7 completed, 1 not yet recruiting, 1 recruiting, 1 terminated. 7 Not applicable, 2 Phase 1, 1 Early Phase 1, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 7 | Completed 5, Not yet recruiting 1, Recruiting 1 |
| Phase 1 | 2 | Completed 1, Unknown 1 |
| Early Phase 1 | 1 | Completed 1 |
| Phase 4 | 1 | Terminated 1 |
Follow this drug Literature Review of Substance P trials Research Report on Substance P
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Substance P-Induced Migraine Attacks Without Aura Substance P, Placebo - Migraine | Not applicable | Recruiting | Danish Headache Center | 21 | 2025-05-13 | 2025-06-05 |
| Effects of Substance P on Headache Induction in Healthy Individuals Substance P, Placebo - Healthy Volunteers Only | Not applicable | Not yet recruiting | Danish Headache Center | 21 | 2024-10-14 | 2024-10-15 |
| Substance P Challenge in Healthy Participants Substance P, Normal Saline, Histamine - Skin Diseases | Not applicable | Completed | GlaxoSmithKline | 32 | 2021-03-02 | 2025-01-20 |
| Mechanism(s) Underlying Hypotensive Response to ARB/NEP Inhibition - Aim 1 Valsartan, LCZ696, Bradykinin - Hypertension | Phase 4 | Terminated | Vanderbilt University Medical Center | 4 | 2018-11-15 | 2025-08-03 |
| Neuropeptide Therapy of Recent Onset Type 1 Diabetes Substance P - Diabetes Mellitus, Type 1 | Phase 1 | Unknown | Vanilloid Genetics Inc. | 12 | 2016-05-01 | 2020-05-21 |
| Effect of Urocortins in Patients With Heart Failure Urocortin 2, Urocortin 3 and Substance P - Heart Failure, Endothelium | Not applicable | Completed | University of Edinburgh | 22 | 2012-05-01 | 2013-06-25 |
| Pharmacogenetics of Ace Inhibitor-Associated Angioedema Sitagliptin (DPP4 inhibitor), Substance P,, bradykinin - Hypertension, Diabetes Type 2 | Not applicable | Completed | Vanderbilt University | 44 | 2011-11-01 | 2015-11-04 |
| Effects of Urocortins on Forearm Arterial Blood Flow in Healthy Volunteers (Protocol 3) NO clamp, Saline, Fluconazole - Vascular Disease, Heart Disease | Not applicable | Completed | University of Edinburgh | 10 | 2011-07-01 | 2012-05-15 |
| Reduction of IgE Antibody in Human Allergic Subjects substance P, substance P injections - Seasonal Allergic Rhinitis | Phase 1 | Completed | Northwestern University | 40 | 2011-01-01 | 2018-08-21 |
| Effects of Urocortins on Forearm Arterial Blood Flow in Healthy Volunteers (Protocol 2) Urocortin 2, Urocortin 3, Saline placebo - Vascular Disease, Heart Disease | Not applicable | Completed | University of Edinburgh | 12 | 2010-08-01 | 2024-05-02 |
| Leptin Infusion and Endothelial Vasomotor Response Leptin infusion plus vasodilators in healthy men, Leptin infusion in healthy men, Vasodilators in CAD patients - Endothelial Dysfunction, Obesity | Early Phase 1 | Completed | Stefan Soderberg | 103 | 2006-01-01 | 2023-05-09 |
Heart Failure (3) · Headache (2) · Heart Diseases (2) · Hypertension (2) · Vascular Diseases (2) · Aneurysm (1) · Diabetes Mellitus (1) · Diabetes Mellitus, Type 1 (1) · Diabetes Mellitus, Type 2 (1) · Migraine Disorders (1) · Obesity (1) · Pain (1) · Rhinitis, Allergic (1) · Rhinitis, Allergic, Seasonal (1) · Skin Diseases (1)
University of Edinburgh (3) · Danish Headache Center (2) · GlaxoSmithKline (1) · Northwestern University (1) · Stefan Soderberg (1) · Vanderbilt University (1) · Vanderbilt University Medical Center (1) · Vanilloid Genetics Inc. (1)
United Kingdom (4) · United States (3) · Denmark (2) · Canada (1) · Netherlands (1) · Sweden (1)
David E Newby, PhD FRCP (2) · David E Newby, PhD, FRCP (1) · Etienne Sochett, MD (1) · Nancy J Brown, MD (1) · Paul A Greenberger, M.D. (1)
PMID 23525432, PMID 24516103, PMID 25158865, PMID 40066842, PMID 40369974