6 completed, 4 terminated, 2 withdrawn, 1 unknown. 6 Not applicable, 3 Phase 1, 2 Phase 4, 1 Early Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 6 | Completed 3, Withdrawn 2, Terminated 1 |
| Phase 1 | 3 | Completed 1, Terminated 1, Unknown 1 |
| Phase 4 | 2 | Completed 1, Terminated 1 |
| Early Phase 1 | 1 | Completed 1 |
| Phase 2 | 1 | Terminated 1 |
Follow Bradykinin: new trials by email Literature Review of Bradykinin trials Research Report on Bradykinin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Mechanism(s) Underlying Hypotensive Response to ARB/NEP Inhibition - Aim 1 Valsartan, LCZ696, Bradykinin - Hypertension | Phase 4 | Terminated | Vanderbilt University Medical Center | 4 | 2018-11-15 | 2025-08-03 |
| Comparative Effects of Aspirin and NHP-544C Bradykinin, Aspirin 81 mg, Aspirin 162 mg - Healthy | Not applicable | Completed | Vanderbilt University | 61 | 2014-07-01 | 2016-07-12 |
| Nebivolol and Endothelial Regulation of Fibrinolysis (NERF) Nebivolol, Metoprolol, Placebo - Prehypertension, Hypertension | Phase 4 | Completed | University of Colorado, Boulder | 44 | 2012-02-01 | 2019-06-25 |
| Pharmacogenetics of Ace Inhibitor-Associated Angioedema Sitagliptin (DPP4 inhibitor), Substance P,, bradykinin - Hypertension, Diabetes Type 2 | Not applicable | Completed | Vanderbilt University | 44 | 2011-11-01 | 2015-11-04 |
| Intracoronary Bradykinin Mediated t-PA Release in Heart Transplant Recipients Bradykinin - Heart Transplantation | Not applicable | Withdrawn | Vanderbilt University | 2008-10-01 | 2017-03-20 | |
| Brachial Artery t-PA Release in Heart Transplant Recipients Bradykinin - Heart Transplantation | Not applicable | Withdrawn | Vanderbilt University | 2008-10-01 | 2016-07-15 | |
| Renin-Angiotensin Aldosterone System and Fibrinolysis Interaction in Humans-Specific Aim 3 Control (bradykinin), L-NMMA + bradykinin, Isosorbide + L-NMMA + bradykinin - Obesity | Not applicable | Completed | Vanderbilt University | 24 | 2007-12-01 | 2013-02-25 |
| Characterization of Brachial Arterial t-PA Release, Endothelial Function, Obesity and Inflammation Bradykinin - Obesity | Not applicable | Terminated | Vanderbilt University | 13 | 2007-01-01 | 2017-07-14 |
| Leptin Infusion and Endothelial Vasomotor Response Leptin infusion plus vasodilators in healthy men, Leptin infusion in healthy men, Vasodilators in CAD patients - Endothelial Dysfunction, Obesity | Early Phase 1 | Completed | Stefan Soderberg | 103 | 2006-01-01 | 2023-05-09 |
| Tissue-Type Plasminogen Activator (t-PA) Release Predicts Major Adverse Cardiac Events (MACE) in Patients With Non-critical Coronary Artery Disease Bradykinin - Coronary Artery Disease | Phase 1 | Terminated | Vanderbilt University | 16 | 2003-12-01 | 2026-06-01 |
| Endothelial Hyperpolarization in Humans Tetraethylammonium (TEA), L-NG-monomethyl Arginine (L-NMMA), Bradykinin - Hyperlipidemia | Phase 2 | Terminated | Emory University | 174 | 2002-07-01 | 2018-08-15 |
| Effects of Miconazole on Blood Flow Miconazole, L-NMMA, Bradykinin - Healthy | Phase 1 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 15 | 2000-02-01 | 2008-03-04 |
| Vasoreactivity in Carriers of Genetic Polymorphisms sodium nitroprusside, bradykinin, acetylcholine - Healthy | Phase 1 | Unknown | Heidelberg University | 100 | 1999-11-01 | 2005-09-12 |
Hypertension (3) · Obesity (3) · Aneurysm (2) · Coronary Artery Disease (1) · Diabetes Mellitus (1) · Diabetes Mellitus, Type 2 (1) · Hyperlipidemias (1) · Prehypertension (1)
Vanderbilt University (7) · Emory University (1) · Heidelberg University (1) · National Heart, Lung, and Blood Institute (NHLBI) (1) · Stefan Soderberg (1) · University of Colorado, Boulder (1) · Vanderbilt University Medical Center (1)
United States (11) · Germany (1) · Sweden (1) · United Kingdom (1)
Nancy J Brown, MD (3) · James AS Muldowney, MD (2) · Arshed A Quyyumi, MD (1) · Christopher DeSouza, Ph.D. (1) · Douglas Vaughn, MD (1) · Walter E Haefeli, MD (1)
PMID 19841473, PMID 21555712, PMID 24516103, PMID 24675657, PMID 24925526, PMID 25158865, PMID 25648989, PMID 27069632, PMID 29122812, PMID 40066842
R01HL060906 (1), R01HL079115 (1), R01HL085740 (1), UL1RR024975 (1)