) · Legacy Health System (2) · Medical University of Vienna (2) · National Eye Institute (NEI) (2) · Netherlands Institute for Innovative Ocular Surgery (2)
United States (49) · France (15) · Germany (12) · Denmark (8) · Spain (8) · Netherlands (7) · United Kingdom (5) · Belgium (4) · Canada (4) · China (4) · Austria (3) · Singapore (3) · Italy (2) · Mexico (2) · Turkey (Türkiye) (2)
Francis W Price, Jr, MD (5) · Shona Pendse, MD, MMSc (3) · Bernard Delbosc, MD, PhD (2) · Jonathan Lass, MD (2) · Justis P Ehlers, MD (2) · Mark A Terry, MD (2) · Ula Jurkunas, MD (2) · Albert S Jun, MD, PhD (1) · Alfonso L Sabater, MD (1) · Alice Davidson, PhD (1) · Andy Yun, PhD (1) · Anthony J Aldave, MD (1)
PMID 17102659, PMID 33591032, PMID 34633355, PMID 41126474, PMID 10548467, PMID 10656302, PMID 10673340, PMID 10951465, PMID 10976937, PMID 11006081, PMID 11527942, PMID 11778801, PMID 11778802, PMID 11978762, PMID 12126755, PMID 12719068, PMID 14638698, PMID 14741001, PMID 14745032, PMID 15043821, PMID 15068441, PMID 15728537, PMID 16368147, PMID 16805116, PMID 16877401, PMID 16936089, PMID 17013692, PMID 17081868, PMID 17102683, PMID 17224118, PMID 17321396, PMID 17413959, PMID 17449031, PMID 17481941, PMID 17568210, PMID 17681291, PMID 17963111, PMID 17996211, PMID 18216574, PMID 18361985, PMID 18626569, PMID 18724146, PMID 18811121, PMID 19273786, PMID 19298950, PMID 19338611, PMID 19426404, PMID 19442962, PMID 19553507, PMID 19555921
1UG1EY030030-01A1 (1), 1UG1EY030039-01A1 (1), 1UG1EY037206-01 (1), 2015 (1), 2016 (1), 2017 (1), 2018 (1), 5UG1EY030030-05 (1), K23EY022947 (1), R01EY018184 (1), R01EY029023 (1)